Primary Site >> Colorectal Cancer
Gene >> MYC
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Ref: Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. PMID: 6300869 Ref: Amplification and expression of the c-myc oncogene in human lung cancer cell lines. PMID: 6646201 Ref: Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. PMID: 6888561 |
Ref: Human cytomegalovirus DNA sequences with homologies to the cellular genome. PMID: 6086821 |
Ref: Deregulation of c-myc gene expression in human colon carcinoma is not accompanied by amplification or rearrangement of the gene. PMID: 3837853 Ref: Proximity of thyroglobulin and c-myc genes on human chromosome 8. PMID: 3860968 Ref: A simultaneous flow cytometric assay for c-myc oncoprotein and DNA in nuclei from paraffin embedded material. PMID: 3902971 Ref: Expression of c-myc and other cell cycle-dependent genes in human colon neoplasia. PMID: 4063959 |
Ref: Increased expression of the c-myc gene without gene amplification in human lung cancer and colon cancer cell lines. PMID: 3089986 Ref: Detection of the c-myc oncogene product in colonic polyps and carcinomas. PMID: 3511934 |
Ref: A human chromosome 8 region with abnormalities in B cell, HTLV-I+ T cell and c-myc amplified tumours. PMID: 2820714 Ref: The role of the oncogene c-myc in sporadic large bowel cancer and familial polyposis coli. PMID: 2821605 Ref: Prognostic implications of expression of the cellular genes myc, fos, Ha-ras and Ki-ras in colon carcinoma. PMID: 3040597 Ref: A critical appraisal of the immunohistochemical detection of the c-myc oncogene product in colorectal cancer. PMID: 3325094 Ref: A novel tumour marker related to the c-myc oncogene product. PMID: 3331171 Ref: c-myc oncogene expression in colorectal cancer. PMID: 3545431 Ref: Protooncogene abnormalities in colon cancers and adenomatous polyps. PMID: 3557013 Ref: Expression of c-myb protooncogene and other cell cycle-related genes in normal and neoplastic human colonic mucosa. PMID: 3652034 |
Ref: Distribution of the c-myc oncoprotein in normal and neoplastic tissues of the rat colon. PMID: 2577872 Ref: Differential expression of c-myc gene and c-fos gene in premalignant and malignant tissues from patients with familial polyposis coli. PMID: 2842040 Ref: Modulation of c-myc by transforming growth factor-beta in human colon carcinoma cells. PMID: 2893611 Ref: [Oncogene expression in colonic cancers]. PMID: 3051685 Ref: Phenotypic and genetic alterations in pre-cancerous cells in the colon. PMID: 3052255 Ref: Effect of polyamine depletion on c-myc expression in human colon carcinoma cells. PMID: 3128541 Ref: Alterations in c-myc expression in relation to maturational status of human colon carcinoma cells. PMID: 3164710 Ref: Inhibition of mitogen stimulated growth of human colon cancer cells by interferon. PMID: 3166905 Ref: Characterization of transforming growth factor-beta-resistant subclones isolated from a transforming growth factor-beta-sensitive human colon carcinoma cell line. PMID: 3191488 Ref: Oncogene expression in adenocarcinomas of the colon and in colon tumor-derived cell lines. PMID: 3282475 Ref: The c-myc protein is constitutively expressed at elevated levels in colorectal carcinoma cell lines. PMID: 3283655 Ref: Biological characterization and oncogene expression in human colorectal carcinoma cell lines. PMID: 3338874 Ref: Noncorrelation of the expression of the c-myc oncogene in colorectal carcinoma with recurrence of disease or patient survival. PMID: 3342413 |
Ref: Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells. PMID: 2498320 Ref: Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells. PMID: 2511847 Ref: Evidence that the familial adenomatous polyposis gene is involved in a subset of colon cancers with a complementable defect in c-myc regulation. PMID: 2542967 Ref: The emerging genetics of cancer. PMID: 2648625 Ref: Reversible suppression of c-myc expression in a human colon carcinoma line by the anticancer agent N-methylformamide. PMID: 2660982 Ref: Expression of the myc gene family in different stages of human colorectal cancer. PMID: 2668847 Ref: Effects of growth stimulatory factors on mitogenicity and c-myc expression in poorly differentiated and well differentiated human colon carcinoma cells. PMID: 2674694 Ref: Proliferation of the human colon carcinoma cell line HT29: autocrine growth and deregulated expression of the c-myc oncogene. PMID: 2684395 Ref: Expression of c-myc oncogene in colorectal polyps as a biological marker for monitoring malignant potential. PMID: 2743265 |
Ref: Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer. PMID: 1693276 Ref: Inhibitory effects of transforming growth factor beta 1 on mitogenic response, transforming growth factor alpha, and c-myc in quiescent, well-differentiated colon carcinoma cells. PMID: 1701348 Ref: Inhibition of c-myc expression in human promyelocytic leukemia and colon adenocarcinoma cells by 6-thioguanine. PMID: 1702632 Ref: Rearrangement, amplification and overexpression of c-Ha Ras gene in premalignant lesion of Turcot's syndrome. PMID: 1703248 Ref: Expression of c-myc and c-fos mRNA in colorectal carcinoma in man. PMID: 1980763 Ref: Changes in c-myc and c-fos expression in a human tumor cell line following exposure to bifunctional alkylating agents. PMID: 2104539 Ref: Isolation of human colon carcinoma cells for resistance to a single interferon associated with cross-resistance to multiple recombinant interferons: alpha, beta, and gamma. PMID: 2138228 Ref: Circulating antibodies against c-myc oncogene product in sera of colorectal cancer patients. PMID: 2142141 Ref: Characteristics of cell lines established from human gastric carcinoma. PMID: 2158397 Ref: Alteration and enhanced expression of the c-myc oncogene in human colorectal carcinomas. PMID: 2188234 Ref: Immunohistochemical demonstration of altered intracellular localization of the C-Myc oncogene product in human colorectal neoplasms. PMID: 2193134 Ref: c-myc overexpression is a tumor-specific phenomenon in a subset of human colorectal carcinomas. PMID: 2196264 Ref: Comparison of deoxyribonucleic acid ploidy and nuclear expressed p62 c-myc oncogene in the prognosis of colorectal cancer. PMID: 2200214 Ref: Oncogenes and suppressor genes: their involvement in colon cancer. PMID: 2229991 Ref: Evidence for c-myc in the signaling pathway for TGF-beta in well-differentiated human colon carcinoma cells. PMID: 2273056 Ref: Risk and surveillance of individuals with heritable factors for colorectal cancer. WHO Collaborating Centre for the Prevention of Colorectal Cancer. PMID: 2289301 Ref: c-myc Oncogene expression in colorectal cancer: its use in prognosis and role in colorectal carcinogenesis. PMID: 2346285 |
Ref: Human papillomavirus type-related DNA and c-myc oncogene alterations in colon cancer cell lines. PMID: 1645245 Ref: Genetics of colon cancer. PMID: 1652174 Ref: Are there molecular targets for therapy of colon cancer? PMID: 1664228 Ref: [Diagnosis of colorectal cancer from DNA level]. PMID: 1846282 Ref: Correlation between chromosome 5q deletions and different mechanisms of c-myc overexpression in human colorectal cancer. PMID: 1847643 Ref: Use of the OM-11-906 monoclonal antibody for determining p62 c-myc expression by flow cytometry in relation to prognosis in colorectal cancer. PMID: 1874294 Ref: Regulation of the expression of major histocompatibility complex class I genes in human colorectal cancer. PMID: 1905582 Ref: c-myc protein product is a marker of DNA synthesis but not of malignancy in human gastrointestinal tissues and tumours. PMID: 1933191 Ref: Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression. PMID: 1933888 Ref: Aggressive subtypes of human colorectal tumors frequently exhibit amplification of the c-myc gene. PMID: 1992440 Ref: Enhanced expression of oncogene-encoded mRNA in a rat model of colon cancer. PMID: 2012108 Ref: Differential regulation of c-myc and transforming growth factor-alpha messenger RNA expression in poorly differentiated and well-differentiated colon carcinoma cells during the establishment of a quiescent state. PMID: 2015589 |
Ref: Colorectal carcinoma as a genetic phenomenon. PMID: 1294935 Ref: Action of tiazofurin and 8-Cl-cAMP in human colon and pancreatic cancer cells. PMID: 1364229 Ref: Association of genetic alterations of c-myc, c-fos, and c-Ha-ras proto-oncogenes in colorectal tumors. Frequency and clinical significance. PMID: 1373678 Ref: Increased expression of cytokeratin and ferritin-H genes in tumorigenic clones of the SW 613-S human colon carcinoma cell line. PMID: 1377134 Ref: Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene. PMID: 1378845 Ref: Distribution of cells expressing myc proteins in human colorectal epithelium, polyps, and malignant tumors. PMID: 1394214 Ref: TGF-alpha production correlates with tumorigenicity in clones of the SW613-S human colon carcinoma cell line. PMID: 1399125 Ref: Expression of p53 protein in invasive colorectal carcinomas of different histologic types. PMID: 1451054 Ref: [Complex characteristics of the alterations of oncogenes HER-2/ERBB-2, HER-1/ERBB-1, HRAS-1, C-MYC and antioncogenes p53, RB1, as well as deletions of loci of chromosome 17 in colon carcinoma]. PMID: 1470178 Ref: Pattern of growth factor, proto-oncogene and carcinoembryonic antigen gene expression in human colorectal carcinoma cell lines. PMID: 1495747 Ref: Oncogenesis in ovarian cancer. PMID: 1502889 Ref: Molecular genetics of colorectal carcinoma. PMID: 1511369 Ref: DNA polymerase beta mutations in human colorectal cancer. PMID: 1511447 Ref: A serine protease-inhibitory benzamidine derivative inhibits the growth of human colon carcinoma cells. PMID: 1517149 Ref: Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma. PMID: 1540900 Ref: Sensitivity of nuclear c-myc levels and induction to differentiation-inducing agents in human colon tumor cell lines. PMID: 1540946 Ref: Immunohistochemical detection of c-myc products in colorectal cancer and proliferative cell rate. PMID: 1542492 Ref: ras and c-myc protein expression in colorectal carcinoma. Study of cancer-prone patients. PMID: 1568393 Ref: Patterns of methylation of the c-myc gene in human colorectal cancer progression. PMID: 1586594 Ref: Posttranscriptional regulation of c-myc proto-oncogene expression and growth inhibition by recombinant human interferon-beta ser17 in a human colon carcinoma cell line. PMID: 1586975 Ref: Suppression of deregulated c-MYC expression in human colon carcinoma cells by chromosome 5 transfer. PMID: 1741403 Ref: Growth-inhibition of ht29 cells exposed to N-methylformamide correlates with altered expression of alpha-6/beta-4 integrin. PMID: 21584516 |
Ref: Models of neoplasia and their diagnostic implications: a historical perspective. PMID: 8222248 Ref: Genetic events responsible for colorectal tumorigenesis: achievements and challenges. PMID: 8249174 Ref: Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins. PMID: 8253532 Ref: Regulation of c-myc expression by sodium butyrate in the colon carcinoma cell line Caco-2. PMID: 8325387 Ref: Over-expression of the c-myc proto-oncogene in colorectal carcinoma. PMID: 8347498 Ref: [Detection of drug resistant-genes in cisplatin-resistant colon carcinoma cells by RT-PCR assay. II]. PMID: 8361021 Ref: Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells. PMID: 8376401 Ref: Prothymosin-alpha mRNA expression correlates with that of c-myc in human colon cancer. PMID: 8378090 Ref: Characterization of the DiFi rectal carcinoma cell line derived from a familial adenomatous polyposis patient. PMID: 8385096 Ref: Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma. PMID: 8392984 Ref: Changes of proliferative activity and phenotypes in spontaneous differentiation of a colon cancer cell line. PMID: 8393433 Ref: Lack of prognostic value of immunoreactivity for p62 oncoprotein in colorectal carcinoma. PMID: 8409682 Ref: Effects of all-trans retinoic acid as a potential chemopreventive agent on the formation of azoxymethane-induced aberrant crypt foci: differential expression of c-myc and c-fos MRNA and protein. PMID: 8449605 Ref: [Analysis of molecular mechanism in colorectal tumorigenesis]. PMID: 8458595 Ref: DNA ploidy, c-myc oncoprotein p62 and v-H-ras oncoprotein p21 in colorectal carcinoma. PMID: 8461612 |
Ref: [Etiology of colorectal cancer]. PMID: 7557283 Ref: c-myc mRNA overexpression is associated with lymph node metastasis in colorectal cancer. PMID: 7654441 Ref: Growth and intestinal differentiation are independently regulated in HT29 colon cancer cells. PMID: 7929596 Ref: Ki-ras and c-myc oncogene expression measured by coamplification polymerase chain reaction. PMID: 8002989 Ref: Investigation of c-myc oncogene amplification in colorectal cancer. PMID: 8012933 Ref: Structural analysis of c-myc in human sporadic colorectal carcinomas. PMID: 8074458 Ref: A study of c-myc oncogene expression and amplification in colorectal cancer. PMID: 8086630 Ref: Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells. PMID: 8264588 Ref: The overexpression of the sialyl-lewis(x) moiety is an independent and a more consistent marker of colon carcinogenesis than the overexpression of C-myc and ki-ras oncogenes. PMID: 21567012 |
Ref: Phosphotyrosine, p62 c-myc and p21 c-Ha-ras proteins in colonic epithelium of normal and dimethylhydrazine-treated rats: an immunohistochemical analysis. PMID: 7537485 Ref: Growth control of human colon-adenocarcinoma-derived Caco-2 cells by vitamin-D compounds and extracellular calcium in vitro: relation to c-myc-oncogene and vitamin-D-receptor expression. PMID: 7558419 Ref: Quantifying c-myc expression in c-myc antisense phosphorothioate oligodeoxynucleotide-treated leukemic and colon cancer cell lines. PMID: 7564322 Ref: Growth regulation of human colon adenocarcinoma-derived cells by calcium, vitamin D and epidermal growth factor. PMID: 7602383 Ref: Influence of protein tyrosine phosphorylation on the expression of the c-myc oncogene in cancer of the large bowel. PMID: 7642726 Ref: DNA repair in the endogenous and episomal amplified c-myc oncogene loci in human tumor cells. PMID: 7731719 Ref: Transforming growth factor beta isoform-specific differences in interactions with type I and II transforming growth factor beta receptors. PMID: 7743502 Ref: IGF-2 autocrine stimulation in tumorigenic clones of a human colon-carcinoma cell line. PMID: 7759165 Ref: The proto-oncogene FGF-3 is constitutively expressed in tumorigenic, but not in non-tumorigenic, clones of a human colon carcinoma cell line. PMID: 7784081 Ref: Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors. PMID: 7794080 Ref: Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro. PMID: 7799924 Ref: p53, myc, APC, hMSH2, ras, etc. in colorectal cancer - a never ending story! PMID: 8750144 Ref: Evidence for a mutual regulation of p53 and c-myc expression in human colorectal cancer metastases. PMID: 8750149 Ref: Correlation between c-myc protein expression and phases of the cell cycle in human colorectal carcinomas. PMID: 8823991 Ref: Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines. PMID: 21556635 |
Ref: Apoptotic cell death and its relationship to carcinogenesis in colorectal carcinoma. PMID: 8608567 Ref: Differential effect of interleukin-4 and transforming growth factor beta 1 on expression of proto-oncogenes and autocrine insulin-like growth factor II in colorectal carcinoma cells. PMID: 8645306 Ref: Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease. PMID: 8674385 Ref: Induction of DNA double-strand breaks by ionizing radiation at the c-myc locus compared with the whole genome: a study using pulsed-field gel electrophoresis and gene probing. PMID: 8691019 Ref: Oncogene expression in patients with familial polyposis coli/Gardner's syndrome. PMID: 8753850 Ref: Molecular changes of colorectal cancer in Singapore. PMID: 8779542 Ref: c-Myc inactivation by mutant Max alters growth and morphology of NCI-H-630 colon cancer cells. PMID: 8841436 Ref: Selenite supplementation decreases expression of MAZ in HT29 human colon adenocarcinoma cells. PMID: 8844723 Ref: The pattern of prothymosin alpha gene expression coincides with that of myc proto-oncogenes during mouse embryogenesis. PMID: 8866647 Ref: Genetic aspects of colorectal cancer: the surgeon's view. PMID: 8898451 Ref: Higher expression of oncoproteins c-myc, c-erb B-2/neu, PCNA, and p53 in metastasizing colorectal cancer than in nonmetastasizing tumors. PMID: 8915491 Ref: Overexpression and amplification of c-myc during progression of human colorectal cancer. PMID: 8960139 Ref: Overexpression of the c-myc proto-oncogene in colorectal carcinoma is associated with a reduced mortality that is abrogated by point mutation of the p53 tumor suppressor gene. PMID: 9816266 Ref: Genes mediating programmed cell death: an immunohistochemical study of bcl-2, c-myc and p53 expression in colorectal neoplasia. PMID: 16696064 Ref: Genetics of colorectal cancer (Review). PMID: 21541519 Ref: Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells. PMID: 21541530 Ref: Increased induction of apoptosis of human colorectal cancer cells after preoperative treatment with 5-fluorouracil. PMID: 21594360 |
Ref: Pretreatment by tubulin agents decreases C-MYC induction in human colon carcinoma cell line HT29-D4. PMID: 9070886 Ref: Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial. PMID: 9135021 Ref: Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma. PMID: 9221853 Ref: Analysis of ornithine decarboxylase messenger ribonucleic acid expression in colorectal carcinoma. PMID: 9293942 Ref: Common patterns of genetic evolution in human solid tumors. PMID: 9298807 Ref: Apoptosis in colorectal carcinoma occurring in patients aged 45 years and under: relationship to prognosis, mitosis, and immunohistochemical demonstration of p53, c-myc and bcl-2 protein products. PMID: 9306959 Ref: Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy. PMID: 9336744 Ref: Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line. PMID: 9354939 Ref: Critical issues in the evolving management of rectal cancer. PMID: 9422268 Ref: Phosphorothioated antisense c-myc oligonucleotide inhibits the growth of human colon carcinoma cells. PMID: 9494542 Ref: [The molecular biology and genetics of colorectal carcinoma]. PMID: 9739886 Ref: [Closely relationship between expression of endoplasmic reticulum molecular chaperone Grp94 and c-myc oncogene in human colorectal carcinoma cell lines]. PMID: 10743065 Ref: Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells. PMID: 12503187 Ref: ras and myc analysis in primary and metastatic colorectal carcinomas. PMID: 21533375 |
Ref: Preclinical characterization and in vivo imaging studies of an engineered recombinant technetium-99m-labeled metallothionein-containing anti-carcinoembryonic antigen single-chain antibody. PMID: 9443738 Ref: Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels. PMID: 9462700 Ref: Prognostic significance of c-myc mRNA expression assessed by semi-quantitative RT-PCR in patients with colorectal cancer. PMID: 9468576 Ref: Differences in transglutaminase mRNA after polyamine depletion in two cell lines. PMID: 9486143 Ref: Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. PMID: 9508765 Ref: Differential modulation of human (Caco-2) colon cancer cell line phenotype by short chain fatty acids. PMID: 9521097 Ref: Moderate amplifications of the c-myc gene correlate with molecular and clinicopathological parameters in colorectal cancer. PMID: 9649157 Ref: Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. PMID: 9719459 Ref: Genetic abnormalities and microsatellite instability in colorectal cancer. PMID: 9727619 Ref: Identification of c-MYC as a target of the APC pathway. PMID: 9727977 Ref: Growth regulation of human colon cancer cells by epidermal growth factor and 1,25-dihydroxyvitamin D3 is mediated by mutual modulation of receptor expression. PMID: 10070321 |
Ref: Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene. PMID: 9927200 Ref: NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species. PMID: 9990295 Ref: Cancer genetics: tumor suppressor meets oncogene. PMID: 10021355 Ref: Identification of Tcf4 residues involved in high-affinity beta-catenin binding. PMID: 10080941 Ref: A common human skin tumour is caused by activating mutations in beta-catenin. PMID: 10192393 Ref: The adenomatous polyposis coli tumour suppressor gene regulates c-MYC transcription in colon cancer cells. PMID: 10205190 Ref: Flow cytometric DNA analysis is useful in detecting multiple genetic alterations in squamous cell carcinoma of the esophagus. PMID: 10357400 Ref: Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay. PMID: 10383126 Ref: beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. PMID: 10514384 Ref: A correlation of APC and c-myc mRNA levels in lung cancer cell lines. PMID: 10523691 Ref: Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. PMID: 10523844 Ref: Isolation and characterization of a novel TP53-inducible gene, TP53TG3. PMID: 10534768 Ref: Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. PMID: 10559252 Ref: beta-catenin signaling and cancer. PMID: 10580987 Ref: Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. PMID: 10632348 Ref: Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma. PMID: 11819478 |
Ref: The Yin-Yang of TCF/beta-catenin signaling. PMID: 10549354 Ref: Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3,N0,M0) colorectal cancer. PMID: 10644313 Ref: Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta. PMID: 10660115 Ref: Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts. PMID: 10677374 Ref: Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. PMID: 10702403 Ref: Elevated levels of RanBP7 mRNA in colorectal carcinoma are associated with increased proliferation and are similar to the transcription pattern of the proto-oncogene c-myc. PMID: 10799331 Ref: gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. PMID: 10837025 Ref: Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells. PMID: 10840001 Ref: Dietary calcium and growth modulation of human colon cancer cells: role of the extracellular calcium-sensing receptor. PMID: 10917132 Ref: Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis. PMID: 10928042 Ref: Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. PMID: 10987283 Ref: Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. PMID: 10993886 Ref: The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design. PMID: 11097346 Ref: Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells. PMID: 11103814 Ref: Increase of GKLF messenger RNA and protein expression during progression of breast cancer. PMID: 11103818 Ref: Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines. PMID: 11205258 Ref: [beta-Catenin induces invasive growth by activating matrix metalloproteinases in colorectal carcinoma]. PMID: 11217438 Ref: Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin. PMID: 11341469 Ref: The Incidence of Apoptosis During Colorectal Tumorigenesis. PMID: 11493977 |
Ref: A retro-inverso peptide homologous to helix 1 of c-Myc is a potent and specific inhibitor of proliferation in different cellular systems. PMID: 11099487 Ref: beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. PMID: 11181454 Ref: Effect of the nonsteroidal anti-inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells. PMID: 11260862 Ref: Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression. PMID: 11306486 Ref: Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. PMID: 11326276 Ref: Molecular markers are predictors of recurrence and survival in patients with Dukes B and Dukes C colorectal adenocarcinoma. PMID: 11330579 Ref: A buckwheat protein product suppresses 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by reducing cell proliferation. PMID: 11385078 Ref: c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo. PMID: 11406570 Ref: Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas. PMID: 11420670 Ref: Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer. PMID: 11445004 Ref: Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. PMID: 11470825 Ref: Replication timing of amplified genetic regions relates to intranuclear localization but not to genetic activity or G/R band. PMID: 11478846 Ref: Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells. PMID: 11506814 Ref: beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. PMID: 11526497 Ref: Genetic markers of survival and liver recurrence after resection of liver metastases from colorectal cancer. PMID: 11571982 Ref: Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma. PMID: 11572874 Ref: Overexpression of an mRNA-binding protein in human colorectal cancer. PMID: 11641779 Ref: E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells. PMID: 11705881 Ref: Modification of the sensitivity to cisplatin with c-myc over-expression or down-regulation in colon cancer cells. PMID: 11707650 Ref: Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. PMID: 11733561 Ref: Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells. PMID: 11737227 Ref: Nitric oxide and endothelin-1,2 in actinic keratosis and basal cell carcinoma: changes in nitric oxide/endothelin ratio. PMID: 11737437 Ref: Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines. PMID: 11751426 Ref: Activation of c-MYC and c-MYB proto-oncogenes is associated with decreased apoptosis in tumor colon progression. PMID: 11848471 Ref: The Effects of Butyrate and the Role of c-myc in N.1 Ovarian Carcinoma Cells Determined by Northern Blotting. PMID: 21340801 |
Ref: Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. PMID: 11756231 Ref: Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. PMID: 11793365 Ref: Beta-catenin--a linchpin in colorectal carcinogenesis? PMID: 11839557 Ref: 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin. PMID: 11847216 Ref: Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane. PMID: 11931531 Ref: Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas. PMID: 11943708 Ref: Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. PMID: 11950812 Ref: Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1. PMID: 11986304 Ref: APC-dependent regulation of ornithine decarboxylase in human colon tumor cells. PMID: 12112318 Ref: Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane. PMID: 12148579 Ref: Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam. PMID: 12174906 Ref: Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. PMID: 12189186 Ref: Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin. PMID: 12209953 Ref: Local expression of insulin-like growth factor-I affects angiogenesis in colorectal cancer. PMID: 12218293 Ref: The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. PMID: 12408868 Ref: Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. PMID: 12414619 Ref: Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A. PMID: 12450255 Ref: Association of human polyomavirus JCV with colon cancer: evidence for interaction of viral T-antigen and beta-catenin. PMID: 12460931 Ref: Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. PMID: 12466962 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 Ref: Overexpression of Wnt target genes in adenomas of familial adenomatous polyposis patients. PMID: 12530096 Ref: Incidence of apoptosis increases with age in colorectal cancer. PMID: 12559416 |
Ref: c-myc down-regulation induces apoptosis in human cancer cell lines exposed to RPR-115135 (C31H29NO4), a non-peptidomimetic farnesyltransferase inhibitor. PMID: 12490573 Ref: Germline APC mutation on the beta-catenin binding site is associated with a decreased apoptotic level in colorectal adenomas. PMID: 12527714 Ref: Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor beta-induced repression of c-myc. PMID: 12591729 Ref: Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes. PMID: 12605985 Ref: Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. PMID: 12622871 Ref: Molecular targeting and pharmacogenomics in the management of advanced bladder cancer. PMID: 12673700 Ref: Effect of apoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level. PMID: 12736715 Ref: Differential effects of cigarette smoke extracts on cell proliferation in gastric and colon cells. PMID: 12743985 Ref: Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cells. PMID: 12761500 Ref: Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin. PMID: 12800193 Ref: Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. PMID: 12810952 Ref: Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. PMID: 12856716 Ref: Simultaneous changes in the function and expression of beta 1 integrins during the growth arrest of poorly differentiated colorectal cells (LISP-1). PMID: 12886464 Ref: [Study on the antisense inhibition effect of liposome-mediated radiolabled antisense oligonucleotides of c-myc mRNA]. PMID: 12910676 Ref: Effects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines. PMID: 12970888 Ref: A protein knockdown strategy to study the function of beta-catenin in tumorigenesis. PMID: 14516475 Ref: Multiple effects of paclitaxel are modulated by a high c-myc amplification level. PMID: 14516787 Ref: Role of c-Myc in nitric oxide-mediated suppression of cytochrome P450 3A4. PMID: 14575816 Ref: c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis. PMID: 14583781 Ref: Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. PMID: 14601048 Ref: Recursive partitioning as an approach to selection of immune markers for tumor diagnosis. PMID: 14613989 Ref: Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. PMID: 14675489 Ref: TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. PMID: 14695187 |
Ref: Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene. PMID: 14644095 Ref: Increased expression of a Myc target gene Mina53 in human colon cancer. PMID: 14695334 Ref: N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. PMID: 14728717 Ref: Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue. PMID: 15079086 Ref: Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups. PMID: 15126105 Ref: Thermal enhancement of oxaliplatin-induced inhibition of cell proliferation and cell cycle progression in human carcinoma cell lines. PMID: 15204521 Ref: Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. PMID: 15235586 Ref: Thermodynamics of i-tetraplex formation in the nuclease hypersensitive element of human c-myc promoter. PMID: 15249220 Ref: K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma. PMID: 15493579 Ref: Wnt-signaling and apoptosis after neoadjuvant short-term radiotherapy for rectal cancer. PMID: 15547689 |
Ref: Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. PMID: 15365767 Ref: Experimental study of the killing effects of oxymatrine on human colon cancer cell line SW1116. PMID: 15667553 Ref: Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. PMID: 15713675 Ref: Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. PMID: 15716339 Ref: Clinicopathologic correlation of up-regulated genes identified using cDNA microarray and real-time reverse transcription-PCR in human colorectal cancer. PMID: 15734970 Ref: DNA copy number changes at 8q11-24 in metastasized colorectal cancer. PMID: 15750208 Ref: Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription. PMID: 15817155 Ref: High frequency trans-splicing in a cell line producing spliced and polyadenylated RNA polymerase I transcripts from an rDNA-myc chimeric gene. PMID: 15849319 Ref: Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection. PMID: 15896923 Ref: Long-term exposure of the HT-29 human intestinal epithelial cell line to TNF causes sustained up-regulation of the polymeric Ig receptor and proinflammatory genes through transcriptional and posttranscriptional mechanisms. PMID: 15905574 Ref: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. PMID: 15922743 Ref: HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. PMID: 15928669 Ref: Molecular markers that predict response to colon cancer therapy. PMID: 15934813 Ref: Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: effects on proliferation, differentiation, and gene expression. PMID: 15935729 Ref: Overexpression of c-myc and loss of heterozygosity on 2p, 3p, 5q, 17p and 18q in sporadic colorectal carcinoma. PMID: 15943002 Ref: Identification of MYCBP as a beta-catenin/LEF-1 target using DNA microarray analysis. PMID: 15979100 Ref: Upregulation of a functional form of the beta4 integrin subunit in colorectal cancers correlates with c-Myc expression. PMID: 16007143 Ref: Bcr is a negative regulator of the Wnt signalling pathway. PMID: 16211085 Ref: Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU. PMID: 16224182 Ref: Tumor-targeting peptide-PNA-peptide chimeras for imaging overexpressed oncogene mRNAs. PMID: 16248097 Ref: Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. PMID: 16288056 Ref: p53, Bcl-2 and C-Myc expressions in colorectal carcinoma associated with schistosomiasis in Egypt. PMID: 16308474 Ref: Approximately 580 Kb surrounding the MYC gene is amplified in head and neck squamous cell carcinoma of Indian patients. PMID: 16325511 Ref: Non-invasive detection of c-myc p64, c-myc p67 and c-erbb-2 in colorectal cancer. PMID: 16334444 Ref: A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene. PMID: 16382048 Ref: Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia. PMID: 16471312 Ref: ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. PMID: 16787331 |
Ref: Induction of apoptosis by puerarin in colon cancer HT-29 cells. PMID: 16055262 Ref: p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. PMID: 16170570 Ref: Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. PMID: 16299030 Ref: An overview of apoptosis and the prevention of colorectal cancer. PMID: 16326109 Ref: Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of c-myc suppression by interferon-gamma in situ. PMID: 16367922 Ref: Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. PMID: 16426922 Ref: Decrease in c-Myc activity enhances cancer cell sensitivity to vinblastine. PMID: 16428936 Ref: An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis. PMID: 16452196 Ref: RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling. PMID: 16505104 Ref: The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. PMID: 16510874 Ref: Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. PMID: 16543245 Ref: Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. PMID: 16574648 Ref: Construction of a novel DNA decoy that inhibits the oncogenic beta-catenin/T-cell factor pathway. PMID: 16648570 Ref: let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. PMID: 16651716 Ref: CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. PMID: 16778892 Ref: Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. PMID: 16797627 Ref: Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis. PMID: 16804918 Ref: Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). PMID: 16820966 Ref: Mutational analysis of MYC in common epithelial cancers and acute leukemias. PMID: 16856965 Ref: Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling. PMID: 16926625 Ref: Inhibitory effect of caffeic acid phenethyl ester on the growth of SW480 colorectal tumor cells involves beta-catenin associated signaling pathway down-regulation. PMID: 16937493 Ref: Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer. PMID: 16940161 Ref: Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. PMID: 16953238 Ref: Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. PMID: 16954380 Ref: Signal transduction cross-talk during colorectal tumorigenesis. PMID: 16998321 Ref: Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription. PMID: 17005722 Ref: ECA39 is a novel distant metastasis-related biomarker in colorectal cancer. PMID: 17007058 Ref: Distinct nuclear arrangement of active and inactive c-myc genes in control and differentiated colon carcinoma cells. PMID: 17046748 Ref: Modulation of oncogenic transcription and alternative splicing by beta-catenin and an RNA aptamer in colon cancer cells. PMID: 17079480 Ref: Effects of gastrin 17 on beta-catenin/Tcf-4 pathway in Colo320WT colon cancer cells. PMID: 17167838 |
Ref: HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer. PMID: 16882699 Ref: Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway. PMID: 16963252 Ref: Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines. PMID: 17219422 Ref: Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. PMID: 17258704 Ref: The FBXW7 beta-form is suppressed in human glioma cells. PMID: 17274947 Ref: Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. PMID: 17278192 Ref: Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer. PMID: 17283120 Ref: c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability. PMID: 17297307 Ref: Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. PMID: 17317856 Ref: Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas. PMID: 17325483 Ref: Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent. PMID: 17371277 Ref: Profiling of selenomethionine responsive genes in colon cancer by microarray analysis. PMID: 17374985 Ref: Myc deletion rescues Apc deficiency in the small intestine. PMID: 17377531 Ref: Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines. PMID: 17389773 Ref: Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection. PMID: 17390015 Ref: Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. PMID: 17390031 Ref: The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. PMID: 17395983 Ref: Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. PMID: 17452451 Ref: 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. PMID: 17462534 Ref: Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. PMID: 17506908 Ref: De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity. PMID: 17521618 Ref: Mesalazine downregulates c-Myc in human colon cancer cells. A key to its chemopreventive action? PMID: 17539984 Ref: Regulation of E-cadherin and beta-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function. PMID: 17557293 Ref: Analysis of pathway activity in primary tumors and NCI60 cell lines using gene expression profiling data. PMID: 17572360 Ref: Epidermal growth factor receptor R497K polymorphism is a favorable prognostic factor for patients with colorectal carcinoma. PMID: 17575224 Ref: Intraovarian activins are required for female fertility. PMID: 17609433 Ref: Clearing the TRAIL for Cancer Therapy. PMID: 17613431 Ref: CIP2A inhibits PP2A in human malignancies. PMID: 17632056 Ref: Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. PMID: 17632092 Ref: Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling. PMID: 17634137 Ref: [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells]. PMID: 17650425 Ref: Hypoxia upregulates carcinoembryonic antigen expression in cancer cells. PMID: 17657737 Ref: Involvement of RNA helicases p68 and p72 in colon cancer. PMID: 17699760 Ref: Turning the tables: Myc activates Wnt in breast cancer. PMID: 17726380 Ref: Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor. PMID: 17784872 Ref: Expression of Myc target gene mina53 in subtypes of human lymphoma. PMID: 17786344 Ref: A proteomics analysis of cell signaling alterations in colorectal cancer. PMID: 17848589 Ref: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. PMID: 17875709 Ref: Chemotherapy-resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the non-SP, a higher expression of c-Myc and TRAIL-receptor DR4. PMID: 17881904 Ref: [Expression and significance of APC, beta-catenin, C-myc, and Cyclin D1 proteins in colorectal carcinoma]. PMID: 17927853 Ref: Multimodality optical imaging and 18F-FDG uptake in wild-type p53-containing and p53-null human colon tumor xenografts. PMID: 17932466 Ref: MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. PMID: 17942906 Ref: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. PMID: 17997817 Ref: Investigation of miRNA biology by bioinformatic tools and impact of miRNAs in colorectal cancer--regulatory relationship of c-Myc and p53 with miRNAs. PMID: 18079974 Ref: ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells. PMID: 18161931 Ref: Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression. PMID: 18171987 |
Ref: A role for iron in Wnt signalling. PMID: 17700530 Ref: The role of signal transducers and activators of transcription in colon cancer. PMID: 17981761 Ref: Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. PMID: 17993259 Ref: Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. PMID: 18084253 Ref: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. PMID: 18097482 Ref: PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. PMID: 18161004 Ref: Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis. PMID: 18166348 Ref: Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility. PMID: 18190704 Ref: Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. PMID: 18283038 Ref: Sulindac suppresses beta-catenin expression in human cancer cells. PMID: 18291362 Ref: Methylation alterations are not a major cause of PTTG1 misregulation. PMID: 18426563 Ref: Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc. PMID: 18444242 Ref: Delivery of a DNAzyme targeting c-myc to HT29 colon carcinoma cells using a gold nanoparticulate approach. PMID: 18444511 Ref: Two distinct amplification events of the c-myc locus in a colorectal tumour. PMID: 18446811 Ref: Depletion of c-Myc inhibits human colon cancer colo 320 cells' growth. PMID: 18454692 Ref: Why diabetes patients are more prone to the development of colon cancer? PMID: 18456417 Ref: Oncogene and tumor suppressor gene expression changes in the peripheral blood leukocytes of patients with colorectal cancer. PMID: 18468340 Ref: Mucronulatol from Caribbean propolis exerts cytotoxic effects on human tumor cell lines. PMID: 18538108 Ref: PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. PMID: 18544567 Ref: Multiple loci with different cancer specificities within the 8q24 gene desert. PMID: 18577746 Ref: Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells. PMID: 18583030 Ref: C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine. PMID: 18593890 Ref: siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells. PMID: 18694522 Ref: Importance of Wnt signaling in the tumor stroma microenvironment. PMID: 18781892 Ref: c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs. PMID: 18802399 Ref: Differential proteome expression associated with urokinase plasminogen activator receptor (uPAR) suppression in malignant epithelial cancer. PMID: 18808175 Ref: AP4 encodes a c-MYC-inducible repressor of p21. PMID: 18818310 Ref: A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. PMID: 18852287 Ref: Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colon. PMID: 19404440 |
Ref: Calcium, calcium-sensing receptor and colon cancer. PMID: 18725175 Ref: p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors. PMID: 18951899 Ref: Increased expression of beta-catenin, phosphorylated glycogen synthase kinase 3beta, cyclin D1, and c-myc in laterally spreading colorectal tumors. PMID: 19064714 Ref: Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. PMID: 19067737 Ref: Hexachlorophene suppresses beta-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells. PMID: 19091460 Ref: Downregulation of human telomerase reverse transcriptase through anti-C-myc siRNA in human colon cancer Colo 320 cells. PMID: 19116866 Ref: Evaluation of tumour-associated antigen (TAA) miniarray in immunodiagnosis of colon cancer. PMID: 19140877 Ref: HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53. PMID: 19150257 Ref: The knockdown of c-myc expression by RNAi inhibits cell proliferation in human colon cancer HT-29 cells in vitro and in vivo. PMID: 19183865 Ref: The c-MYC-AP4-p21 cascade. PMID: 19270520 Ref: c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy. PMID: 19273283 Ref: Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression. PMID: 19287963 Ref: MAP kinases in proliferating human colon cancer Caco-2 cells. PMID: 19301097 Ref: Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. PMID: 19359472 Ref: Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. PMID: 19360348 Ref: PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling. PMID: 19383367 Ref: An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types. PMID: 19399471 Ref: Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors. PMID: 19420964 Ref: Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. PMID: 19421758 Ref: Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. PMID: 19437480 Ref: Murine models of colorectal cancer. PMID: 19444507 Ref: Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism. PMID: 19445940 Ref: Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21(WAF1/CIP1) and proliferating cell nuclear antigen. PMID: 19481339 Ref: Suppression of N-myc downstream-regulated gene 2 is associated with induction of Myc in colorectal cancer and correlates closely with differentiation. PMID: 19483300 Ref: Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. PMID: 19502595 Ref: Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer. PMID: 19531654 Ref: Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells. PMID: 19549798 Ref: Comprehensive analysis of the clinical significance of inducing pluripotent stemness-related gene expression in colorectal cancer cells. PMID: 19554373 Ref: The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. PMID: 19561607 Ref: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. PMID: 19562678 Ref: Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein. PMID: 19581307 Ref: Integrin alpha6Bbeta4 inhibits colon cancer cell proliferation and c-Myc activity. PMID: 19586553 Ref: Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. PMID: 19602591 Ref: Retraction: siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells. PMID: 19607687 Ref: Isoreserpine promotes beta-catenin degradation via Siah-1 up-regulation in HCT116 colon cancer cells. PMID: 19607803 Ref: [Periplocin extracted from cortex periplocae induces apoptosis of SW480 cells through inhibiting the Wnt/beta-catenin signaling pathway]. PMID: 19624870 Ref: [Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarrays]. PMID: 19648079 Ref: Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. PMID: 19662683 Ref: Functional and clinical significance of variants localized to 8q24 in colon cancer. PMID: 19690179 Ref: Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer. PMID: 19691111 Ref: [Effect of siRNA targeting c-Myc and VEGF on human colorectal cancer cells]. PMID: 19742345 Ref: The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta. PMID: 19779850 Ref: Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer. PMID: 19787239 Ref: Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. PMID: 19789310 Ref: Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas. PMID: 20029639 Ref: PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells. PMID: 20032390 Ref: [Clinical application of alternative splicing form of c-myc suppressor FUSE-binding protein-interacting repressor for cancer detection and treatment]. PMID: 20077813 Ref: Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin. PMID: 20141613 Ref: Editorial retraction. Down-regulation of human telomerase reverse transcriptase through anti-c-myc siRNA in human colon cancer Colo 320 cells. PMID: 20183618 |
Ref: 4-hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity. PMID: 19733043 Ref: Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance. PMID: 19739118 Ref: Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. PMID: 19784072 Ref: Recent insights into the pathogenesis of colorectal cancer. PMID: 19786869 Ref: PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. PMID: 19912441 Ref: Murrayafoline A attenuates the Wnt/beta-catenin pathway by promoting the degradation of intracellular beta-catenin proteins. PMID: 19962966 Ref: A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers. PMID: 19966299 Ref: Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats. PMID: 20061362 Ref: Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells. PMID: 20065031 Ref: Accelerated expression of a Myc target gene Mina53 in aggressive hepatocellular carcinoma. PMID: 20070393 Ref: Expression profile of significant immortalization genes in colon cancer. PMID: 20127035 Ref: Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine. PMID: 20140021 Ref: Human papillomavirus DNA and oncogene alterations in colorectal tumors. PMID: 20232185 Ref: Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. PMID: 20354121 Ref: A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. PMID: 20383323 Ref: Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer. PMID: 20442291 Ref: Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. PMID: 20454513 Ref: Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation. PMID: 20470206 Ref: Periplocin from Cortex periplocae inhibits cell growth and down-regulates survivin and c-myc expression in colon cancer in vitro and in vivo via beta-catenin/TCF signaling. PMID: 20596624 Ref: Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-beta/Smad signaling pathway. PMID: 20603835 Ref: An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer. PMID: 20627891 Ref: Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules. PMID: 20628792 Ref: New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells. PMID: 20630067 Ref: F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. PMID: 20638938 Ref: Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro. PMID: 20663323 Ref: Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers. PMID: 20663927 Ref: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. PMID: 20691072 Ref: NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer. PMID: 20705583 Ref: Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. PMID: 20708588 Ref: Proteomic profiling of human colon cancer cells treated with the histone deacetylase inhibitor belinostat. PMID: 20717991 Ref: The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. PMID: 20724530 Ref: Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. PMID: 20736363 Ref: Transcriptional attenuation in colon carcinoma cells in response to butyrate. PMID: 20841488 Ref: Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8. PMID: 20846456 Ref: Growth inhibition effect of beta-catenin small interfering RNA-mediated gene silencing on human colon carcinoma HT-29 cells. PMID: 20950152 Ref: Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer. PMID: 21039844 Ref: B55beta-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. PMID: 21075311 Ref: miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. PMID: 21092188 Ref: S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer. PMID: 21152119 |
Ref: Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors. PMID: 19922946 Ref: A model-based strategy to investigate the role of microRNA regulation in cancer signalling networks. PMID: 20809366 Ref: Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active beta-catenin. PMID: 20856206 Ref: The multifaceted proteins Reptin and Pontin as major players in cancer. PMID: 21111787 Ref: Significance of Lgr5(+ve) cancer stem cells in the colon and rectum. PMID: 21125339 Ref: MicroRNA expression profile of colon cancer stem-like cells in HT29 adenocarcinoma cell line. PMID: 21130073 Ref: Difluorinated-curcumin (CDF): a novel curcumin analog is a potent inhibitor of colon cancer stem-like cells. PMID: 21161336 Ref: IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. PMID: 21252116 Ref: Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells. PMID: 21271458 Ref: Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines. PMID: 21284881 Ref: Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. PMID: 21291235 Ref: Expression of p53, Ki-67 and c-Myc proteins is predictive of the surgical molecular margin in colorectal carcinoma. PMID: 21298377 Ref: Clinical validation of colorectal cancer biomarkers identified from bioinformatics analysis of public expression data. PMID: 21304002 Ref: Parafibromin expression is an independent prognostic factor for colorectal carcinomas. PMID: 21315421 Ref: SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. PMID: 21368833 Ref: Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells. PMID: 21370894 Ref: Apoptotic Cell Death and Inhibition of Wnt/beta-Catenin Signaling Pathway in Human Colon Cancer Cells by an Active Fraction (HS7) from Taiwanofungus camphoratus. PMID: 21423639 Ref: The antiproliferative effect of dietary fiber phenolic compounds ferulic acid and p-coumaric acid on the cell cycle of Caco-2 cells. PMID: 21500097 Ref: Digital analysis of the expression levels of multiple colorectal cancer-related genes by multiplexed digital-PCR coupled with hydrogel bead-array. PMID: 21509397 Ref: High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde. PMID: 21513580 Ref: Multiple Wnt/ss-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops. PMID: 21533051 Ref: Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling. PMID: 21600193 Ref: Evaluating markers for treatment selection based on survival time. PMID: 21611957 Ref: EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators. PMID: 21653642 Ref: Direct reprogramming of stem cell properties in colon cancer cells by CD44. PMID: 21701559 Ref: Protein kinase CK2alpha is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes. PMID: 21702981 Ref: P-cadherin promotes liver metastasis and is associated with poor prognosis in colon cancer. PMID: 21703417 Ref: Enormous influence of TNIK knockdown on intracellular signals and cell survival. PMID: 21710359 Ref: Novel Indolocarbazole Derivative 12-(alpha-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand. PMID: 21772991 Ref: S100A4-induced cell motility and metastasis is restricted by the Wnt/beta-catenin pathway inhibitor calcimycin in colon cancer cells. PMID: 21795396 Ref: Molecular basis for the actions of Hsp90 inhibitors and cancer therapy. PMID: 21811259 Ref: Protein kinase C zeta is a positive modulator of canonical Wnt signaling pathway in tumoral colon cell lines. PMID: 21859831 Ref: C086, a novel analog of curcumin, induces growth inhibition and down-regulation of NFkappaB in colon cancer cells and xenograft tumors. PMID: 21900746 Ref: Tissue microarrays in Chinese human rectal cancer: study of expressions of the tumor-associated genes. PMID: 22024062 Ref: Hedgehog signaling and the Gli code in stem cells, cancer, and metastases. PMID: 22114144 Ref: Wnt-pathway activation in intestinal-type sinonasal adenocarcinoma. PMID: 22125792 Ref: Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development. PMID: 22142333 Ref: Protein kinase A antagonist inhibits beta-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice. PMID: 22168384 Ref: Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model. PMID: 22171126 |
Ref: Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. PMID: 21813470 Ref: gamma-Tocotrienol inhibits cell viability through suppression of beta-catenin/Tcf signaling in human colon carcinoma HT-29 cells. PMID: 21852086 Ref: Astragalus saponins modulate cell invasiveness and angiogenesis in human gastric adenocarcinoma cells. PMID: 21864667 Ref: USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway. PMID: 21928107 Ref: MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells. PMID: 22072622 Ref: P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth. PMID: 22100495 Ref: VDR/RXR and TCF4/beta-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression. PMID: 22108803 Ref: Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells. PMID: 22134768 Ref: Methylselenol, a selenium metabolite, plays common and different roles in cancerous colon HCT116 cell and noncancerous NCM460 colon cell proliferation. PMID: 22171558 Ref: The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells. PMID: 22172953 Ref: The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. PMID: 22190494 Ref: Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells. PMID: 22205615 Ref: An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. PMID: 22222631 Ref: Structure-based discovery of a novel inhibitor targeting the beta-catenin/Tcf4 interaction. PMID: 22224445 Ref: Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells. PMID: 22285861 Ref: Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. PMID: 22294162 Ref: CIP2A overexpression is associated with c-Myc expression in colorectal cancer. PMID: 22310977 Ref: CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency. PMID: 22345154 Ref: REGgamma is associated with multiple oncogenic pathways in human cancers. PMID: 22361172 Ref: Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells. PMID: 22384170 Ref: Synthetic lethality-based therapeutics: perspectives for applications in colorectal cancer. PMID: 22385509 Ref: The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression. PMID: 22395148 Ref: Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PMID: 22438825 Ref: Ellagic acid modulates antioxidant status, ornithine decarboxylase expression, and aberrant crypt foci progression in 1,2-dimethylhydrazine-instigated colon preneoplastic lesions in rats. PMID: 22439659 Ref: Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. PMID: 22465936 Ref: Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and beta-catenin interactions. PMID: 22466651 Ref: Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. PMID: 22473991 Ref: SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression. PMID: 22496461 Ref: Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition. PMID: 22547830 Ref: The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer. PMID: 22558377 Ref: 8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. PMID: 22666420 Ref: Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer. PMID: 22682314 Ref: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. PMID: 22800197 Ref: Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948. PMID: 22807617 Ref: In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract. PMID: 22818000 Ref: K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc. PMID: 22826122 Ref: Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice. PMID: 22876303 Ref: Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells. PMID: 22877649 Ref: Human telomerase reverse transcriptase (hTERT) is a target gene of beta-catenin in human colorectal tumors. PMID: 22894902 Ref: Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma. PMID: 22895545 Ref: Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer. PMID: 22989882 Ref: Role of FBXL20 in human colorectal adenocarcinoma. PMID: 23023584 Ref: Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. PMID: 23045412 Ref: Identification of potential pathways involved in induction of apoptosis by butyrate and 4-benzoylbutyrate in HT29 colorectal cancer cells. PMID: 23057685 Ref: Effects of siRNA targeting c-Myc and VEGF on human colorectal cancer Volo cells. PMID: 23169760 Ref: Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. PMID: 23172913 |
Ref: Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/beta-catenin signalling and reduces colon pre-neoplasia in rats. PMID: 22716201 Ref: Methylselenol, a selenium metabolite, modulates p53 pathway and inhibits the growth of colon cancer xenografts in Balb/c mice. PMID: 22841391 Ref: Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation. PMID: 22965873 Ref: The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer. PMID: 22976378 Ref: SAP155-mediated c-myc suppressor far-upstream element-binding protein-interacting repressor splicing variants are activated in colon cancer tissues. PMID: 23113893 Ref: Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells. PMID: 23142292 Ref: SSEA-3 as a novel amplifying cancer cell surface marker in colorectal cancers. PMID: 23175153 Ref: c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1alpha. PMID: 23237807 Ref: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. PMID: 23333577 Ref: 2,3,6-Trisubstituted quinoxaline derivative, a small molecule inhibitor of the Wnt/beta-catenin signaling pathway, suppresses cell proliferation and enhances radiosensitivity in A549/Wnt2 cells. PMID: 23348226 Ref: Differentiation-inducing factor-1 suppresses the expression of c-Myc in the human cancer cell lines. PMID: 23357875 Ref: Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. PMID: 23368921 Ref: Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling. PMID: 23376422 Ref: A non-enzymatic function of Golgi glycosyltransferases: mediation of Golgi fragmentation by interaction with non-muscle myosin IIA. PMID: 23396488 Ref: Cardiotonic steroids-mediated Na+/K+-ATPase targeting could circumvent various chemoresistance pathways. PMID: 23412992 Ref: Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. PMID: 23454242 Ref: Excellence in cell signaling research recognized with major new award. PMID: 23497077 Ref: Tumor-suppressive microRNA-145 targets catenin delta-1 to regulate Wnt/beta-catenin signaling in human colon cancer cells. PMID: 23499891 Ref: Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines. PMID: 23520519 Ref: Resveratrol inhibits proliferation, angiogenesis and induces apoptosis in colon cancer cells: calorie restriction is the force to the cytotoxicity. PMID: 23536519 Ref: Cardamonin suppresses the proliferation of colon cancer cells by promoting beta-catenin degradation. PMID: 23538439 Ref: Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression. PMID: 23594796 Ref: Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells. PMID: 23602914 Ref: Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis. PMID: 23617763 Ref: S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/beta-catenin pathway. PMID: 23637971 Ref: Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis. PMID: 23722564 Ref: Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs. PMID: 23736004 Ref: The IkappaB family member Bcl-3 stabilizes c-Myc in colorectal cancer. PMID: 23794716 Ref: CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. PMID: 23796952 Ref: GPR48, a poor prognostic factor, promotes tumor metastasis and activates beta-catenin/TCF signaling in colorectal cancer. PMID: 23803691 Ref: MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death. PMID: 23816886 Ref: Interaction of 14-3-3sigma with KCMF1 suppresses the proliferation and colony formation of human colon cancer stem cells. PMID: 23840115 Ref: Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with beta-catenin/TCF4 interaction in colorectal cancer cells. PMID: 23844215 Ref: Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. PMID: 23848964 Ref: Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of beta-catenin signaling. PMID: 23855266 Ref: TNFalpha and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. PMID: 23866118 Ref: PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy. PMID: 23887393 Ref: Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/beta-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]. PMID: 23922913 Ref: Anti-proliferative effects of a new docosapentaenoic acid monoacylglyceride in colorectal carcinoma cells. PMID: 23932824 Ref: Expression of Tra2 beta in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis. PMID: 23935626 Ref: Cadmium modifies the cell cycle and apoptotic profiles of human breast cancer cells treated with 5-fluorouracil. PMID: 23941782 Ref: Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. PMID: 23951239 Ref: Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors. PMID: 23966164 Ref: Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis. PMID: 24006069 Ref: Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling. PMID: 24015932 Ref: Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines. PMID: 24023739 Ref: CIP2A influences survival in colon cancer and is critical for maintaining Myc expression. PMID: 24098375 Ref: Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells. PMID: 24118446 Ref: Coumarins and lignans from Zanthoxylum schinifolium and their anticancer activities. PMID: 24144361 Ref: Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer. PMID: 24149323 Ref: [c-MYC-mediated regulations in colorectal cancer]. PMID: 24196628 Ref: Inhibition of beta-catenin signaling involved in the biological activities of a lignan E2S isolated from Carya cathayensis fruits. PMID: 24218372 Ref: Tumorigenesis and tumor progression related gene expression profiles in colorectal cancer. PMID: 24240588 Ref: Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/beta-catenin signal pathway. PMID: 24244343 Ref: Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via beta-catenin/GSK-3beta modulation in colorectal carcinoma. PMID: 24303084 Ref: Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations. PMID: 24317174 Ref: USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation. PMID: 24332849 Ref: Octreotide stimulates somatostatin receptor-induced apoptosis of SW480 colon cancer cells by activation of glycogen synthase kinase-3beta, A Wnt/beta-catenin pathway modulator. PMID: 24634935 |
Ref: Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer. PMID: 23681918 Ref: A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. PMID: 23752193 Ref: Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells. PMID: 24027017 Ref: High-throughput fluorescence anisotropy screen for inhibitors of the oncogenic mRNA binding protein, IMP-1. PMID: 24108120 Ref: The inflammatory mediator leukotriene D(4) induces subcellular beta-catenin translocation and migration of colon cancer cells. PMID: 24211746 Ref: Tussilagone suppresses colon cancer cell proliferation by promoting the degradation of beta-catenin. PMID: 24269588 Ref: Nuclear AXIN2 represses MYC gene expression. PMID: 24299953 Ref: CHIP/Stub1 functions as a tumor suppressor and represses NF-kappaB-mediated signaling in colorectal cancer. PMID: 24302614 Ref: Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer. PMID: 24390711 Ref: High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PMID: 24427302 Ref: Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling. PMID: 24467841 Ref: Tumor suppressor NDRG2 tips the balance of oncogenic TGF-beta via EMT inhibition in colorectal cancer. PMID: 24492480 Ref: Asterosaponins from the Starfish Astropecten monacanthus suppress growth and induce apoptosis in HL-60, PC-3, and SNU-C5 human cancer cell lines. PMID: 24492728 Ref: Immunohistochemistry for myc predicts survival in colorectal cancer. PMID: 24503701 Ref: The myc 3' wnt-responsive element suppresses colonic tumorigenesis. PMID: 24567369 Ref: Clock genes: their role in colorectal cancer. PMID: 24587674 Ref: CELLFOOD induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways. PMID: 24598211 Ref: Tumor suppressor DLC-1 induces apoptosis and inhibits the growth and invasion of colon cancer cells through the Wnt/beta-catenin signaling pathway. PMID: 24604602 Ref: beta-catenin regulates NF-kappaB activity via TNFRSF19 in colorectal cancer cells. PMID: 24623448 Ref: Masking epistasis between MYC and TGF-beta pathways in antiangiogenesis-mediated colon cancer suppression. PMID: 24627270 Ref: Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation. PMID: 24628919 Ref: WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer. PMID: 24657851 Ref: Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. PMID: 24662484 Ref: Targeted repression of AXIN2 and MYC gene expression using designer TALEs. PMID: 24667606 Ref: Stress-induced cleavage of Myc promotes cancer cell survival. PMID: 24696454 Ref: Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer. PMID: 24722295 Ref: MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. PMID: 24785257 Ref: Plumbagin downregulates Wnt signaling independent of p53 in human colorectal cancer cells. PMID: 24828199 Ref: ZNF281/ZBP-99: a new player in epithelial-mesenchymal transition, stemness, and cancer. PMID: 24838609 Ref: ITF2 prevents activation of the beta-catenin-TCF4 complex in colon cancer cells and levels decrease with tumor progression. PMID: 24846398 Ref: Predictive simulation approach for designing cancer therapeutic regimens with novel biological mechanisms. PMID: 24847381 Ref: Propolis cinnamic acid derivatives induce apoptosis through both extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA expression. PMID: 24854570 Ref: Elf3 drives beta-catenin transactivation and associates with poor prognosis in colorectal cancer. PMID: 24874735 Ref: Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer. PMID: 24889212 Ref: Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase. PMID: 24890449 Ref: The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. PMID: 24919179 Ref: Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells. PMID: 24921652 Ref: Halogenated diarylacetylenes repress c-myc expression in cancer cells. PMID: 24930834 Ref: FBXL20 acts as an invasion inducer and mediates E-cadherin in colorectal adenocarcinoma. PMID: 24932313 Ref: Involvement of SET in the Wnt signaling pathway and the development of human colorectal cancer. PMID: 24944693 Ref: HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. PMID: 24946763 Ref: Two Natural ent-kauranoids as Novel Wnt Signaling Inhibitors. PMID: 24955294 Ref: The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. PMID: 24960159 Ref: The organochlorine p,p'-dichlorodiphenyltrichloroethane induces colorectal cancer growth through Wnt/beta-catenin signaling. PMID: 24968063 Ref: GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the beta-catenin signaling. PMID: 24977433 Ref: MACC1 promotes carcinogenesis of colorectal cancer via beta-catenin signaling pathway. PMID: 25003996 Ref: Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands. PMID: 25015035 Ref: The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. PMID: 25023051 Ref: LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/beta-catenin signaling pathway in colorectal cancer cells. PMID: 25025569 Ref: PKM2 depletion induces the compensation of glutaminolysis through beta-catenin/c-Myc pathway in tumor cells. PMID: 25041845 Ref: PVT1 dependence in cancer with MYC copy-number increase. PMID: 25043044 Ref: Molecular mechanisms associated with PTHrP-induced proliferation of colon cancer cells. PMID: 25053227 Ref: [Expression of Runx3 and C-myc in human colorectal cancer]. PMID: 25057081 Ref: The impact of pyrvinium pamoate on colon cancer cell viability. PMID: 25060218 Ref: A combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cells. PMID: 25123131 Ref: Transcriptional dynamics in colorectal carcinogenesis: new insights into the role of c-Myc and miR17 in benign to cancer transformation. PMID: 25125661 Ref: C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. PMID: 25185650 Ref: Molecular mechanism of activating protein-4 regulated growth of hepatocellular carcinoma. PMID: 25195135 Ref: Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. PMID: 25200342 Ref: Expression QTL-based analyses reveal the mechanisms underlying colorectal cancer predisposition. PMID: 25201067 Ref: Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. PMID: 25205133 Ref: AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway. PMID: 25216185 Ref: Activation of c-Myc and Cyclin D1 by JCV T-Antigen and beta-catenin in colon cancer. PMID: 25229241 Ref: Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. PMID: 25253726 Ref: Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway. PMID: 25285768 Ref: Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation. PMID: 25352148 Ref: Expression profiling of rectal tumors defines response to neoadjuvant treatment related genes. PMID: 25380052 Ref: Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. PMID: 25386076 Ref: p, p'-Dichlorodiphenyldichloroethylene induces colorectal adenocarcinoma cell proliferation through oxidative stress. PMID: 25386960 Ref: [Relationship between multi-gene proteins in colorectal carcinoma complicated with chronic schistosomiasis: an immunohistochemical study by using tissue microarray techniques]. PMID: 25434139 Ref: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. PMID: 25443414 |
Ref: c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2alpha and promotes tumor angiogenesis and metastasis by upregulating FGF2. PMID: 24704828 Ref: CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. PMID: 25060070 Ref: Steroidal constituents from the edible sea urchin Diadema savignyi Michelin induce apoptosis in human cancer cells. PMID: 25211186 Ref: Multiple mucin depleted foci, high proliferation and low apoptotic response in the onset of colon carcinogenesis of the PIRC rat, mutated in Apc. PMID: 25257656 Ref: S-Adenosylmethionine and methylthioadenosine inhibit beta-catenin signaling by multiple mechanisms in liver and colon cancer. PMID: 25338671 Ref: miR-31 promotes proliferation of colon cancer cells by targeting E2F2. PMID: 25362258 Ref: MicroRNA-93 suppress colorectal cancer development via Wnt/beta-catenin pathway downregulating. PMID: 25371073 Ref: A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer: Research for Reprogramming of Cancer Cells by MicroRNAs. PMID: 25384704 Ref: beta1 integrin mediates colorectal cancer cell proliferation and migration through regulation of the Hedgehog pathway. PMID: 25387809 Ref: Combined use of vitamin D3 and metformin exhibits synergistic chemopreventive effects on colorectal neoplasia in rats and mice. PMID: 25416412 Ref: Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer. PMID: 25500543 Ref: Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. PMID: 25548100 Ref: A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/beta-catenin signaling. PMID: 25600769 Ref: Keratin 1 plays a critical role in golgi localization of core 2 N-acetylglucosaminyltransferase M via interaction with its cytoplasmic tail. PMID: 25605727 Ref: FBXW7 acts as an independent prognostic marker and inhibits tumor growth in human osteosarcoma. PMID: 25622249 Ref: The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC. PMID: 25632068 Ref: A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells. PMID: 25659031 Ref: The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells. PMID: 25689483 Ref: The anticancer effect of (1S,2S,3E,7E,11E)-3,7,11, 15-cembratetraen-17,2-olide(LS-1) through the activation of TGF-beta signaling in SNU-C5/5-FU, fluorouracil-resistant human colon cancer cells. PMID: 25786063 Ref: CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells. PMID: 25788983 Ref: Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after gamma-irradiation through Wnt/beta-catenin pathway. PMID: 25827435 Ref: Genetic dissimilarity between primary colorectal carcinomas and their lymph node metastases: ploidy, p53, bcl-2, and c-myc expression--a pilot study. PMID: 25840688 Ref: c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. PMID: 25895136 Ref: Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer. PMID: 25904505 Ref: [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells]. PMID: 25907934 Ref: Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer. PMID: 25911689 Ref: Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. PMID: 25913757 Ref: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer. PMID: 25934076 Ref: TRAF4 promotes the growth and invasion of colon cancer through the Wnt/beta-catenin pathway. PMID: 25973026 Ref: Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity. PMID: 25979483 Ref: MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression. PMID: 26003165 Ref: The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-beta-Responsive Colon Carcinoma. PMID: 26012475 Ref: Synergistic apoptosis-inducing effect of aspirin and isosorbide mononitrate on human colon cancer cells. PMID: 26094902 Ref: A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer. PMID: 26137537 Ref: TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells. PMID: 26140605 Ref: Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells. PMID: 26144048 Ref: Targeting MYC Translation in Colorectal Cancer. PMID: 26152922 Ref: Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio. PMID: 26167492 Ref: Genome-wide transcriptome analysis reveals inactivation of Wnt/beta-catenin by 3,3'-diindolylmethane inhibiting proliferation of colon cancer cells. PMID: 26203047 Ref: Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the beta-catenin pathway in colorectal cancer. PMID: 26210065 Ref: Aberrant Expression of CCAT1 Regulated by c-Myc Predicts the Prognosis of Hepatocellular Carcinoma. PMID: 26225650 Ref: Positive feedback loop of hepatoma-derived growth factor and beta-catenin promotes carcinogenesis of colorectal cancer. PMID: 26296979 Ref: Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. PMID: 26317652 Ref: Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells. PMID: 26318418 Ref: Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer. PMID: 26328044 Ref: miRNA-144 suppresses proliferation and migration of colorectal cancer cells through GSPT1. PMID: 26349975 Ref: c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer. PMID: 26426996 Ref: Ginsenoside Rg3 inhibits colon cancer cell migration by suppressing nuclear factor kappa B activity. PMID: 26427115 Ref: The consensus molecular subtypes of colorectal cancer. PMID: 26457759 Ref: Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells. PMID: 26463716 Ref: miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells. PMID: 26487644 Ref: Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells. PMID: 26506423 Ref: Tissue-Specific Effects of Reduced beta-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. PMID: 26528816 Ref: Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth. PMID: 26586936 Ref: Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/beta-catenin signaling pathway. PMID: 26617747 Ref: Circadian gene expression predicts patient response to neoadjuvant chemoradiation therapy for rectal cancer. PMID: 26617816 Ref: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes. PMID: 26625825 Ref: Regulation of MYC gene expression by aberrant Wnt/beta-catenin signaling in colorectal cancer. PMID: 26629312 Ref: Verification of ALDH Activity as a Biomarker in Colon Cancer Stem Cells-Derived HT-29 Cell Line. PMID: 26634106 Ref: The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer. PMID: 26637399 Ref: Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PMID: 26678268 |
Ref: PRDM1, a Tumor-Suppressor Gene, is Induced by Genkwadaphnin in Human Colon Cancer SW620 Cells. PMID: 26096175 Ref: Integrin alpha1beta1 expression is controlled by c-MYC in colorectal cancer cells. PMID: 26096932 Ref: Aspirin and salicylic acid decrease c-Myc expression in cancer cells: a potential role in chemoprevention. PMID: 26314861 Ref: hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer. PMID: 26607374 Ref: Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells. PMID: 26609171 Ref: All Trans-Retinoic Acid Mediates MED28/HMG Box-Containing Protein 1 (HBP1)/beta-Catenin Signaling in Human Colorectal Cancer Cells. PMID: 26660958 Ref: Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy. PMID: 26717967 Ref: Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression. PMID: 26733171 Ref: Deregulated expression of cryptochrome genes in human colorectal cancer. PMID: 26768731 Ref: Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells by PML and p53. PMID: 26795951 Ref: Distribution of the c-MYC gene product in colorectal neoplasia. PMID: 26826706 Ref: Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression. PMID: 26848526 Ref: Ochratoxin A and T-2 Toxin Induce Clonogenicity and Cell Migration in Human Colon Carcinoma and Fetal Lung Fibroblast Cell Lines. PMID: 26849850 Ref: A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1. PMID: 26860615 Ref: Expression of hepatocyte growth factor and c-Met is characteristic of alpha-fetoprotein-producing colorectal adenocarcinoma: A report of three cases. PMID: 26870275 Ref: Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development. PMID: 26908355 Ref: Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia. PMID: 26923190 Ref: Topoisomerase IIalpha mediates TCF-dependent epithelial-mesenchymal transition in colon cancer. PMID: 26947016 Ref: Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. PMID: 26983878 Ref: Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-kappaB. PMID: 26998041 Ref: Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/beta-catenin pathway to promote growth and metastasis in colorectal cancer. PMID: 27012187 Ref: Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis. PMID: 27013588 Ref: HDAC1 controls CIP2A transcription in human colorectal cancer cells. PMID: 27029072 Ref: Inhibition of GLI1 Expression by Targeting the CRD-BP-GLI1 mRNA Interaction Using a Specific Oligonucleotide. PMID: 27036131 Ref: Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease. PMID: 27063727 Ref: Comparative analysis of copy number variations in ulcerative colitis associated and sporadic colorectal neoplasia. PMID: 27080994 Ref: [c-Myc regulation of ATP-binding cassette transporter reverses chemoresistance in CD133(+) colon cancer stem cells]. PMID: 27108904 Ref: microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway. PMID: 27191497 Ref: Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. PMID: 27218826 Ref: The MYC 3' Wnt-Responsive Element Drives Oncogenic MYC Expression in Human Colorectal Cancer Cells. PMID: 27223305 Ref: miR-17-92a-1 cluster host gene (MIR17HG) evaluation and response to neoadjuvant chemoradiotherapy in rectal cancer. PMID: 27226732 Ref: Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells. PMID: 27255403 Ref: KSR1 and EPHB4 Regulate Myc and PGC1beta To Promote Survival of Human Colon Tumors. PMID: 27273865 Ref: Inhibitory effects of Hedyotis diffusa Willd. on colorectal cancer stem cells. PMID: 27313710 Ref: 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis. PMID: 27387680 Ref: Elucidation of a novel phenformin derivative on glucose-deprived stress responses in HT-29 cells. PMID: 27392906 Ref: SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ss-catenin signaling. PMID: 27429045 Ref: Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression. PMID: 27455418 Ref: The Effect of (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-Olide (LS-1) from Lobophyyum sp. on the Apoptosis Induction of SNU-C5 Human Colorectal Cancer Cells. PMID: 27469141 Ref: Anticancer Activity of Buttermilk Against SW480 Colon Cancer Cells is Associated with Caspase-Independent Cell Death and Attenuation of Wnt, Akt, and ERK Signaling. PMID: 27472445 Ref: Cationic microRNA-delivering nanocarriers for efficient treatment of colon carcinoma in xenograft model. PMID: 27482839 Ref: Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa. PMID: 27524493 Ref: MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation. PMID: 27566402 Ref: MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression. PMID: 27568568 Ref: miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli. PMID: 27595705 Ref: Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model. PMID: 27612418 Ref: Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ss-catenin. PMID: 27619912 Ref: Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer. PMID: 27626684 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. PMID: 27672289 Ref: Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-kappaB. PMID: 27698868 Ref: Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. PMID: 27699933 Ref: LDB1 overexpression is a negative prognostic factor in colorectal cancer. PMID: 27713177 Ref: Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. PMID: 27729975 Ref: Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells. PMID: 27748801 Ref: Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. PMID: 27748879 Ref: Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients. PMID: 27756887 Ref: Combination of three-gene immunohistochemical panel and magnetic resonance imaging-detected extramural vascular invasion to assess prognosis in non-advanced rectal cancer patients. PMID: 27784970 Ref: c-Myc is regulated by HIF-2alpha in chronic hypoxia and influences sensitivity to 5-FU in colon cancer. PMID: 27793037 Ref: [Pancreatic acinar neoplasms : Comparative molecular characterization]. PMID: 27807633 Ref: FoxO3a confers cetuximab resistance in RAS wild-type metastatic colorectal cancer through c-Myc. PMID: 27825133 Ref: CCAT1 promotes laryngeal squamous cell carcinoma cell proliferation and invasion. PMID: 27830017 Ref: Bile acid: a potential inducer of colon cancer stem cells. PMID: 27908290 Ref: Identification of potential therapeutic targets for colorectal cancer by bioinformatics analysis. PMID: 28105216 |
Ref: Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer. PMID: 27473587 Ref: Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and Tumorigenesis in Colorectal Cancer Cells. PMID: 27712600 Ref: Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. PMID: 27899379 Ref: Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC. PMID: 27903583 Ref: Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and beta-Catenin Signaling. PMID: 27983919 Ref: Morin and Esculetin supplementation modulates c-myc induced energy metabolism and attenuates neoplastic changes in rats challenged with the procarcinogen 1,2 - dimethylhydrazine. PMID: 27989504 Ref: Elevated expression of TrpC5 and GLUT1 is associated with chemoresistance in colorectal cancer. PMID: 28000878 Ref: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. PMID: 28030835 Ref: Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116. PMID: 28036279 Ref: Knockdown of Tripartite Motif-Containing Protein 37 (TRIM37) Inhibits the Proliferation and Tumorigenesis in Colorectal Cancer Cells. PMID: 28081740 Ref: Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development. PMID: 28162896 Ref: Research of the relationship between beta-catenin and c-myc-mediated Wnt pathway and laterally spreading tumors occurrence. PMID: 28165564 Ref: Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. PMID: 28173629 Ref: Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. PMID: 28183047 Ref: H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells. PMID: 28189050 Ref: MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. PMID: 28211508 Ref: The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target. PMID: 28223542 Ref: miRNA-320a inhibits tumor proliferation and invasion by targeting c-Myc in human hepatocellular carcinoma. PMID: 28243124 Ref: Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells. PMID: 28244854 Ref: NDRG2 gene copy number is not altered in colorectal carcinoma. PMID: 28246586 Ref: Nucleome Analysis Reveals Structure-Function Relationships for Colon Cancer. PMID: 28258094 Ref: Chronic inflammation confers to the metabolic reprogramming associated with tumorigenesis of colorectal cancer. PMID: 28278072 Ref: Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. PMID: 28284059 Ref: Effects of di(2-ethylhexyl)phthalate exposure on 1,2-dimethyhydrazine-induced colon tumor promotion in rats. PMID: 28284729 Ref: A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat. PMID: 28289824 Ref: Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3beta/beta-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model. PMID: 28315345 Ref: The evaluation of the anti-cancer activity of ixazomib on Caco2 colon solid tumor cells, comparison with bortezomib. PMID: 28327055 Ref: Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-kappaB and STAT3 Signaling. PMID: 28331523 Ref: p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. PMID: 28339031 Ref: Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines. PMID: 28345468 Ref: The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression. PMID: 28381186 Ref: The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels. PMID: 28408437 Ref: Long non-coding RNA CCAT1 is overexpressed in oral squamous cell carcinomas and predicts poor prognosis. PMID: 28413645 Ref: Reciprocal control of lncRNA-BCAT1 and beta-catenin pathway reveals lncRNA-BCAT1 long non-coding RNA acts as a tumor suppressor in colorectal cancer. PMID: 28416735 Ref: Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors. PMID: 28423651 Ref: Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade. PMID: 28423670 Ref: The regulation of beta-catenin activity and function in cancer: therapeutic opportunities. PMID: 28430641 Ref: Morphoproteomic-Guided Treatment of Chemotherapy Resistant Colon Cancer using Natural Based Therapies: A Case Study. PMID: 28442526 Ref: Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells. PMID: 28445985 Ref: Discovery of small molecule inhibitors of the Wnt/beta-catenin signaling pathway by targeting beta-catenin/Tcf4 interactions. PMID: 28474989 Ref: Synergistic role of Cul1 and c-Myc: Prognostic and predictive biomarkers in colorectal cancer. PMID: 28560438 Ref: Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway. PMID: 28576751 Ref: Silencing of long non-coding RNA CCAT2 depressed malignancy of oral squamous cell carcinoma via Wnt/beta-catenin pathway. PMID: 28671055 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: HMGB3 promotes growth and migration in colorectal cancer by regulating WNT/beta-catenin pathway. PMID: 28678825 Ref: Colorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc. PMID: 28699179 Ref: Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development. PMID: 28704539 Ref: The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer. PMID: 28731158 Ref: miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer. PMID: 28749470 Ref: Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer. PMID: 28764718 Ref: R-spondin 2 promotes proliferation and migration via the Wnt/beta-catenin pathway in human hepatocellular carcinoma. PMID: 28789406 Ref: Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. PMID: 28790461 Ref: Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways. PMID: 28807224 Ref: Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. PMID: 28829588 Ref: Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. PMID: 28847964 Ref: Down regulation of the long non-coding RNA PCAT-1 induced growth arrest and apoptosis of colorectal cancer cells. PMID: 28855110 Ref: NFATc3 mediates the sensitivity of gastric cancer cells to arsenic sulfide. PMID: 28881766 Ref: Transgenic overexpression of NanogP8 in the mouse prostate is insufficient to initiate tumorigenesis but weakly promotes tumor development in the Hi-Myc mouse model. PMID: 28881767 Ref: SATB2/beta-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer. PMID: 28887549 Ref: RASSF6 downregulation promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal cancer. PMID: 28903410 Ref: PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition. PMID: 28915620 Ref: To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer. PMID: 28930145 Ref: Polyyne-Enriched Extract from Oplopanax elatus Significantly Ameliorates the Progression of Colon Carcinogenesis in Apc(Min/+) Mice. PMID: 28937627 Ref: The BET-Bromodomain Inhibitor JQ1 synergized ABT-263 against colorectal cancer cells through suppressing c-Myc-induced miR-1271-5p expression. PMID: 28950657 Ref: A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer. PMID: 28962550 Ref: Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PMID: 28968471 Ref: miR-223 promotes colon cancer by directly targeting p120 catenin. PMID: 28969027 Ref: SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/beta-Catenin complex. PMID: 28970068 Ref: Synergism between alpha-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway. PMID: 29039600 Ref: Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression. PMID: 29042944 Ref: Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300. PMID: 29069825 Ref: Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of Wnt/beta-catenin signaling pathway. PMID: 29080197 Ref: Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF-beta/Smad pathway in vitro and in vivo. PMID: 29085481 Ref: Exploring conserved mRNA-miRNA interactions in colon and lung cancers. PMID: 29118934 Ref: A Proteomics Analysis Reveals 9 Up-Regulated Proteins Associated with Altered Cell Signaling in Colon Cancer Patients. PMID: 29128960 Ref: Long noncoding RNA HNF1A-AS1 indicates a poor prognosis of colorectal cancer and promotes carcinogenesis via activation of the Wnt/beta-catenin signaling pathway. PMID: 29145164 Ref: Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production. PMID: 29167573 Ref: Exome and transcriptome sequencing identifies loss of PDLIM2 in metastatic colorectal cancers. PMID: 29184442 Ref: Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer. PMID: 29258530 Ref: Network analysis of common genes related to esophageal, gastric, and colon cancers. PMID: 29379595 Ref: Characterization of Cancer Stem Cells in Colon Adenocarcinoma Metastasis to the Liver. PMID: 29404335 Ref: Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma. PMID: 29511478 |
Ref: MicroRNA-184 inhibits proliferation and promotes apoptosis of human colon cancer SW480 and HCT116 cells by downregulating C-MYC and BCL-2. PMID: 28782841 Ref: Knockdown of long non-coding RNA prostate cancer-associated ncRNA transcript 1 inhibits multidrug resistance and c-Myc-dependent aggressiveness in colorectal cancer Caco-2 and HT-29 cells. PMID: 28884413 Ref: Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery. PMID: 29119627 Ref: Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer. PMID: 29206819 Ref: A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267. PMID: 29267898 Ref: Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1. PMID: 29274585 Ref: Vitex rotundifolia Fruit Suppresses the Proliferation of Human Colorectal Cancer Cells through Down-regulation of Cyclin D1 and CDK4 via Proteasomal-Dependent Degradation and Transcriptional Inhibition. PMID: 29298515 Ref: Emodin inhibits colon cancer cell invasion and migration by suppressing epithelialmesenchymal transition via the Wnt/beta-catenin pathway. PMID: 29301594 Ref: RvD1 inhibits TNFalpha-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells. PMID: 29305860 Ref: Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells. PMID: 29314290 Ref: The key genes underlying pathophysiology association between the type 2-diabetic and colorectal cancer. PMID: 29319171 Ref: The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. PMID: 29346117 Ref: Long non-coding RNA DLEU7-AS1 promotes the occurrence and development of colorectal cancer via Wnt/beta-catenin pathway. PMID: 29364477 Ref: Thyroid Hormone Promotes beta-Catenin Activation and Cell Proliferation in Colorectal Cancer. PMID: 29380230 Ref: miR-522-3p Promotes Tumorigenesis in Human Colorectal Cancer via Targeting Bloom Syndrome Protein. PMID: 29386092 Ref: MYC Regulates alpha6 Integrin Subunit Expression and Splicing Under Its Pro-Proliferative ITGA6A Form in Colorectal Cancer Cells. PMID: 29401653 Ref: Ectopic expression of miR-147 inhibits stem cell marker and epithelial-mesenchymal transition (EMT)-related protein expression in colon cancer cells. PMID: 29426374 Ref: Anti-inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer. PMID: 29434827 Ref: Low-dose paclitaxel downregulates MYC proto-oncogene bHLH transcription factor expression in colorectal carcinoma cells. PMID: 29434885 Ref: Co-inhibition of BET proteins and NF-kappaB as a potential therapy for colorectal cancer through synergistic inhibiting MYC and FOXM1 expressions. PMID: 29472532 Ref: Oncogene c-Myc promotes epitranscriptome m(6)A reader YTHDF1 expression in colorectal cancer. PMID: 29484125 Ref: LncRNA CCAT2 promoted osteosarcoma cell proliferation and invasion. PMID: 29502343 Ref: Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells. PMID: 29507187 Ref: Studying the mechanism of PLAGL2 overexpression and its carcinogenic characteristics based on 3'-untranslated region in colorectal cancer. PMID: 29512763 Ref: BRAF and EGFR inhibitors synergize to increase cytotoxic effects and decrease stem cell capacities in BRAF(V600E)-mutant colorectal cancer cells. PMID: 29534162 Ref: TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [(18)F] fluorodeoxyglucose ((18)F-FDG PET). PMID: 29581845 Ref: Identification of Response Elements on Promoters Using Site-Directed Mutagenesis and Chromatin Immunoprecipitation. PMID: 29589300 Ref: Long noncoding RNA BC200 regulates cell growth and invasion in colon cancer. PMID: 29625226 Ref: Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3beta and F-box and WD repeat domain-containing 7. PMID: 29628506 Ref: Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture. PMID: 29642386 Ref: Long non-coding RNA XIST sponges miR-34a to promotes colon cancer progression via Wnt/beta-catenin signaling pathway. PMID: 29679755 Ref: Multi-panel assay of serum autoantibodies in colorectal cancer. PMID: 29691673 Ref: Inhibitory effects of aesculetin on the proliferation of colon cancer cells by the Wnt/beta-catenin signaling pathway. PMID: 29725434 Ref: Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/beta-Catenin Signaling. PMID: 29730655 Ref: MicroRNA hsa-let-7e-5p as a potential prognosis marker for rectal carcinoma with liver metastases. PMID: 29731866 Ref: Long non-coding RNA SNHG1 predicts a poor prognosis and promotes colon cancer tumorigenesis. PMID: 29749530 Ref: LncRNA H19/miR-29b-3p/PGRN Axis Promoted Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Acting on Wnt Signaling. PMID: 29754471 Ref: PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. PMID: 29760071 Ref: Distinct Histopathologic and Molecular Alterations in Inflammatory Bowel Disease-Associated Intestinal Adenocarcinoma: c-MYC Amplification is Common and Associated with Mucinous/Signet Ring Cell Differentiation. PMID: 29788391 Ref: Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells. PMID: 29794421 Ref: Tumor Necrosis Factor Ligand-Related Molecule 1A Regulates the Occurrence of Colitis-Associated Colorectal Cancer. PMID: 29796912 Ref: Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/beta-catenin signaling. PMID: 29802196 Ref: Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells. PMID: 29805745 Ref: Simultaneous identification of clinically relevant single nucleotide variants, copy number alterations and gene fusions in solid tumors by targeted next-generation sequencing. PMID: 29854313 Ref: Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis. PMID: 29875662 Ref: Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers. PMID: 29882899 Ref: R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells. PMID: 29886802 Ref: The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids. PMID: 29915160 Ref: WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage. PMID: 29925347 Ref: Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF-kappaB pathway in vitro. PMID: 29928339 Ref: STAT3/c-Myc Axis-Mediated Metabolism Alternations of Inflammation-Related Glycolysis Involve with Colorectal Carcinogenesis. PMID: 29932015 Ref: MACC1 silencing inhibits cell proliferation and induces cell apoptosis of lung adenocarcinoma cells through the beta-catenin pathway. PMID: 29940751 Ref: The long noncoding RNA BC0209135 inhibits the cell invasion through Wnt/beta-catenin signaling in colorectal cancer. PMID: 29949151 Ref: Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling. PMID: 29957460 Ref: The TGFbeta-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs. PMID: 29986714 Ref: Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/beta-catenin signaling pathway. PMID: 30008817 Ref: Inhibitory effect of selenomethionine on carcinogenesis in the model of human colorectal cancer in vitro and its link to the Wnt/beta-catenin pathway. PMID: 30016378 Ref: A Rare Missense Variant in TCF7L2 Associates with Colorectal Cancer Risk by Interacting with a GWAS-Identified Regulatory Variant in the MYC Enhancer. PMID: 30026326 Ref: Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC-driven oncogenic program in colorectal cancer. PMID: 30038405 Ref: CYP24A1 Inhibition Facilitates the Antiproliferative Effect of 1,25(OH)2D3 Through Downregulation of the WNT/beta-Catenin Pathway and Methylation-Mediated Regulation of CYP24A1 in Colorectal Cancer Cells. PMID: 30052060 Ref: MicroRNA-552 links Wnt signaling to p53 tumor suppressor in colorectal cancer. PMID: 30066856 Ref: A natural flavonoid lawsonaringenin induces cell cycle arrest and apoptosis in HT-29 colorectal cancer cells by targeting multiple signalling pathways. PMID: 30088202 Ref: hmiR-34c-3p upregulation inhibits the proliferation of colon cancer cells by targeting EIF3D. PMID: 30096129 Ref: 4-Acetyl-Antroquinonol B Suppresses SOD2-Enhanced Cancer Stem Cell-Like Phenotypes and Chemoresistance of Colorectal Cancer Cells by Inducing hsa-miR-324 re-Expression. PMID: 30103475 Ref: Pimozide suppresses colorectal cancer via inhibition of Wnt/beta-catenin signaling pathway. PMID: 30107167 Ref: Hypomethylation of NANOG promoter in colonic mucosal cells of obese patients: a possible role of NF-kappaB. PMID: 30157990 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: Upregulation of C/EBPalpha contributes to colorectal cancer growth, metastasis and indicates poor survival outcome. PMID: 30210916 Ref: Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK-1-eIF4G-eIF4E signaling. PMID: 30221473 Ref: Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/beta-Catenin Signaling Pathway. PMID: 30231258 Ref: Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4- yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor. PMID: 30253346 Ref: Upregulation of long noncoding RNA CCAT1-L promotes epithelial-mesenchymal transition in gastric adenocarcinoma. PMID: 30254457 Ref: Baicalin, the major component of traditional Chinese medicine Scutellaria baicalensis induces colon cancer cell apoptosis through inhibition of oncomiRNAs. PMID: 30262902 Ref: Using of keratin substrate for enrichment of HT29 colorectal cancer stem-like cells. PMID: 30281900 Ref: Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers. PMID: 30318507 Ref: SERUM- AND GLUCOCORTICOID-INDUCED KINASE SGK1 DIRECTLY PROMOTES THE DIFFERENTIATION OF COLORECTAL CANCER CELLS AND RESTRAINS METASTASIS. PMID: 30322876 Ref: MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/beta-catenin signaling axis. PMID: 30338942 Ref: Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc. PMID: 30343112 Ref: NUP153 overexpression suppresses the proliferation of colorectal cancer by negatively regulating Wnt/beta-catenin signaling pathway and predicts good prognosis. PMID: 30347601 Ref: Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. PMID: 30348989 Ref: HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX. PMID: 30365520 |