Primary Site >> Biliary tract Cancer

Gene >> NFE2L2

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Ref: Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer.
PMID: 18692501
Ref: Redox modulation and human bile duct cancer inhibition by curcumin.
PMID: 20510329
Ref: Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters.
PMID: 20626588
Ref: Correlation of Nrf2, HO-1, and MRP3 in gallbladder cancer and their relationships to clinicopathologic features and survival.
PMID: 20828733
Ref: Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells.
PMID: 20938215
Ref: Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinoma.
PMID: 21577322
Ref: Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways.
PMID: 22213475
Ref: Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2.
PMID: 22901367
Ref: Association of NRF2 polymorphism with cholangiocarcinoma prognosis in Thai patients.
PMID: 24528044
Ref: Repression of Nrf2 enhances antitumor effect of 5-fluorouracil and gemcitabine on cholangiocarcinoma cells.
PMID: 25708948
Ref: Nrf2 inhibition sensitizes cholangiocarcinoma cells to cytotoxic and antiproliferative activities of chemotherapeutic agents.
PMID: 27015836
Ref: The NmrA-like family domain containing 1 pseudogene Loc344887 is amplified in gallbladder cancer and promotes epithelial-mesenchymal transition.
PMID: 28245089