Primary Site >> Biliary tract Cancer

Gene >> MSH6

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Ref: Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer.
PMID: 9808525
 Ref: Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain.
PMID: 11920650
 Ref: Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval.
PMID: 15503134
Ref: Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder.
PMID: 15692793
 Ref: High-level microsatellite instability is not involved in gallbladder carcinogenesis.
PMID: 15963980
 Ref: Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability.
PMID: 17653761
Ref: Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers--ready for prime time?
PMID: 17962726
 Ref: Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions.
PMID: 19252434
 Ref: DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases.
PMID: 20395525
 Ref: Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas.
PMID: 21307665
 Ref: Microsatellite instability in gallbladder carcinoma.
PMID: 25680569
 Ref: Intratumoral heterogeneity of intrahepatic cholangiocarcinoma.
PMID: 28146430
 Ref: Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Biliary Tract Cancers Associated with Lynch Syndrome.
PMID: 29238914
Ref: Microsatellite Instability Occurs Rarely in Patients with Cholangiocarcinoma: A Retrospective Study from a German Tertiary Care Hospital.
PMID: 29747443