Primary Site >> Colorectal Cancer
Gene >> MECOM
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Ref: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. PMID: 16462766 Ref: [EVI1 and its role in myelodysplastic syndrome, myeloid leukemia and other malignant diseases]. PMID: 16995417 Ref: Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide. PMID: 17145882 |
Ref: The Evi1, microRNA-143, K-Ras axis in colon cancer. PMID: 21276449 Ref: Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis. PMID: 21980434 |
Ref: Overexpression of Evi-1 oncoprotein represses TGF-beta signaling in colorectal cancer. PMID: 22161860 Ref: EVI1 targets DeltaNp63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon cancer cells. PMID: 23665236 |
Ref: Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PMID: 24586749 |
Ref: Intratumoral Heterogeneity of Frameshift Mutations in MECOM Gene is Frequent in Colorectal Cancers with High Microsatellite Instability. PMID: 27620344 Ref: Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer. PMID: 28749961 |
Ref: Ecotropic viral integration site 1 promotes metastasis independent of epithelial mesenchymal transition in colon cancer cells. PMID: 29339729 |