Primary Site >> Biliary tract Cancer

Gene >> NOS2

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Ref: Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.
PMID: 10646872
 Ref: Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes.
PMID: 11208728
Ref: Significance of contracted cholecystitis lesions as high risk for gallbladder carcinogenesis.
PMID: 11410319
 Ref: Correlated expression of inducible nitric oxide synthase and P53, Bax in benign and malignant diseased gallbladder.
PMID: 14704000
 Ref: Relationship between inducible nitric oxide synthase expression and angiogenesis in primary gallbladder carcinoma tissue.
PMID: 14991947
 Ref: Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line.
PMID: 15862573
Ref: Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.
PMID: 15887117
Ref: Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion.
PMID: 16094703
 Ref: iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel.
PMID: 16570287
 Ref: Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
PMID: 18676870
 Ref: Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters.
PMID: 19696162
Ref: Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program.
PMID: 19697352
 Ref: Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma.
PMID: 23260331
 Ref: Quercetin and EGCG exhibit chemopreventive effects in cholangiocarcinoma cells via suppression of JAK/STAT signaling pathway.
PMID: 24038588
 Ref: Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors.
PMID: 29693152