Primary Site >> Colorectal Cancer
Gene >> MSH2
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Ref: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. PMID: 8252616 Ref: Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. PMID: 8371783 Ref: Lynch Syndrome PMID: 20301390 |
Ref: Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes. PMID: 7521009 Ref: Hereditary non-polyposis colorectal cancer--morphologies, genes and mutations. PMID: 7523876 Ref: Direct mutational analysis in a family with hereditary non-polyposis colorectal cancer. PMID: 7717919 Ref: [Hereditary non-polyposis colorectal cancer: HNPCC]. PMID: 7736246 Ref: Advances in the genetics and molecular biology of colorectal tumors. PMID: 7803543 Ref: Intron splice acceptor site sequence variation in the hereditary non-polyposis colorectal cancer gene hMSH2. PMID: 7833117 Ref: [Hereditary non-polyposis colorectal cancer; HNPCC]. PMID: 7837674 Ref: Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes. PMID: 7838728 Ref: Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development. PMID: 7874129 Ref: [Genes, heredity and colorectal cancer]. PMID: 7878358 Ref: DNA loop repair by human cell extracts. PMID: 7973637 Ref: Southwestern internal medicine conference: hereditary predisposition to colorectal cancer: new insights. PMID: 7977449 Ref: What is hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 7979195 Ref: 25 years of HNPCC. PMID: 7979196 Ref: Genes involved in hereditary nonpolyposis colorectal carcinoma. PMID: 7979203 Ref: The International Collaborative Group on HNPCC. PMID: 7979204 Ref: The inherited component of cancer. PMID: 7987639 Ref: Colon cancer and DNA repair: have mismatches met their match? PMID: 8036718 Ref: Genetic basis of hereditary nonpolyposis colorectal carcinoma (HNPCC). PMID: 8074840 Ref: Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. PMID: 8137274 Ref: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. PMID: 8145827 Ref: Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. PMID: 8182040 Ref: Hereditary nonpolyposis colon cancer: analysis of linkage to 2p15-16 places the COCA1 locus telomeric to D2S123 and reveals genetic heterogeneity in seven Canadian families. PMID: 8198129 |
Ref: Contribution of molecular oncology in the detection of colorectal carcinomas. PMID: 7491839 Ref: MSH2 deficient mice are viable and susceptible to lymphoid tumours. PMID: 7550317 Ref: In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer. PMID: 7557107 Ref: Clinical implications of advances in the molecular genetics of colorectal cancer. PMID: 7571049 Ref: Founding mutations and Alu-mediated recombination in hereditary colon cancer. PMID: 7584997 Ref: Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. PMID: 7585634 Ref: Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. PMID: 7585651 Ref: Genetic instability of microsatellites in hematological neoplasms. PMID: 7596185 Ref: Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. PMID: 7604264 Ref: Genetic linkage analysis in hereditary non-polyposis colon cancer syndrome. PMID: 7616541 Ref: Chromosome 2p linkage analysis in hereditary non-polyposis colon cancer. PMID: 7620112 Ref: Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. PMID: 7674315 Ref: DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. PMID: 7757980 Ref: Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. PMID: 8521394 Ref: Mutation screening in the hMLH1 gene in Swedish hereditary nonpolyposis colon cancer families. PMID: 8521398 Ref: Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas. PMID: 8589682 Ref: Microsatellite instability in keratoacanthoma. PMID: 8625045 Ref: Multistep carcinogenesis in colorectal cancers. PMID: 8629105 Ref: p53, myc, APC, hMSH2, ras, etc. in colorectal cancer - a never ending story! PMID: 8750144 |
Ref: Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues. PMID: 8542572 Ref: Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. PMID: 8577718 Ref: Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome). PMID: 8600057 Ref: Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. PMID: 8612988 Ref: DNA lesion-recognizing proteins and the p53 connection. PMID: 8615613 Ref: Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas. PMID: 8622690 Ref: Genetic heterogeneity and unmapped genes for colorectal cancer. PMID: 8640829 Ref: [Progress of research on tumor suppressor genes]. PMID: 8641669 Ref: Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype. PMID: 8649458 Ref: MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis. PMID: 8674041 Ref: Loss of DNA mismatch repair in acquired resistance to cisplatin. PMID: 8674066 Ref: [Familial cancer and oncogenic factors]. PMID: 8678487 Ref: Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. PMID: 8690195 Ref: Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine. PMID: 8690794 Ref: MSH2 sequence variations and inherited colorectal cancer susceptibility. PMID: 8695231 Ref: Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer. PMID: 8700523 Ref: Mutation of the hMSH2 gene in two families with hereditary nonpolyposis colorectal cancer. PMID: 8723682 Ref: Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. PMID: 8766523 Ref: DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. PMID: 8776590 Ref: Microsatellite instability differences between familial and sporadic ovarian cancers. PMID: 8824498 Ref: Complex genetic predisposition to cancer in an extended HNPCC family with an ancestral hMLH1 mutation. PMID: 8863153 Ref: Recent developments in hereditary nonpolyposis colorectal cancer. PMID: 8865457 Ref: Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. PMID: 8872463 Ref: Mutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome. PMID: 8880570 Ref: Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. PMID: 8895729 Ref: The role of DNA mismatch repair in platinum drug resistance. PMID: 8895738 Ref: [Mutations of hMSH2 gene and hMLH1 gene in human colovectal carcinomas]. PMID: 8920666 Ref: [Genetic steps in colorectal cancer]. PMID: 8920676 Ref: Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability. PMID: 8932328 Ref: Processing of O6-methylguanine by mismatch correction in human cell extracts. PMID: 8939600 Ref: Mutations of the transforming growth factor-beta type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. PMID: 8952554 Ref: Mismatch repair and cancer. PMID: 8977028 Ref: Microsatellite instability in early onset and familial colorectal cancer. PMID: 9004127 Ref: [Microsatellite instability--a new aspects in genetics and molecular biology of hereditary nonpolyposis and sporadic colorectal tumors]. PMID: 9082661 Ref: DNA mismatch repair deficient mice in cancer research. PMID: 9110401 |
Ref: Characterization of MSH2 and MLH1 mutations in Italian families with hereditary nonpolyposis colorectal cancer. PMID: 8993976 Ref: Mutations in MLH1 are more frequent than in MSH2 in sporadic colorectal cancers with microsatellite instability. PMID: 8993979 Ref: Clinical and molecular features of the hereditary mixed polyposis syndrome. PMID: 9024286 Ref: MutS homologs in mammalian cells. PMID: 9024626 Ref: Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer. PMID: 9032648 Ref: Advances in molecular genetics. PMID: 9046882 Ref: Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria. PMID: 9048925 Ref: Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled. PMID: 9052445 Ref: Microsatellite instability in human solid tumors. PMID: 9060003 Ref: An update of HNPCC (Lynch syndrome). PMID: 9062584 Ref: Using genetic information to make surgical decisions: report of a case of a 13-year-old boy with colon cancer. PMID: 9075764 Ref: MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis. PMID: 9087566 Ref: DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load. PMID: 9088350 Ref: Mutations predisposing to hereditary nonpolyposis colorectal cancer. PMID: 9111864 Ref: Muir-Torre syndrome: clinical features and molecular genetic analysis. PMID: 9217825 Ref: Mean age of tumor onset in hereditary nonpolyposis colorectal cancer (HNPCC) families correlates with the presence of mutations in DNA mismatch repair genes. PMID: 9218993 Ref: Disease expression in Swiss hereditary non-polyposis colorectal cancer (HNPCC) kindreds. PMID: 9221805 Ref: Female embryonic lethality in mice nullizygous for both Msh2 and p53. PMID: 9288110 Ref: Mutator phenotype in Msh2-deficient murine embryonic fibroblasts. PMID: 9288785 Ref: Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 Eastern United States hereditary nonpolyposis colorectal cancer pedigrees. PMID: 9288790 Ref: DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. PMID: 9294177 Ref: Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. PMID: 9307272 Ref: Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations. PMID: 9311737 Ref: Widespread microsatellite instability in sebaceous tumours of patients with the Muir-Torre syndrome. PMID: 9349329 Ref: Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. PMID: 9354436 Ref: Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. PMID: 9371516 Ref: Undectable expression of hMLH1 protein in sporadic colorectal cancer with replication error phenotype. PMID: 9378008 Ref: Germline hMSH2 and hMLH1 gene mutations in incomplete HNPCC families. PMID: 9399661 Ref: Etiology, natural history, management and molecular genetics of hereditary nonpolyposis colorectal cancer (Lynch syndromes): genetic counseling implications. PMID: 9419392 Ref: Identification of concurrent germ-line mutations in hMSH2 and/or hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds. PMID: 9419403 Ref: Molecular biology of colorectal cancer. PMID: 9438104 Ref: An intronic germline transition in the HNPCC gene hMSH2 is associated with sporadic colorectal cancer. PMID: 9470849 Ref: Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. PMID: 9491849 Ref: Mutational analysis of the hMSH2 gene in a wide variety of tumors. PMID: 21528233 Ref: Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression. PMID: 21590118 |
Ref: A microsatellite within the MUC1 locus at 1q21 is altered in the neoplastic cells of breast cancer patients. PMID: 9406583 Ref: Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors. PMID: 9445183 Ref: Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent. PMID: 9448296 Ref: Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. PMID: 9485033 Ref: Characterization of MLH1 and MSH2 alternative splicing and its relevance to molecular testing of colorectal cancer susceptibility. PMID: 9490293 Ref: Molecular genetics and clinical-pathology features of hereditary nonpolyposis colorectal carcinoma (Lynch syndrome): historical journey from pedigree anecdote to molecular genetic confirmation. PMID: 9499183 Ref: Genetic identification and management of hereditary nonpolyposis colorectal cancer. PMID: 9499460 Ref: Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. PMID: 9500552 Ref: Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair. PMID: 9500919 Ref: MLH1 and MSH2 constitutional mutations in colorectal cancer families not meeting the standard criteria for hereditary nonpolyposis colorectal cancer. PMID: 9506527 Ref: A novel missense mutation in the DNA mismatch repair gene hMLH1 present among East Asians but not among Europeans. PMID: 9526167 Ref: Expression of hMSH2 and hMLH1 in colorectal carcinomas with microsatellite instability. PMID: 9542742 Ref: Mismatch repair deficiency leads to a unique mode of colorectal tumorigenesis characterized by intratumoral heterogeneity. PMID: 9546427 Ref: Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population. PMID: 9559626 Ref: Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer. PMID: 9559627 Ref: Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. PMID: 9563488 Ref: Microsatellite instability in human solid tumors. PMID: 9587112 Ref: Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. PMID: 9592192 Ref: Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. PMID: 9593786 Ref: DGGE screening of mutations in mismatch repair genes (hMSH2 and hMLH1) in 34 Swedish families with colorectal cancer. PMID: 9611074 Ref: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. PMID: 9618505 Ref: Prediction-based threading of the hMSH2 DNA mismatch repair protein. PMID: 9619444 Ref: Novel germline mutations of hMSH2 in a patient with hereditary nonpolyposis colorectal cancer (HNPCC) and in a patient with six primary cancers. PMID: 9621522 Ref: [Analysis of genomic instability by fluorescence DNA sequencer]. PMID: 9627490 Ref: Functional genetic tests of DNA mismatch repair protein activity in Saccharomyces cerevisiae. PMID: 9630599 Ref: Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria. PMID: 9634524 Ref: Ongoing and unsaid on oxaliplatin: the hope. PMID: 9647613 Ref: Search for chromosome instability in lymphocytes with germ-line mutations in DNA mismatch repair genes. PMID: 9648558 Ref: Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. International Collaborative Group on HNPCC. PMID: 9669805 Ref: Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. PMID: 9677427 Ref: Lack of PMS2 gene-truncating mutations in patients with hereditary colorectal cancer. PMID: 9683794 Ref: Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. PMID: 9699680 Ref: Genetics of colonic cancer. PMID: 9705533 Ref: Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. PMID: 9709044 Ref: Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls. PMID: 9718327 Ref: Point mutations of ornithine decarboxylase gene are an infrequent event in colorectal cancer but a missense mutation was found in a replication error positive patient with hMSH2 germline mutation. PMID: 9730154 Ref: Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma: different clinical and molecular implications. PMID: 9731891 Ref: Microsatellite instability in young patients with colorectal cancer. PMID: 9736405 Ref: Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. PMID: 9736731 Ref: [Molecular cancer disposition diagnosis exemplified by colorectal carcinoma. What is the contribution of pathology?]. PMID: 9746911 Ref: A novel in frame deletion of codons 188-190 in the hMSH2 gene of a slovenian patient with hereditary non-polyposis colorectal cancer. PMID: 9748699 Ref: Colonic cancer in a 34-yr-old woman: should it prompt microsatellite instability studies and mismatch repair gene testing? PMID: 9772075 Ref: Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. PMID: 9777938 Ref: Human exonuclease I interacts with the mismatch repair protein hMSH2. PMID: 9788596 Ref: The impact of molecular diagnosis on familial colorectal cancer. PMID: 9806477 Ref: MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. PMID: 9811473 Ref: Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer. PMID: 9824623 Ref: Excess of hMLH1 germline mutations in Swiss families with hereditary non-polyposis colorectal cancer. PMID: 9833759 Ref: Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer. PMID: 9841970 Ref: [Germline mutation analysis in hMLH 1 and hMSH 2 genes in hereditary nonpolyposis colorectal cancer and colorectal cancer patients with familial history]. PMID: 9845760 Ref: Reduced COX-2 protein in colorectal cancer with defective mismatch repair. PMID: 9850081 Ref: Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer. PMID: 9855004 Ref: Hereditary Factors in Gynecologic Cancer. PMID: 10388122 Ref: hMLH1 mutations in hereditary nonpolyposis colorectal cancer kindreds. Mutations in brief no. 182. Online. PMID: 10660333 Ref: Hereditary nonpolyposis colorectal cancer: an approach to the selection of candidates to genetic testing based on clinical and molecular characteristics. PMID: 15178966 |
Ref: hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. PMID: 9892201 Ref: Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. PMID: 9916805 Ref: Causes and consequences of microsatellite instability in endometrial carcinoma. PMID: 9927063 Ref: Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer. PMID: 9929971 Ref: A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer. PMID: 10051005 Ref: Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. PMID: 10070967 Ref: Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants. PMID: 10077620 Ref: Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene. PMID: 10077621 Ref: Reduction in hMSH2 mRNA levels by premature translation termination: implications for mutation screening in hereditary nonpolyposis colorectal cancer. PMID: 10080150 Ref: Colorectal cancer and the Muir-Torre syndrome in a Gypsy family: a review. PMID: 10086635 Ref: Family history characteristics, tumor microsatellite instability and germline MSH2 and MLH1 mutations in hereditary colorectal cancer. PMID: 10190329 Ref: Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15. PMID: 10190549 Ref: Mismatch repair gene defects contribute to the genetic basis of double primary cancers of the colorectum and endometrium. PMID: 10196371 Ref: Loci for efficient detection of microsatellite instability in hereditary non-polyposis colorectal cancer. PMID: 10203581 Ref: A century of progress in hereditary nonpolyposis colorectal cancer (Lynch syndrome). PMID: 10211513 Ref: Mutated gene-specific phenotypes of dinucleotide repeat instability in human colorectal carcinoma cell lines deficient in DNA mismatch repair. PMID: 10321739 Ref: Microsatellite instability-a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer. PMID: 10323887 Ref: Germline hMSH2 and differential somatic mutations in patients with Turcot's syndrome. PMID: 10337989 Ref: Public health perspectives on testing for colorectal cancer susceptibility genes. PMID: 10343885 Ref: Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. PMID: 10348818 Ref: Establishment and characterization of 12 human colorectal-carcinoma cell lines. PMID: 10362137 Ref: Immunocytochemical detection of hMSH2 and hMLH1 expression in oral SCC. PMID: 10368636 Ref: Hereditary colorectal cancer in the general population: from cancer registration to molecular diagnosis. PMID: 10369701 Ref: Influence of selection criteria on mutation detection in patients with hereditary nonpolyposis colorectal cancer. PMID: 10375096 Ref: Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis. PMID: 10378593 Ref: Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population. PMID: 10378595 Ref: Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects. PMID: 10382540 Ref: Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer. PMID: 10386556 Ref: Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours. PMID: 10389971 Ref: Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds. PMID: 10404063 Ref: 6-thioguanine resistance in a human colon carcinoma cell line with unaltered levels of hypoxanthine guanine phosphoribosyltransferase activity. PMID: 10404070 Ref: Mutations in Bcl10 are very rare in colorectal cancer. PMID: 10408399 Ref: [Familial cancer: recent advances]. PMID: 10410140 Ref: Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer. PMID: 10413423 Ref: Screening for colorectal cancer and other GI cancers. PMID: 10416884 Ref: Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error. PMID: 10418831 Ref: BAT-26 identifies sporadic colorectal cancers with mutator phenotype: a correlative study with clinico-pathological features and mutations in mismatch repair genes. PMID: 10419591 Ref: Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. PMID: 10419916 Ref: Microsatellite instability and expression of MLH1 and MSH2 in normal and malignant endometrial and ovarian epithelium in hereditary nonpolyposis colorectal cancer family members. PMID: 10432927 Ref: Rectal cancer in a 13-year-old boy without a detectable germline mutation in FAP and HNPCC genes. PMID: 10433009 Ref: Choice of management strategy for colorectal cancer based on a diagnostic immunohistochemical test for defective mismatch repair. PMID: 10446111 Ref: Evaluation of the replication error phenotype in relation to molecular and clinicopathological features in hereditary and early onset colorectal cancer. PMID: 10448273 Ref: Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. PMID: 10468602 Ref: Mutator phenotypes of common polymorphisms and missense mutations in MSH2. PMID: 10469597 Ref: Replication error in colorectal carcinoma: association with loss of heterozygosity at mismatch repair loci and clinicopathological variables. PMID: 10470121 Ref: hMLH1, hMSH2 and hMSH6 mutations in hereditary non-polyposis colorectal cancer families from southern Sweden. PMID: 10471527 Ref: Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer. PMID: 10480359 Ref: Various mutation screening techniques in the DNA mismatch repair genes hMSH2 and hMLH1. PMID: 10495924 Ref: Microsatellite alterations in serum DNA of patients with colorectal cancer. PMID: 10496533 Ref: Mouse models for colorectal cancer. PMID: 10498885 Ref: Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer. PMID: 10507723 Ref: Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. PMID: 10523644 Ref: Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors. PMID: 10524526 Ref: [Muir-Torre syndrome and familial colorectal cancer: 2 families with molecular genetic analysis]. PMID: 10530344 Ref: Microsatellite instability is rare in rectal carcinomas and signifies hereditary cancer. PMID: 10533476 Ref: Germ-line msh6 mutations in colorectal cancer families. PMID: 10537275 Ref: Genetic susceptibility to non-polyposis colorectal cancer. PMID: 10544223 Ref: Strategies for screening for hereditary non-polyposis colorectal cancer. PMID: 10544224 Ref: HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. PMID: 10545954 Ref: [HNPCC syndrome, microsatellite instability and NF1 gene alteration]. PMID: 10572231 Ref: Assessment of pathogenicity criteria for constitutional missense mutations of the hereditary nonpolyposis colorectal cancer genes MLH1 and MSH2. PMID: 10573010 Ref: 1998 Runme Shaw Memorial Lecture: somatic evolution of cancer. PMID: 10575514 Ref: Clinical and molecular diagnosis of hereditary non-polyposis colorectal cancer: problems and pitfalls in an extended pedigree. PMID: 10575566 Ref: A proven de novo germline mutation in HNPCC. PMID: 10594000 Ref: Missense mutations in hMLH1 associated with colorectal cancer. PMID: 10598809 Ref: Two types of sporadic multiple colorectal cancers with and without HNPCC-like genetic instability. PMID: 10626171 Ref: Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part II: Hereditary nonpolyposis colorectal carcinoma as a model. PMID: 10630171 Ref: Genetic testing and counseling for hereditary forms of colorectal cancer. PMID: 10630180 Ref: [Identification and genetic counseling of people with HNPCC (hereditary nonpolyposis colorectal cancer): old and new research goals]. PMID: 10637951 Ref: Towards a molecular classification of colorectal cancer. PMID: 10647627 Ref: Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines. PMID: 10674020 Ref: Microsatellite instability and hMSH2 gene mutation in a triple cancer (colon cancer, endometrial cancer, ovarian cancer) patient in hereditary non-polyposis colorectal cancer (HNPCC) kindred. PMID: 10680334 Ref: [The Lynch syndrome]. PMID: 10687268 Ref: [Aspirin suppresses microsatellite instability]. PMID: 10714217 Ref: Germline mutation and genome instability. PMID: 10772416 Ref: [Muir-Torre syndrome and HNPCC: importance of clinical diagnosis and genetic investigation in family members]. PMID: 10914216 Ref: Analysis of microsatellite instability in cervical cancer. PMID: 11240745 Ref: [Mutation of human mismatch repair genes in hereditary nonpolyposis colorectal cancer (HNPCC) families]. PMID: 11776847 |
Ref: Microsatellite instability as a predictor of a mutation in a DNA mismatch repair gene in familial colorectal cancer. PMID: 10564582 Ref: Microsatellite instability and MLH1 and MSH2 germline defects are related to clinicopathological features in sporadic colorectal cancer. PMID: 10601588 Ref: Four novel MSH2 / MLH1 gene mutations in portuguese HNPCC families. PMID: 10612836 Ref: Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers. PMID: 10673298 Ref: Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer. PMID: 10682661 Ref: Chronic inflammatory bowel disease and cancer. PMID: 10690586 Ref: Sequence analysis of the mismatch repair gene hMSH6 in the germline of patients with familial and sporadic colorectal cancer. PMID: 10699937 Ref: Detection of mutations in mismatch repair genes in Portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach. PMID: 10713887 Ref: Microsatellite instability in colorectal-cancer patients with suspected genetic predisposition. PMID: 10719736 Ref: Mutator phenotype due to loss of heterozygosity in diploid yeast strains with mutations in MSH2 and MLH1. PMID: 10720737 Ref: Mismatch repair proteins and microsatellites hit clinical practice. PMID: 10721415 Ref: Routine detection of the replication error phenotype in clinical tumor specimens using fluorescence-SSCP. PMID: 10723572 Ref: Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: associations with family history and histopathology. PMID: 10728595 Ref: Extensive molecular screening for hereditary non-polyposis colorectal cancer. PMID: 10732761 Ref: Atypical clustering of gynecologic malignancies: A family study including molecular analysis of candidate genes. PMID: 10739686 Ref: Value of pedigree/clinical data, immunohistochemistry and microsatellite instability analyses in reducing the cost of determining hMLH1 and hMSH2 gene mutations in patients with colorectal cancer. PMID: 10741294 Ref: Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA. PMID: 10748159 Ref: Mismatch repair defects in cancer. PMID: 10753784 Ref: Genetic analysis of multiple synchronous lesions of the colon adenoma-carcinoma sequence. PMID: 10755401 Ref: Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair. PMID: 10762011 Ref: HMSH6 alterations in patients with microsatellite instability-low colorectal cancer. PMID: 10786688 Ref: Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers. PMID: 10793088 Ref: Hereditary nonpolyposis colorectal cancer. PMID: 10805952 Ref: Expression of the human mismatch repair gene hMSH2: a potential marker for urothelial malignancy. PMID: 10820356 Ref: Association of a duodenal follicular lymphoma and hereditary nonpolyposis colorectal cancer. PMID: 10824932 Ref: Population-based molecular detection of hereditary nonpolyposis colorectal cancer. PMID: 10829038 Ref: Cell type specificity in alternative splicing of the human mismatch repair gene hMSH2. PMID: 10854094 Ref: DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. PMID: 10861262 Ref: Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. PMID: 10861263 Ref: Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instability. PMID: 10861474 Ref: Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice. PMID: 10866310 Ref: Novel germline mutation (300-305delAGTTGA) in the human MSH2 gene in hereditary non-polyposis colorectal cancer (HNPCC). PMID: 10874318 Ref: The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea. PMID: 10896919 Ref: Molecular genetics of hereditary nonpolyposis colorectal cancer. PMID: 10911905 Ref: Pathology of hereditary nonpolyposis colorectal cancer. PMID: 10911906 Ref: Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype. 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Ref: Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds. PMID: 11112663 Ref: Optimization of experimental conditions for RNA-based sequencing of MLH1 and MSH2 genes. PMID: 11139242 Ref: DHPLC mutation analysis of the hereditary nonpolyposis colon cancer (HNPCC) genes hMLH1 and hMSH2. PMID: 11179758 Ref: Microsatellite instability and mismatch-repair protein expression in hereditary and sporadic colorectal carcinogenesis. PMID: 11221877 Ref: Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. PMID: 11245417 Ref: MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. PMID: 11245474 Ref: Deficient DNA mismatch repair: a common etiologic factor for colon cancer. PMID: 11257106 Ref: Carcinogenesis in the GI tract: from morphology to genetics and back again. PMID: 11266532 Ref: Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development. PMID: 11285204 Ref: Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. PMID: 11289147 Ref: MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer. PMID: 11291077 Ref: Microsatellite instability and hMLH1/hMSH2 expression in Barrett esophagus-associated adenocarcinoma. PMID: 11301392 Ref: Infrequent frameshift mutations in the simple repeat sequences of hMLH3 in hereditary nonpolyposis colorectal cancers. PMID: 11302343 Ref: Microsatellite Instability and hMLH1 and hMSH2 expression analysis in familial and sporadic colorectal cancer. PMID: 11304573 Ref: Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer. PMID: 11306449 Ref: Hereditary non-polyposis colorectal cancer (HNPCC): new germline mutation (190-191 del AA) in the human MLH1 gene and review of clinical guidelines for surveillance of affected families. PMID: 11309221 Ref: Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers. PMID: 11317354 Ref: Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree. PMID: 11333868 Ref: Allelic loss of chromosome 2p21-16.3 is associated with reduced survival in sporadic colorectal cancer. PMID: 11336166 Ref: Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancer. PMID: 11343035 Ref: [From gene to disease; from DNA 'mismatch' repair genes to hereditary non-polyposis colorectal carcinoma]. PMID: 11346916 Ref: Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. PMID: 11358903 Ref: Immunohistochemistry for MSH2 and MHL1: a method for identifying mismatch repair deficient colorectal cancer. PMID: 11376026 Ref: Causes of microsatellite instability in colorectal tumors: implications for hereditary non-polyposis colorectal cancer screening. PMID: 11376800 Ref: Four novel MSH2 and MLH1 frameshift mutations and occurrence of a breast cancer phenocopy in hereditary nonpolyposis colorectal cancer. PMID: 11385712 Ref: Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 11389088 Ref: Hereditary nonpolyposis colorectal cancer with gynecologic malignancies: report of two families in Taiwan. PMID: 11393127 Ref: [Multidisciplinary management of hereditary colorectal cancer]. PMID: 11407044 Ref: Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide. PMID: 11416201 Ref: A novel germline 1.8-kb deletion of hMLH1 mimicking alternative splicing: a founder mutation in the Chinese population. PMID: 11420710 Ref: [Genetics-based prognosis evaluation of patients surgically treated for sporadic colorectal cancer]. PMID: 11443839 Ref: [When and how to investigate a mutation predisposing to the Lynch syndrome]. PMID: 11450192 Ref: Investigation of G2-phase chromosomal radiosensitivity in hereditary non-polyposis colorectal cancer cells. PMID: 11454277 Ref: Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype. PMID: 11470537 Ref: hMLH1 and hMSH2 expression in human hepatocellular carcinoma. PMID: 11494037 Ref: Clinical and biologic heterogeneity of hereditary nonpolyposis colorectal cancer. PMID: 11494233 Ref: Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. PMID: 11498787 Ref: CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer. PMID: 11507050 Ref: Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. PMID: 11507063 Ref: The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. PMID: 11522654 Ref: The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. PMID: 11524701 Ref: MLH1 and MSH2 protein immunohistochemistry is useful for detection of hereditary non-polyposis colorectal cancer in young patients. PMID: 11532035 Ref: Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. PMID: 11555625 Ref: Genotype and phenotype of a new 2-bp deletion of hMSH2 at codon 233. PMID: 11561760 Ref: Motivations and psychosocial impact of genetic testing for HNPCC. PMID: 11562928 Ref: Comparison of Alu-PCR, microsatelite instability, and immunohistochemical analyses in finding features characteristic for hereditary nonpolyposis colorectal cancer. PMID: 11570578 Ref: Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study. PMID: 11579115 Ref: Evaluation of Bethesda guidelines in relation to microsatellite instability. PMID: 11584201 Ref: Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. PMID: 11585736 Ref: Mechanisms of oncogenesis in colon versus rectal cancer. PMID: 11592095 Ref: Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients. PMID: 11592777 Ref: Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma. PMID: 11598481 Ref: MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. PMID: 11600610 Ref: Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer. PMID: 11601928 Ref: 1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice. PMID: 11604476 Ref: MSH2 and MLH1 immunodetection and the prognosis of colon cancer. PMID: 11604984 Ref: Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma. PMID: 11606365 Ref: The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer. PMID: 11606497 Ref: Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes. PMID: 11691782 Ref: The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. PMID: 11691795 Ref: Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair. PMID: 11698339 Ref: Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression. PMID: 11704838 Ref: Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation. PMID: 11719462 Ref: Minisatellite instability is found in colorectal tumours with mismatch repair deficiency. PMID: 11720433 Ref: Sixteen rare sequence variants of the hMLH1 and hMSH2 genes found in a cohort of 254 suspected HNPCC (hereditary non-polyposis colorectal cancer) patients: mutations or polymorphisms? PMID: 11726306 Ref: Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. PMID: 11733361 Ref: [Clinical significance of a carcinogenesis model of colorectal carcinoma]. PMID: 11765350 Ref: Fhit protein expression in hereditary and sporadic colorectal cancers. PMID: 11769399 Ref: hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer. PMID: 12132870 Ref: Age at diagnosis of cancer as predictor of mutation occurrence in families suspected of HNPCC. PMID: 14564042 Ref: The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative study. PMID: 14574003 Ref: Mutations of the 'minor' mismatch repair gene MSH6 in typical and atypical hereditary nonpolyposis colorectal cancer. PMID: 14574004 Ref: Chemotherapy resistant ovarian cancer in carriers of an hMSH2 mutation? PMID: 14574006 Ref: Genotype and phenotype in hereditary nonpolyposis colon cancer: a study of families with different vs. shared predisposing mutations. PMID: 14574010 Ref: Prediction of the outcome of genetic testing in HNPCC kindreds using the revised Amsterdam criteria and immunohistochemistry. PMID: 14574174 Ref: Immunohistochemical Analysis for hMLH1 and hMSH2 Expression in Colorectal Cancer. PMID: 21318818 Ref: Immunostaining human paraffin-embedded sections for mismatch repair proteins. PMID: 21340794 |
Ref: Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant. PMID: 11709755 Ref: Seven novel MLH1 and MSH2 germline mutations in hereditary nonpolyposis colorectal cancer. PMID: 11754112 Ref: Frequency of hereditary non-polyposis colorectal cancer in Danish colorectal cancer patients. PMID: 11772966 Ref: Proficient mismatch repair protein expression in Hodgkin and Reed Sternberg cells. PMID: 11774265 Ref: An insight into the genetic pathway of adenocarcinoma of the small intestine. PMID: 11788563 Ref: Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation. PMID: 11807791 Ref: A homozygous germ-line mutation in the human MSH2 gene predisposes to hematological malignancy and multiple cafe-au-lait spots. PMID: 11809679 Ref: Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation. PMID: 11839719 Ref: Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing. PMID: 11839723 Ref: Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. PMID: 11844828 Ref: High-frequency microsatellite instability is associated with defective DNA mismatch repair in human melanoma. PMID: 11851879 Ref: Non-Hodgkin's lymphoma in a patient with probable hereditary nonpolyposis colon cancer: report of a case and review of the literature. PMID: 11852345 Ref: Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC). PMID: 11852992 Ref: Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors. PMID: 11854177 Ref: Associations between family history of colorectal cancer and genetic alterations in tumors. PMID: 11857362 Ref: Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer. PMID: 11861375 Ref: Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer. PMID: 11870540 Ref: Mutation analysis of MLH1 and MSH2 genes performed by denaturing high-performance liquid chromatography. PMID: 11879922 Ref: DNA mismatch repair defects: role in colorectal carcinogenesis. PMID: 11900875 Ref: Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry. PMID: 11910346 Ref: Is reduced expression of mismatch repair genes MLH1 and MSH2 in patients with sporadic colorectal cancer related to their prognosis? PMID: 11918085 Ref: Evaluation of screening strategy for detecting hereditary nonpolyposis colorectal carcinoma. PMID: 11920458 Ref: Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain. PMID: 11920650 Ref: Report of 16 kindreds and one kindred with hMLH1 germline mutation. PMID: 11925604 Ref: Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors. PMID: 11929830 Ref: Alterations of BAT-26 identify a subset of gastric cancer with distinct clinicopathologic features and better postoperative prognosis. PMID: 11941977 Ref: Evidence for an age-related influence of microsatellite instability on colorectal cancer survival. PMID: 11948461 Ref: Expression of the hMSH6 mismatch-repair protein in colon cancer and HeLa cells. PMID: 11971198 Ref: Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level. PMID: 11973647 Ref: [Hereditary non-polyposis colorectal cancer (HNPCC)]. PMID: 11977537 Ref: High frequency of microsatellite instability and loss of mismatch-repair protein expression in patients with double primary tumors of the endometrium and colorectum. PMID: 12015776 Ref: Functional analysis of MSH6 mutations linked to kindreds with putative hereditary non-polyposis colorectal cancer syndrome. PMID: 12019211 Ref: A hMLH1 genomic mutation and associated novel mRNA defects in a hereditary non-polyposis colorectal cancer family. PMID: 12052501 Ref: Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. PMID: 12057899 Ref: [Muir-Torre syndrome]. PMID: 12063922 Ref: RER and LOH association with sporadic colorectal cancer in Taiwanese patients. PMID: 12063967 Ref: hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer. PMID: 12095971 Ref: Human colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are not defective in DNA mismatch repair proteins. PMID: 12107548 Ref: A novel germline mutation of hMLH1 in a patient with hereditary non-polyposis colorectal cancer. PMID: 12110639 Ref: Hereditary non-polyposis colorectal cancer (HNPCC): phenotype-genotype correlation between patients with and without identified mutation. PMID: 12112654 Ref: Mouse models for human DNA mismatch-repair gene defects. PMID: 12114115 Ref: Immunohistochemical pattern of MLH1/MSH2 expression is related to clinical and pathological features in colorectal adenocarcinomas with microsatellite instability. PMID: 12118112 Ref: [Immunohistochemistry and genotype analysis of tumors. First part: Which future for the immunochemical diagnosis of cancer?]. PMID: 12124491 Ref: Microsatellite instability and immunostaining for MSH-2 and MLH-1 in cutaneous and internal tumors from patients with the Muir-Torre syndrome. PMID: 12139636 Ref: [Genealogical research of hereditary nonpolyposis colorectal cancer]. PMID: 12139794 Ref: [Recent notions on intestinal cancerogenesis, their implications in genetic risk screening and preventive action of non-steroid anti-inflammatory agents]. PMID: 12145848 Ref: Increased sensitivity of colorectal cancer cell lines with microsatellite instability to 5-fluorouracil in vitro. PMID: 12150741 Ref: Mismatch repair, p53 and beta-catenin proteins in colorectal cancer. PMID: 12174887 Ref: Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma. PMID: 12177781 Ref: Impact of microsatellite testing and mismatch repair protein expression on the clinical interpretation of genetic testing in hereditary non-polyposis colorectal cancer. PMID: 12200596 Ref: Frequency of the Amsterdam criteria in a regional German cohort of patients with colorectal cancer. PMID: 12297979 Ref: The novel germline mutation of hMSH2 gene in a case of a colon cancer patient without family history. PMID: 12324578 Ref: Impact of gender and parent of origin on the phenotypic expression of hereditary nonpolyposis colorectal cancer in a large Newfoundland kindred with a common MSH2 mutation. PMID: 12352241 Ref: [Essential to discover hereditary colorectal and endometrial cancer. Mutations in "HNPCC individuals" can cause several different tumors]. PMID: 12362848 Ref: Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach. PMID: 12373605 Ref: Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants. PMID: 12377806 Ref: Predominance of CIN versus MSI in the development of rectal cancer at young age. PMID: 12379157 Ref: After hMSH2 and hMLH1--what next? Analysis of three-generational, population-based, early-onset colorectal cancer families. PMID: 12385013 Ref: Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region. PMID: 12397640 Ref: Analysis of mismatch repair defects in the familial occurrence of lymphoma and colorectal cancer. PMID: 12400605 Ref: Comparison of selection strategies for genetic testing of patients with hereditary nonpolyposis colorectal carcinoma: effectiveness and cost-effectiveness. PMID: 12404277 Ref: Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review. PMID: 12419761 Ref: Antibody-based screening for hereditary nonpolyposis colorectal carcinoma compared with microsatellite analysis and sequencing. PMID: 12436451 Ref: Very low incidence of microsatellite instability in intraductal papillary-mucinous neoplasm of the pancreas. PMID: 12448010 Ref: The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population. PMID: 12454801 Ref: Frequent microsatellite instability in sporadic tumors of the upper urinary tract. PMID: 12460887 Ref: Hereditary risk of women's cancers. PMID: 12475549 Ref: Mutation searching in colorectal cancer studies: experience with a denaturing high-pressure liquid chromatography system for exon-by-exon scanning of tumour suppressor genes. PMID: 12555990 Ref: Correlation of mismatch repair genes immunohistochemistry and microsatellite instability status in HNPCC-associated tumours. PMID: 12555992 |
Ref: Combined deficiency of hMLH1, hMSH2, hMSH3 and hMSH6 is an independent prognostic factor in colorectal cancer. PMID: 12469183 Ref: Morphologic reappraisal of serrated colorectal polyps. PMID: 12502929 Ref: Defective mismatch-repair in patients with multiple primary tumours including colorectal cancer. PMID: 12509957 Ref: Two mismatch repair gene mutations found in a colon cancer patient--which one is pathogenic? PMID: 12522549 Ref: A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells. PMID: 12538492 Ref: Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors. PMID: 12547705 Ref: Glutathione S-transferase M1 associated with cancer occurrence in Korean HNPCC families carrying the hMLH1/hMSH2 mutation. PMID: 12579293 Ref: Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer. PMID: 12591727 Ref: A636P is associated with early-onset colon cancer in Ashkenazi Jews. PMID: 12595050 Ref: The immunohistochemical detection of mismatch repair gene proteins (MLH1, MSH2, MSH6, and PMS2): practical aspects in antigen retrieval and biotin blocking protocols. PMID: 12610360 Ref: Early-age-at-onset colorectal cancer and microsatellite instability as markers of hereditary nonpolyposis colorectal cancer. PMID: 12626904 Ref: Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine. PMID: 12627520 Ref: Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration HNPCC family: molecular genetic, diagnostic, and management implications. PMID: 12650804 Ref: Genetic analysis of familial colorectal cancer in Israeli Arabs. PMID: 12655564 Ref: Novel MLH1 and MSH2 germline mutations in the first HNPCC families identified in Slovakia. PMID: 12655568 Ref: Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay. PMID: 12660027 Ref: The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications. PMID: 12667026 Ref: Methylation of the hMLH1 and hMSH2 promoter in early-onset sporadic colorectal carcinomas with microsatellite instability. PMID: 12673483 Ref: An early stage small bowel adenocarcinoma with microsatellite instability phenotype in a case of hereditary nonpolyposis colorectal cancer. PMID: 12673494 Ref: Detection of hotspot mutations and polymorphisms using an enhanced PCR-RFLP approach. PMID: 12673796 Ref: The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. PMID: 12687013 Ref: Identification of a deletion in the mismatch repair gene, MSH2, using mouse-human cell hybrids monosomal for chromosome 2. PMID: 12694232 Ref: Microsatellite instability is often observed in esophageal carcinoma patients with allelic loss in the FHIT/FRA3B locus. PMID: 12697969 Ref: The role of hMLH3 in familial colorectal cancer. PMID: 12702580 Ref: Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability. PMID: 12712438 Ref: Reduced expression of hMSH2 protein is correlated to poor survival for soft tissue sarcoma patients. PMID: 12712483 Ref: Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 [correction of hMLH6] immunostaining. PMID: 12741892 Ref: Genetic testing for hereditary nonpolyposis colorectal cancer. PMID: 12769209 Ref: [Clinicopathological features of typical and non-typical hereditary non-polyposis colorectal cancer and their germline mutation of hMLH1 and hMSH2]. PMID: 12783672 Ref: Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene. PMID: 12792735 Ref: Little evidence for involvement of MLH3 in colorectal cancer predisposition. PMID: 12800209 Ref: Cancer history and loss of MSH2 and MLH1 protein expression in patients with endometrial hyperplasia. PMID: 12801268 Ref: Tissue microarray technology: validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistochemical expression. PMID: 12802583 Ref: Characterization of mutator pathway in younger-age-onset colorectal adenocarcinomas. PMID: 12808326 Ref: Relationship between microsatellite instability, response and survival in palliative patients with colorectal cancer undergoing first-line chemotherapy. PMID: 12820457 Ref: Germline mutations at microsatellite loci in homozygous and heterozygous mutants for mismatch repair and PCNA genes in Drosophila. PMID: 12826283 Ref: Evidence of a preferred molecular pathway in patients with synchronous colorectal cancer. PMID: 12833454 Ref: Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. PMID: 12885834 Ref: Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat. PMID: 12901791 Ref: Microsatellite instability and mutations in DNA mismatch repair genes in sporadic colorectal cancers. PMID: 12907901 Ref: Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum. PMID: 12910497 Ref: Possible alternative carcinogenesis pathway featuring microsatellite instability in colorectal cancer stroma. PMID: 12915883 Ref: Germline hMLH1 promoter mutation in a Newfoundland HNPCC kindred. PMID: 12919137 Ref: Low mutation rate of hMSH2 and hMLH1 in Taiwanese hereditary non-polyposis colorectal cancer. PMID: 12919140 Ref: Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome. PMID: 12920072 Ref: [Mutation analysis on MSH2 and MLH1 genes in patients of colorectal cancer at early age]. PMID: 12930688 Ref: Identification and characterization of genomic rearrangements of MSH2 and MLH1 in Lynch syndrome (HNPCC) by novel techniques. PMID: 12938096 Ref: Microsatellite instability in a pleomorphic rhabdomyosarcoma in a patient with hereditary non-polyposis colorectal cancer. PMID: 12940783 Ref: BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. PMID: 14500346 Ref: Microsatellite instability and mutation analysis among southern Italian patients with colorectal carcinoma: detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases. PMID: 14504054 Ref: Lack of microsatellite instability in neoplasms of ampulla of Vater. PMID: 14516316 Ref: High throughput detection of microsatellite instability by denaturing high-performance liquid chromatography. PMID: 14517950 Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 Ref: MSH6 germline mutations are rare in colorectal cancer families. PMID: 14520694 Ref: Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. PMID: 14522894 Ref: Brostallicin (PNU-166196)--a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells. PMID: 14562032 Ref: Hyperplastic polyps in hereditary nonpolyposis colorectal cancer. PMID: 14572584 Ref: Does the occurrence of certain rare cancers indicate an inherited cancer susceptibility? PMID: 14574163 Ref: Histopathology and mismatch repair status of 458 consecutive colorectal carcinomas. PMID: 14576472 Ref: The novel germline mutation of hMSH2 gene in a case of a hereditary non-polyposis colorectal cancer (HNPCC) patient who meets the revised Amsterdam criteria. PMID: 14594944 Ref: Abnormal vascular network complexity: a new phenotypic marker in hereditary non-polyposis colorectal cancer syndrome. 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Ref: Microsatellite instability analysis and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer? PMID: 14652751 Ref: Microsatellite instability mutator phenotype in hepatocellular carcinoma in non-alcoholic and non-virally infected normal livers. PMID: 14656944 Ref: The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells. PMID: 14673178 Ref: Aetiology of colorectal cancer and relevance of monogenic inheritance. PMID: 14684585 Ref: Clinical and molecular biologic characteristics of early-onset versus late-onset colorectal carcinoma in Filipinos. PMID: 14708047 Ref: Genetic detection of Chinese hereditary nonpolyposis colorectal cancer. PMID: 14716824 Ref: Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer. 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PMID: 16840983 Ref: Prognostic significance of histological features and biological parameters in stage I (pT1 and pT2) colorectal adenocarcinoma. PMID: 16860493 Ref: Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. PMID: 16874859 Ref: Gynecological tumors revealing hereditary nonpolyposis colorectal cancer: analysis of a large Lebanese pedigree. PMID: 16884359 Ref: MLH3 mutation in endometrial cancer. PMID: 16885347 Ref: Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis. PMID: 16890597 Ref: Do MSI-L sporadic colorectal tumors develop through "mild mutator pathway"? PMID: 16891863 Ref: Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. PMID: 16906516 Ref: Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium. PMID: 16908935 Ref: Mapping of the methylation pattern of the hMSH2 promoter in colon cancer, using bisulfite genomic sequencing. PMID: 16911791 Ref: Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis. PMID: 16929496 Ref: Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act". PMID: 16938659 Ref: MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease. PMID: 16940983 Ref: Development of a Premature Stop Codon-detection method based on a bacterial two-hybrid system. PMID: 16948859 Ref: DNA repair pathway profiling and microsatellite instability in colorectal cancer. PMID: 16951227 Ref: Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. PMID: 16951683 Ref: Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients. PMID: 16952542 Ref: A de novo MLH1 germ line mutation in a 31-year-old colorectal cancer patient. PMID: 16955466 Ref: Identification of germline MLH1 alterations in familial prostate cancer. PMID: 16963262 Ref: Assessing the predictive accuracy of hMLH1 and hMSH2 mutation probability models. PMID: 16969708 Ref: A novel mutation detection approach of hMLH1 and hMSH2 genes for screening of colorectal cancer. PMID: 16971051 Ref: Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene. PMID: 16996571 Ref: Prediction of MLH1 and MSH2 mutations in Lynch syndrome. PMID: 17003395 Ref: Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal cancer in a Chinese population. PMID: 17011982 Ref: Correlation of microsatellite status, proliferation, apoptotic and selected immunohistochemical markers in colorectal carcinoma studied with tissue microarray. PMID: 17019973 Ref: Microsatellite instability accounts for tumor site-related differences in clinicopathologic variables and prognosis in human colon cancers. PMID: 17026563 Ref: Inherited association of breast and colorectal cancer: limited role of CHEK2 compared with high-penetrance genes. PMID: 17026620 Ref: Genetic instability on chromosome 17 in the epithelium of non-polypoid colorectal carcinomas compared to polypoid lesions. PMID: 17032312 Ref: Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer. PMID: 17054581 Ref: Genetics of hereditary nonpolyposis colorectal cancer. PMID: 17061614 Ref: Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology. PMID: 17065421 Ref: The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer. PMID: 17080293 Ref: Frequency of hereditary non-polyposis colorectal cancer among unselected patients with colorectal cancer in Germany. PMID: 17095871 Ref: Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan. PMID: 17106811 Ref: Very low prevalence of germline MSH6 mutations in hereditary non-polyposis colorectal cancer suspected patients with colorectal cancer without microsatellite instability. PMID: 17117178 Ref: Loss of p27 expression and microsatellite instability in sporadic colorectal cancer. PMID: 17123889 Ref: The T/G mutation in exon 8 of hMSH2 gene in the sporadic colon cancer patients. PMID: 17139886 Ref: [Microsatellite instability among patients with colorectal cancer]. PMID: 17186090 Ref: Two germline alterations in mismatch repair genes found in a HNPCC patient with poor family history. PMID: 17189986 Ref: Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family. PMID: 17203532 Ref: [Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium]. PMID: 17216011 Ref: Early genetic instability of both epithelial and stromal cells in esophageal squamous cell carcinomas, contrasted with Barrett's adenocarcinomas. PMID: 17287898 Ref: [Fenotypical diversity of hereditary non-polyposis colorectal carcinoma. Pedigree and genetical analysis of two mutation carrier patients]. PMID: 17432081 Ref: The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria. PMID: 20223014 |
Ref: Colorectal cancer in a population with endemic Schistosoma mansoni: is this an at-risk population? PMID: 16786317 Ref: Genomic rearrangements in MSH2, MLH1 or MSH6 are rare in HNPCC patients carrying point mutations. PMID: 16837128 Ref: Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer. PMID: 16902769 Ref: Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. PMID: 17021745 Ref: Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies. PMID: 17039269 Ref: The phenotypic expression of three MSH2 mutations in large Newfoundland families with Lynch syndrome. PMID: 17039271 Ref: No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer. PMID: 17043646 Ref: A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene. PMID: 17051350 Ref: Assessment of microsatellite instability in colorectal carcinoma at an Indian center. PMID: 17160686 Ref: A missense germline mutation in exon 7 of the MSH2 gene in a HNPCC family from center-Italy. PMID: 17165155 Ref: Alterations in cell proliferation and apoptosis in colon cancers with microsatellite instability. PMID: 17187355 Ref: Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. PMID: 17200375 Ref: Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC. PMID: 17203173 Ref: The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1. PMID: 17224235 Ref: Eyelid sebaceous carcinoma associated with Muir-Torre syndrome in two cases. PMID: 17237705 Ref: 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. PMID: 17241873 Ref: Germline novel MSH2 deletions and a founder MSH2 deletion associated with anticipation effects in HNPCC. PMID: 17250661 Ref: Novel germline and somatic mutations of the MSH2 gene in hereditary non-polyposis colorectal cancer. PMID: 17250671 Ref: [Study the value of screening hereditary nonpolyposis colorectal cancer kindreds by detecting the expression of hMLH1/hMSH2 with tissue microarray]. PMID: 17253179 Ref: Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. PMID: 17258725 Ref: Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin. PMID: 17258738 Ref: Medulloblastoma, acute myelocytic leukemia and colonic carcinomas in a child with biallelic MSH6 mutations. PMID: 17259933 Ref: Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. PMID: 17278092 Ref: Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors. PMID: 17284719 Ref: Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. PMID: 17312306 Ref: Exploring the potential chemopreventative effect of aspirin and rofecoxib on hereditary nonpolyposis colorectal cancer-like endometrial cancer cells in vitro through mechanisms involving apoptosis, the cell cycle, and mismatch repair gene expression. PMID: 17316360 Ref: DNA mismatch repair initiates 6-thioguanine--induced autophagy through p53 activation in human tumor cells. PMID: 17317843 Ref: Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). PMID: 17327285 Ref: A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer. PMID: 17333219 Ref: A new variant database for mismatch repair genes associated with Lynch syndrome. PMID: 17347989 Ref: Nationwide study of clinical and molecular features of hereditary non-polyposis colorectal cancer (HNPCC) in Latvia. PMID: 17348456 Ref: Beta2-microglobulin mutations in microsatellite unstable colorectal tumors. PMID: 17373663 Ref: MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer. PMID: 17374836 Ref: Turcot syndrome confirmed with molecular analysis. PMID: 17389002 Ref: Genetic testing in colorectal cancer: who, when, how and why. PMID: 17392593 Ref: [Familial and genetic study in a large Chinese kindred with hereditary nonpolyposis colorectal cancer]. PMID: 17407090 Ref: Is surveillance of the small bowel indicated for Lynch syndrome families? PMID: 17409122 Ref: Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. PMID: 17414604 Ref: Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer. PMID: 17417778 Ref: Immunohistochemical staining for mismatch repair proteins, and its relevance in the diagnosis of hereditary non-polyposis colorectal cancer. PMID: 17440950 Ref: Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. PMID: 17445998 Ref: Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer. PMID: 17453358 Ref: No difference in the occurrence of mismatch repair defects and APC and CTNNB1 genes mutation in a multi-racial colorectal carcinoma patient cohort. PMID: 17454753 Ref: Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma. PMID: 17460459 Ref: Clinical and molecular analysis of hereditary non-polyposis colorectal cancer in Chinese colorectal cancer patients. PMID: 17461458 Ref: Detection of metachronous neoplasms in colorectal cancer patients: identification of risk factors. PMID: 17468913 Ref: A mononucleotide markers panel to identify hMLH1/hMSH2 germline mutations. PMID: 17473388 Ref: Estimating cancer risk in HNPCC by the GRL method. PMID: 17473834 Ref: Microsatellite instability markers for identifying early-onset colorectal cancers caused by germ-line mutations in DNA mismatch repair genes. PMID: 17504984 Ref: Genotype-phenotype correlations in individuals with a founder mutation in the MLH1 gene and hereditary non-polyposis colorectal cancer. PMID: 17505997 Ref: Microsatellite instability in Ewing tumor is not associated with loss of mismatch repair protein expression. PMID: 17530287 Ref: Predictive value of MSH2 gene expression in colorectal cancer treated with capecitabine. PMID: 17531106 Ref: [Mismatch repair (MMR) efficiency and MSH2 gene mutation in human colorectal carcinoma cell line COLO320HSR]. PMID: 17555131 Ref: Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing. PMID: 17569143 Ref: High proportion of large genomic rearrangements in hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC) families of the Basque Country. PMID: 17582678 Ref: [Microsatellite analysis and hMLH1/hMSH2 expression detection in young patients with colorectal cancer: value in screening hereditary nonpolyposis colorectal cancer]. PMID: 17584637 Ref: Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer. PMID: 17606714 Ref: TGF-beta signaling alterations and susceptibility to colorectal cancer. PMID: 17613544 Ref: Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players. PMID: 17613548 Ref: The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis. PMID: 17615258 Ref: Heterogeneous staining for mismatch repair proteins during population-based prescreening for hereditary nonpolyposis colorectal cancer. PMID: 17652638 Ref: Uterine carcinosarcoma associated with hereditary nonpolyposis colorectal cancer. PMID: 17666659 Ref: Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer. PMID: 17717427 Ref: Frequency of constitutional MSH6 mutations in a consecutive series of families with clinical suspicion of HNPCC. PMID: 17718861 Ref: Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions. PMID: 17723178 Ref: Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer. PMID: 17724798 Ref: Hereditary nonpolyposis colorectal cancer: diagnostic strategies and their implications. PMID: 17764220 Ref: [Screening the hereditary nonpolyposis colorectal cancer by revised Bethesda guideline: a cohort study of 110 cases]. PMID: 17785078 Ref: [A new oncogenetic service of counseling and diagnosing for hereditary non-polyposis colorectal cancer (HNPCC)]. PMID: 17803162 Ref: Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register. PMID: 17846840 Ref: Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families. PMID: 17854147 Ref: Germline hMSH2 promoter mutation in a Chinese HNPCC kindred: evidence for dual role of LOH. PMID: 17894833 Ref: Muir-Torre syndrome. PMID: 17902735 Ref: Familial colorectal cancer syndrome X. PMID: 17920898 Ref: Clinicopathological characteristics of colorectal cancer with family history: an evaluation of family history as a predictive factor for microsatellite instability. PMID: 17923762 Ref: Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer. PMID: 17925543 Ref: MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer. PMID: 17942459 Ref: Data reduction for prediction: a case study on robust coding of age and family history for the risk of having a genetic mutation. PMID: 17948867 Ref: Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. PMID: 17950381 Ref: Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers--ready for prime time? PMID: 17962726 Ref: SNP-Array genotyping and spectral karyotyping reveal uniparental disomy as early mutational event in MSS- and MSI-colorectal cancer cell lines. PMID: 18000373 Ref: Frequency of defective DNA mismatch repair in colorectal cancer among the Alaska Native people. PMID: 18006922 Ref: Humanizing mismatch repair in yeast: towards effective identification of hereditary non-polyposis colorectal cancer alleles. PMID: 18031259 Ref: Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis. PMID: 18091433 Ref: hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. PMID: 18214062 Ref: Mismatch repair protein MSH2, cytokeratin 18 and cytokeratin 20 expression: clinicopathological correlation and prognostic value in colorectal cancer patients. PMID: 18265645 Ref: MSI is frequently recognized among gastric cancer patients with a family history of cancer. PMID: 18265677 Ref: [Colorectal serrated adenoma: diagnostic criteria and clinical implications]. PMID: 18314605 Ref: [Need of new clinical criteria for the identification of genetic Lynch syndrome]. PMID: 18331697 Ref: [How and when to search for microsatellite instability in colorectal cancer in 2008?]. PMID: 18554553 |
Ref: Correlation between patient weight and defects in DNA mismatch repair: is this the link between an increased risk of previous cancer in thinner women with endometrial cancer? PMID: 17466051 Ref: A novel MSH2 germline mutation in a Druze HNPCC family. PMID: 17661183 Ref: Homozygous PMS2 germline mutations in two families with early-onset haematological malignancy, brain tumours, HNPCC-associated tumours, and signs of neurofibromatosis type 1. PMID: 17851451 Ref: Strategy in clinical practice for classification of unselected colorectal tumours based on mismatch repair deficiency. PMID: 17868408 Ref: Is MSH2 a breast cancer susceptibility gene? PMID: 17922223 Ref: Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). PMID: 17939062 Ref: Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases. PMID: 17943475 Ref: Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repair. PMID: 18022218 Ref: Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. PMID: 18027856 Ref: Classification of ambiguous mutations in DNA mismatch repair genes identified in a population-based study of colorectal cancer. PMID: 18033691 Ref: Validation and extension of the PREMM1,2 model in a population-based cohort of colorectal cancer patients. PMID: 18061181 Ref: Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. PMID: 18095365 Ref: A prospective, multicenter, population-based study of BRAF mutational analysis for Lynch syndrome screening. PMID: 18096441 Ref: Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. PMID: 18097574 Ref: Working through a diagnostic challenge: colonic polyposis, Amsterdam criteria, and a mismatch repair mutation. PMID: 18176851 Ref: Non-Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene. PMID: 18181177 Ref: Single nucleotide polymorphism detection in the hMSH2 gene using conformation-sensitive CE. PMID: 18186537 Ref: Detection of hMSH2 and hMLH1 mutations in Chinese hereditary non-polyposis colorectal cancer kindreds. PMID: 18186571 Ref: Detection of mismatch repair gene germline mutation carrier among Chinese population with colorectal cancer. PMID: 18257912 Ref: Detection of microsatellite instability in colorectal cancer using an alternative multiplex assay of quasi-monomorphic mononucleotide markers. PMID: 18258928 Ref: Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. PMID: 18272544 Ref: Tumor histology helps to identify Lynch syndrome among colorectal cancer patients. PMID: 18283560 Ref: Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. PMID: 18299982 Ref: No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients. PMID: 18301448 Ref: Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features. PMID: 18301950 Ref: Immunoexpression of hMSH2 and hMLH1 in oral squamous cell carcinoma and its relationship to histological grades of malignancy. PMID: 18331286 Ref: Common variants in mismatch repair genes and risk of colorectal cancer. PMID: 18364438 Ref: Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. PMID: 18384130 Ref: Screening for urinary tract cancer with urine cytology in Lynch syndrome and familial colorectal cancer. PMID: 18389386 Ref: Mutation spectrum in HNPCC in the Israeli population. PMID: 18389388 Ref: The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. PMID: 18398828 Ref: A novel missense MSH2 gene mutation in a patient of a Korean family with hereditary nonpolyposis colorectal cancer. PMID: 18406877 Ref: Compound heterozygosity for two MSH6 mutations in a patient with early onset colorectal cancer, vitiligo and systemic lupus erythematosus. PMID: 18409202 Ref: Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas. PMID: 18415027 Ref: CpG island methylation in familial colorectal cancer patients not fulfilling the Amsterdam criteria. PMID: 18437011 Ref: Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites instability. A comment on the Revised Bethesda Guidelines. PMID: 18446350 Ref: Cost analysis of biomarker testing for mismatch repair deficiency in node-positive colorectal cancer. PMID: 18457354 Ref: Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification. PMID: 18470917 Ref: Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes. PMID: 18481196 Ref: Contribution of common monoallelic MUTYH gene variants in German patients with familial colorectal cancer. PMID: 18503156 Ref: Inherited cancer predisposition syndromes in Greece. PMID: 18505076 Ref: Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. PMID: 18509181 Ref: The first functional study of MLH3 mutations found in cancer patients. PMID: 18521850 Ref: Association of family history with cancer recurrence and survival among patients with stage III colon cancer. PMID: 18523220 Ref: [Comparison of clinical and genetic phenotypes between Chinese and Korean hereditary nonpolyposis colorectal cancer families]. PMID: 18543228 Ref: Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway. PMID: 18546042 Ref: The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population. PMID: 18547406 Ref: Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part II. The utility of microsatellite instability testing. PMID: 18556776 Ref: Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers. PMID: 18581137 Ref: Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group. PMID: 18594845 Ref: Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status. PMID: 18595133 Ref: The response of human colonocytes to folate deficiency in vitro: functional and proteomic analyses. PMID: 18597513 Ref: Comparison of predictive models, clinical criteria and molecular tumour screening for the identification of patients with Lynch syndrome in a population-based cohort of colorectal cancer patients. PMID: 18603628 Ref: Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients. PMID: 18618713 Ref: IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer. PMID: 18623088 Ref: Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer. PMID: 18624996 Ref: Report of a family segregating mutations in both the APC and MSH2 genes: juvenile onset of colorectal cancer in a double heterozygote. PMID: 18629513 Ref: [Clinical value of screening hereditary nonpolyposis colorectal cancer in China with protocol recommended by NCCN guidelines]. PMID: 18636350 Ref: [Study of germline mutation of hMSH2, hMSH6 and hMLH1 and methylation of hMLH1 in microsatellite instability colorectal cancer]. PMID: 18636359 Ref: Altered DNA mismatch repair expression in synchronous and metachronous colorectal cancers. PMID: 18639494 Ref: Transgenerational epigenetic inheritance in health and disease. PMID: 18662779 Ref: Gynecologic malignancies in Ashkenazi families with the MSH2 A636P founder mutation. PMID: 18674656 Ref: Interpretation of immunohistochemistry for mismatch repair proteins is only reliable in a specialized setting. PMID: 18677806 Ref: Differences and evolution of the methods for the assessment of microsatellite instability. PMID: 18679418 Ref: Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States. PMID: 18708397 Ref: Constitutional mismatch repair-deficiency syndrome: have we so far seen only the tip of an iceberg? PMID: 18709565 Ref: Clinical features and hMSH2/hMLH1 germ-line mutations in Chinese patients with hereditary nonpolyposis colorectal cancer. PMID: 18713544 Ref: Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. PMID: 18718023 Ref: Identification in daily practice of patients with Lynch syndrome (hereditary nonpolyposis colorectal cancer): revised Bethesda guidelines-based approach versus molecular screening. PMID: 18759827 Ref: [Hereditary non-polyposis colorectal cancer. Report of four siblings]. PMID: 18769833 Ref: Multiplex SNaPshot genotyping for detecting loss of heterozygosity in the mismatch-repair genes MLH1 and MSH2 in microsatellite-unstable tumors. PMID: 18772310 Ref: MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system. PMID: 18781619 Ref: [Lynch syndrome I: a case report]. PMID: 18798480 Ref: [Comparison of the sensibility and specificity between single-stranded conformation polymorphism and denaturing high-performance liquid chromatography in screening hMSH2 and hMLH1 gene mutations in hereditary non-polyposis colorectal cancer]. PMID: 18803051 Ref: Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. PMID: 18922920 Ref: Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. PMID: 18949393 Ref: Risk of gynecologic cancers in Danish hereditary non-polyposis colorectal cancer families. PMID: 18972272 Ref: Novel approaches in evaluation of pathogenicity of single-base exonic germline changes involving the mismatch repair genes MLH1 and MSH2 in diagnostics of Lynch syndrome. PMID: 18999873 Ref: Report on de-novo mutation in the MSH2 gene as a rare event in hereditary nonpolyposis colorectal cancer. PMID: 19047842 Ref: Muir-Torre syndrome: a rare but important disorder. PMID: 19055168 Ref: [Anticancer effects of tea polyphenols on colorectal cancer with microsatellite instability in nude mice]. PMID: 19063841 Ref: MSH-2 and MLH-1 protein expression in Muir Torre syndrome-related and sporadic sebaceous neoplasms. PMID: 19069357 Ref: Lynch syndrome and related familial colorectal cancers. PMID: 19105568 Ref: [Dentistry anomalies in patients with Lynch syndrome and familial adenomatous polyposis]. PMID: 19127816 Ref: Analysis of hMLH1 and hMSH2 expression in cisplatin-treated ovarian cancer patients. PMID: 19175039 Ref: The genomics of colorectal cancer: state of the art. PMID: 19424478 Ref: Thyroid cancer in a patient with a germline MSH2 mutation. Case report and review of the Lynch syndrome expanding tumour spectrum. PMID: 19706203 Ref: Risk analysis of colorectal cancer in women with endometrial carcinoma. PMID: 21479448 |
Ref: Hereditary ovarian cancer. PMID: 18656380 Ref: The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status. PMID: 18722765 Ref: Recurring MLH1 deleterious mutations in unrelated Chinese Lynch syndrome families in Singapore. PMID: 18726168 Ref: A simple colostomy implantation model for evaluating colon cancer. PMID: 18773212 Ref: Compound heterozygosity for two MSH2 mutations suggests mild consequences of the initiation codon variant c.1A>G of MSH2. PMID: 18781192 Ref: Identification and characterization of a novel MLH1 genomic rearrangement as the cause of HNPCC in a Tunisian family: evidence for a homologous Alu-mediated recombination. PMID: 18792805 Ref: High risk of endometrial cancer in colorectal cancer kindred is pathognomonic for MMR-mutation carriers. PMID: 18841495 Ref: MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres. PMID: 18986375 Ref: Identifying Muir-Torre syndrome in a patient with glioblastoma multiforme. PMID: 19028998 Ref: Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. PMID: 19029193 Ref: Phenotypic mismatch repair hMSH2 and hMLH1 gene expression profiles in primary non-small cell lung carcinomas. PMID: 19056144 Ref: Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test. PMID: 19072991 Ref: Three new nonsense mutations of MLH1 and MSH2 genes in Korean families with hereditary nonpolyposis colorectal cancer. PMID: 19100506 Ref: Homozygosity of MSH2 c.1906G-->C germline mutation is associated with childhood colon cancer, astrocytoma and signs of Neurofibromatosis type I. PMID: 19101824 Ref: Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer. PMID: 19115210 Ref: Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel. PMID: 19127559 Ref: Sarcomas associated with hereditary nonpolyposis colorectal cancer: broad anatomical and morphological spectrum. PMID: 19130300 Ref: Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression. PMID: 19154585 Ref: Large genomic rearrangements and germline epimutations in Lynch syndrome. PMID: 19173287 Ref: An interstitial deletion at 3p21.3 results in the genetic fusion of MLH1 and ITGA9 in a Lynch syndrome family. PMID: 19188145 Ref: Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans. 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