Primary Site >> Stomach Cancer
Gene >> MSH2
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Ref: Lynch Syndrome PMID: 20301390 |
Ref: Frequent microsatellite instability in primary small cell lung cancer. PMID: 8174113 |
Ref: [Progress of research on tumor suppressor genes]. PMID: 8641669 Ref: Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. PMID: 8766523 Ref: [Analyses of mutator gene mutations in familial gastric cancers]. PMID: 8920667 Ref: [Microsatellite instability--a new aspects in genetics and molecular biology of hereditary nonpolyposis and sporadic colorectal tumors]. PMID: 9082661 |
Ref: Infrequent hMSH2 mutations in sporadic gastric adenocarcinoma with microsatellite instability. PMID: 9066723 Ref: Disease expression in Swiss hereditary non-polyposis colorectal cancer (HNPCC) kindreds. PMID: 9221805 Ref: Mutational analysis of the hMSH2 gene in a wide variety of tumors. PMID: 21528233 |
Ref: Frequent microsatellite instability and loss of heterozygosity in the region including BRCA1 (17q21) in young patients with gastric cancer. PMID: 9592181 Ref: Infrequent frameshift mutations of polynucleotide repeats in multiple primary cancers affecting the esophagus and other organs. PMID: 9824204 |
Ref: hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. PMID: 9892201 Ref: Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. PMID: 10070967 Ref: Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. PMID: 10348818 Ref: Origin of microsatellite instability in gastric cancer. PMID: 10393852 Ref: Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing. PMID: 10404064 Ref: Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error. PMID: 10418831 |
Ref: Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. PMID: 10585582 Ref: Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes. PMID: 10719371 Ref: Routine detection of the replication error phenotype in clinical tumor specimens using fluorescence-SSCP. PMID: 10723572 Ref: Microsatellite instability is associated with genetic alteration but not with low levels of expression of the human mismatch repair proteins hMSH2 and hMLH1. PMID: 10785599 Ref: Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract. PMID: 10807889 Ref: Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instability. PMID: 10861474 Ref: The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea. PMID: 10896919 Ref: Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation. PMID: 10918391 |
Ref: Correlation between microsatellite instability and metachronous disease recurrence after endoscopic mucosal resection in patients with early stage gastric carcinoma. PMID: 11180080 Ref: Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences. PMID: 11213834 Ref: Genetic alterations in gastric cancers from British patients. PMID: 11376803 Ref: Hereditary nonpolyposis colorectal cancer with gynecologic malignancies: report of two families in Taiwan. PMID: 11393127 Ref: Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability. PMID: 11422806 Ref: A genome-wide study of microsatellite instability in advanced gastric carcinoma. PMID: 11443614 Ref: Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype. PMID: 11470537 Ref: hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer. PMID: 12132870 Ref: Mutations of the 'minor' mismatch repair gene MSH6 in typical and atypical hereditary nonpolyposis colorectal cancer. PMID: 14574004 |
Ref: Alterations of BAT-26 identify a subset of gastric cancer with distinct clinicopathologic features and better postoperative prognosis. PMID: 11941977 Ref: [Muir-Torre syndrome]. PMID: 12063922 Ref: Distinct clinical features and outcomes of gastric cancers with microsatellite instability. PMID: 12065777 Ref: hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer. PMID: 12095971 Ref: A novel germline mutation of hMLH1 in a patient with hereditary non-polyposis colorectal cancer. PMID: 12110639 Ref: [Genealogical research of hereditary nonpolyposis colorectal cancer]. PMID: 12139794 Ref: Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells. PMID: 12145807 Ref: Very low incidence of microsatellite instability in intraductal papillary-mucinous neoplasm of the pancreas. PMID: 12448010 |
Ref: Studies on microsatellite instability in p16 gene and expression of hMSH2 mRNA in human gastric cancer tissues. PMID: 12632492 Ref: Lymphocyte-rich gastric cancer: associations with Epstein-Barr virus, microsatellite instability, histology, and survival. PMID: 12861059 Ref: Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer. PMID: 12861399 Ref: High throughput detection of microsatellite instability by denaturing high-performance liquid chromatography. PMID: 14517950 Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 |
Ref: Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation. PMID: 14762794 Ref: Novel germline hMSH2 genomic deletion and somatic hMSH2 mutations in a hereditary nonpolyposis colorectal cancer family. PMID: 15063132 Ref: Geno- and pheno-typic characterization in ten patients with double-primary gastric and colorectal adenocarcinomas. PMID: 15083323 Ref: Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines. PMID: 15133479 Ref: [Expression of hMSH2 and hMLH1 in stomach cancer and their correlation with Helicobacter pylori infection]. PMID: 15142449 Ref: Clinical and genetic features of International Collaborative Group-hereditary nonpolyposis colorectal cancer families and suspected hereditary nonpolyposis colorectal cancer families. PMID: 15161546 Ref: [Clinical features and hMSH2/hMLH1 germline mutation screening of Chinese hereditary nonpolyposis colorectal cancer patients]. PMID: 15200905 Ref: E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. PMID: 15288293 Ref: Clinical features and mismatch repair gene mutation screening in Chinese patients with hereditary nonpolyposis colorectal carcinoma. PMID: 15309712 Ref: Characterization of mutator phenotype in familial colorectal cancer patients not fulfilling amsterdam criteria. PMID: 15448003 Ref: Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer. PMID: 15526354 |
Ref: Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval. PMID: 15503134 Ref: Frequent microsatellite instability in primary esophageal carcinoma associated with extraesophageal primary carcinoma. PMID: 15540218 Ref: Microsatellite instability and DNA mismatch repair deficiency testing in hereditary and sporadic gastrointestinal cancers. PMID: 15749237 Ref: [Mutation detection of mismatch repair genes in hereditary nonpolyposis colorectal cancer by denaturing high-performance liquid chromatography]. PMID: 15842942 Ref: Effect of Helicobacter pylori infection on the expression of DNA mismatch repair protein. PMID: 15904475 Ref: Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy. PMID: 16049280 Ref: High frequency of microsatellite instability in intestinal-type gastric cancer in Korean patients. PMID: 16134765 Ref: [Expression of cyclooxygenase-2, hMLH1 and hMSH2 proteins, and their relationship with microsatellite instability in gastric carcinoma]. PMID: 16438886 |
Ref: Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers. PMID: 16546499 Ref: Carcinogenesis in the remnant stomach following distal gastrectomy with billroth II reconstruction is associated with high-level microsatellite instability. PMID: 16619551 Ref: Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum. PMID: 16786121 Ref: Clinical and genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer families. PMID: 16810763 Ref: Demonstration and characterization of mutations induced by Helicobacter pylori organisms in gastric epithelial cells. PMID: 16882331 Ref: Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium. PMID: 16908935 Ref: Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China. PMID: 16929514 Ref: Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal cancer in a Chinese population. PMID: 17011982 Ref: Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer. PMID: 17054581 Ref: Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan. PMID: 17106811 |
Ref: Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register. PMID: 17846840 Ref: MSI is frequently recognized among gastric cancer patients with a family history of cancer. PMID: 18265677 |
Ref: A novel MSH2 germline mutation in a Druze HNPCC family. PMID: 17661183 Ref: Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. PMID: 18202787 Ref: Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype. PMID: 18206535 Ref: [Comparison of clinical and genetic phenotypes between Chinese and Korean hereditary nonpolyposis colorectal cancer families]. PMID: 18543228 Ref: DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. PMID: 18641418 Ref: Helicobacter pylori infection and expression of DNA mismatch repair proteins. PMID: 19034977 Ref: Muir-Torre syndrome: a rare but important disorder. PMID: 19055168 Ref: DNA mismatch repair gene methylation in gastric cancer in individuals from northern Brazil. PMID: 19181186 |
Ref: Recurring MLH1 deleterious mutations in unrelated Chinese Lynch syndrome families in Singapore. PMID: 18726168 Ref: Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype. PMID: 19117018 Ref: Analysis of microsatellite instability, protein expression and methylation status of hMLH1 and hMSH2 genes in gastric carcinomas. PMID: 19621725 Ref: Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients. PMID: 19671196 Ref: [Hereditary non-polyposis colorectal cancer associated with hereditary gastric cancer. A case report.]. PMID: 19858019 |
Ref: Aberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patients. PMID: 19894224 Ref: Risk and epidemiological time trends of gastric cancer in Lynch syndrome carriers in the Netherlands. PMID: 19900449 Ref: Biallelic MYH germline mutations as cause of Muir-Torre syndrome. PMID: 19998059 Ref: Patient with eight metachronous gastrointestinal cancers thought to be hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 20118596 Ref: Clinicopathologic characteristics of colorectal cancer patients with synchronous and metachronous gastric cancer. PMID: 20532772 Ref: Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients. PMID: 20803768 |
Ref: Non-truncating hMLH1 variants identified in Slovenian gastric cancer patients are not associated with Lynch Syndrome: a functional analysis report. PMID: 21136174 Ref: Gastric cancer and concomitant renal cancer: a systematic immunohistochemical and molecular analysis. PMID: 21687951 Ref: The MLH1 2101C>A (Q701K) variant increases the risk of gastric cancer in Chinese males. PMID: 22136435 Ref: HER-2/neu and E-cadherin Expression and Microsatellite Instability in Gastric Dysplasia. PMID: 25197528 |
Ref: The founder Ashkenazi Jewish mutations in the MSH2 and MSH6 genes in Israeli patients with gastric and pancreatic cancer. PMID: 22219001 Ref: Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study. PMID: 22331944 Ref: Polymorphisms in MSH2 gene and risk of gastric cancer, and interactions with lifestyle factors in a Chinese population. PMID: 22386861 Ref: Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population. PMID: 22740958 |
Ref: Outcome and status of microsatellite stability in Japanese atomic bomb survivors with early gastric carcinoma. PMID: 23149851 Ref: Differential clinicopathologic features in microsatellite-unstable gastric cancers with and without MLH1 methylation. PMID: 23266441 Ref: The significance of mismatch repair genes in gastric cancer. PMID: 23575079 Ref: Aberrant DNA methylation of P16, MGMT, hMLH1 and hMSH2 genes in combination with the MTHFR C677T genetic polymorphism in gastric cancer. PMID: 23803092 Ref: Synchronous rectal and gastric cancer in a fighter pilot: aeromedical concerns. PMID: 24426647 Ref: BRAF mutation in multiple primary cancer with colorectal cancer and stomach cancer. PMID: 24759670 |
Ref: ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas. PMID: 23887303 Ref: Pyloric gland adenoma in Lynch syndrome. PMID: 24518125 Ref: Role of endometrial cancer abnormal MMR protein in screening Lynch-syndrome families. PMID: 25400828 |
Ref: Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors. PMID: 25213383 Ref: Microsatellite instability: an update. PMID: 25701956 Ref: Family with MSH2 mutation presenting with keratoacanthoma and precancerous skin lesions. PMID: 26077460 Ref: [Gender-specific aspects of Lynch syndrome--an update]. PMID: 26284327 Ref: Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer. PMID: 26343070 Ref: Loss of ARID1A Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and Clinicopathologic Features. PMID: 26468418 Ref: [A Family Affected by Lynch Syndrome Caused by MSH6 Germline Mutation]. PMID: 26805314 |
Ref: Epstein-Barr virus positivity, not mismatch repair-deficiency, is a favorable risk factor for lymph node metastasis in submucosa-invasive early gastric cancer. PMID: 26573601 Ref: Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. PMID: 26681312 Ref: Polymorphisms in mismatch repair genes are associated with risk and microsatellite instability of gastric cancer, and interact with life exposures. PMID: 26724419 Ref: Biomarkers of EBV-positive Gastric Cancers: Loss of PTEN Expression is Associated with Poor Prognosis and Nodal Metastasis. PMID: 27221363 Ref: Comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy. PMID: 27331626 Ref: Expression of Mismatch Repair Proteins in Early and Advanced Gastric Cancer in Poland. PMID: 27527654 Ref: Receptor tyrosine kinase amplified gastric cancer: Clinicopathologic characteristics and proposed screening algorithm. PMID: 27765925 |
Ref: Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization. PMID: 26371427 Ref: Distinct expression profile of key molecules in crawling-type early gastric carcinoma. PMID: 27734272 Ref: Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway. PMID: 27862371 Ref: New EPCAM founder deletion in Polish population. PMID: 28369810 Ref: Evaluation of the Three Customized MSI Panels to Improve the Detection of Microsatellite Instability in Gastric Cancer. PMID: 28397474 Ref: Complementary utility of targeted next-generation sequencing and immunohistochemistry panels as a screening platform to select targeted therapy for advanced gastric cancer. PMID: 28418920 Ref: Chromosomal Instability in Gastric Cancer Biology. PMID: 28431273 Ref: Comparison between mononucleotide and dinucleotide marker panels in gastric cancer with loss of hMLH1 or hMSH2 expression. PMID: 28525661 Ref: ALK-positive gastric inflammatory myofibroblastic tumor in an adult with familial adenomatous polyposis and diffuse fundic polyposis. PMID: 28923119 Ref: Genetic Gastric Cancer Susceptibility in the International Clinical Cancer Genomics Community Research Network. PMID: 29025585 Ref: Prevalence and characteristics of hereditary non-polyposis colorectal cancer (HNPCC) syndrome in immigrant Asian colorectal cancer patients. PMID: 29237405 |
Ref: Same MSH2 Gene Mutation But Variable Phenotypes in 2 Families With Lynch Syndrome: Two Case Reports and Review of Genotype-Phenotype Correlation. PMID: 29383008 Ref: Morphologic and Immunohistochemical Appraisal of Primary Gastric Carcinomas. PMID: 29438113 Ref: Tumor development in Japanese patients with Lynch syndrome. PMID: 29672549 Ref: Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature review. PMID: 29783979 Ref: Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer. PMID: 30043858 Ref: A retrospective study of extracolonic, non-endometrial cancer in Swedish Lynch syndrome families. PMID: 30386444 Ref: Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation. PMID: 30387329 |