Primary Site >> Colorectal Cancer
Gene >> MUC5AC
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Ref: Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin. PMID: 6193872 |
Ref: Detection of a circulating gastrointestinal cancer antigen in sera of patients with gastrointestinal malignancies by a double determinant immunoassay with monoclonal antibodies against human blood group determinants. PMID: 6198117 |
Ref: Characterization of Lewis antigens in normal colon and gastrointestinal adenocarcinomas. PMID: 2582419 |
Ref: Multiparameter evaluation of the expression in situ of normal and tumor-associated antigens in human colorectal carcinoma. PMID: 3461200 Ref: Expression of Lewisa, Lewisb, X, and Y blood group antigens in human colonic tumors and normal tissue and in human tumor-derived cell lines. PMID: 3510728 |
Ref: The expression of Lewis antigens in neoplasms of the gastrointestinal tract. PMID: 2633112 |
Ref: Carbohydrate antigen expression in colorectal cancer. PMID: 2103494 |
Ref: [Expression and clinical significance of type-1 blood group antigens (Lea, Leb, CA19-9) in colorectal cancer--comparison with CEA]. PMID: 1675759 Ref: [Carbohydrate antigens as a tumor-associated antigen and prognostic indicators in carcinomas of the breast, esophagus, stomach, colorectum, and pancreas]. PMID: 1944163 |
Ref: The recognition of cancer-associated fucosylated antigens in colorectal cancer by a novel monoclonal antibody, YB-2. PMID: 8038519 |
Ref: Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma. PMID: 8536891 Ref: The transcripts of the apomucin genes MUC2, MUC4, and MUC5AC are large and appear as distinct bands. PMID: 8910010 Ref: Alteration in mucin gene expression and biological properties of HT29 colon cancer cell subpopulations. PMID: 8983291 |
Ref: Polypeptide:N-acetylgalactosaminyltransferase activities towards the mucin MUC5AC peptide motif using microsomal preparations of normal and tumoral digestive mucosa. PMID: 9587664 Ref: Selection of tumor antigens as targets for immune attack using immunohistochemistry: protein antigens. PMID: 9829729 Ref: Expression of mucin genes and carbohydrate epitopes in 19 human colon carcinoma cell lines. PMID: 10100757 |
Ref: Molecular mechanisms of expression of Lewis b antigen and other type I Lewis antigens in human colorectal cancer. PMID: 10336994 Ref: Serrated adenoma and colorectal cancer. PMID: 10398112 Ref: Malignant and other properties of human colon carcinoma cells after suppression of sulfomucin production in vitro. PMID: 10411100 |
Ref: Differential expression of MUC2 and MUC5AC mucin genes in primary ovarian and metastatic colonic carcinoma. PMID: 10872659 Ref: Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells. PMID: 10938388 |
Ref: Differential expression of the chromosome 11 mucin genes in colorectal cancer. PMID: 11673830 |
Ref: Immunoreactivity of Lewis blood group and mucin peptide core antigens: correlations with grade of dysplasia and malignant transformation in the colorectal adenoma-carcinoma sequence. PMID: 11813869 Ref: Expression of MUC5AC in colorectal carcinoma and relationship with prognosis. PMID: 12167106 Ref: Phenotypic expression of gastrointestinal differentiation markers in colorectal adenocarcinomas with liver metastasis. PMID: 12555994 Ref: The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins. PMID: 12652076 |
Ref: Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma. PMID: 12493022 Ref: The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells. PMID: 12597771 Ref: Requirement of both mucins and proteoglycans in cell-cell dissociation and invasiveness of colon carcinoma HT-29 cells. PMID: 12640674 Ref: Abnormal expression of gastric mucin in human and rat aberrant crypt foci during colon carcinogenesis. PMID: 14610314 |
Ref: Mucins and mucin binding proteins in colorectal cancer. PMID: 15000151 Ref: Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. PMID: 15014022 Ref: Differential mucin expression in colon carcinoma HT-29 clones with variable resistance to 5-fluorouracil and methotrexate. PMID: 15050369 Ref: Mucin core protein expression by colorectal mucinous carcinomas with or without mucus hyperplasia. PMID: 15069618 Ref: Differentiation pathways in duodenal and ampullary carcinomas: a comparative study on mucin and trefoil peptide expression, including gastric and colon carcinomas. PMID: 15071739 Ref: Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression. PMID: 15087663 Ref: Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and colon. PMID: 15198362 |
Ref: Overexpression of CD10 and reduced MUC2 expression correlate with the development and progression of colorectal neoplasms. PMID: 15901128 Ref: Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum. PMID: 16142311 Ref: CD10 expression in colorectal carcinoma correlates with liver metastasis. PMID: 16175325 |
Ref: Humoral immune response to MUC5AC in patients with colorectal polyps and colorectal carcinoma. PMID: 16409634 Ref: Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasms. PMID: 16609910 Ref: Clinicopathological characteristics, microsatellite instability, and expression of mucin core proteins and p53 in colorectal mucinous adenocarcinomas in relation to location. PMID: 16645863 Ref: Inverse effects of mucin on survival of matched hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer patients. PMID: 16857798 |
Ref: Progression of tumors arising from large ACF is associated with the MUC5AC expression during rat colon MNNG carcinogenis. PMID: 17066439 Ref: Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon. PMID: 17163399 Ref: In vitro differentiation of HT-29 M6 mucus-secreting colon cancer cells involves a trychostatin A and p27(KIP1)-inducible transcriptional program of gene expression. PMID: 17311291 Ref: Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma. PMID: 17316416 Ref: Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1. PMID: 17459061 Ref: Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer. PMID: 17565737 Ref: Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity? PMID: 17679024 Ref: CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. PMID: 17906616 Ref: Biochemical and immunohistochemical characterisation of mucins in 8 cases of colonic disease--a pilot study. PMID: 17969773 Ref: [Expression and clinical significance of Mucin and E-cadherin in colorectal tumors]. PMID: 17991319 Ref: Mucins in the colorectal neoplastic spectrum with reference to conventional and serrated adenomas. PMID: 18080919 |
Ref: Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. PMID: 18027866 Ref: Serrated polyps with "intermediate features" of sessile serrated polyp and microvesicular hyperplastic polyp: a practical approach to the classification of nondysplastic serrated polyps. PMID: 18300810 Ref: Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges? PMID: 18329969 Ref: Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence. PMID: 18370954 |
Ref: Colonic carcinoma with a pancreatic acinar cell differentiation. A case report. PMID: 19908063 |
Ref: CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. PMID: 19926591 Ref: REG IV overexpression in an early stage of colorectal carcinogenesis: an immunohistochemical study. PMID: 20183800 Ref: Gene expression profiling of colorectal mucinous adenocarcinomas. PMID: 20485009 Ref: Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma. PMID: 20731025 Ref: Mucin core protein expression in serrated polyps of the large intestine. PMID: 20803031 Ref: Immunohistochemical analysis of colorectal cancer with gastric phenotype: claudin-18 is associated with poor prognosis. PMID: 20846265 |
Ref: Primary pulmonary adenocarcinoma with enteric differentiation resembling metastatic colorectal carcinoma: a report of the second case negative for cytokeratin 7. PMID: 20727680 Ref: Development of a serum biomarker assay that differentiates tumor-associated MUC5AC (NPC-1C ANTIGEN) from normal MUC5AC. PMID: 21197415 Ref: Seromic profiling of colorectal cancer patients with novel glycopeptide microarray. PMID: 21344374 Ref: Caco-2 and LS174T cell lines provide different models for studying mucin expression in colon cancer. PMID: 21470648 Ref: Filiform serrated adenomatous polyposis arising in a diverted rectum of an inflammatory bowel disease patient. PMID: 21569098 Ref: [Advanced poorly differentiated adenocarcinoma of the colon with micropapillary carcinoma components except specific cytokeratin expressions, report of a case]. PMID: 22139489 |
Ref: The use of specific monoclonal antibodies to target immunogenic tumor membrane proteins in patients with recurrent pancreatic and colon cancer. PMID: 22283657 Ref: Early colorectal carcinomas: CD10 expression, mucin phenotype and submucosal invasion. PMID: 22924846 Ref: MUC5AC/beta-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors. PMID: 23112547 |
Ref: Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5. PMID: 23303185 Ref: Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins. PMID: 23370770 Ref: Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms. PMID: 23403822 Ref: Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study. PMID: 23409082 Ref: Transmembrane mucin MUC1 overexpression and its association with CD10(+) myeloid cells, transforming growth factor-beta1 expression, and tumor budding grade in colorectal cancer. PMID: 23566254 Ref: Anti-tumor activity of a novel monoclonal antibody, NPC-1C, optimized for recognition of tumor antigen MUC5AC variant in preclinical models. PMID: 23591984 Ref: TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells. PMID: 23741618 Ref: Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. PMID: 23807779 Ref: Differential mucin phenotypes and their significance in a variation of colorectal carcinoma. PMID: 23840140 Ref: Somatic molecular changes and histo-pathological features of colorectal cancer in Tunisia. PMID: 23983431 Ref: Mucinous differentiation in colorectal cancer: molecular, histological and clinical aspects. PMID: 24494463 |
Ref: Predictors of lymph node metastasis in T1 colorectal carcinoma: an immunophenotypic analysis of 265 patients. PMID: 25003285 Ref: Aberrant SOX2 expression in colorectal cancers does not correlate with mucinous differentiation and gastric mucin MUC5AC expression. PMID: 25108707 Ref: Reversed polarity of the glandular epithelial cells in micropapillary carcinoma of the large intestine and the EMA/MUC1 immunostain. PMID: 25158820 Ref: REG4 independently predicts better prognosis in non-mucinous colorectal cancer. PMID: 25295732 Ref: A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study: MUC3 is a novel prognostic factor. PMID: 25551773 Ref: [Molecular characterization of Lynch syndrome in Tunisia]. PMID: 25775284 |
Ref: Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma. PMID: 25081749 Ref: MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer. PMID: 25403854 Ref: Poorly differentiated adenocarcinoma of the colon: subsite location and clinicopathologic features. PMID: 25416528 Ref: Gastric-type expression signature in serrated pathway-associated colorectal tumors. PMID: 25704805 Ref: Immunohistochemical study of MUC1, MUC2 and MUC5AC in colorectal carcinoma and review of literature. PMID: 25731647 |
Ref: The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential. PMID: 26476272 Ref: Early detection of colonic dysplasia by magnetic resonance molecular imaging with a contrast agent raised against the colon cancer marker MUC5AC. PMID: 26762591 Ref: Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer. PMID: 26898938 Ref: Colorectal cancer in Crohn's colitis is comparable to sporadic colorectal cancer. PMID: 27026089 Ref: Mucinous Balls Tangled With Mesothelial Cells and MUC2-Positive Cancer Cells in the Ascites of Pseudomyxoma Peritonei. PMID: 27079739 Ref: MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance. PMID: 27298226 Ref: Differential expression of mucins in Middle Eastern patients with colorectal cancer. PMID: 27347157 Ref: A phase 1 dose-escalation study of NEO-102 in patients with refractory colon and pancreatic cancer. PMID: 27449137 Ref: Abrogation of MUC5AC Expression Contributes to the Apoptosis and Cell Cycle Arrest of Colon Cancer Cells. PMID: 27610469 Ref: Gastric Proteins MUC5AC and TFF1 as Potential Diagnostic Markers of Colonic Sessile Serrated Adenomas/Polyps. PMID: 28430953 |
Ref: Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance. PMID: 27705923 Ref: Histochemical and immunohistochemical study of mucinous rectal carcinoma. PMID: 28616090 Ref: Differential expression of CK20, beta-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X. PMID: 28824332 Ref: SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer. PMID: 29456503 |
Ref: Immunohistochemical and genetic characteristics of a colorectal mucin-rich variant of traditional serrated adenoma. PMID: 29729192 Ref: Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients. PMID: 30361067 |