Primary Site >> Stomach Cancer
Gene >> MLH1
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Ref: Lynch Syndrome PMID: 20301390 |
Ref: The tumor spectrum in HNPCC. PMID: 7979199 |
Ref: Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. PMID: 8766523 Ref: [Analyses of mutator gene mutations in familial gastric cancers]. PMID: 8920667 Ref: Analysis for microsatellite instability and mutations of the DNA mismatch repair gene hMLH1 in familial gastric cancer. PMID: 8938136 Ref: [Microsatellite instability--a new aspects in genetics and molecular biology of hereditary nonpolyposis and sporadic colorectal tumors]. PMID: 9082661 |
Ref: Disease expression in Swiss hereditary non-polyposis colorectal cancer (HNPCC) kindreds. PMID: 9221805 |
Ref: Growth suppression mediated by transfection of wild-type hMLH1 in human cancer cells expressing endogenous truncated hMLH1 protein. PMID: 9472100 Ref: Frequent microsatellite instability and loss of heterozygosity in the region including BRCA1 (17q21) in young patients with gastric cancer. PMID: 9592181 Ref: Absence or decreased levels of the hMLH1 protein in human gastric carcinoma cell lines: implication of hMLH1 in alkylation tolerance. PMID: 9750018 Ref: [HNPCC-associated stomach carcinomas display aggressive growth in orthotopic transplantation to the SCID mouse]. PMID: 14518342 |
Ref: hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. PMID: 9892201 Ref: Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. PMID: 10070967 Ref: Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. PMID: 10348818 Ref: Origin of microsatellite instability in gastric cancer. PMID: 10393852 Ref: Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing. PMID: 10404064 Ref: Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. PMID: 10404093 Ref: Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error. PMID: 10418831 Ref: Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. PMID: 10495421 Ref: Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. PMID: 10554013 Ref: [Correlation between histological and molecular mechanisms of carcinogenesis in stomach cancer]. PMID: 10714197 |
Ref: Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. PMID: 10585582 Ref: A comparison of microsatellite instability in early onset gastric carcinomas from relatively low and high incidence European populations. PMID: 10629076 Ref: Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes. PMID: 10719371 Ref: [One of the etiological factors of digestive tract cancers in Chinese: the missense mutation Val384Asp in the hMLH1 gene]. PMID: 10751526 Ref: Microsatellite instability is associated with genetic alteration but not with low levels of expression of the human mismatch repair proteins hMSH2 and hMLH1. PMID: 10785599 Ref: Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract. PMID: 10807889 Ref: Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instability. PMID: 10861474 Ref: The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea. PMID: 10896919 Ref: [Update on gastroenterology]. PMID: 10903787 Ref: Mutation analysis of the hMTH1 gene in sporadic human ovarian cancer. PMID: 10938385 Ref: Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype. PMID: 10980110 |
Ref: Correlation between microsatellite instability and metachronous disease recurrence after endoscopic mucosal resection in patients with early stage gastric carcinoma. PMID: 11180080 Ref: Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences. PMID: 11213834 Ref: Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes. PMID: 11238060 Ref: Genetic and epigenetic changes in stomach cancer. PMID: 11243597 Ref: Microsatellite instability as a tool for the classification of gastric cancer. PMID: 11286759 Ref: CpG island methylation in premalignant stages of gastric carcinoma. PMID: 11306456 Ref: Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. PMID: 11313962 Ref: Microsatellite instability of papillary subtype of human gastric adenocarcinoma and hMLH1 promoter hypermethylation in the surrounding mucosa. PMID: 11350605 Ref: Multiple primary malignancies: An epidemiological and pedigree analysis of 57 patients with at least three tumours. PMID: 11373110 Ref: Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues. PMID: 11413518 Ref: Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability. PMID: 11422806 Ref: Second primary cancers after sporadic and familial colorectal cancer. PMID: 11440965 Ref: A genome-wide study of microsatellite instability in advanced gastric carcinoma. PMID: 11443614 Ref: Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype. PMID: 11470537 Ref: DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas. PMID: 11496321 Ref: [Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography]. PMID: 11798868 Ref: Promoter methylation status of the DNA repair genes hMLH1 and MGMT in gastric carcinoma and metaplastic mucosa. PMID: 11872960 Ref: [Esophageal, gastric and colorectal tumors]. PMID: 11894400 Ref: hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer. PMID: 12132870 Ref: Mutations of the 'minor' mismatch repair gene MSH6 in typical and atypical hereditary nonpolyposis colorectal cancer. PMID: 14574004 |
Ref: Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography. PMID: 11809901 Ref: Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. PMID: 11896626 Ref: Comprehensive analysis of promoter methylation and altered expression of hMLH1 in gastric cancer cell lines with microsatellite instability. PMID: 11935297 Ref: Distinct clinical features and outcomes of gastric cancers with microsatellite instability. PMID: 12065777 Ref: hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer. PMID: 12095971 Ref: A novel germline mutation of hMLH1 in a patient with hereditary non-polyposis colorectal cancer. PMID: 12110639 Ref: [Genealogical research of hereditary nonpolyposis colorectal cancer]. PMID: 12139794 Ref: Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells. PMID: 12145807 Ref: Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. PMID: 12163364 Ref: Analysis for phenotype of HNPCC in China. PMID: 12378626 Ref: Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. PMID: 12448005 Ref: Very low incidence of microsatellite instability in intraductal papillary-mucinous neoplasm of the pancreas. PMID: 12448010 Ref: Molecular and cellular phenotypic profiles of gastric noninvasive neoplasia. PMID: 12480914 Ref: Profile of methylated CpG sites of hMLH1 promoter in primary gastric carcinoma with microsatellite instability. PMID: 12588445 |
Ref: Silencing-specific methylation and single nucleotide polymorphism of hMLH1 promoter in gastric carcinomas. PMID: 12508345 Ref: Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability. PMID: 12679904 Ref: Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability. PMID: 12692837 Ref: Profile of aberrant CpG island methylation along multistep gastric carcinogenesis. PMID: 12695555 Ref: Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis. PMID: 12746473 Ref: Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. PMID: 12763209 Ref: Lymphocyte-rich gastric cancer: associations with Epstein-Barr virus, microsatellite instability, histology, and survival. PMID: 12861059 Ref: Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer. PMID: 12861399 Ref: Microsatellite instability in gastric cancer is closely associated with hMLH1 hypermethylation at the proximal region of the promoter. PMID: 12964042 Ref: Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. PMID: 14507661 Ref: Genetic alterations and polymorphisms in gastric cancer. PMID: 14517582 Ref: High throughput detection of microsatellite instability by denaturing high-performance liquid chromatography. PMID: 14517950 Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 Ref: Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. PMID: 14534543 Ref: DNA methylation of multiple genes in gastric carcinoma: association with histological type and CpG island methylator phenotype. PMID: 14556664 Ref: Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. PMID: 14695142 Ref: [Microsatellite instability and loss of heterozygosity in neoplastic and preneoplastic gastric lesions]. PMID: 14743682 |
Ref: Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia. PMID: 14702190 Ref: Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. PMID: 14742272 Ref: Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation. PMID: 14762794 Ref: Standardized approach for microsatellite instability detection in gastric carcinomas. PMID: 15017590 Ref: Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas. PMID: 15064707 Ref: Correlation of hMLH1 and HPP1 hypermethylation in gastric, but not in esophageal and cardiac adenocarcinoma. PMID: 15069683 Ref: Geno- and pheno-typic characterization in ten patients with double-primary gastric and colorectal adenocarcinomas. PMID: 15083323 Ref: Mutations in the hMLH1 gene in Slovenian patients with gastric carcinoma. PMID: 15099349 Ref: Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines. PMID: 15133479 Ref: [Expression of hMSH2 and hMLH1 in stomach cancer and their correlation with Helicobacter pylori infection]. PMID: 15142449 Ref: Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers--a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas. PMID: 15154009 Ref: Clinical and genetic features of International Collaborative Group-hereditary nonpolyposis colorectal cancer families and suspected hereditary nonpolyposis colorectal cancer families. PMID: 15161546 Ref: [Clinical features and hMSH2/hMLH1 germline mutation screening of Chinese hereditary nonpolyposis colorectal cancer patients]. PMID: 15200905 Ref: E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. PMID: 15288293 Ref: DNA hypermethylation in gastric cancer. PMID: 15298619 Ref: Clinical features and mismatch repair gene mutation screening in Chinese patients with hereditary nonpolyposis colorectal carcinoma. PMID: 15309712 Ref: Characterization of mutator phenotype in familial colorectal cancer patients not fulfilling amsterdam criteria. PMID: 15448003 Ref: [Clinical features and mutation analysis of a poly-(A)8 tract in M3 cholinergic receptor gene in Chinese HNPCC families]. PMID: 15476321 Ref: Synergistic interaction between gefitinib (Iressa, ZD1839) and paclitaxel against human gastric carcinoma cells. PMID: 15494644 Ref: BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas. PMID: 15616773 Ref: [Study on the relationship between genetic polymorphism Val384Asp in hMLH1 gene and the risk of four different carcinomas]. PMID: 15769334 |
Ref: Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. PMID: 15498792 Ref: Frequent microsatellite instability in primary esophageal carcinoma associated with extraesophageal primary carcinoma. PMID: 15540218 Ref: The profile of hMLH1 methylation and microsatellite instability in colorectal and non-small cell lung cancer. PMID: 15583832 Ref: Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma. PMID: 15701853 Ref: Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias. PMID: 15735977 Ref: Microsatellite instability and DNA mismatch repair deficiency testing in hereditary and sporadic gastrointestinal cancers. PMID: 15749237 Ref: [Methylation of hMLH1 gene promoter in gastric carcinoma with microsatellite instability]. PMID: 15757526 Ref: Clinical phenotype and prevalence of hereditary nonpolyposis colorectal cancer syndrome in Chinese population. PMID: 15770724 Ref: DNA hypermethylation of tumor-related genes in gastric carcinoma. PMID: 15831994 Ref: [Mutation detection of mismatch repair genes in hereditary nonpolyposis colorectal cancer by denaturing high-performance liquid chromatography]. PMID: 15842942 Ref: Effect of Helicobacter pylori infection on the expression of DNA mismatch repair protein. PMID: 15904475 Ref: HMLH1 gene mutation in gastric cancer patients and their kindred. PMID: 15918206 Ref: Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer. PMID: 15942635 Ref: Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. PMID: 15991278 Ref: Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer. PMID: 16007118 Ref: Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy. PMID: 16049280 Ref: Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas. PMID: 16053512 Ref: Aberrant CpG island methylation in early-onset sporadic gastric carcinoma. PMID: 16075282 Ref: Microsatellite instability is linked to loss of hMLH1 expression in advanced gastric cancers: lack of a relationship with the histological type and phenotype. PMID: 16086119 Ref: High frequency of microsatellite instability in intestinal-type gastric cancer in Korean patients. PMID: 16134765 Ref: [Promoter methylation profile in gastric cancer]. PMID: 16163424 Ref: Composite glandular-endocrine cell carcinomas of the stomach: clinicopathologic and methylation study. PMID: 16218931 Ref: Relationship between the extent of chromosomal losses and the pattern of CpG methylation in gastric carcinomas. PMID: 16224153 Ref: Tumor microsatellite instability in early onset gastric cancer. PMID: 16237216 Ref: Expression of tumor suppressor and tumor-related proteins in differentiated carcinoma, undifferentiated carcinoma with tubular component and pure undifferentiated carcinoma of the stomach. PMID: 16254038 Ref: [Prophylactic gastric surgery]. PMID: 16292563 Ref: [Expression of cyclooxygenase-2, hMLH1 and hMSH2 proteins, and their relationship with microsatellite instability in gastric carcinoma]. PMID: 16438886 Ref: Case report: familial gastric cancer and chordoma in the same family. PMID: 20223035 Ref: Hereditary colorectal cancer in china. PMID: 20223042 |
Ref: Accumulation of DNA methylation is associated with tumor stage in gastric cancer. PMID: 16475210 Ref: Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. PMID: 16482617 Ref: Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers. PMID: 16546499 Ref: RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas. PMID: 16557577 Ref: Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel. PMID: 16619216 Ref: Carcinogenesis in the remnant stomach following distal gastrectomy with billroth II reconstruction is associated with high-level microsatellite instability. PMID: 16619551 Ref: CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus. PMID: 16707594 Ref: Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum. PMID: 16786121 Ref: DNA methylation as a marker for the past and future. PMID: 16799880 Ref: CDH1/E-cadherin germline mutations in early-onset gastric cancer. PMID: 16801346 Ref: Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma. PMID: 16805821 Ref: Clinical and genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer families. PMID: 16810763 Ref: Demonstration and characterization of mutations induced by Helicobacter pylori organisms in gastric epithelial cells. PMID: 16882331 Ref: Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium. PMID: 16908935 Ref: Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China. PMID: 16929514 Ref: Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal cancer in a Chinese population. PMID: 17011982 Ref: Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer. PMID: 17054581 Ref: Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan. PMID: 17106811 |
Ref: Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study. PMID: 17267619 Ref: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. PMID: 17376510 Ref: Aberrant methylation within RUNX3 CpG island associated with the nuclear and mitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. PMID: 17591800 Ref: Expression of Fhit, Mlh1, p16INK4A and E-cadherin in early gastric neoplasia: Correlation with histological grade and gastric phenotype. PMID: 17671701 Ref: [Frequent promoter hypermethylation of several tumor suppressor genes in gastric carcinoma and foveolar epithelium]. PMID: 18069630 Ref: Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines. PMID: 18069755 Ref: MSI is frequently recognized among gastric cancer patients with a family history of cancer. PMID: 18265677 Ref: Genetic and epigenetic markers to identify high risk patients for multiple early gastric cancers after treatment with endoscopic mucosal resection. PMID: 18398497 |
Ref: A novel MSH2 germline mutation in a Druze HNPCC family. PMID: 17661183 Ref: Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. PMID: 18202787 Ref: Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype. PMID: 18206535 Ref: [Gastric cancer: histological type, histogenesis, and gene abnormalities]. PMID: 18281780 Ref: Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival. PMID: 18440592 Ref: Knock-down of methylenetetrahydrofolate reductase reduces gastric cancer cell survival: an in vitro study. PMID: 18486501 Ref: [Comparison of clinical and genetic phenotypes between Chinese and Korean hereditary nonpolyposis colorectal cancer families]. PMID: 18543228 Ref: Promoter methylation of cancer-related genes in gastric carcinoma. PMID: 18566573 Ref: Increased frequency of CpG island methylator phenotype and CDH1 methylation in a gastric cancer high-risk region of china. PMID: 18607505 Ref: DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. PMID: 18641418 Ref: [Gene methylation patterns in digestive tumors]. PMID: 18769787 Ref: Reprimo as a potential biomarker for early detection in gastric cancer. PMID: 18829507 Ref: Circulating DNA in the blood of gastric cancer patients. PMID: 18837952 Ref: Helicobacter pylori infection and expression of DNA mismatch repair proteins. PMID: 19034977 Ref: Muir-Torre syndrome: a rare but important disorder. PMID: 19055168 Ref: [Histone H3 lysine 9 methylation is associated with the expression of hMLH1 and DNA methylation in gastric cancer cells]. PMID: 19080631 Ref: DNA mismatch repair gene methylation in gastric cancer in individuals from northern Brazil. PMID: 19181186 |
Ref: Recurring MLH1 deleterious mutations in unrelated Chinese Lynch syndrome families in Singapore. PMID: 18726168 Ref: Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. PMID: 19081245 Ref: Influence of Helicobacter pylori infection on the expression of MLH1 and MGMT in patients with chronic gastritis and gastric cancer. PMID: 19089477 Ref: Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype. PMID: 19117018 Ref: Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associated with EBV infection. PMID: 19118057 Ref: Evidence of tumor microsatellite instability in gastric cancer with familial aggregation. PMID: 19152022 Ref: Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. PMID: 19336228 Ref: A new mutation in Muir-Torre syndrome associated with familiar transmission of different gastrointestinal adenocarcinomas. PMID: 19423266 Ref: Analysis of microsatellite instability, protein expression and methylation status of hMLH1 and hMSH2 genes in gastric carcinomas. PMID: 19621725 Ref: Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients. PMID: 19671196 Ref: [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells]. PMID: 19742343 Ref: [Hereditary non-polyposis colorectal cancer associated with hereditary gastric cancer. A case report.]. PMID: 19858019 |
Ref: Aberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patients. PMID: 19894224 Ref: Risk and epidemiological time trends of gastric cancer in Lynch syndrome carriers in the Netherlands. PMID: 19900449 Ref: Aberrant gene methylation in the lymph nodes provides a possible marker for diagnosing micrometastasis in gastric cancer. PMID: 19957042 Ref: Biallelic MYH germline mutations as cause of Muir-Torre syndrome. PMID: 19998059 Ref: Helicobacter pylori and EBV in gastric carcinomas: methylation status and microsatellite instability. PMID: 20082476 Ref: BCL2L10 is frequently silenced by promoter hypermethylation in gastric cancer. PMID: 20428828 Ref: Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly. PMID: 20590835 Ref: Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients. PMID: 20803768 Ref: Microsatellite instability with promoter methylation and silencing of hMLH1 can regionally occur during progression of gastric carcinoma. PMID: 20831982 Ref: EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1. PMID: 20978327 |
Ref: A new familial gastric cancer-related gene polymorphism: T1151A in the mismatch repair gene hMLH1. PMID: 20177793 Ref: MSI phenotype and MMR alterations in familial and sporadic gastric cancer. PMID: 20533283 Ref: Non-truncating hMLH1 variants identified in Slovenian gastric cancer patients are not associated with Lynch Syndrome: a functional analysis report. PMID: 21136174 Ref: [HNPCC (hereditary non-polyposis colorectal cancer) or Lynch syndrome: a syndrome related to a failure of DNA repair system]. PMID: 21459714 Ref: EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1. PMID: 21538028 Ref: Gastric cancer and concomitant renal cancer: a systematic immunohistochemical and molecular analysis. PMID: 21687951 Ref: Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). PMID: 21831520 Ref: Spreading of Alu methylation to the promoter of the MLH1 gene in gastrointestinal cancer. PMID: 22022465 Ref: [Metachronous urothelial cancer in bilateral upper urinary tracts and bladder associated with hereditary nonpolyposis colorectal cancer]. PMID: 22089154 Ref: The MLH1 2101C>A (Q701K) variant increases the risk of gastric cancer in Chinese males. PMID: 22136435 Ref: Clinicopathological and patient characteristics of early gastric neoplasia endoscopically resected with loss of Mlh1 expression. PMID: 22866067 |
Ref: Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry. PMID: 22144422 Ref: Prognostic significance of aberrant gene methylation in gastric cancer. PMID: 22206050 Ref: The founder Ashkenazi Jewish mutations in the MSH2 and MSH6 genes in Israeli patients with gastric and pancreatic cancer. PMID: 22219001 Ref: Germline promoter hypermethylation of tumor suppressor genes in gastric cancer. PMID: 22228973 Ref: Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study. PMID: 22331944 Ref: Association between p16, hMLH1 and E-cadherin promoter hypermethylation and intake of local hot salted tea and sun-dried foods in Kashmiris with gastric tumors. PMID: 22502664 Ref: Expression of AID, P53, and Mlh1 proteins in endoscopically resected differentiated-type early gastric cancer. PMID: 22737274 Ref: Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population. PMID: 22740958 Ref: ARID1A expression loss in gastric cancer: pathway-dependent roles with and without Epstein-Barr virus infection and microsatellite instability. PMID: 22915242 Ref: Promoter methylation of tumor-related genes in gastric carcinogenesis. PMID: 22936446 Ref: Promoter methylation status of DNA repair gene (hMLH1) in gastric carcinoma patients of the Kashmir valley. PMID: 23098428 Ref: Demethylation of the region around exon 2 of MLH1 gene in gastrointestinal cancer. PMID: 23155252 Ref: [Genetic and epigenetic alterations in gastric carcinogenesis]. PMID: 23198549 |
Ref: Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells. PMID: 22968820 Ref: Outcome and status of microsatellite stability in Japanese atomic bomb survivors with early gastric carcinoma. PMID: 23149851 Ref: Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. PMID: 23196062 Ref: Differential clinicopathologic features in microsatellite-unstable gastric cancers with and without MLH1 methylation. PMID: 23266441 Ref: Diet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer. PMID: 23534741 Ref: Molecular and survival differences between familial and sporadic gastric cancers. PMID: 23555086 Ref: The significance of mismatch repair genes in gastric cancer. PMID: 23575079 Ref: The hMLH1 promoter polymorphisms and cancer susceptibility in Asian populations: a meta-analysis. PMID: 23587910 Ref: MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults. PMID: 23716983 Ref: Synchronous rectal and gastric cancer in a fighter pilot: aeromedical concerns. PMID: 24426647 Ref: Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer. PMID: 24550949 Ref: [The systems of molecular genetic markers under cancer of stomach]. PMID: 24640104 Ref: BRAF mutation in multiple primary cancer with colorectal cancer and stomach cancer. PMID: 24759670 Ref: Gastric cancers with microsatellite instability sharing clinical features, chemoresistance and germline MSH6 variants. PMID: 26181448 |
Ref: ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas. PMID: 23887303 Ref: Role of hMLH1 and E-cadherin promoter methylation in gastric cancer progression. PMID: 24022108 Ref: SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review. PMID: 24503755 Ref: Pyloric gland adenoma in Lynch syndrome. PMID: 24518125 Ref: Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer. PMID: 24737431 Ref: p16 Methylation is associated with chemosensitivity to fluorouracil in patients with advanced gastric cancer. PMID: 24816738 Ref: Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer. PMID: 24938706 Ref: [Promoter region methylation of DNA damage repair genes in human gastric cancer]. PMID: 25331470 Ref: Role of endometrial cancer abnormal MMR protein in screening Lynch-syndrome families. PMID: 25400828 Ref: Epigenetic alterations in a gastric leiomyoma. PMID: 25544907 Ref: [A case of gastric cancer developed after pylorus-preserving gastrectomy in a patient with lynch syndrome]. PMID: 25731490 |
Ref: Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. PMID: 24510342 Ref: Predictive value of CHFR and MLH1 methylation in human gastric cancer. PMID: 24748501 Ref: Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors. PMID: 25213383 Ref: [Colorectal Carcinoma with Suspected Lynch Syndrome: A Multidisciplinary Algorithm]. PMID: 25372301 Ref: Genomic assays for Epstein-Barr virus-positive gastric adenocarcinoma. PMID: 25613731 Ref: [Effect of methylation of hMLH1 gene promotor on stage tumorigenesis and progression of human gastric cancer]. PMID: 25656127 Ref: Microsatellite instability: an update. PMID: 25701956 Ref: ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression. PMID: 25980581 Ref: Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype. PMID: 26033320 Ref: Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer. PMID: 26121593 Ref: Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer. PMID: 26343070 Ref: Loss of ACSS2 expression predicts poor prognosis in patients with gastric cancer. PMID: 26381042 Ref: Loss of ARID1A Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and Clinicopathologic Features. PMID: 26468418 Ref: AID, p53 and MLH1 expression in early gastric neoplasms and the correlation with the background mucosa. PMID: 26622562 Ref: [A Family Affected by Lynch Syndrome Caused by MSH6 Germline Mutation]. PMID: 26805314 Ref: Implication of Reprimo and hMLH1 gene methylation in early diagnosis of gastric carcinoma. PMID: 26823831 |
Ref: Epstein-Barr virus positivity, not mismatch repair-deficiency, is a favorable risk factor for lymph node metastasis in submucosa-invasive early gastric cancer. PMID: 26573601 Ref: Effects of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: analysis of molecular alterations by a randomised controlled trial. PMID: 26671747 Ref: Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. PMID: 26681312 Ref: Polymorphisms in mismatch repair genes are associated with risk and microsatellite instability of gastric cancer, and interact with life exposures. PMID: 26724419 Ref: Gene methylation profile of gastric cancerous tissue according to tumor site in the stomach. PMID: 26810771 Ref: Various ARID1A expression patterns and their clinical significance in gastric cancers. PMID: 26826411 Ref: Braf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer. PMID: 27116958 Ref: Biomarkers of EBV-positive Gastric Cancers: Loss of PTEN Expression is Associated with Poor Prognosis and Nodal Metastasis. PMID: 27221363 Ref: Comprehensive mutation profiling of mucinous gastric carcinoma. PMID: 27313181 Ref: Comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy. PMID: 27331626 Ref: Expression of Mismatch Repair Proteins in Early and Advanced Gastric Cancer in Poland. PMID: 27527654 Ref: Epigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment. PMID: 27566570 Ref: [Incidence and Characteristics of Mismatch Repair Protein Deficiency in Elderly Gastric Cancer Patients]. PMID: 27760966 Ref: Receptor tyrosine kinase amplified gastric cancer: Clinicopathologic characteristics and proposed screening algorithm. PMID: 27765925 Ref: [Molecular Pathogenesis of Colorectal Cancer]. PMID: 27951718 |
Ref: Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization. PMID: 26371427 Ref: Distinct expression profile of key molecules in crawling-type early gastric carcinoma. PMID: 27734272 Ref: High-throughput Protein and mRNA Expression-based Classification of Gastric Cancers Can Identify Clinically Distinct Subtypes, Concordant With Recent Molecular Classifications. PMID: 27819872 Ref: New EPCAM founder deletion in Polish population. PMID: 28369810 Ref: Effect of histone modifications on hMLH1 alternative splicing in gastric cancer. PMID: 28381181 Ref: Evaluation of the Three Customized MSI Panels to Improve the Detection of Microsatellite Instability in Gastric Cancer. PMID: 28397474 Ref: Complementary utility of targeted next-generation sequencing and immunohistochemistry panels as a screening platform to select targeted therapy for advanced gastric cancer. PMID: 28418920 Ref: Chromosomal Instability in Gastric Cancer Biology. PMID: 28431273 Ref: Prognostic value of MLH1 promoter methylation in male patients with esophageal squamous cell carcinoma. PMID: 28454461 Ref: Lymphoepithelioma-like gastric carcinoma: clinicopathological characteristics and infection status. PMID: 28457323 Ref: Comparison between mononucleotide and dinucleotide marker panels in gastric cancer with loss of hMLH1 or hMSH2 expression. PMID: 28525661 Ref: Gastric Medullary Carcinoma with Sporadic Mismatch Repair Deficiency and a TP53 R273C Mutation: An Unusual Case with Wild-Type BRAF. PMID: 28840050 Ref: ALK-positive gastric inflammatory myofibroblastic tumor in an adult with familial adenomatous polyposis and diffuse fundic polyposis. PMID: 28923119 Ref: Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice. PMID: 29081696 Ref: Promoter methylation of tumor-related genes as a potential biomarker using blood samples for gastric cancer detection. PMID: 29100425 Ref: Crosstalk between mismatch repair and base excision repair in human gastric cancer. PMID: 29156686 Ref: [Current status of hereditary gastrointestinal neoplasms]. PMID: 29178089 Ref: Prevalence and characteristics of hereditary non-polyposis colorectal cancer (HNPCC) syndrome in immigrant Asian colorectal cancer patients. PMID: 29237405 |
Ref: Epigenetic Silencing of the MLH1 Promoter in Relation to the Development of Gastric Cancer and its use as a Biomarker for Patients with Microsatellite Instability: a Systematic Analysis. PMID: 29334683 Ref: Influence of hypoxia-related genetic polymorphisms on the prognosis of patients with metastatic gastric cancer treated with EOF. PMID: 29399184 Ref: Morphologic and Immunohistochemical Appraisal of Primary Gastric Carcinomas. PMID: 29438113 Ref: Pathway- and clinical-factor-based risk model predicts the prognosis of patients with gastric cancer. PMID: 29532879 Ref: Tumor development in Japanese patients with Lynch syndrome. PMID: 29672549 Ref: Association Between hMLH1 Promoter Methylation and Risk of Gastric Cancer: A Meta-Analysis. PMID: 29719511 Ref: Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature review. PMID: 29783979 Ref: MLH1 Promoter Methylation and Prediction/Prognosis of Gastric Cancer: A Systematic Review and Meta and Bioinformatic Analysis. PMID: 29896277 Ref: Lifestyle chemical carcinogens associated with mutations in cell cycle regulatory genes increases the susceptibility to gastric cancer risk. PMID: 30209766 Ref: A retrospective study of extracolonic, non-endometrial cancer in Swedish Lynch syndrome families. PMID: 30386444 Ref: Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation. PMID: 30387329 |