Primary Site >> Biliary tract Cancer

Gene >> MDM2

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Ref: TP53 mutations and mdm2 protein overexpression in cholangiocarcinomas.
PMID: 10718212
Ref: Overexpression of MDM2 protein in intrahepatic cholangiocarcinoma: relationship with p53 overexpression, Ki-67 labeling, and clinicopathological features.
PMID: 10963376
 Ref: Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma.
PMID: 11580146
 Ref: Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis.
PMID: 15619210
 Ref: Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome.
PMID: 16505435
 Ref: Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma.
PMID: 18677542
 Ref: [Prognosis factors of cholangiocarcinoma: contribution of recent molecular biology tools].
PMID: 19357015
 Ref: Potential genotype-specific single nucleotide polymorphism interaction of common variation in p53 and its negative regulator mdm2 in cholangiocarcinoma susceptibility.
PMID: 22807971
 Ref: Regional differences in gallbladder cancer pathogenesis: insights from a comparison of cell cycle-regulatory, PI3K, and pro-angiogenic protein expression.
PMID: 23212762
Ref: Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
PMID: 24349281
 Ref: MDM2 SNP309 is an ethnicity-dependent risk factor for digestive tract cancers.
PMID: 24338709
 Ref: Cholangiocarcinoma: Correlation between Molecular Profiling and Imaging Phenotypes.
PMID: 26207380
Ref: 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway.
PMID: 26309394
 Ref: Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets.
PMID: 26500333
Ref: Differentiation and prognostic markers in ampullary cancer: Role of p53, MDM2, CDX2, mucins and cytokeratins.
PMID: 27688085
 Ref: MDM2 Amplification in Intrahepatic Cholangiocarcinomas: Its Relationship With Large-Duct Type Morphology and Uncommon KRAS Mutations.
PMID: 29309301
Ref: Histological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinoma.
PMID: 30170977