Primary Site >> Colorectal Cancer

Gene >> MBD2

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Ref: Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
PMID: 10544038
Ref: Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets.
PMID: 12124339
Ref: Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus.
PMID: 12584607
Ref: The expression of de novo DNA methylase DNMT3b, of the methyl-CpG binding protein MBD2b and of 5-MCDG glycosylase shows two waves of induction during CaCO-2 cell differentiation.
PMID: 15823509
Ref: Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription.
PMID: 16735507
Ref: MBD2 is required for correct spatial gene expression in the gut.
PMID: 17353267
Ref: Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells.
PMID: 17464181
Ref: Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence.
PMID: 17538945
Ref: MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells.
PMID: 18931530
Ref: PcG proteins, DNA methylation, and gene repression by chromatin looping.
PMID: 19053175
Ref: Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.
PMID: 19329758
Ref: Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice.
PMID: 23770133
Ref: Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis.
PMID: 24067901
Ref: Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue.
PMID: 24129635
Ref: Epigenetic synergy between decitabine and platinum derivatives.
PMID: 26366234
Ref: Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis.
PMID: 27073989
Ref: Epigenetic silencing of serine protease HTRA1 drives polyploidy.
PMID: 27388476