Primary Site >> Colorectal Cancer
Gene >> MSH6
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Ref: Lynch Syndrome PMID: 20301390 |
Ref: Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype. PMID: 8649458 Ref: Molecular cloning of the N-terminus of GTBP. PMID: 8838326 Ref: Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. PMID: 8968088 Ref: Mismatch repair and cancer. PMID: 8977028 |
Ref: MutS homologs in mammalian cells. PMID: 9024626 Ref: Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair. PMID: 9214593 Ref: Mean age of tumor onset in hereditary nonpolyposis colorectal cancer (HNPCC) families correlates with the presence of mutations in DNA mismatch repair genes. PMID: 9218993 Ref: DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. PMID: 9294177 Ref: Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. PMID: 9307272 Ref: Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. PMID: 9331106 Ref: Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas. PMID: 9401011 Ref: Drastic genetic instability of tumors and normal tissues in Turcot syndrome. PMID: 9419979 Ref: Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. PMID: 9491849 |
Ref: RER phenotype and its associated mutations in familial gastric cancer. PMID: 9498272 Ref: Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. PMID: 9500462 Ref: Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair. PMID: 9500919 Ref: Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. PMID: 9592192 Ref: DGGE screening of mutations in mismatch repair genes (hMSH2 and hMLH1) in 34 Swedish families with colorectal cancer. PMID: 9611074 Ref: Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. PMID: 9677427 Ref: Genetics of colonic cancer. PMID: 9705533 Ref: Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. PMID: 9709044 Ref: Microsatellite instability in young patients with colorectal cancer. PMID: 9736405 Ref: Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. PMID: 9736731 Ref: [Molecular cancer disposition diagnosis exemplified by colorectal carcinoma. What is the contribution of pathology?]. PMID: 9746911 Ref: Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer. PMID: 9855004 Ref: Hereditary Factors in Gynecologic Cancer. PMID: 10388122 |
Ref: Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. PMID: 9916805 Ref: Causes and consequences of microsatellite instability in endometrial carcinoma. PMID: 9927063 Ref: Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer. PMID: 9929971 Ref: The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. PMID: 10023666 Ref: Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene. PMID: 10077621 Ref: Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15. PMID: 10190549 Ref: A century of progress in hereditary nonpolyposis colorectal cancer (Lynch syndrome). PMID: 10211513 Ref: Mutated gene-specific phenotypes of dinucleotide repeat instability in human colorectal carcinoma cell lines deficient in DNA mismatch repair. PMID: 10321739 Ref: Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. PMID: 10348818 Ref: Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects. PMID: 10382540 Ref: [Familial cancer: recent advances]. PMID: 10410140 Ref: Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer. PMID: 10413423 Ref: BAT-26 identifies sporadic colorectal cancers with mutator phenotype: a correlative study with clinico-pathological features and mutations in mismatch repair genes. PMID: 10419591 Ref: Evaluation of the replication error phenotype in relation to molecular and clinicopathological features in hereditary and early onset colorectal cancer. PMID: 10448273 Ref: Regional reproducibility of microsatellite instability in sporadic colorectal cancer. PMID: 10469448 Ref: Replication error in colorectal carcinoma: association with loss of heterozygosity at mismatch repair loci and clinicopathological variables. PMID: 10470121 Ref: hMLH1, hMSH2 and hMSH6 mutations in hereditary non-polyposis colorectal cancer families from southern Sweden. PMID: 10471527 Ref: Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer. PMID: 10480359 Ref: Various mutation screening techniques in the DNA mismatch repair genes hMSH2 and hMLH1. PMID: 10495924 Ref: Mouse models for colorectal cancer. PMID: 10498885 Ref: Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer. PMID: 10507723 Ref: Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. PMID: 10523644 Ref: Germ-line msh6 mutations in colorectal cancer families. PMID: 10537275 Ref: Genetic susceptibility to non-polyposis colorectal cancer. PMID: 10544223 Ref: Strategies for screening for hereditary non-polyposis colorectal cancer. PMID: 10544224 Ref: HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. PMID: 10545954 Ref: Clinical and molecular diagnosis of hereditary non-polyposis colorectal cancer: problems and pitfalls in an extended pedigree. PMID: 10575566 Ref: Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability. PMID: 10597289 Ref: Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part II: Hereditary nonpolyposis colorectal carcinoma as a model. PMID: 10630171 Ref: Genetic testing and counseling for hereditary forms of colorectal cancer. PMID: 10630180 Ref: Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. PMID: 10637515 Ref: Frameshift mutations and a length polymorphism in the hMSH3 gene and the spectrum of microsatellite instability in sporadic colon cancer. PMID: 10665647 Ref: Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines. PMID: 10674020 Ref: [Aspirin suppresses microsatellite instability]. PMID: 10714217 Ref: Germline mutation and genome instability. PMID: 10772416 Ref: hMSH6 deficiency and inactivation of the alphaE-catenin invasion-suppressor gene in HCT-8 colon cancer cells. PMID: 10919711 Ref: Analysis of microsatellite instability in cervical cancer. PMID: 11240745 |
Ref: The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences. PMID: 10601558 Ref: Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. PMID: 10607839 Ref: Sequence analysis of the mismatch repair gene hMSH6 in the germline of patients with familial and sporadic colorectal cancer. PMID: 10699937 Ref: Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium. PMID: 10717241 Ref: Atypical clustering of gynecologic malignancies: A family study including molecular analysis of candidate genes. PMID: 10739686 Ref: Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA. PMID: 10748159 Ref: Mismatch repair defects in cancer. PMID: 10753784 Ref: HMSH6 alterations in patients with microsatellite instability-low colorectal cancer. PMID: 10786688 Ref: DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. PMID: 10861262 Ref: Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. PMID: 10861263 Ref: Molecular genetics of hereditary nonpolyposis colorectal cancer. PMID: 10911905 Ref: Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation. PMID: 10918391 Ref: Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer. PMID: 10934138 Ref: Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity. PMID: 10959092 Ref: Genetic alterations of sporadic colorectal cancer with microsatellite instability, especially characteristics of primary multiple colorectal cancers. PMID: 10962455 Ref: Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in colon cancer cell lines defective in mismatch repair. PMID: 10987307 Ref: The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. PMID: 11048711 Ref: Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients. PMID: 11054716 Ref: [Response of metastatic colorectal cancers to treatment with CPT11 (irinotecan): implications of the mismatched base repair system]. PMID: 11084429 Ref: High throughput genetic screening for the detection of hereditary non-polyposis colon cancer (HNPCC) using capillary electrophoresis. PMID: 11121520 Ref: Do MSH6 mutations contribute to double primary cancers of the colorectum and endometrium? PMID: 11153917 |
Ref: MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. PMID: 11245474 Ref: Deficient DNA mismatch repair: a common etiologic factor for colon cancer. PMID: 11257106 Ref: Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer. PMID: 11290569 Ref: MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer. PMID: 11291077 Ref: Infrequent frameshift mutations in the simple repeat sequences of hMLH3 in hereditary nonpolyposis colorectal cancers. PMID: 11302343 Ref: Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer. PMID: 11306449 Ref: Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers. PMID: 11317354 Ref: Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree. PMID: 11333868 Ref: Allelic loss of chromosome 2p21-16.3 is associated with reduced survival in sporadic colorectal cancer. PMID: 11336166 Ref: [From gene to disease; from DNA 'mismatch' repair genes to hereditary non-polyposis colorectal carcinoma]. PMID: 11346916 Ref: Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 11389088 Ref: Heterocyclic amine induced apoptotic response in the human lymphoblastoid cell line TK6 is linked to mismatch repair status. PMID: 11425520 Ref: Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype. PMID: 11470537 Ref: Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. PMID: 11498787 Ref: Relationship between grade of microsatellite instability and target genes of mismatch repair pathways in sporadic colorectal carcinoma. PMID: 11508658 Ref: The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. PMID: 11524701 Ref: Genotype and phenotype of a new 2-bp deletion of hMSH2 at codon 233. PMID: 11561760 Ref: MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. PMID: 11600610 Ref: PTEN gene mutations in colorectal cancers displaying microsatellite instability. PMID: 11689295 Ref: The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. PMID: 11691795 Ref: Mutations of the 'minor' mismatch repair gene MSH6 in typical and atypical hereditary nonpolyposis colorectal cancer. PMID: 14574004 Ref: Chemotherapy resistant ovarian cancer in carriers of an hMSH2 mutation? PMID: 14574006 Ref: Prediction of the outcome of genetic testing in HNPCC kindreds using the revised Amsterdam criteria and immunohistochemistry. PMID: 14574174 |
Ref: Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant. PMID: 11709755 Ref: Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation. PMID: 11807791 Ref: High-frequency microsatellite instability is associated with defective DNA mismatch repair in human melanoma. PMID: 11851879 Ref: Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC). PMID: 11852992 Ref: Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer. PMID: 11861375 Ref: DNA mismatch repair defects: role in colorectal carcinogenesis. PMID: 11900875 Ref: Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain. PMID: 11920650 Ref: Expression of the hMSH6 mismatch-repair protein in colon cancer and HeLa cells. PMID: 11971198 Ref: Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer. PMID: 11996796 Ref: High frequency of microsatellite instability and loss of mismatch-repair protein expression in patients with double primary tumors of the endometrium and colorectum. PMID: 12015776 Ref: Functional analysis of MSH6 mutations linked to kindreds with putative hereditary non-polyposis colorectal cancer syndrome. PMID: 12019211 Ref: Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer. PMID: 12036916 Ref: A hMLH1 genomic mutation and associated novel mRNA defects in a hereditary non-polyposis colorectal cancer family. PMID: 12052501 Ref: Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. PMID: 12057899 Ref: Human colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are not defective in DNA mismatch repair proteins. PMID: 12107548 Ref: Base excision repair as a therapeutic target in colon cancer. PMID: 12231545 Ref: [Essential to discover hereditary colorectal and endometrial cancer. Mutations in "HNPCC individuals" can cause several different tumors]. PMID: 12362848 Ref: Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach. PMID: 12373605 Ref: Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants. PMID: 12377806 Ref: Analysis of mismatch repair defects in the familial occurrence of lymphoma and colorectal cancer. PMID: 12400605 Ref: Frequent microsatellite instability in sporadic tumors of the upper urinary tract. PMID: 12460887 Ref: Mutational analysis of the hMSH6 gene in familial and early-onset colorectal and endometrial cancer in Israeli patients. PMID: 12537658 Ref: Correlation of mismatch repair genes immunohistochemistry and microsatellite instability status in HNPCC-associated tumours. PMID: 12555992 |
Ref: Combined deficiency of hMLH1, hMSH2, hMSH3 and hMSH6 is an independent prognostic factor in colorectal cancer. PMID: 12469183 Ref: Two mismatch repair gene mutations found in a colon cancer patient--which one is pathogenic? PMID: 12522549 Ref: A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells. PMID: 12538492 Ref: Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors. PMID: 12547705 Ref: Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer. PMID: 12591727 Ref: A636P is associated with early-onset colon cancer in Ashkenazi Jews. PMID: 12595050 Ref: The immunohistochemical detection of mismatch repair gene proteins (MLH1, MSH2, MSH6, and PMS2): practical aspects in antigen retrieval and biotin blocking protocols. PMID: 12610360 Ref: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based detection of microsatellite instabilities in coding DNA sequences: a novel approach to identify DNA-mismatch repair-deficient cancer cells. PMID: 12651806 Ref: Identification of a deletion in the mismatch repair gene, MSH2, using mouse-human cell hybrids monosomal for chromosome 2. PMID: 12694232 Ref: The role of hMLH3 in familial colorectal cancer. PMID: 12702580 Ref: Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability. PMID: 12712438 Ref: Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. PMID: 12732731 Ref: Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 [correction of hMLH6] immunostaining. PMID: 12741892 Ref: Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene. PMID: 12792735 Ref: Little evidence for involvement of MLH3 in colorectal cancer predisposition. PMID: 12800209 Ref: Microsatellite instability and mutations in DNA mismatch repair genes in sporadic colorectal cancers. PMID: 12907901 Ref: Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum. PMID: 12910497 Ref: Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome. PMID: 12920072 Ref: Identification and characterization of genomic rearrangements of MSH2 and MLH1 in Lynch syndrome (HNPCC) by novel techniques. PMID: 12938096 Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 Ref: MSH6 germline mutations are rare in colorectal cancer families. PMID: 14520694 Ref: Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. PMID: 14522894 Ref: Hyperplastic polyps in hereditary nonpolyposis colorectal cancer. PMID: 14572584 Ref: [Molecular changes in development and progression of urothelial carcinoma]. PMID: 16888910 |
Ref: Microsatellite instability analysis and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer? PMID: 14652751 Ref: The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells. PMID: 14673178 Ref: Aetiology of colorectal cancer and relevance of monogenic inheritance. PMID: 14684585 Ref: Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations. PMID: 14756672 Ref: Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation. PMID: 14762794 Ref: Effect of exogenous MSH6 and POLD1 expression on the mutation rate of the HPRT locus in a human colon cancer cell line with mutator phenotype, DLD-1. PMID: 14767555 Ref: Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression. PMID: 14871813 Ref: Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer. PMID: 14871975 Ref: Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden. PMID: 14961575 Ref: Eight novel MSH6 germline mutations in patients with familial and nonfamilial colorectal cancer selected by loss of protein expression in tumor tissue. PMID: 14974087 Ref: [Transforming growth factor beta receptor II mutations in RER positive colorectal cancers]. PMID: 14989920 Ref: Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival. PMID: 15017435 Ref: Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: genetic reclassification and correlation with clinical features. PMID: 15118395 Ref: [Molecular pathology in hereditary colorectal cancer. Recommendations of the Collaborative German Study Group on hereditary colorectal cancer funded by the German Cancer Aid (Deutsche Krebshilfe)]. PMID: 15138699 Ref: The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer. PMID: 15184898 Ref: HNPCC: six new pathogenic mutations. PMID: 15217520 Ref: Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance. PMID: 15236168 Ref: Two Japanese kindreds occurring endometrial cancer meeting new clinical criteria for hereditary non-polyposis colorectal cancer (HNPCC), Amsterdam Criteria II. PMID: 15238104 Ref: Immunohistochemistry and microsatellite instability testing for selecting MLH1, MSH2 and MSH6 mutation carriers in hereditary non-polyposis colorectal cancer. PMID: 15289847 Ref: Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status. PMID: 15294875 Ref: Clinical features and mismatch repair gene mutation screening in Chinese patients with hereditary nonpolyposis colorectal carcinoma. PMID: 15309712 Ref: A homozygous MSH6 mutation in a child with cafe-au-lait spots, oligodendroglioma and rectal cancer. PMID: 15340263 Ref: Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes. PMID: 15350299 Ref: MSH6 missense mutations are often associated with no or low cancer susceptibility. PMID: 15354210 Ref: Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series. PMID: 15361209 Ref: Germline mutations in MLH1, MSH2 and MSH6 in Korean hereditary non-polyposis colorectal cancer families. PMID: 15365995 Ref: Characterization of mutator phenotype in familial colorectal cancer patients not fulfilling amsterdam criteria. PMID: 15448003 Ref: Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary Nonpolyposis Colorectal Cancer Consortium. PMID: 15483016 Ref: Identification of HNPCC by molecular analysis of colorectal and endometrial tumors. PMID: 15528786 Ref: Role of the pathologist in the diagnosis of hereditary non-polyposis colorectal cancer. PMID: 15528787 Ref: Diagnostic application of hMLH1 methylation in hereditary non-polyposis colorectal cancer. PMID: 15528793 Ref: [Recognising hereditary non-polyposis colorectal cancer without a clear family history]. PMID: 15532325 Ref: High-throughput gene sequencing assay development for hereditary nonpolyposis colon cancer. PMID: 15555211 Ref: Six novel heterozygous MLH1, MSH2, and MSH6 and one homozygous MLH1 germline mutations in hereditary nonpolyposis colorectal cancer. PMID: 15571801 Ref: What is the best way to assess microsatellite instability status in colorectal cancer? Study on a population base of 462 colorectal cancers. PMID: 15577673 Ref: [Genetic predisposition and ovarian cancer]. PMID: 15630879 Ref: Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas. PMID: 18521406 |
Ref: Signet ring cell carcinoma of the colorectum: correlations between microsatellite instability, clinicopathologic features and survival. PMID: 15492759 Ref: Microsatellite instability and expression of mismatch repair genes in sporadic endometrial cancer coexisting with colorectal or breast cancer. PMID: 15583795 Ref: DNA mismatch repair-dependent response to fluoropyrimidine-generated damage. PMID: 15611052 Ref: Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms. PMID: 15613860 Ref: Inherited susceptibility to colorectal cancer. PMID: 15660526 Ref: Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma. PMID: 15704157 Ref: Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer. PMID: 15713769 Ref: BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes. PMID: 15782118 Ref: Microsatellite instability testing in colorectal carcinoma: choice of markers affects sensitivity of detection of mismatch repair-deficient tumors. PMID: 15788665 Ref: No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer. PMID: 15805151 Ref: Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? PMID: 15837969 Ref: TGFBR1*6A may contribute to hereditary colorectal cancer. PMID: 15860866 Ref: Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). PMID: 15872200 Ref: The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha. PMID: 15886699 Ref: Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. PMID: 15887099 Ref: High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. PMID: 15930362 Ref: What the physician needs to know about Lynch syndrome: an update. PMID: 15938070 Ref: Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 15942939 Ref: Frequency of hereditary non-polyposis colorectal cancer among Uruguayan patients with colorectal cancer. PMID: 15952990 Ref: A homozygous mutation in MSH6 causes Turcot syndrome. PMID: 16000562 Ref: Phenotype associated with recessively inherited mutations in DNA mismatch repair (MMR) genes. PMID: 16042583 Ref: DNA mismatch repair status may influence anti-neoplastic effects of butyrate. PMID: 16042586 Ref: The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers. PMID: 16106253 Ref: Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer. PMID: 16116158 Ref: Isolated loss of PMS2 expression in colorectal cancers: frequency, patient age, and familial aggregation. PMID: 16166421 Ref: Morphology and microsatellite instability in sporadic serrated and non-serrated colorectal cancer. PMID: 16177963 Ref: Molecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes. PMID: 16181381 Ref: High frequency of hereditary colorectal cancer in Newfoundland likely involves novel susceptibility genes. PMID: 16203774 Ref: Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway. PMID: 16243801 Ref: Low prevalence of germline hMSH6 mutations in colorectal cancer families from Spain. PMID: 16270383 Ref: Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome. PMID: 16283884 Ref: Mutational analysis of hMsh6 in Israeli HNPCC and HNPCC-like families. PMID: 16341805 Ref: Long term follow-up of HNPCC gene mutation carriers: compliance with screening and satisfaction with counseling and screening procedures. PMID: 16341806 Ref: Deletion Mutations in an Australian Series of HNPCC Patients. PMID: 20223028 |
Ref: A novel MSH2 germline mutation in homozygous state in two brothers with colorectal cancers diagnosed at the age of 11 and 12 years. PMID: 16372347 Ref: MUTYH and the mismatch repair system: partners in crime? PMID: 16408224 Ref: Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor. PMID: 16418736 Ref: The genetics of HNPCC: application to diagnosis and screening. PMID: 16434208 Ref: Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome). PMID: 16472587 Ref: Occult endometrial cancer and decision making for prophylactic hysterectomy in hereditary nonpolyposis colorectal cancer patients. PMID: 16476474 Ref: First report of a de novo germline mutation in the MLH1 gene. PMID: 16521201 Ref: Polyposis and early cancer in a patient with low penetrant mutations in MSH6 and APC: hereditary colorectal cancer as a polygenic trait. PMID: 16525781 Ref: Optimization of antibodies for detection of the mismatch repair proteins MLH1, MSH2, MSH6, and PMS2 using a biotin-free visualization system. PMID: 16540742 Ref: Cancer risks for mismatch repair gene mutation carriers: a population-based early onset case-family study. PMID: 16616355 Ref: Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer. PMID: 16636019 Ref: Birt-Hogg-Dube gene mutations in human endometrial carcinomas with microsatellite instability. PMID: 16691634 Ref: DNA mismatch repair as an effector for promoting phorbol ester-induced apoptotic DNA damage and cell killing: implications in tumor promotion. PMID: 16721813 Ref: Elevated microsatellite instability at selected tetranucleotide repeats does not correlate with clinicopathologic features of bladder cancer. PMID: 16762487 Ref: Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years. PMID: 16765042 Ref: Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smoking. PMID: 16771955 Ref: Histologic features distinguish microsatellite-high from microsatellite-low and microsatellite-stable colorectal carcinomas, but do not differentiate germline mutations from methylation of the MLH1 promoter. PMID: 16784982 Ref: Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer. PMID: 16807412 Ref: The added value of PMS2 immunostaining in the diagnosis of hereditary nonpolyposis colorectal cancer. PMID: 16817031 Ref: Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas. PMID: 16826164 Ref: Factors associated with enrollment in cancer genetics research. PMID: 16835336 Ref: MLH3 mutation in endometrial cancer. PMID: 16885347 Ref: Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis. PMID: 16890597 Ref: Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis. PMID: 16929496 Ref: Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act". PMID: 16938659 Ref: MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease. PMID: 16940983 Ref: Identification of germline MLH1 alterations in familial prostate cancer. PMID: 16963262 Ref: Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene. PMID: 16996571 Ref: Correlation of microsatellite status, proliferation, apoptotic and selected immunohistochemical markers in colorectal carcinoma studied with tissue microarray. PMID: 17019973 Ref: Microsatellite instability accounts for tumor site-related differences in clinicopathologic variables and prognosis in human colon cancers. PMID: 17026563 Ref: Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer. PMID: 17054581 Ref: Frequency of hereditary non-polyposis colorectal cancer among unselected patients with colorectal cancer in Germany. PMID: 17095871 Ref: Very low prevalence of germline MSH6 mutations in hereditary non-polyposis colorectal cancer suspected patients with colorectal cancer without microsatellite instability. PMID: 17117178 |
Ref: Genomic rearrangements in MSH2, MLH1 or MSH6 are rare in HNPCC patients carrying point mutations. PMID: 16837128 Ref: Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer. PMID: 16902769 Ref: Persistent mismatch repair deficiency following targeted correction of hMLH1. PMID: 17082796 Ref: Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC. PMID: 17203173 Ref: Mismatch repair polymorphisms and the risk of colorectal cancer. PMID: 17205513 Ref: Medulloblastoma, acute myelocytic leukemia and colonic carcinomas in a child with biallelic MSH6 mutations. PMID: 17259933 Ref: Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors. PMID: 17284719 Ref: Patient preferences regarding recontact by cancer genetics clinicians. 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PMID: 28341698 Ref: Homozygous germ-line mutation of the PMS2 mismatch repair gene: a unique case report of constitutional mismatch repair deficiency (CMMRD). PMID: 28381238 Ref: Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer. PMID: 28405764 Ref: A molecular inversion probe-based next-generation sequencing panel to detect germline mutations in Chinese early-onset colorectal cancer patients. PMID: 28445943 Ref: A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer). PMID: 28460341 Ref: Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2. PMID: 28466842 Ref: [Molecular Pathology of Colorectal Cancer, Microsatellite Instability - the Detection, the Relationship to the Pathophysiology and Prognosis]. 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Ref: The 116G > A MSH6 and IVS1-1121C > T PMS2 Genes Polymorphisms Modulate the Risk of the Sporadic Colorectal Cancer Development in Polish Population. PMID: 28451866 Ref: RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers. PMID: 28573495 Ref: Constitutional mismatch repair deficiency and Lynch syndrome among consecutive Arab Bedouins with colorectal cancer in Israel. PMID: 28608265 Ref: Screening for Lynch syndrome in young Saudi colorectal cancer patients using microsatellite instability testing and next generation sequencing. PMID: 28643016 Ref: Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. PMID: 28754778 Ref: Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations. 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PMID: 30108684 Ref: Fusobacterium nucleatum Infection in Colorectal Cancer: Linking Inflammation, DNA Mismatch Repair and Genetic and Epigenetic Alterations. PMID: 30116794 Ref: Rare compound heterozygous mutations in gene MSH6 cause constitutive mismatch repair deficiency syndrome. PMID: 30147880 Ref: Universal Lynch Syndrome Screening Should be Performed in All Upper Tract Urothelial Carcinomas. PMID: 30148743 Ref: Cancer Risks for PMS2-Associated Lynch Syndrome. PMID: 30161022 Ref: Prevalence and clinicopathological characteristics of mismatch repair-deficient colorectal carcinoma in early onset cases as compared with late-onset cases: a retrospective cross-sectional study in Northeastern Iran. PMID: 30166308 Ref: DNA mismatch repair and CD133-marked cancer stem cells in colorectal carcinoma. PMID: 30221090 Ref: Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition. 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