Primary Site >> Pancreatic Cancer
Gene >> MUC4
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Ref: Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. PMID: 8143972 Ref: Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines. PMID: 8157358 |
Ref: In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. PMID: 7657125 |
Ref: Human MUC4 mucin cDNA and its variants in pancreatic carcinoma. PMID: 10920259 Ref: Retinoic acid-dependent transforming growth factor-beta 2-mediated induction of MUC4 mucin expression in human pancreatic tumor cells follows retinoic acid receptor-alpha signaling pathway. PMID: 10938282 |
Ref: Alternate splicing at the 3'-end of the human pancreatic tumor-associated mucin MUC4 cDNA. PMID: 11135323 Ref: Characterization of human mucin gene MUC4 promoter: importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells. PMID: 11418607 Ref: Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. PMID: 11751498 |
Ref: AMOP, a protein module alternatively spliced in cancer cells. PMID: 11893501 Ref: MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. PMID: 12090430 |
Ref: Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. PMID: 14695172 |
Ref: Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. PMID: 14729877 Ref: Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. PMID: 14744777 Ref: A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis. PMID: 15184872 Ref: Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy. PMID: 15494719 Ref: (111)In/(125/131)I-Labeled anti-mucin-1 murine, chimeric or humanized antibody hPAM4 PMID: 21834178 |
Ref: The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. PMID: 15461591 Ref: Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia. PMID: 15867264 Ref: [Clinical significance of the expression of MUC4 mRNA in peripheral blood mononuclear cells of pancreatic cancer patients]. PMID: 16274046 |
Ref: Quantitative analysis of MUC1 and MUC5AC mRNA in pancreatic juice for preoperative diagnosis of pancreatic cancer. PMID: 16052519 Ref: Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates. PMID: 17019794 Ref: MUC4-expressing pancreatic adenocarcinomas show elevated levels of both T1 and T2 cytokines: potential pathobiologic implications. PMID: 17032197 Ref: Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas. PMID: 17079941 Ref: The expression of MUC4 and MUC5AC is related to the biologic malignancy of intraductal papillary mucinous neoplasms of the pancreas. PMID: 17079945 Ref: A series of 64 cases of pancreatic cystic neoplasia from an institutional study of China. PMID: 17143961 |
Ref: MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms. PMID: 16799633 Ref: Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy. PMID: 17234748 Ref: MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. PMID: 17406026 Ref: Mucin expression profile in pancreatic cancer and the precursor lesions. PMID: 17520199 Ref: IFN-gamma-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-gamma response. PMID: 17525742 Ref: Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells. PMID: 17595659 Ref: Transcription factor AP-2alpha represses both the mucin MUC4 expression and pancreatic cancer cell proliferation. PMID: 17621592 Ref: On the role of transforming growth factor-beta in the growth inhibitory effects of retinoic acid in human pancreatic cancer cells. PMID: 18157915 |
Ref: MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. PMID: 18381409 Ref: MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. PMID: 18475301 Ref: Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. PMID: 18492726 Ref: [Immunohistochemical study of mucins in chronic pancreatitis and ductal adenocarcinoma of the pancreas]. PMID: 18807519 Ref: Precursor lesions of pancreatic cancer. PMID: 20485640 Ref: MUC4 as a diagnostic marker in cancer. PMID: 23495864 |
Ref: Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin. PMID: 19738614 |
Ref: Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells. PMID: 19757157 Ref: MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies. PMID: 20303649 Ref: Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. PMID: 20423995 Ref: Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung. PMID: 20553613 |
Ref: Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas. PMID: 20717734 Ref: The increase in the expression and hypomethylation of MUC4 gene with the progression of pancreatic ductal adenocarcinoma. PMID: 20922503 Ref: Novel INTeraction of MUC4 and galectin: potential pathobiological implications for metastasis in lethal pancreatic cancer. PMID: 21059814 Ref: Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering. PMID: 21391573 Ref: Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer. PMID: 21886786 Ref: MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. PMID: 21983127 |
Ref: Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells. PMID: 22105367 Ref: Mucin production determines sensitivity to bortezomib and gemcitabine in pancreatic cancer cells. PMID: 22266985 Ref: Mucin-based targeted pancreatic cancer therapy. PMID: 22372499 Ref: The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. PMID: 22393391 Ref: Nicotine, IFN-gamma and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. PMID: 22537161 Ref: Mathematical modelling unravels regulatory mechanisms of interferon-gamma-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells. PMID: 22757586 Ref: MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1. PMID: 22791819 Ref: Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy. PMID: 23102107 |
Ref: The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. PMID: 22580602 Ref: Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation. PMID: 22614008 Ref: Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer. PMID: 23446997 Ref: Transcriptional regulation of human MUC4 gene: identification of a novel inhibitory element and its nuclear binding protein. PMID: 23813057 Ref: Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. PMID: 23920124 Ref: Expression of MUC4 mucin is observed mainly in the intestinal type of intraductal papillary mucinous neoplasm of the pancreas. PMID: 23921963 Ref: Generation of CTL responses against pancreatic cancer in vitro using dendritic cells co-transfected with MUC4 and survivin RNA. PMID: 23928463 Ref: Comparison of MUC4 expression in primary pancreatic cancer and paired lymph node metastases. PMID: 24047396 Ref: Development of a mucin4-targeting SPIO contrast agent for effective detection of pancreatic tumor cells in vitro and in vivo. PMID: 24147888 Ref: MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer. PMID: 24204560 Ref: Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: applications in diagnosis and therapy. PMID: 24278292 |
Ref: Anterior gradient 2 and mucin 4 expression mirrors tumor cell differentiation in pancreatic adenocarcinomas, but aberrant anterior gradient 2 expression predicts worse patient outcome in poorly differentiated tumors. PMID: 24177142 Ref: MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-kappaB signaling in pancreatic cancer. PMID: 24240113 Ref: MUC4-induced nuclear translocation of beta-catenin: a novel mechanism for growth, metastasis and angiogenesis in pancreatic cancer. PMID: 24374017 Ref: Pancreatic cancer counterattack: MUC4 mediates Fas-independent apoptosis of antigen-specific cytotoxic T lymphocyte. PMID: 24534824 Ref: Upregulation of the splice variant MUC4/Y in the pancreatic cancer cell line MIA PaCa-2 potentiates proliferation and suppresses apoptosis: new insight into the presence of the transcript variant of MUC4. PMID: 24676527 Ref: Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis. PMID: 24681997 Ref: Diagnosis of pancreatic neoplasms using a novel method of DNA methylation analysis of mucin expression in pancreatic juice. PMID: 24714692 Ref: Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. PMID: 24884523 Ref: Synthesis, characterization, and evaluation of poly (D,L-lactide-co-glycolide)-based nanoformulation of miRNA-150: potential implications for pancreatic cancer therapy. PMID: 24971005 Ref: Analysis of MUC4 expression in human pancreatic cancer xenografts in immunodeficient mice. PMID: 25075011 Ref: Apicidin sensitizes pancreatic cancer cells to gemcitabine by epigenetically regulating MUC4 expression. PMID: 25275019 Ref: Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback lo PMID: 25367394 |
Ref: miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer. PMID: 24608432 Ref: A decrease in miR-150 regulates the malignancy of pancreatic cancer by targeting c-Myb and MUC4. PMID: 25522282 Ref: NCOA3-mediated upregulation of mucin expression via transcriptional and post-translational changes during the development of pancreatic cancer. PMID: 25531332 Ref: Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer. PMID: 25686822 Ref: Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells. PMID: 26035354 Ref: Clinicopathological and prognostic significance of MUC4 expression in cancers: evidence from meta-analysis. PMID: 26379819 Ref: The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-kappaB and RalB signaling pathways. PMID: 26477488 Ref: Targeting MUC4 in pancreatic cancer: miRNAs. PMID: 26682251 |
Ref: The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. PMID: 26526617 Ref: Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival. PMID: 27109098 Ref: Semiquantitative immunohistochemistry for mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) profiling of pancreatic ductal cell adenocarcinoma improves diagnostic and prognostic performance. PMID: 27165582 Ref: Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer. PMID: 27185392 Ref: DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells. PMID: 27230679 Ref: Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas. PMID: 27283771 Ref: The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer. PMID: 27287498 Ref: MUC4 is negatively regulated through the Wnt/beta-catenin pathway via the Notch effector Hath1 in colorectal cancer. PMID: 27551331 Ref: Effects of RNAi-mediated MUC4 gene silencing on the proliferation and migration of human pancreatic carcinoma BxPC-3 cells. PMID: 27748843 Ref: Mucins in neoplasms of pancreas, ampulla of Vater and biliary system. PMID: 27795812 |
Ref: NIDO, AMOP and vWD domains of MUC4 play synergic role in MUC4 mediated signaling. PMID: 28060749 Ref: Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells. PMID: 28262838 Ref: MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma. PMID: 28460571 Ref: Multiplex detection of pancreatic cancer biomarkers using a SERS-based immunoassay. PMID: 28937361 |
Ref: Detection and proteomic characterization of extracellular vesicles in human pancreatic juice. PMID: 29550476 Ref: Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-beta1/FAK/ERK pathway. PMID: 29777904 Ref: Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. PMID: 30236127 Ref: Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer. PMID: 30268674 |