Primary Site >> Pancreatic Cancer
Gene >> MEN1
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Ref: Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients. PMID: 8912868 |
Ref: Tracking the MEN1 gene. PMID: 9324134 Ref: Multiple endocrine neoplasia type 1 presented with manic-depressive disorder: a case report with an identified MEN1 gene mutation. PMID: 9438006 |
Ref: Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors. PMID: 9721882 |
Ref: Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects. PMID: 10090472 Ref: The gene for multiple endocrine neoplasia type 1: recent findings. PMID: 10423035 |
Ref: Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors. PMID: 10882148 Ref: Large and asymptomatic pancreatic islet cell tumor in a patient with multiple endocrine neoplasia type 1. PMID: 11216636 |
Ref: Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors. PMID: 11238532 Ref: Prospective study of the natural history of gastrinoma in patients with MEN1: definition of an aggressive and a nonaggressive form. PMID: 11701693 |
Ref: Frequent deletion of chromosome 3 in malignant sporadic pancreatic endocrine tumors. PMID: 11997184 |
Ref: Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective study. PMID: 12724631 Ref: Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. PMID: 12941803 |
Ref: Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. PMID: 15060136 Ref: Clinical genetic testing and early surgical intervention in patients with multiple endocrine neoplasia type 1 (MEN 1). PMID: 15082967 Ref: Zollinger-Ellison syndrome revisited: diagnosis, biologic markers, associated inherited disorders, and acid hypersecretion. PMID: 15527675 |
Ref: Prospective endoscopic ultrasonographic evaluation of the frequency of nonfunctioning pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1. PMID: 16454829 Ref: Small neuroendocrine pancreatic tumors in multiple endocrine neoplasia type 1 (MEN1): least significant change of tumor diameter as determined by endoscopic ultrasound (EUS) imaging. PMID: 16915538 Ref: Multiple endocrine neoplasia type 1. PMID: 17014705 Ref: New splicing mutation of MEN1 gene affecting the translocation of menin to the nucleus. PMID: 17185897 |
Ref: Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas. PMID: 17179192 Ref: [Operative management and long-term survival in patients with neuroendocrine tumors of the pancreas--experience with 144 patients]. PMID: 17252361 Ref: Long-term follow-up of patients with multiple endocrine neoplasia type 1. PMID: 17379960 Ref: [Endocrine tumors of the pancreas (EPTs) in multiple endocrine neoplasia (MEN1): up-date on prognostic factors, diagnostic procedures and treatment]. PMID: 17961653 Ref: Molecular genetic events in gastrointestinal and pancreatic neuroendocrine tumors. PMID: 18041590 |
Ref: Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients. PMID: 18300794 Ref: Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor. PMID: 18520436 Ref: Gonadotroph adenoma in multiple endocrine neoplasia type 1. PMID: 18753103 Ref: Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies. PMID: 18798544 |
Ref: Global expression profiling of sex cord stromal tumors from Men1 heterozygous mice identifies altered TGF-beta signaling, decreased Gata6 and increased Csf1r expression. PMID: 19058182 Ref: Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma. PMID: 19170121 |
Ref: Multiple endocrine neoplasia type 1-associated cystic pancreatic endocrine neoplasia and multifocal cholesterol granulomas. PMID: 20403035 |
Ref: Glucagon expression in cystic pancreatic neuroendocrine neoplasms: an immunohistochemical analysis. PMID: 20922407 Ref: A new mutation in the menin gene causes the multiple endocrine neoplasia type 1 syndrome with adrenocortical carcinoma. PMID: 21069576 Ref: Attenuated expression of menin and p27 (Kip1) in an aggressive case of multiple endocrine neoplasia type 1 (MEN1) associated with an atypical prolactinoma and a malignant pancreatic endocrine tumor. PMID: 21441703 Ref: Surgical management of neuroendocrine tumors of the gastrointestinal tract. PMID: 21936439 |
Ref: Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. PMID: 22575867 Ref: Multiple endocrine neoplasia: the Chilean experience. PMID: 22584699 Ref: Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. PMID: 23102680 |
Ref: A new double substitution mutation in the MEN1 gene: a limited penetrance and a specific phenotype. PMID: 23188049 Ref: Multiple microvascular alterations in pancreatic islets and neuroendocrine tumors of a Men1 mouse model. PMID: 23583653 Ref: PRSS1_p.Leu81Met mutation results in autoimmune pancreatitis. PMID: 23745036 Ref: Current understanding of the molecular biology of pancreatic neuroendocrine tumors. PMID: 23840053 Ref: [Various neuroendocrine tumors in a family with multiple endocrine neoplasia type 1]. PMID: 24334135 |
Ref: Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. PMID: 24293293 Ref: Thoracic and duodenopancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: natural history and function of menin in tumorigenesis. PMID: 24389729 Ref: GSK-3beta protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation. PMID: 24425879 Ref: PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors. PMID: 24912192 Ref: A Novel Deletion Mutation in the MEN1 Gene in a Patient with Prolactinoma and a Family History of Pancreatic Tumors. PMID: 24936550 Ref: Genetic Analysis of Multiple Endocrine Neoplasia Type 1 (MEN1) Leads to Misdiagnosis of an Extremely Rare Presentation of Intrasellar Cavernous Hemangioma as MEN1. PMID: 25031887 Ref: Multiple gene mutations in patients with type 2 autoimmune pancreatitis and its clinical features. PMID: 26155104 |
Ref: Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines. PMID: 26087898 Ref: Pancreatic Neuroendocrine Tumors: an Update. PMID: 26722203 |
Ref: Interplay between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of the Hedgehog signaling pathway. PMID: 26454216 Ref: Progranulin Stimulates Proliferation of Mouse Pancreatic Islet Cells and Is Overexpressed in the Endocrine Pancreatic Tissue of an MEN1 Mouse Model. PMID: 26495792 Ref: Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report. PMID: 26678657 |
Ref: Pancreatic Neuroendocrine Neoplasms: Basic Biology, Current Treatment Strategies and Prospects for the Future. PMID: 28098761 Ref: Germline and somatic genetic changes in multicentric tumors obtained from a patient with multiple endocrine neoplasia type 1. PMID: 28503312 Ref: Pancreatic gangliocytic paraganglioma harboring lymph node metastasis: a case report and literature review. PMID: 28764742 Ref: [Multiple endocrine neoplasia]. PMID: 28902384 Ref: Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors. PMID: 29259370 |
Ref: Pancreatic neuroendocrine tumors in MEN1 disease: a mono-centric longitudinal and prognostic study. PMID: 28567607 Ref: Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing. PMID: 29092957 Ref: Genomic landscape of pancreatic neuroendocrine tumours: the International Cancer Genome Consortium. PMID: 29321190 Ref: Long-term follow-up and novel splice donor mutation in MEN1 in a Chinese family. PMID: 29416715 Ref: Site-Specific Genomic Alterations in a Well-Differentiated Pancreatic Neuroendocrine Tumor With High-Grade Progression. PMID: 29521944 Ref: Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3. PMID: 29596894 Ref: A Case of Gastric Neuroendocrine Neoplasm with Mixed Grade: a Distinct Type of "High"-grade Well-Differentiated Neuroendocrine Neoplasm. PMID: 29675587 Ref: Recent Topics Around Multiple Endocrine Neoplasia Type 1. PMID: 29897580 Ref: Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms. PMID: 30021865 Ref: Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer. PMID: 30062048 Ref: A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-Resistant Tumors. PMID: 30254185 |