Primary Site >> Colorectal Cancer
Gene >> NAT2
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Ref: Distribution of acetyltransferase activities in the intestines of rapid and slow acetylator rabbits. PMID: 1860167 |
Ref: Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. PMID: 1306111 Ref: Acetyltransferases and susceptibility to chemicals. PMID: 1471166 |
Ref: Polymorphic N-acetylation of 2-aminofluorene by cell-free colon extracts from inbred mice. PMID: 7686075 Ref: Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol. PMID: 7902079 Ref: Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. PMID: 8102597 Ref: Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus. PMID: 8425184 |
Ref: Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. PMID: 7881341 |
Ref: Polymorphisms in drug-metabolizing enzymes as modifiers of cancer risk. PMID: 7497646 Ref: Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. PMID: 7585580 Ref: Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. PMID: 7627961 Ref: Acetylation polymorphism and prevalence of colorectal adenomas. PMID: 7743494 Ref: Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. PMID: 8844812 |
Ref: Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl. PMID: 8564966 Ref: Predictors of N-acetyltransferase activity: should caffeine phenotyping and NAT2 genotyping be used interchangeably in epidemiological studies? PMID: 8781741 Ref: Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility. PMID: 8895986 |
Ref: Meat consumption and preparation, and genetic susceptibility in relation to colorectal adenomas. PMID: 9103318 Ref: Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking. PMID: 9107426 Ref: Association of extracolonic manifestations of familial adenomatous polyposis with acetylation phenotype in a large FAP kindred. PMID: 9156320 Ref: Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases. PMID: 9202744 Ref: The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. PMID: 9202751 Ref: Relationship between acetylator status, smoking, and diet and colorectal cancer risk in the north-east of England. PMID: 9230278 Ref: N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions. PMID: 9301503 Ref: Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl. PMID: 9356307 Ref: Pilot study of free and conjugated urinary mutagenicity during consumption of pan-fried meats: possible modulation by cruciferous vegetables, glutathione S-transferase-M1, and N-acetyltransferase-2. PMID: 9403034 |
Ref: Increased frequency of wild-type arylamine-N-acetyltransferase allele NAT2*4 homozygotes in Portuguese patients with colorectal cancer. PMID: 9472690 Ref: N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients. PMID: 9528834 Ref: Urinary mutagenicity on TA98 and YG1024 Salmonella typhimurium strains after a hamburger meal: influence of GSTM1 and NAT2 genotypes. PMID: 9568593 Ref: Expression of arylamine N-acetyltransferase in human intestine. PMID: 9577349 Ref: Somatic mutations, acetylator status, and prognosis in colorectal cancer. PMID: 9659162 Ref: Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas. PMID: 9682272 Ref: A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer. PMID: 9699660 Ref: Detection of mutations and polymorphism of N-acetyltransferase 1 gene in Indian, Malay and Chinese populations. PMID: 9731716 Ref: NAT2, GSTM-1, cigarette smoking, and risk of colon cancer. PMID: 9865425 Ref: Relationship between polymorphism of N-acetyltransferase gene and susceptibility to colorectal carcinoma in a Chinese population. PMID: 9918135 Ref: Polymorphisms in xenobiotic conjugation and disease predisposition. PMID: 10022251 Ref: Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. PMID: 10026993 |
Ref: Meat consumption, genetic susceptibility, and colon cancer risk: a United States multicenter case-control study. PMID: 9950235 Ref: Colorectal adenomatous and hyperplastic polyps: smoking and N-acetyltransferase 2 polymorphisms. PMID: 9950242 Ref: Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer. PMID: 10207630 Ref: Colorectal cancer: molecules and populations. PMID: 10359544 Ref: Meat, metabolic genotypes and risk for colorectal cancer. PMID: 10443949 Ref: Polymorphic NATs and cancer predisposition. PMID: 10493262 Ref: Combined influence of genetic and dietary factors on colorectal cancer incidence in Japanese Americans. PMID: 10854493 Ref: Genotypes of glutathione S-transferase M1 and N-acetyltransferase 2 in Japanese patients with gastric cancer. PMID: 11957090 |
Ref: Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. PMID: 10667461 Ref: Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer. PMID: 10680724 Ref: N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review. PMID: 10791558 Ref: Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer. PMID: 11059519 Ref: Associations between family history of cancer and genes coding for metabolizing enzymes (United States). PMID: 11075868 Ref: N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site? PMID: 11099063 |
Ref: Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. PMID: 11245417 Ref: Metabolic genotypes and risk for colorectal cancer. PMID: 11422615 Ref: Polymorphisms and colorectal tumor risk. PMID: 11487538 Ref: Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk. PMID: 11751443 |
Ref: Arylamine N-acetyltransferase type 2 and glutathione S-transferases M1 and T1 polymorphisms in familial adenomatous polyposis. PMID: 11773864 Ref: Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study. PMID: 12074508 Ref: Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer risk. PMID: 12165742 Ref: GSTM-1 and NAT2 and genetic alterations in colon tumors. PMID: 12195642 Ref: Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. PMID: 12351146 Ref: Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii. PMID: 12351160 Ref: A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. PMID: 12419832 Ref: Low-penetrance genes and their involvement in colorectal cancer susceptibility. PMID: 12433710 Ref: Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer. PMID: 12505289 Ref: [Clinical relevance of N-acetyltransferase type 2 (NAT2) genetic polymorphism]. PMID: 12611196 |
Ref: Family history of colon cancer: what does it mean and how is it useful? PMID: 12568823 Ref: Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer. PMID: 12584178 Ref: Rapid N-acetyltransferase 2 imputed phenotype and smoking may increase risk of colorectal cancer in women (Netherlands). PMID: 12814209 Ref: Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancer. PMID: 14504199 Ref: Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes. PMID: 14601045 |
Ref: Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. PMID: 14724163 Ref: Meat consumption patterns and preparation, genetic variants of metabolic enzymes, and their association with rectal cancer in men and women. PMID: 15051825 Ref: Impact of GSTT1, GSTM1, GSTP1 and NAT2 genotypes on KRAS2 and TP53 gene mutations in colorectal cancer. PMID: 15069679 Ref: CYP1A1, cigarette smoking, and colon and rectal cancer. PMID: 15496536 Ref: Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer. PMID: 15736440 Ref: Molecular epidemiology of colon cancer. PMID: 20396547 |
Ref: Relationship between metabolic enzyme polymorphism and colorectal cancer. PMID: 15637738 Ref: The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women. PMID: 15671210 Ref: Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer. PMID: 15700302 Ref: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. PMID: 16006997 Ref: Genetic polymorphisms of N-acetyltransferase 2 and colorectal cancer risk. PMID: 16015704 Ref: The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans. PMID: 16157215 Ref: Cancer and molecular biomarkers of phase 2. PMID: 16399374 Ref: [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]. PMID: 16471212 |
Ref: N-acetyltransferase 2 gene polymorphism in patients with colorectal carcinoma. PMID: 15617035 Ref: N-acetyltransferase (NAT) 2 acetylator status and age of onset in patients with hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 16337339 Ref: Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption. PMID: 16434594 Ref: N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients. PMID: 16827944 Ref: Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma. PMID: 16981843 Ref: NAT2, meat consumption and colorectal cancer incidence: an ecological study among 27 countries. PMID: 17006723 Ref: Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility. PMID: 17010218 Ref: Genetic polymorphisms in xenobiotic clearance genes and their influence on disease expression in hereditary nonpolyposis colorectal cancer patients. PMID: 17119063 Ref: NAT2 gene polymorphism and sporadic colorectal cancer. Prevalence, tumor stage and prognosis. A preliminary study in 70 patients. PMID: 17205146 |
Ref: N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer. PMID: 16896994 Ref: Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. PMID: 16926176 Ref: Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. PMID: 17191090 Ref: NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan. PMID: 17525862 Ref: Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma. PMID: 17537267 Ref: Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. PMID: 18159984 |
Ref: Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study. PMID: 18022202 Ref: Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer. PMID: 18372103 Ref: Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. PMID: 18990750 |
Ref: Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. PMID: 18992263 Ref: NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer. PMID: 19107910 Ref: Somatic alterations, metabolizing genes and smoking in rectal cancer. PMID: 19358278 Ref: GSTM1 and NAT2 polymorphisms and colon, lung and bladder cancer risk: a case-control study. PMID: 19443391 Ref: Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan. PMID: 19452301 Ref: Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study. PMID: 19549810 Ref: Gene-smoking interaction on colorectal adenoma and cancer risk: review and meta-analysis. PMID: 19589345 Ref: Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline. PMID: 19666988 |
Ref: Case-control studies of gene-environment interaction: Bayesian design and analysis. PMID: 19930190 Ref: Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. PMID: 20937634 Ref: NAT2 polymorphisms and sporadic colorectal cancer survival. PMID: 21188325 |
Ref: Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. PMID: 21081473 Ref: N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer. PMID: 21390146 |
Ref: Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk. PMID: 21618522 Ref: Absence of association between N-acetyltransferase 2 acetylator status and colorectal cancer susceptibility: based on evidence from 40 studies. PMID: 22403658 Ref: A meta-analysis of the relationship between NAT2 polymorphism and colorectal cancer susceptibility. PMID: 22588343 Ref: N-Acetyltransferase 2 and glutathione s-transferase M1 in colon and rectal cancer cases from an industrialized area. PMID: 22686318 Ref: Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk. PMID: 22724046 Ref: N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies. PMID: 22905173 Ref: Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer. PMID: 23271930 |
Ref: Systematic review: diet-gene interactions and the risk of colorectal cancer. PMID: 23216531 |
Ref: Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study. PMID: 24318358 Ref: GSTM1-null genotype as a risk factor for sporadic colorectal cancer in a Romanian population. Association with the NAT2-rapid-acetylator phenotype and exposure to environmental factors. PMID: 24467372 Ref: CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. PMID: 24939416 |
Ref: Bayesian analysis on meta-analysis of case-control studies accounting for within-study correlation. PMID: 22143403 Ref: Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies. PMID: 25342387 Ref: Interactions between meat intake and genetic variation in relation to colorectal cancer. PMID: 25491747 Ref: Dietary heterocyclic amine intake, NAT2 genetic polymorphism, and colorectal adenoma risk: the colorectal adenoma study in Tokyo. PMID: 25604583 Ref: In-depth analysis of the critical genes and pathways in colorectal cancer. PMID: 26239303 Ref: Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans. PMID: 26683305 |
Ref: N-acetyl transferase 2/environmental factors and their association as a modulating risk factor for sporadic colon and rectal cancer. PMID: 27883249 Ref: Colorectal Cancer Carcinogenesis: a Multivariate Genetic Model in a Cohort of Romanian Population. PMID: 28397463 Ref: Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228). PMID: 28817838 |
Ref: The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis. PMID: 29721061 |