Primary Site >> Colorectal Cancer
Gene >> MUTYH
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Ref: MUTYH-Associated Polyposis PMID: 23035301 |
Ref: Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors. PMID: 11818965 Ref: Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations. PMID: 12393807 |
Ref: Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. PMID: 12707038 Ref: Exposing the MYtH about base excision repair and human inherited disease. PMID: 12915454 Ref: Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. PMID: 12937124 Ref: Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles. PMID: 12966098 Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 Ref: Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. PMID: 14633673 |
Ref: Exclusion of an extracolonic disease modifier locus on chromosome 1p33-36 in a large Swiss familial adenomatous polyposis kindred. PMID: 14735163 Ref: Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer. PMID: 14991577 Ref: Molecular analysis of the APC and MYH genes in Czech families affected by FAP or multiple adenomas: 13 novel mutations. PMID: 15024739 Ref: Role of inherited defects of MYH in the development of sporadic colorectal cancer. PMID: 15034862 Ref: Expression of DNA repair protein: MYH, NTH1, and MTH1 in colorectal cancer. PMID: 15143881 Ref: MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. PMID: 15236166 Ref: Simple and complex genetics of colorectal cancer susceptibility. PMID: 15264271 Ref: Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. PMID: 15449173 Ref: Colorectal cancer and inherited mutations in base-excision repair. PMID: 15465463 Ref: Molecular basis and diagnostics of hereditary colorectal cancers. PMID: 15478312 Ref: Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk. PMID: 15523092 |
Ref: Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. PMID: 15560738 Ref: Intraductal papillary mucinous neoplasm of the pancreas in a patient with attenuated familial adenomatous polyposis. PMID: 15623495 Ref: Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and G365D murine MYH. PMID: 15661655 Ref: A kindred with MYH-associated polyposis and pilomatricomas. PMID: 15690400 Ref: Familial risks for colorectal cancer show evidence on recessive inheritance. PMID: 15704173 Ref: Re: Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk. PMID: 15713969 Ref: [Hereditary colorectal cancer]. PMID: 15725711 Ref: Genetics of hereditary colorectal cancer. PMID: 15726502 Ref: Germline susceptibility to colorectal cancer due to base-excision repair gene defects. PMID: 15931596 Ref: Is prophylactic colectomy indicated in patients with MYH-associated polyposis? PMID: 15932553 Ref: Germline mutations in the MYH gene in Swedish familial and sporadic colorectal cancer. PMID: 15943555 Ref: Hereditary colorectal cancer syndromes. PMID: 15947872 Ref: Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. PMID: 15987719 Ref: MutYH (MYH) and colorectal cancer. PMID: 16042573 Ref: A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis. PMID: 16134146 Ref: Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP). PMID: 16140997 Ref: Attenuated familial adenomatous polyposis and Muir-Torre syndrome linked to compound biallelic constitutional MYH gene mutations. PMID: 16207212 Ref: Correlation of polyp number and family history of colon cancer with germline MYH mutations. PMID: 16234049 Ref: What's new in hereditary colorectal cancer? PMID: 16253015 Ref: [From gene to disease; MutYH-associated polyposis coli (MAP)]. PMID: 16425850 Ref: Inherited colorectal cancer syndromes. PMID: 20011298 |
Ref: DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients. PMID: 16152625 Ref: Prevalence of MYH germline mutations in Swiss APC mutation-negative polyposis patients. PMID: 16287072 Ref: MUTYH and the mismatch repair system: partners in crime? PMID: 16408224 Ref: Twelve years of endoscopic surveillance in a family carrying biallelic Y165C MYH defect: report of a case. PMID: 16416081 Ref: Familial adenomatous polyposis. PMID: 16454848 Ref: Multiplex tetra-primer amplification refractory mutation system PCR to detect 6 common germline mutations of the MUTYH gene associated with polyposis and colorectal cancer. PMID: 16455870 Ref: Risk of colorectal cancer in monoallelic and biallelic carriers of MYH mutations: a population-based case-family study. PMID: 16492921 Ref: Chromosomal instability in MYH- and APC-mutant adenomatous polyps. PMID: 16510566 Ref: MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype. PMID: 16557584 Ref: [Current concepts in the genetics of hereditary and sporadic colorectal cancer and the role of genetics in patient management. Hereditary colorectal cancers]. PMID: 16579336 Ref: Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. PMID: 16609022 Ref: Novel findings in Swedish patients with MYH-associated polyposis: mutation detection and clinical characterization. PMID: 16616356 Ref: Genetics of colorectal cancer. PMID: 16629258 Ref: Microsatellite stable colorectal cancers in clinically suspected hereditary nonpolyposis colorectal cancer patients without vertical transmission of disease are unlikely to be caused by biallelic germline mutations in MYH. PMID: 16645203 Ref: [Genetic mechanisms in the hereditary predisposition to colorectal cancer]. PMID: 16670730 Ref: Oxidative DNA damage and human cancer: need for cohort studies. PMID: 16771692 Ref: Increased frequency of disease-causing MYH mutations in colon cancer families. PMID: 16774938 Ref: Association of MUTYH and colorectal cancer. PMID: 16804517 Ref: Genetic predisposition to colorectal cancer: new pieces in the pediatric puzzle. PMID: 16819371 Ref: Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH. PMID: 16831587 Ref: [Hereditary forms of colorectal adenomatous polyposis]. PMID: 16836001 Ref: Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis. PMID: 16890597 Ref: [MYH and colorectal cancer. A significant advance?]. PMID: 16938257 Ref: Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. PMID: 16941501 Ref: Duodenal carcinoma in MUTYH-associated polyposis. PMID: 16943222 Ref: Colorectal cancer risk in monoallelic carriers of MYH variants. PMID: 16960817 Ref: The genetics of FAP and FAP-like syndromes. PMID: 16998667 Ref: Singapore familial adenomatous polyposis (FAP) patients with classical adenomatous polyposis but undetectable APC mutations have accelerated cancer progression. PMID: 17026565 Ref: Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition. PMID: 17029639 Ref: The role of MYH and microsatellite instability in the development of sporadic colorectal cancer. PMID: 17031395 Ref: Implication of MYH in colorectal polyposis. PMID: 17122612 Ref: [Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium]. PMID: 17216011 Ref: New insights into the molecular pathogenesis of colorectal cancer. PMID: 20151020 Ref: MUTYH Mutations Do Not Cause HNPCC or Late Onset Familial Colorectal Cancer. PMID: 20223013 |
Ref: MUTYH-associated polyposis--from defect in base excision repair to clinical genetic testing. PMID: 17161978 Ref: Balance between endoscopic and genetic information in the choice of ileorectal anastomosis for familial adenomatous polyposis. PMID: 17192888 Ref: Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. PMID: 17200375 Ref: Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. PMID: 17258725 Ref: Patient preferences regarding recontact by cancer genetics clinicians. PMID: 17308889 Ref: Hereditary colorectal cancer syndromes: an overview. PMID: 17311698 Ref: Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study. PMID: 17368238 Ref: Analysis of inherited MYH/(MutYH) mutations in British Asian patients with colorectal cancer. PMID: 17369389 Ref: Genetic testing in colorectal cancer: who, when, how and why. PMID: 17392593 Ref: Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer. PMID: 17417778 Ref: Caring for patients at risk for hereditary colorectal cancer. PMID: 17476735 Ref: Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis. PMID: 17489848 Ref: Pediatric adenomatous polyposis syndromes: an update. PMID: 17511923 Ref: Mutation analysis of the MYH gene in unrelated Czech APC mutation-negative polyposis patients. PMID: 17524638 Ref: The patient with multiple intestinal polyps. PMID: 17544108 Ref: Base-excision repair of oxidative DNA damage. PMID: 17581577 Ref: Cost-utility analysis of genetic screening in families of patients with germline MUTYH mutations. PMID: 17605803 Ref: Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics. PMID: 17674103 Ref: Germline mutations of the MYH gene in Korean patients with multiple colorectal adenomas. PMID: 17703316 Ref: [A colo-colic invagination on the basis of MutYH-associated polyposis in a boy aged 14]. PMID: 17715770 Ref: [Inherited mutations of MUTYH and colorectal cancer]. PMID: 17717836 Ref: High frequency of chromosome 14 deletion in early-onset colon cancer. PMID: 17726634 Ref: [MYH associated polyposis: severe phenotype in the homozygosity for the 1103delC mutation]. PMID: 17868535 Ref: National study of colorectal cancer genetics. PMID: 17895893 Ref: Recently identified colon cancer predispositions: MYH and MSH6 mutations. PMID: 17920897 Ref: Familial colorectal cancer syndrome X. PMID: 17920898 Ref: The use of genetic testing in hereditary colorectal cancer syndromes: genetic testing in HNPCC, (A)FAP and MAP. PMID: 17922849 Ref: The thorough screening of the MUTYH gene in a large French cohort of sporadic colorectal cancers. PMID: 17931073 Ref: Can we identify the high-risk patients to be screened? A genetic approach. PMID: 17947814 Ref: Similar colorectal cancer risk in patients with monoallelic and biallelic mutations in the MYH gene identified in a population with adenomatous polyposis. PMID: 17949294 Ref: Germline mutation prevalence in the base excision repair gene, MYH, in patients with endometrial cancer. PMID: 17956577 Ref: Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer. PMID: 18022921 Ref: Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis. PMID: 18091433 Ref: The value of MUTYH testing in patients with early onset microsatellite stable colorectal cancer referred for hereditary nonpolyposis colon cancer syndrome testing. PMID: 18294051 |
Ref: Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families. PMID: 18027849 Ref: Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. PMID: 18095365 Ref: Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G > T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue. PMID: 18172263 Ref: Working through a diagnostic challenge: colonic polyposis, Amsterdam criteria, and a mismatch repair mutation. PMID: 18176851 Ref: Guidelines for the clinical management of familial adenomatous polyposis (FAP). PMID: 18194984 Ref: Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population. PMID: 18271935 Ref: Management of MUTYH-associated neoplasia in Australia. PMID: 18298557 Ref: No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients. PMID: 18301448 Ref: DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention. PMID: 18374480 Ref: Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. PMID: 18403596 Ref: Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families. PMID: 18433509 Ref: The role of MYH gene in genetic predisposition to colorectal cancer: another piece of the puzzle. PMID: 18495334 Ref: Contribution of common monoallelic MUTYH gene variants in German patients with familial colorectal cancer. PMID: 18503156 Ref: High frequency of copy-neutral LOH in MUTYH-associated polyposis carcinomas. PMID: 18506705 Ref: Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. PMID: 18515411 Ref: Characterization of mutant MUTYH proteins associated with familial colorectal cancer. PMID: 18534194 Ref: Pathological features of colorectal carcinomas in MYH-associated polyposis. PMID: 18564191 Ref: Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. PMID: 18612690 Ref: Report of a family segregating mutations in both the APC and MSH2 genes: juvenile onset of colorectal cancer in a double heterozygote. PMID: 18629513 Ref: A haplotype variation affecting the mitochondrial transportation of hMYH protein could be a risk factor for colorectal cancer in Chinese. PMID: 18811933 Ref: Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population. PMID: 18823566 Ref: [Hereditary colorectal cancer]. PMID: 18853126 Ref: [Gastroenterological oncology: in patients with colorectal cancer, when should the presence of mutations in the MYH gene be suspected?]. PMID: 18928755 Ref: The genomics of colorectal cancer: state of the art. PMID: 19424478 Ref: MUTYH Associated Polyposis (MAP). PMID: 19506731 |
Ref: Endometrial cancer and somatic G>T KRAS transversion in patients with constitutional MUTYH biallelic mutations. PMID: 18980800 Ref: Analysis of MUTYH genotypes and colorectal phenotypes in patients With MUTYH-associated polyposis. PMID: 19032956 Ref: Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study. PMID: 19245865 Ref: Hereditary colorectal cancer: MYH-associated polyposis and other newly identified disorders. PMID: 19258188 Ref: Implication of adenomatous polyposis coli and MUTYH mutations in familial colorectal polyposis. PMID: 19279422 Ref: Implications of familial colorectal cancer risk profiles and microsatellite instability status. PMID: 19307499 Ref: Genetic variants in MUTYH are not associated with endometrial cancer risk. PMID: 19338676 Ref: Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH. PMID: 19394335 Ref: Introduction to molecular and clinical genetics of colorectal cancer syndromes. PMID: 19414141 Ref: MUTYH-associated polyposis. PMID: 19414147 Ref: MUTYH-associated polyposis carcinomas frequently lose HLA class I expression - a common event amongst DNA-repair-deficient colorectal cancers. PMID: 19462419 Ref: Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas. PMID: 19527492 Ref: Relative role of APC and MUTYH mutations in the pathogenesis of familial adenomatous polyposis. PMID: 19593690 Ref: Clinical implications of the colorectal cancer risk associated with MUTYH mutation. PMID: 19620482 Ref: Association of MUTYH and MSH6 germline mutations in colorectal cancer patients. PMID: 19685280 Ref: Expanded extracolonic tumor spectrum in MUTYH-associated polyposis. PMID: 19732775 Ref: MUTYH-associated polyposis and colorectal cancer. PMID: 19793568 Ref: Familial adenomatous polyposis. PMID: 19822006 Ref: Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer. PMID: 19836313 Ref: MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer. PMID: 20110747 |
Ref: Adenoma development in a patient with MUTYH-associated polyposis (MAP): new insights into the natural course of polyp development. PMID: 19672709 Ref: Mutation analysis of the APC gene in Taiwanese FAP families: low incidence of APC germline mutation in a distinct subgroup of FAP families. PMID: 19768578 Ref: MUTYH mutations associated with familial adenomatous polyposis: functional characterization by a mammalian cell-based assay. PMID: 19953527 Ref: Biallelic MYH germline mutations as cause of Muir-Torre syndrome. PMID: 19998059 Ref: Common variants in human CRC genes as low-risk alleles. PMID: 20149637 Ref: Increased MUTYH mutation frequency among Dutch families with breast cancer and colorectal cancer. PMID: 20191381 Ref: Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine. PMID: 20399712 Ref: Functional analysis of MUTYH mutated proteins associated with familial adenomatous polyposis. PMID: 20418187 Ref: Hereditary and familial colon cancer. PMID: 20420945 Ref: [Characteristics of patients with familial adenomatous polyposis in Spain. First results of the Spanish Registry of Familial Adenomatous Polyposis]. PMID: 20466390 Ref: Increased cancer predisposition in family members of colorectal cancer patients harboring the p.V600E BRAF mutation: a population-based study. PMID: 20570909 Ref: Papillary thyroid cancer in a patient with MUTYH-associated polyposis (MAP). PMID: 20625837 Ref: MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions. PMID: 20640893 Ref: The genetic basis of colorectal cancer in a population-based incident cohort with a high rate of familial disease. PMID: 20682701 Ref: Simplifying the detection of MUTYH mutations by high resolution melting analysis. PMID: 20687945 Ref: The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis. PMID: 20706593 Ref: Ser 524 is a phosphorylation site in MUTYH and Ser 524 mutations alter 8-oxoguanine (OG): a mismatch recognition. PMID: 20724227 Ref: MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer. PMID: 20924129 Ref: Colorectal cancer survival advantage in MUTYH-associated polyposis and Lynch syndrome families. PMID: 21044965 Ref: Survival of MUTYH-associated polyposis patients with colorectal cancer and matched control colorectal cancer patients. PMID: 21044966 Ref: A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants. PMID: 21063410 Ref: Rectum-sparing surgery may be appropriate for biallelic MutYH-associated polyposis. PMID: 21178863 Ref: A protocol for genetic evaluation of patients with multiple colorectal adenomas and without evidence of APC gene mutation. PMID: 21287799 |
Ref: MUTYH-associated polyposis (MAP). PMID: 20663686 Ref: Prevalence of MYH-associated polyposis related to three recurrent mutations in Morocco. PMID: 20939750 Ref: Association between monoallelic MUTYH mutation and colorectal cancer risk: a meta-regression analysis. PMID: 21061173 Ref: Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer. PMID: 21171015 Ref: Lynch syndrome in Tunisia: first description of clinical features and germline mutations. PMID: 21311894 Ref: Lynch syndrome and MYH-associated polyposis: review and testing strategy. PMID: 21325953 Ref: Analysis of the oxidative damage repair genes NUDT1, OGG1, and MUTYH in patients from mismatch repair proficient HNPCC families (MSS-HNPCC). PMID: 21355073 Ref: Frequency of the common germline MUTYH mutations p.G396D and p.Y179C in patients diagnosed with colorectal cancer in Southern Brazil. PMID: 21424714 Ref: Map syndrome (MYH Associated Polyposis) colorectal cancer, etiopathological connections. PMID: 21505584 Ref: Role of nucleotide excision repair proteins in oxidative DNA damage repair: an updating. PMID: 21568835 Ref: High resolution melting analysis for a rapid identification of heterozygous and homozygous sequence changes in the MUTYH gene. PMID: 21777424 Ref: MOLECULAR BASIS OF HEREDITARY COLORECTAL CANCER. PMID: 21779143 Ref: Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. PMID: 21901162 Ref: The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP). PMID: 22103048 Ref: [Hereditary colorectal cancer; familial adenomatous polyposis, MUTYH associated polyposis and Lynch syndrome]. PMID: 22213932 |
Ref: Genotype-phenotype correlation in colorectal polyposis. PMID: 21696383 Ref: Evidence for accelerated colorectal adenoma--carcinoma progression in MUTYH-associated polyposis? PMID: 21846783 Ref: Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry. PMID: 22144422 Ref: Base excision repair and cancer. PMID: 22252118 Ref: The first mutations in the MYH gene reported in Moroccan colon cancer patients. PMID: 22266422 Ref: Clinical and molecular detection of inherited colorectal cancers in northeast Italy: a first prospective study of incidence of Lynch syndrome and MUTYH-related colorectal cancer in Italy. PMID: 22278153 Ref: Role of the microenvironment in the tumourigenesis of microsatellite unstable and MUTYH-associated polyposis colorectal cancers. PMID: 22294774 Ref: Common MUTYH mutations and colorectal cancer risk in multiethnic populations. PMID: 22371070 Ref: MUTYH hotspot mutations in unselected colonoscopy patients. PMID: 22469480 Ref: MUTYH gene expression and alternative splicing in controls and polyposis patients. PMID: 22473953 Ref: French experts report on MUTYH-associated polyposis (MAP). PMID: 22538434 Ref: Alterations of the base excision repair gene MUTYH in sporadic colorectal cancer. PMID: 22641385 Ref: ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing. PMID: 22658618 Ref: High prevalence of the c.1227_1228dup (p.Glu410GlyfsX43) mutation in Tunisian families affected with MUTYH-associated-polyposis. PMID: 22744763 Ref: Familial colon cancer syndromes: an update of a rapidly evolving field. PMID: 22864806 Ref: MUTYH-associated polyposis (MAP), the syndrome implicating base excision repair in inherited predisposition to colorectal tumors. PMID: 22876359 Ref: Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancer. PMID: 23019048 Ref: A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer. PMID: 23049789 Ref: [Homozygous germline mutation in MUTYH gene in familial adenomatous polyposis]. PMID: 23677194 |
Ref: [Hyperplastic polyposis syndrome: phenotypic diversity and association to colorectal cancer]. PMID: 22809968 Ref: Clinical and molecular features of attenuated adenomatous polyposis in northern Italy. PMID: 22976915 Ref: Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review. PMID: 23007840 Ref: A bi-national perspective on the management of young patients with colorectal cancer. PMID: 23347438 Ref: Understanding the role of the Q338H MUTYH variant in oxidative damage repair. PMID: 23460202 Ref: Clinical characterization and mutation spectrum in Hispanic families with adenomatous polyposis syndromes. PMID: 23460355 Ref: Role of MUTYH in human cancer. PMID: 23507534 Ref: Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients. PMID: 23544471 Ref: An association selected polymorphisms of XRCC1, OGG1 and MUTYH gene and the level of efficiency oxidative DNA damage repair with a risk of colorectal cancer. PMID: 23618615 Ref: Colorectal cancer in a monoallelic MYH mutation carrier. PMID: 23625202 Ref: Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis. PMID: 23852950 Ref: E. coli and colon cancer: is mutY a culprit? PMID: 23933175 Ref: Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility. PMID: 24039736 Ref: Genes and SNPs associated with non-hereditary and hereditary colorectal cancer. PMID: 24289550 Ref: Role of MYH polymorphisms in sporadic colorectal cancer in China: a case-control, population-based study. PMID: 24377541 Ref: MUTYH the base excision repair gene family member associated with colorectal cancer polyposis. PMID: 24834277 |
Ref: MUTYH-associated colorectal cancer and adenomatous polyposis. PMID: 23605219 Ref: How do researchers manage genetic results in practice? The experience of the multinational Colon Cancer Family Registry. PMID: 23703702 Ref: Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. PMID: 23946381 Ref: Colorectal cancer risk variants on 11q23 and 15q13 are associated with unexplained adenomatous polyposis. PMID: 24253443 Ref: ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis). PMID: 24310308 Ref: Mammalian MutY homolog (MYH or MUTYH) protects cells from oxidative DNA damage. PMID: 24315136 Ref: Therapy-associated polyposis as a late sequela of cancer treatment. PMID: 24362051 Ref: Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer. PMID: 24444654 Ref: Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory. PMID: 24506336 Ref: Biallelic MUTYH mutations can mimic Lynch syndrome. PMID: 24518836 Ref: MYH polyposis syndrome: clinical findings, genetics issues and management. PMID: 24643704 Ref: Two Chinese pedigrees for adenomatous polyposis coli: new mutations at codon 1309 and predisposition to phenotypic variations. PMID: 24664542 Ref: DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3beta and expressions of cyclin D1 and TCF7L2 in cancer model mice. PMID: 24670930 Ref: [Clinical and genetic features of APC- and MYH-mutation-negative patients with multiple polyposis of large bowel that tested by conventional methods]. PMID: 24791470 Ref: Phenotype characteristics of patients with colonic serrated polyposis syndrome: a study of 23 cases. PMID: 24795265 Ref: Prevalence of germline MUTYH mutations among Lynch-like syndrome patients. PMID: 24953332 Ref: Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells. PMID: 25030372 Ref: MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death. PMID: 25310643 Ref: [The alternative way of colorectal cancer developing. The histogenetic and molecular features of serrated lesions (review, continued)]. PMID: 25842399 Ref: Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma. PMID: 25937855 Ref: Gastrointestinal polyposis syndromes for the general gastroenterologist. PMID: 28839754 |
Ref: Analysis of current testing practices for biallelic MUTYH mutations in MUTYH-associated polyposis. PMID: 24620956 Ref: Exome sequencing identifies MUTYH mutations in a family with colorectal cancer and an atypical phenotype. PMID: 24691292 Ref: Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP. PMID: 24801760 Ref: Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer. PMID: 25058500 Ref: Hereditary and common familial colorectal cancer: evidence for colorectal screening. PMID: 25501924 Ref: Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas. PMID: 25529843 Ref: Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing. PMID: 25559809 Ref: Racial variation in frequency and phenotypes of APC and MUTYH mutations in 6,169 individuals undergoing genetic testing. PMID: 25590978 Ref: Increased risk for colorectal adenomas and cancer in mono-allelic MUTYH mutation carriers: results from a cohort of North-African Jews. PMID: 25822476 Ref: Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases. PMID: 25892863 Ref: Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. PMID: 25913757 Ref: The genetic basis of familial adenomatous polyposis and its implications for clinical practice and risk management. PMID: 25931827 Ref: Familial colorectal cancer. PMID: 25955461 Ref: Potential role of Escherichia coli DNA mismatch repair proteins in colon cancer. PMID: 26014615 Ref: Somatic c.34G>T KRAS mutation: a new prescreening test for MUTYH-associated polyposis? PMID: 26056087 Ref: Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry. PMID: 26086041 Ref: The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis. PMID: 26109431 Ref: Mitochondrial variants in MT-CO2 and D-loop instability are involved in MUTYH-associated polyposis. PMID: 26138249 Ref: The Mendelian colorectal cancer syndromes. PMID: 26169059 Ref: High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults With Colorectal Cancer. PMID: 26195711 Ref: Risk of colorectal cancer for people with a mutation in both a MUTYH and a DNA mismatch repair gene. PMID: 26202870 Ref: Identification of a novel mutation associated with familial adenomatous polyposis and colorectal cancer. PMID: 26252958 Ref: Next-generation sequencing for genetic testing of familial colorectal cancer syndromes. PMID: 26300997 Ref: Hereditary Colorectal Cancer: Genetics and Screening. PMID: 26315524 Ref: Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1. PMID: 26377631 Ref: Molecular Features and Methylation Status in Early Onset ( PMID: 26557847 Ref: [A Case of Serrated Polyposis Syndrome with Early Colon Cancer]. PMID: 26805315 |
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