Primary Site >> Liver Cancer
Gene >> MMP9
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Ref: Expression of type-IV collagenases in human tumor cell lines that can form liver colonies in chick embryos. PMID: 8262676 |
Ref: Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control. PMID: 10767785 Ref: Recurrence or metastasis of HCC:predictors, early detection and experimental antiangiogenic therapy. PMID: 11819524 Ref: Assessing matrix metalloproteinase expression and activity in hepatocellular carcinomas. PMID: 21341053 |
Ref: Invasiveness of hepatocellular carcinoma cell lines: contribution of hepatocyte growth factor, c-met, and transcription factor Ets-1. PMID: 11527416 |
Ref: A role for matrix metalloproteinases and tumor host interaction in hepatocellular carcinomas. PMID: 12034400 |
Ref: Detection of type IV collagenase activity in malignant ascites. PMID: 14606104 |
Ref: Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection. PMID: 15661146 Ref: [Recombinant adenovirus vectors carrying antisense MMP2 inhibit invasion of HCC cells in vitro]. PMID: 15850513 Ref: Evaluation of stromal metalloproteinases and vascular endothelial growth factors in a spontaneous metastasis model. PMID: 16188254 Ref: Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C. PMID: 16344072 |
Ref: Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. PMID: 16284949 |
Ref: Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis. PMID: 17890288 Ref: MMP2 promoter polymorphism (C-1306T) and risk of recurrence in patients with hepatocellular carcinoma after transplantation. PMID: 18177474 Ref: Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma. PMID: 18932288 |
Ref: Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery. PMID: 19948069 Ref: Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo. PMID: 20210245 |
Ref: Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. PMID: 20038795 Ref: The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs. PMID: 20073580 Ref: [Effects of Smad4 on liver fibrosis and hepatocarcinogenesis in mice treated with CCl4/ethanol]. PMID: 20196951 Ref: Epithelial-mesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma. PMID: 20331628 Ref: CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma. PMID: 20578262 |
Ref: Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator Twist1. PMID: 20219012 Ref: Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9. PMID: 21667159 Ref: miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened. PMID: 21671467 Ref: Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression. PMID: 21760911 Ref: Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. PMID: 21966391 |
Ref: Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA. PMID: 22170570 Ref: Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells. PMID: 22349030 Ref: Low level of low-density lipoprotein receptor-related protein 1 predicts an unfavorable prognosis of hepatocellular carcinoma after curative resection. PMID: 22427881 Ref: PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice. PMID: 22472882 Ref: Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression. PMID: 23050001 |
Ref: Interferon regulatory factor (IRF)-1 and IRF-2 are associated with prognosis and tumor invasion in HCC. PMID: 22805863 Ref: Knockdown of MACC1 expression suppressed hepatocellular carcinoma cell migration and invasion and inhibited expression of MMP2 and MMP9. PMID: 23232575 Ref: Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: role of the S100A4-miR155-SOCS1-MMP9 axis. PMID: 23316018 Ref: Overexpression of Ras homologous C (RhoC) induces malignant transformation of hepatocytes in vitro and in nude mouse xenografts. PMID: 23382905 Ref: Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients. PMID: 23418512 Ref: Hydrogen peroxide stimulates cell motile activity through LPA receptor-3 in liver epithelial WB-F344 cells. PMID: 23510996 Ref: Enhancement of invasion of hepatocellular carcinoma cells through lysophosphatidic acid receptor. PMID: 23569130 Ref: Kruppellike factor expression and correlation with FAK, MMP9 and Ecadherin expression in hepatocellular carcinoma. PMID: 23670717 Ref: Development and characterization of a reliable mouse model of colorectal cancer metastasis to the liver. PMID: 23748471 Ref: High variability in MMP2/TIMP2 and MMP9/TIMP1 expression in secondary liver tumors. PMID: 24068394 Ref: Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1. PMID: 24274578 Ref: Combination of SLC administration and Tregs depletion is an attractive strategy for targeting hepatocellular carcinoma. PMID: 24304581 Ref: The Inhibitory Effect of 3 beta -Hydroxy-12-oleanen-27-oic Acid on Growth and Motility of Human Hepatoma HepG2 Cells through JNK and Akt Signaling Pathway. PMID: 24379889 |
Ref: Snail1-dependent transcriptional repression of Cezanne2 in hepatocellular carcinoma. PMID: 23792447 Ref: The effect of hepatic progenitor cells on experimental hepatocellular carcinoma in the regenerating liver. PMID: 24188385 Ref: Activated hepatic stellate cells promote hepatocellular carcinoma cell migration and invasion via the activation of FAK-MMP9 signaling. PMID: 24284889 Ref: Distinct roles of Akt1 in regulating proliferation, migration and invasion in HepG2 and HCT 116 cells. PMID: 24297510 Ref: Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways. PMID: 24361892 Ref: Inhibition of tumor necrosis factor alpha reduces the outgrowth of hepatic micrometastasis of colorectal tumors in a mouse model of liver ischemia-reperfusion injury. PMID: 24397824 Ref: BVES inhibition triggers epithelial-mesenchymal transition in human hepatocellular carcinoma. PMID: 24442236 Ref: MMP9 processing of HSPB1 regulates tumor progression. PMID: 24465581 Ref: CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis. PMID: 24561613 Ref: Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma. PMID: 24614035 Ref: Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-kappaB and AP-1 activity in human liver cancer cells. PMID: 24641665 Ref: Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling. PMID: 24980220 Ref: TPX2 knockdown suppressed hepatocellular carcinoma cell invasion via inactivating AKT signaling and inhibiting MMP2 and MMP9 expression. PMID: 25232213 Ref: ROCK is involved in vasculogenic mimicry formation in hepatocellular carcinoma cell line. PMID: 25238232 Ref: Silencing HIWI suppresses the growth, invasion and migration of glioma cells. PMID: 25269862 Ref: CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis. PMID: 25326065 Ref: [Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway]. PMID: 25544168 |
Ref: Chloride intracellular channel 1 participates in migration and invasion of hepatocellular carcinoma by targeting maspin. PMID: 24989236 Ref: Increased autophagy sustains the survival and pro-tumourigenic effects of neutrophils in human hepatocellular carcinoma. PMID: 25152203 Ref: Axl activates autocrine transforming growth factor-beta signaling in hepatocellular carcinoma. PMID: 25251599 Ref: TPX2 as a novel prognostic biomarker for hepatocellular carcinoma. PMID: 25263743 Ref: MEK/ERK pathway is positively involved in hypoxia-induced vasculogenic mimicry formation in hepatocellular carcinoma which is regulated negatively by protein kinase A. PMID: 25487444 Ref: RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9. PMID: 25626059 Ref: The involvement of cell surface nucleolin in the initiation of CCR6 signaling in human hepatocellular carcinoma. PMID: 25698534 Ref: ACK1 promotes hepatocellular carcinoma progression via downregulating WWOX and activating AKT signaling. PMID: 25738261 Ref: Inhibition of Hepatocellular Carcinoma by Total Alkaloids of Rubus alceifolius Poir Involves Suppression of Hedgehog Signaling. PMID: 25917815 Ref: High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome. PMID: 26082242 Ref: Effects of Ras homolog gene family, member C gene silencing combined with rapamycin on hepatocellular carcinoma cell growth. PMID: 26165487 Ref: MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1. PMID: 26177288 Ref: Positive feedback loop of hepatoma-derived growth factor and beta-catenin promotes carcinogenesis of colorectal cancer. PMID: 26296979 Ref: Down-regulation of cancer/testis antigen OY-TES-1 attenuates malignant behaviors of hepatocellular carcinoma cells in vitro. PMID: 26339343 Ref: Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma. PMID: 26459497 Ref: A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma. PMID: 26482853 Ref: Toll-like receptor 4 signaling promotes invasion of hepatocellular carcinoma cells through MKK4/JNK pathway. PMID: 26589455 Ref: Isocitrate Dehydrogenase 2 Suppresses the Invasion of Hepatocellular Carcinoma Cells via Matrix Metalloproteinase 9. PMID: 26646705 Ref: GIT1 is a novel prognostic biomarker and facilitates tumor progression via activating ERK/MMP9 signaling in hepatocellular carcinoma. PMID: 26719701 Ref: Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression. PMID: 26788160 |
Ref: Effect of silencing NEK2 on biological behaviors of HepG2 in human hepatoma cells and MAPK signal pathway. PMID: 26337275 Ref: Effect of GnT-V knockdown on the proliferation, migration and invasion of the SMMC7721/R human hepatocellular carcinoma drug-resistant cell line. PMID: 26531171 Ref: Persistence of cirrhosis is maintained by intrahepatic regulatory T cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases. PMID: 26613891 Ref: 14-3-3beta Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells by Modulating Expression of MMP2 and MMP9 through PI3K/Akt/NF-kappaB Pathway. PMID: 26730736 Ref: Chemopreventive and hepatoprotective roles of adiponectin (SULF2 inhibitor) in hepatocelluar carcinoma. PMID: 26733159 Ref: The anti-metastatic effect of 8-MOP on hepatocellular carcinoma is potentiated by the down-regulation of bHLH transcription factor DEC1. PMID: 26808085 Ref: An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+ liver cancer cells induced by CXCL9. PMID: 26883105 Ref: Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells. PMID: 27086923 Ref: Knockdown of RHOC by shRNA suppresses invasion and migration of cholangiocellular carcinoma cells via inhibition of MMP2, MMP3, MMP9 and epithelial-mesenchymal transition. PMID: 27108649 Ref: EFEMP1 inhibits migration of hepatocellular carcinoma by regulating MMP2 and MMP9 via ERK1/2 activity. PMID: 27108677 Ref: Overexpression of hepatocyte nuclear factor 4alpha in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/beta-catenin signaling pathway downregulation. PMID: 27124543 Ref: ZKSCAN3 Facilitates Liver Metastasis of Colorectal Cancer Associated with CEA-expressing Tumor. PMID: 27127149 Ref: Chrysin, Abundant in Morinda citrifolia Fruit Water-EtOAc Extracts, Combined with Apigenin Synergistically Induced Apoptosis and Inhibited Migration in Human Breast and Liver Cancer Cells. PMID: 27137679 Ref: Slit2 and Robo1 induce opposing effects on metastasis of hepatocellular carcinoma Sk-hep-1 cells. PMID: 27176045 Ref: Actinidia chinensis Planch root extract (acRoots) inhibits hepatocellular carcinoma progression by inhibiting EP3 expression. PMID: 27475644 Ref: PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. PMID: 27572739 Ref: RUNX2 promotes hepatocellular carcinoma cell migration and invasion by upregulating MMP9 expression. PMID: 27666365 Ref: Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2. PMID: 27693494 Ref: TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion In Vitro and In Vivo in Human Hepatoma through STAT3 Regulation. PMID: 27834930 Ref: Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids. PMID: 27853186 Ref: PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma. PMID: 27915333 |
Ref: The effects of urotensin II on migration and invasion are mediated by NADPH oxidase-derived reactive oxygen species through the c-Jun N-terminal kinase pathway in human hepatoma cells. PMID: 27988353 Ref: Positive feedback loop of IL-1beta/Akt/RARalpha/Akt signaling mediates oncogenic property of RARalpha in gastric carcinoma. PMID: 28035062 Ref: Systematic analysis of molecular mechanisms for HCC metastasis via text mining approach. PMID: 28108733 Ref: Benzyl-isothiocyanate Induces Apoptosis and Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells in vitro. PMID: 28243328 Ref: The clinical significance and biological function of large tumour suppressor 2 in hepatocellular carcinoma. PMID: 28247446 Ref: miR-320a regulates high mobility group box 1 expression and inhibits invasion and metastasis in hepatocellular carcinoma. PMID: 28317284 Ref: 2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells. PMID: 28356961 Ref: MiR-425-5p promotes invasion and metastasis of hepatocellular carcinoma cells through SCAI-mediated dysregulation of multiple signaling pathways. PMID: 28423650 Ref: Alpha1-ACT Functions as a Tumour Suppressor in Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Signalling Pathway via Activation of PTEN. PMID: 28456796 Ref: Inhibition of ERK1/2 Signaling Impairs the Promoting Effects of TGF-beta1 on Hepatocellular Carcinoma Cell Invasion and Epithelial-Mesenchymal Transition. PMID: 28492136 Ref: Thymidine phosphorylase promotes metastasis and serves as a marker of poor prognosis in hepatocellular carcinoma. PMID: 28530649 Ref: Clonorchis sinensis granulin: identification, immunolocalization, and function in promoting the metastasis of cholangiocarcinoma and hepatocellular carcinoma. PMID: 28545547 Ref: Microenvironment of a tumor-organoid system enhances hepatocellular carcinoma malignancy-related hallmarks. PMID: 28548903 Ref: HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function. PMID: 28592528 Ref: Upregulated long non-coding RNA LOC90784 promotes cell proliferation and invasion and is associated with poor clinical features in HCC. PMID: 28651931 Ref: Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1alpha under hypoxia condition. PMID: 28653891 Ref: SRPX2, an independent prognostic marker, promotes cell migration and invasion in hepatocellular carcinoma. PMID: 28654796 Ref: MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET-SOCS1-MMP9 signaling axis. PMID: 28661477 Ref: Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma. PMID: 28840186 Ref: Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway. PMID: 28904859 Ref: OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma. PMID: 28911005 Ref: Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells. PMID: 29022011 Ref: Notch4 inhibition suppresses invasion and vasculogenic mimicry formation of hepatocellular carcinoma cells. PMID: 29058285 Ref: Loss of Barx1 promotes hepatocellular carcinoma metastasis through up-regulating MGAT5 and MMP9 expression and indicates poor prognosis. PMID: 29069753 Ref: HMGA1 participates in MHCC97H cell proliferation and invasion through the ILK/Akt/GSK3beta signaling pathway. PMID: 29152644 Ref: PSC-derived Galectin-1 inducing epithelial-mesenchymal transition of pancreatic ductal adenocarcinoma cells by activating the NF-kappaB pathway. PMID: 29156810 Ref: CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling. PMID: 29213215 Ref: Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression. PMID: 29234432 |
Ref: Tumor LXR Expression is a Prognostic Marker for Patients with Hepatocellular Carcinoma. PMID: 28508927 Ref: Lectin BS-I inhibits cell migration and invasion via AKT/GSK-3beta/beta-catenin pathway in hepatocellular carcinoma. PMID: 28922551 Ref: Anticancer effects of methanol extract of Myrmecodia platytyrea Becc. leaves against human hepatocellular carcinoma cells via inhibition of ERK and STAT3 signaling pathways. PMID: 29075791 Ref: MicroRNA-124a inhibits cell proliferation and migration in liver cancer by regulating interleukin-11. PMID: 29286137 Ref: Downregulated expression of hepatoma-derived growth factor inhibits migration and invasion of prostate cancer cells by suppressing epithelial-mesenchymal transition and MMP2, MMP9. PMID: 29300772 Ref: Downregulation of castor zinc finger 1 predicts poor prognosis and facilitates hepatocellular carcinoma progression via MAPK/ERK signaling. PMID: 29506567 Ref: The siRNA silencing of DcR3 expression induces Fas ligand-mediated apoptosis in HepG2 cells. PMID: 29725377 Ref: Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelialmesenchymal transition. PMID: 29845189 Ref: MiR-5692a promotes the invasion and metastasis of hepatocellular carcinoma via MMP9. PMID: 30070322 Ref: IFITM3 promotes hepatocellular carcinoma invasion and metastasis by regulating MMP9 through p38/MAPK signaling. PMID: 30087833 Ref: NEK2 Promotes Hepatoma Metastasis and Serves as Biomarker for High Recurrence Risk after Hepatic Resection. PMID: 30145571 Ref: CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases. PMID: 30185549 Ref: Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats. PMID: 30224923 Ref: Capsaicin and sorafenib combination treatment exerts synergistic antihepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling. PMID: 30272354 Ref: Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/cMet signaling. PMID: 30320342 |