Primary Site >> Colorectal Cancer
Gene >> MAPK3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells. PMID: 8175753 |
Ref: Estradiol activation of human colon carcinoma-derived Caco-2 cell growth. PMID: 8813150 |
Ref: Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade. PMID: 9191056 |
Ref: Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase. PMID: 9430710 Ref: Signal transduction mechanisms in neurotensin-mediated cellular regulation. PMID: 9706144 Ref: Increased constitutive activity of mitogen-activated protein kinase and renaturable 85 kDa kinase in human-colorectal cancer. PMID: 9823970 |
Ref: Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation. PMID: 10214865 Ref: Expression and activity of mitogen activated protein kinases in human colorectal carcinoma. PMID: 10323886 Ref: Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics. PMID: 10334194 Ref: Requirement of the MAP kinase cascade for cell cycle progression and differentiation of human intestinal cells. PMID: 10484389 Ref: Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells. PMID: 10519388 Ref: Differential regulation of MAP kinase cascade in human colorectal tumorigenesis. PMID: 10584870 |
Ref: Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. PMID: 10993892 |
Ref: Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites. PMID: 11245463 Ref: EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. PMID: 11259102 Ref: Endothelial cell apoptosis is inhibited by a soluble factor secreted by human colon cancer cells. PMID: 11279602 Ref: Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. PMID: 11322385 Ref: Butyrate and propionate downregulate ERK phosphorylation in HT-29 colon carcinoma cells prior to differentiation. PMID: 11535873 Ref: Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway. PMID: 11806247 Ref: Beta-carotene inhibits growth of human colon carcinoma cells in vitro by induction of apoptosis. PMID: 11843179 Ref: Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides. PMID: 12094622 Ref: Inhibition of Kirsten-ras expression in human colorectal cancer using rationally selected Kirsten-ras antisense oligonucleotides. PMID: 12467236 |
Ref: Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. PMID: 11891209 Ref: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. PMID: 11910351 Ref: Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. PMID: 11986622 Ref: The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. PMID: 11992399 Ref: Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer. PMID: 12174901 Ref: Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. PMID: 12220644 Ref: Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases. PMID: 12221251 Ref: Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin. PMID: 12232764 |
Ref: Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. PMID: 12566304 Ref: Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2. PMID: 12604350 Ref: Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. PMID: 12609989 Ref: Differential effects between amphoterin and advanced glycation end products on colon cancer cells. PMID: 12640679 Ref: Alpha2beta1-integrin signaling by itself controls G1/S transition in a human adenocarcinoma cell line (Caco-2): implication of NADPH oxidase-dependent production of ROS. PMID: 12681287 Ref: Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist. PMID: 12761337 Ref: Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. PMID: 12839952 Ref: Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. PMID: 12851702 Ref: Absence of adhesion triggers differential FAK and SAPKp38 signals in SW620 human colon cancer cells that may inhibit adhesiveness and lead to cell death. PMID: 12876384 Ref: Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 12888657 Ref: Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. PMID: 12944906 Ref: Induction of macrophage migration inhibitory factor by lysophosphatidic acid: relevance to tumor growth and angiogenesis. PMID: 12964047 Ref: Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. PMID: 14556662 Ref: EphA2 up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase and p53-independence. PMID: 14564515 Ref: Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta. PMID: 14587029 |
Ref: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. PMID: 14729633 Ref: Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. PMID: 15010475 Ref: Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. PMID: 15078890 Ref: Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice. PMID: 15122579 Ref: Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. PMID: 15161648 Ref: Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. PMID: 15177310 Ref: Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer. PMID: 15234907 Ref: Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin. PMID: 15247276 Ref: n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. PMID: 15358633 Ref: Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation. PMID: 15383630 Ref: Cell cycle-related signaling pathways modulated by peripheral benzodiazepine receptor ligands in colorectal cancer cells. PMID: 15474510 Ref: Analyses of Galpha-interacting protein and activator of G-protein-signaling-3 functions in macroautophagy. PMID: 15488168 Ref: A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function. PMID: 15489172 Ref: p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression. PMID: 15504345 Ref: EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo. PMID: 15517892 Ref: Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites. PMID: 15548677 |
Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. PMID: 15592498 Ref: Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cells. PMID: 15592929 Ref: beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells. PMID: 15623844 Ref: Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell. PMID: 15655297 Ref: Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. PMID: 15655348 Ref: Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. PMID: 15655524 Ref: The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells. PMID: 15677629 Ref: A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. PMID: 15705869 Ref: H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. PMID: 15713896 Ref: Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells. PMID: 15713899 Ref: LPA2 receptor mediates mitogenic signals in human colon cancer cells. PMID: 15728708 Ref: Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation. PMID: 15735687 Ref: Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. PMID: 15735759 Ref: Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. PMID: 15757891 Ref: Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. PMID: 15790589 Ref: Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition. PMID: 15833869 Ref: (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. PMID: 15860507 Ref: Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasiveness. PMID: 15896466 Ref: HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. PMID: 15899817 Ref: Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. PMID: 15930183 Ref: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP. PMID: 15943809 Ref: Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway. PMID: 15951157 Ref: Bile acid induces hydrophobicity-dependent membrane alterations. PMID: 15951237 Ref: A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040. PMID: 15967111 Ref: Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. PMID: 15975962 Ref: Effects of hepatocyte growth factor/scatter factor on the invasion of colorectal cancer cells in vitro. PMID: 15991286 Ref: The novel gene EG-1 stimulates cellular proliferation. PMID: 16024617 Ref: Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. PMID: 16079301 Ref: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells. PMID: 16127743 Ref: Sulindac metabolites inhibit epidermal growth factor receptor activation and expression. PMID: 16138927 Ref: Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells. PMID: 16142585 Ref: Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. PMID: 16288056 Ref: Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling. PMID: 16327498 |
Ref: Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells. PMID: 16113053 Ref: Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation. PMID: 16169935 Ref: Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase. PMID: 16278684 Ref: Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation. PMID: 16387404 Ref: Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. PMID: 16401637 Ref: Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations. PMID: 16413100 Ref: Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3. PMID: 16472776 Ref: Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. PMID: 16475687 Ref: RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling. PMID: 16505104 Ref: Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. PMID: 16508969 Ref: Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells. PMID: 16524888 Ref: Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways. PMID: 16546990 Ref: Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferation. PMID: 16574647 Ref: Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro. PMID: 16596206 Ref: Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway. PMID: 16611738 Ref: Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells. PMID: 16631161 Ref: Octahedral Pt(IV) complex K101 induces apoptosis via ERK1/2 activation and the p53 pathway in human colon cancer cells. PMID: 16702812 Ref: Adenosine metabolism and cancer. Focus on "Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatases and reducing ERK1/2 activity via a novel pathway". PMID: 16707553 Ref: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner. PMID: 16728583 Ref: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. PMID: 16731769 Ref: [Role of calcium signal in apoptosis and protective mechanism of colon cancer cell line SW480 in response to 5-aminolevulinic acid-photodynamic therapy]. PMID: 16764761 Ref: An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. PMID: 16777983 Ref: Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects. PMID: 16937523 Ref: Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells. PMID: 16972245 Ref: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. PMID: 17007015 Ref: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells. PMID: 17113582 Ref: Sorting nexin 1 down-regulation promotes colon tumorigenesis. PMID: 17145813 |
Ref: Insulin-like growth factors induce apoptosis as well as proliferation in LIM 1215 colon cancer cells. PMID: 16888814 Ref: Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway. PMID: 16963252 Ref: Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium. PMID: 17133351 Ref: Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. PMID: 17149612 Ref: PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. PMID: 17192274 Ref: Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling. PMID: 17220428 Ref: Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation. PMID: 17329004 Ref: Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines: focus on the A(3) adenosine subtype. PMID: 17348028 Ref: XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer. PMID: 17385215 Ref: CXCL10 promotes invasion-related properties in human colorectal carcinoma cells. PMID: 17409450 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 Ref: Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. PMID: 17488804 Ref: Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6. PMID: 17519236 Ref: Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways. PMID: 17531111 Ref: Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells. PMID: 17552361 Ref: Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. PMID: 17553685 Ref: Development of a new Ca2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells. PMID: 17559805 Ref: RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways. PMID: 17587138 Ref: Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain. PMID: 17611409 Ref: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. PMID: 17631291 Ref: Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. PMID: 17632092 Ref: Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. PMID: 17667937 Ref: A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. PMID: 17671083 Ref: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. PMID: 17671177 Ref: Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B. PMID: 17671195 Ref: Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices. PMID: 17706640 Ref: A proteomics analysis of cell signaling alterations in colorectal cancer. PMID: 17848589 Ref: The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro. PMID: 17936921 Ref: [Regulation of promatrilysin expression by tissue factor/actived coagulation factor VII complex in LoVo colon cancer cell line]. PMID: 17940558 Ref: Bilirubin inhibits tumor cell growth via activation of ERK. PMID: 18073533 Ref: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. PMID: 18075315 Ref: Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab. PMID: 18094427 |
Ref: Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels. PMID: 17936723 Ref: Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway. PMID: 18086662 Ref: A sensitive flow cytometry-based nucleotide excision repair assay unexpectedly reveals that mitogen-activated protein kinase signaling does not regulate the removal of UV-induced DNA damage in human cells. PMID: 18093981 Ref: BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. PMID: 18098337 Ref: Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. PMID: 18339887 Ref: Down-modulation of B cell signal transduction by ligation of mucins to CD22. PMID: 18474217 Ref: Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance. PMID: 18507034 Ref: Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells. PMID: 18533112 Ref: Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells. PMID: 18558091 Ref: Suppression of integrin alphaupsilonbeta6 by RNA interference in colon cancer cells inhibits extracellular matrix degradation through the MAPK pathway. PMID: 18566996 Ref: Role of human aquaporin 5 in colorectal carcinogenesis. PMID: 18583321 Ref: Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation. PMID: 18587421 Ref: Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3. PMID: 18771677 Ref: Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901. PMID: 18790789 Ref: Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells. PMID: 18805444 Ref: Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. PMID: 18806830 Ref: Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. PMID: 18936204 Ref: Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells. PMID: 18950493 Ref: Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. PMID: 19014680 Ref: Enhanced proliferation of SNU-407 human colon cancer cells by muscarinic acetylcholine receptors. PMID: 19017493 |
Ref: Tumour cell survival signalling by the ERK1/2 pathway. PMID: 18846109 Ref: Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells. PMID: 19017360 Ref: Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. PMID: 19058300 Ref: Amino acid limitation induces down-regulation of WNT5a at transcriptional level. PMID: 19063862 Ref: Role of miR-143 targeting KRAS in colorectal tumorigenesis. PMID: 19137007 Ref: Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta4. PMID: 19151752 Ref: Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells. PMID: 19169726 Ref: MAP kinases in proliferating human colon cancer Caco-2 cells. PMID: 19301097 Ref: Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo. PMID: 19308290 Ref: Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth. PMID: 19321126 Ref: alphavbeta5/beta6 integrin suppression leads to a stimulation of alpha2beta1 dependent cell migration resistant to PI3K/Akt inhibition. PMID: 19328197 Ref: Role of eotaxin-1 signaling in ovarian cancer. PMID: 19351767 Ref: No functional and transductional significance of specific neuropilin 1 siRNA inhibition in colon carcinoma cell lines lacking VEGF receptor 2. PMID: 19360289 Ref: Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis. PMID: 19372555 Ref: KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer. PMID: 19372556 Ref: Biphasic regulation of cell death and survival by hydrophobic bile acids in HCT116 cells. PMID: 19373611 Ref: Adrenaline induces chemoresistance in HT-29 colon adenocarcinoma cells. PMID: 19380024 Ref: Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. PMID: 19423215 Ref: Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway. PMID: 19472191 Ref: Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. PMID: 19482027 Ref: Biological significance of prolactin in gynecologic cancers. PMID: 19491263 Ref: NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer. PMID: 19499154 Ref: Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of human colon cancer cells. PMID: 19520792 Ref: Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes. PMID: 19608733 Ref: Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. PMID: 19637312 Ref: Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. PMID: 19654295 Ref: Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. PMID: 19685549 Ref: Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. PMID: 19686845 Ref: Prostate-derived factor--a novel inhibitor of drug-induced cell death in colon cancer cells. PMID: 19723892 Ref: 3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226. PMID: 19729215 Ref: TfR2 expression in human colon carcinomas. PMID: 19729324 Ref: Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway. PMID: 19735099 Ref: Heregulin-induced VEGF expression via the ErbB3 signaling pathway in colon cancer. PMID: 19797898 Ref: Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer. PMID: 19816087 Ref: Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line. PMID: 19836435 Ref: PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. PMID: 19930715 Ref: Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt. PMID: 21136969 Ref: Effect of butyrate on the heregulin/ErbB-mediated proliferation of human colorectal cancer cells. PMID: 21475856 |
Ref: Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice. PMID: 19586712 Ref: Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells. PMID: 19782465 Ref: The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. PMID: 19949342 Ref: Hypertonic environment elicits cyclooxygenase-2-driven prostaglandin E2 generation by colon cancer cells: role of cytosolic phospholipase A2-alpha and kinase signaling pathways. PMID: 20004562 Ref: Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. PMID: 20017136 Ref: Deoxycholic acid and selenium metabolite methylselenol exert common and distinct effects on cell cycle, apoptosis, and MAP kinase pathway in HCT116 human colon cancer cells. PMID: 20043263 Ref: Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. PMID: 20056314 Ref: Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells. PMID: 20056842 Ref: K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation. PMID: 20087880 Ref: Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection. PMID: 20111723 Ref: The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta). PMID: 20130018 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. PMID: 20136087 Ref: Applicability of antibody and mRNA expression microarrays for identifying diagnostic and progression markers of early and late stage colorectal cancer. PMID: 20164542 Ref: High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells. PMID: 20181064 Ref: Expression and functional research of TLR4 in human colon carcinoma. PMID: 20228668 Ref: Mechanism of antitumor effect of a novel bFGF binding peptide on human colon cancer cells. PMID: 20331620 Ref: The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. PMID: 20348947 Ref: miR-129 regulates cell proliferation by downregulating Cdk6 expression. PMID: 20404570 Ref: Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells. PMID: 20406951 Ref: Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition. PMID: 20413844 Ref: Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid. PMID: 20429953 Ref: 17beta-estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells. PMID: 20446020 Ref: p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation. PMID: 20453886 Ref: Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association. PMID: 20525880 Ref: Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells. PMID: 20530554 Ref: Signal transduction pathways associated with ATP-induced proliferation of colon adenocarcinoma cells. PMID: 20562007 Ref: Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression. PMID: 20564491 Ref: Monoclonal antibody (mAb)-induced down-regulation of RON receptor tyrosine kinase diminishes tumorigenic activities of colon cancer cells. PMID: 20596675 Ref: Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin. PMID: 20637980 Ref: Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. PMID: 20682650 Ref: Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. PMID: 20808308 Ref: Evidence for a differential modulation of p53-phosphorylating kinases by the cyclin-dependent kinase inhibitor p21WAF1/CIP1. PMID: 20818156 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 Ref: Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells. PMID: 20863062 Ref: GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells. PMID: 20888181 Ref: Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer. PMID: 20944107 Ref: Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities. PMID: 20951582 Ref: Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells. PMID: 21203429 |
Ref: Esculetin inhibits cell proliferation through the Ras/ERK1/2 pathway in human colon cancer cells. PMID: 21109980 Ref: Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and beta-catenin proteins. PMID: 21128180 Ref: Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17. PMID: 21148749 Ref: Activation of PAR2 or/and TLR4 promotes SW620 cell proliferation and migration via phosphorylation of ERK1/2. PMID: 21152870 Ref: Estrogen receptor-beta mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones. PMID: 21161820 Ref: p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis. PMID: 21216846 Ref: Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells. PMID: 21268136 Ref: Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells. PMID: 21271458 Ref: Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression. PMID: 21418393 Ref: Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells. PMID: 21447798 Ref: Involvement of ROS in Curcumin-induced Autophagic Cell Death. PMID: 21461234 Ref: Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models. PMID: 21554739 Ref: Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21(cip). PMID: 21617849 Ref: Involvement of ERK1/2/NF-kappaB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620. PMID: 21625939 Ref: Dual role of insulin-like growth factor-1 in acetyl-CoA carboxylase-alpha activity in human colon cancer cells HCT-8: downregulating its expression and phosphorylation. PMID: 21638027 Ref: ERK1/2 and p38alpha/beta signaling in tumor cell quiescence: opportunities to control dormant residual disease. PMID: 21673068 Ref: A correction to the research article titled: "Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells" by A. S. Little, K. Balmanno, M. J. Sale, S. Newman, J. R. Dry, M. Hampson, P PMID: 21674991 Ref: NK4 gene expression enhances 5-fluorouracil-induced apoptosis of murine colon cancer cells. PMID: 21737644 Ref: VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients. PMID: 21743435 Ref: Consumption of lycopene inhibits the growth and progression of colon cancer in a mouse xenograft model. PMID: 21744871 Ref: Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels. PMID: 21747769 Ref: Differential expression of TNF-alpha signaling molecules and ERK1 in distal and proximal colonic tumors associated with obesity. PMID: 21761118 Ref: Glucagon-like peptide-1 receptor activation inhibits growth and augments apoptosis in murine CT26 colon cancer cells. PMID: 21771884 Ref: TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells. PMID: 21826244 Ref: JNK suppression is essential for 17beta-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. PMID: 21859479 Ref: Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides. PMID: 21895867 Ref: Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. PMID: 21900593 Ref: Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells. PMID: 21907696 Ref: Cancer chemopreventive effects of lycopene: suppression of MMP-7 expression and cell invasion in human colon cancer cells. PMID: 21923160 Ref: Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells. PMID: 21923915 Ref: Neurotensin-induced Erk1/2 phosphorylation and growth of human colonic cancer cells are independent from growth factors receptors activation. PMID: 21945442 Ref: Hypertonic stress induces VEGF production in human colon cancer cell line Caco-2: inhibitory role of autocrine PGE(2). PMID: 21980393 Ref: Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. PMID: 21990345 Ref: Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model. PMID: 22171126 Ref: RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo. PMID: 22812185 Ref: Inhibition of SPHK1 suppresses phorbol 12-myristate 13-acetate-induced metastatic phenotype in colorectal cancer HT-29 cells. PMID: 22812190 |
Ref: Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-kappaB in colon cancer cells. PMID: 21678498 Ref: The pro-apoptotic effect of quercetin in cancer cell lines requires ERbeta-dependent signals. PMID: 21732360 Ref: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. PMID: 21919080 Ref: Thrombin-dependent modulation of beta1-integrin-mediated signaling up-regulates prolidase and HIF-1alpha through p-FAK in colorectal cancer cells. PMID: 21993963 Ref: p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors. PMID: 22020336 Ref: Large procyanidins prevent bile-acid-induced oxidant production and membrane-initiated ERK1/2, p38, and Akt activation in Caco-2 cells. PMID: 22074817 Ref: Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell. PMID: 22076613 Ref: Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro. PMID: 22101170 Ref: Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of beta-catenin. PMID: 22115830 Ref: Carnosine inhibits KRAS-mediated HCT116 proliferation by affecting ATP and ROS production. PMID: 22137144 Ref: Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications. PMID: 22159423 Ref: Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling. PMID: 22260668 Ref: Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. PMID: 22269172 Ref: Soluble vascular endothelial growth factor decoy receptor FP3 exerts potent antiangiogenic effects. PMID: 22273580 Ref: Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation. PMID: 22298595 Ref: The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility. PMID: 22300262 Ref: Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel. PMID: 22305747 Ref: Transforming growth factor-beta1 induces glutathione peroxidase-1 and protects from H2O2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1alpha pathway. PMID: 22307228 Ref: Salicylic acid induces apoptosis in colon carcinoma cells grown in-vitro: influence of oxygen and salicylic acid concentration. PMID: 22342953 Ref: Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation. PMID: 22361730 Ref: ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics. PMID: 22376079 Ref: p38alpha MAPK mediates 17beta-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells. PMID: 22377968 Ref: Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/beta-catenin signaling. PMID: 22387884 Ref: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. PMID: 22409325 Ref: Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. PMID: 22419013 Ref: CacyBP/SIP phosphatase activity in neuroblastoma NB2a and colon cancer HCT116 cells. PMID: 22480271 Ref: Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors. PMID: 22505523 Ref: Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1. PMID: 22511768 Ref: Ras signaling pathway in the chemopreventive action of different ratios of fish oil and corn oil in experimentally induced colon carcinogenesis. PMID: 22519408 Ref: Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. PMID: 22520577 Ref: Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. PMID: 22523035 Ref: Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells. PMID: 22552366 Ref: Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells. PMID: 22552910 Ref: A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. PMID: 22643351 Ref: Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. PMID: 22684547 Ref: Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer. PMID: 22731636 Ref: ESM-1 regulates cell growth and metastatic process through activation of NF-kappaB in colorectal cancer. PMID: 22735811 Ref: Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9. PMID: 22739763 Ref: Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. PMID: 22761867 Ref: The axon guidance molecule Netrin-4 is expressed by Muller cells and contributes to angiogenesis in the retina. PMID: 22777897 Ref: Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis. PMID: 22828150 Ref: EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. PMID: 22865467 Ref: Meprinalpha transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. PMID: 22923609 Ref: Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage. PMID: 22989419 Ref: MAP kinase genes and colon and rectal cancer. PMID: 23027623 Ref: beta-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin? PMID: 23033009 Ref: TLR4 signaling promotes immune escape of human colon cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. PMID: 23035361 Ref: Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. PMID: 23045412 Ref: Alternative dosing of dual PI3K and MEK inhibition in cancer therapy. PMID: 23259591 Ref: Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. PMID: 23300800 Ref: Resveratrol affects protein kinase C activity and promotes apoptosis in human colon carcinoma cells. PMID: 23464396 Ref: Increased Phospho-Keratin 8 Isoforms in Colorectal Tumors Associated with EGFR Pathway Activation and Reduced Apoptosis. PMID: 27398237 |
Ref: Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions. PMID: 21695758 Ref: In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells. PMID: 22264143 Ref: Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. PMID: 22430215 Ref: Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition. PMID: 22948716 Ref: Regulation of the tumor suppressor homeogene Cdx2 by HNF4alpha in intestinal cancer. PMID: 22986531 Ref: Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR. PMID: 23010081 Ref: TGF-beta promotes colorectal cancer cell growth in vitro and in vivo. PMID: 23178467 Ref: Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration. PMID: 23192271 Ref: Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways. PMID: 23199305 Ref: Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1. PMID: 23201159 Ref: Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC alpha/betaII by Gymnasterkoreayne B. PMID: 23219897 Ref: Involvement of PKCalpha activation in TF/VIIa/PAR2-induced proliferation, migration, and survival of colon cancer cell SW620. PMID: 23233043 Ref: The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance. PMID: 23234544 Ref: MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer. PMID: 23325601 Ref: Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells. PMID: 23348408 Ref: Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines. PMID: 23360766 Ref: External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF-kB and induces cell cycle arrest and apoptosis in colorectal cancer cells. PMID: 23363659 Ref: Combined colonic cancer treatment with vitamin D analogs and irinotecan or oxaliplatin. PMID: 23393334 Ref: Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells. PMID: 23438367 Ref: The PEA-15/PED protein regulates cellular survival and invasiveness in colorectal carcinomas. PMID: 23481023 Ref: A Chinese herbal formula, Yi-Qi-Fu-Sheng, inhibits migration/invasion of colorectal cancer by down-regulating MMP-2/9 via inhibiting the activation of ERK/MAPK signaling pathways. PMID: 23506655 Ref: CXCR4 Expression and Treatment with SDF-1alpha or Plerixafor Modulate Proliferation and Chemosensitivity of Colon Cancer Cells. PMID: 23544165 Ref: Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity. PMID: 23567149 Ref: MACC1 down-regulation inhibits proliferation and tumourigenicity of nasopharyngeal carcinoma cells through Akt/beta-catenin signaling pathway. PMID: 23573286 Ref: Melanoidins isolated from heated potato fiber (Potex) affect human colon cancer cells growth via modulation of cell cycle and proliferation regulatory proteins. PMID: 23583803 Ref: Effect of chronic restraint stress on human colorectal carcinoma growth in mice. PMID: 23585898 Ref: TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCalpha and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. PMID: 23616010 Ref: Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation. PMID: 23639480 Ref: Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways. PMID: 23643895 Ref: MiR-339-5p regulates the growth, colony formation and metastasis of colorectal cancer cells by targeting PRL-1. PMID: 23696794 Ref: Olean-12-eno[2,3-c] [1,2,5]oxadiazol-28-oic acid (OEOA) induces G1 cell cycle arrest and differentiation in human leukemia cell lines. PMID: 23696836 Ref: FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer. PMID: 23696849 Ref: Decreased expression of DUSP4 is associated with liver and lung metastases in colorectal cancer. PMID: 23749251 Ref: Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells. PMID: 23786838 Ref: Anticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest. PMID: 23801270 Ref: GPR48, a poor prognostic factor, promotes tumor metastasis and activates beta-catenin/TCF signaling in colorectal cancer. PMID: 23803691 Ref: Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue. PMID: 23818604 Ref: Synthesis and bioevaluation of a series of alpha-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I). PMID: 23820128 Ref: Double targeting of Survivin and XIAP radiosensitizes 3D grown human colorectal tumor cells and decreases migration. PMID: 23830189 Ref: Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer. PMID: 23859041 Ref: Cell-cycle arrest at G2/M and proliferation inhibition by adenovirus-expressed mitofusin-2 gene in human colorectal cancer cell lines. PMID: 23906296 Ref: Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI. PMID: 23942066 Ref: High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/cJun pathway. PMID: 23942851 Ref: Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells. PMID: 23954321 Ref: Synthesis and evaluation of curcumin-related compounds containing benzyl piperidone for their effects on human cancer cells. PMID: 23985704 Ref: Functional expression of the voltage-gated Na(+)-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells. PMID: 23986482 Ref: Mitogen-activated protein kinase phosphatase-1 inhibition and sustained extracellular signal-regulated kinase 1/2 activation in camptothecin-induced human colon cancer cell death. PMID: 24005240 Ref: Multi-kinase modulation for colon cancer therapy. PMID: 24025253 Ref: Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. PMID: 24035834 Ref: Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling. PMID: 24069372 Ref: TIMP-1 promotes accumulation of cancer associated fibroblasts and cancer progression. PMID: 24143225 Ref: Coumarins and lignans from Zanthoxylum schinifolium and their anticancer activities. PMID: 24144361 Ref: A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway. PMID: 24241351 Ref: Down-regulation of miR-126 is associated with colorectal cancer cells proliferation, migration and invasion by targeting IRS-1 via the AKT and ERK1/2 signaling pathways. PMID: 24312276 Ref: The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice. PMID: 24339963 Ref: In Vitro Antiproliferative Effect of Arthrocnemum indicum Extracts on Caco-2 Cancer Cells through Cell Cycle Control and Related Phenol LC-TOF-MS Identification. PMID: 24348703 Ref: In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei. PMID: 26782605 |
Ref: The role of ERK2 in colorectal carcinogenesis is partly regulated by TRAPPC4. PMID: 23625650 Ref: Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity. PMID: 23644655 Ref: Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling. PMID: 23766441 Ref: Ouabain-induced alterations of the apical junctional complex involve alpha1 and beta1 Na,K-ATPase downregulation and ERK1/2 activation independent of caveolae in colorectal cancer cells. PMID: 24186357 Ref: MicroRNA-126 functions as a tumor suppressor in colorectal cancer cells by targeting CXCR4 via the AKT and ERK1/2 signaling pathways. PMID: 24189753 Ref: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. PMID: 24265293 Ref: The ErbB/HER family of protein-tyrosine kinases and cancer. PMID: 24269963 Ref: Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation. PMID: 24363449 Ref: Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. PMID: 24412052 Ref: G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. PMID: 24448357 Ref: PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. PMID: 24448818 Ref: Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway. PMID: 24462916 Ref: Ethanolic extract from Derris scandens Benth mediates radiosensitzation via two distinct modes of cell death in human colon cancer HT-29 cells. PMID: 24641423 Ref: CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition. PMID: 24657657 Ref: EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules. PMID: 24792576 Ref: Xihuang Pill () induces mesenchymal-epithelial transition and inhibits loss of apical-basal polarity in colorectal cancer cell through regulating ZEB1-SCRIB loop. PMID: 24802235 Ref: Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. PMID: 24825889 Ref: Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment. PMID: 24919507 Ref: Heterogeneous EGFR gene copy number increase is common in colorectal cancer and defines response to anti-EGFR therapy. PMID: 24940619 Ref: In vitro antitumor effects of the cold-water extracts of Mediterranean species of genus Pleurotus (higher Basidiomycetes) on human colon cancer cells. PMID: 24940904 Ref: Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark. PMID: 24962785 Ref: Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. PMID: 25051885 Ref: Molecular mechanisms associated with PTHrP-induced proliferation of colon cancer cells. PMID: 25053227 Ref: DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice. PMID: 25053805 Ref: Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. PMID: 25109623 Ref: Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways. PMID: 25111127 Ref: Radixin enhances colon cancer cell invasion by increasing MMP-7 production via Rac1-ERK pathway. PMID: 25136657 Ref: [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PMID: 25157570 Ref: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer. PMID: 25174975 Ref: Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor. PMID: 25175595 Ref: Phospholipase Cdelta1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells. PMID: 25197077 Ref: Effect of light irradiation by light emitting diode on colon cancer cells. PMID: 25202048 Ref: Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines. PMID: 25309914 Ref: Effects of calcium signaling on coagulation factor VIIa-induced proliferation and migration of the SW620 colon cancer cell line. PMID: 25323578 Ref: An RGD motif present in cadherin 17 induces integrin activation and tumor growth. PMID: 25336636 Ref: Kaempferol Downregulates Insulin-like Growth Factor-I Receptor and ErbB3 Signaling in HT-29 Human Colon Cancer Cells. PMID: 25337585 Ref: Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells. PMID: 25338635 Ref: Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation. PMID: 25379021 Ref: Growth suppression of colorectal cancer by plant-derived multiple mAb CO17-1A x BR55 via inhibition of ERK1/2 phosphorylation. PMID: 25405740 Ref: The contribution of activating transcription factor 3 to apoptosis of human colorectal cancer cells by protocatechualdehyde, a naturally occurring phenolic compound. PMID: 25447816 Ref: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. PMID: 25482938 Ref: Egr-1 activation by cancer-derived extracellular vesicles promotes endothelial cell migration via ERK1/2 and JNK signaling pathways. PMID: 25502753 Ref: Mini profile of potential anticancer properties of propofol. PMID: 25502773 Ref: Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells. PMID: 25541940 Ref: PBX3 promotes migration and invasion of colorectal cancer cells via activation of MAPK/ERK signaling pathway. PMID: 25561793 Ref: Extracellular chaperonin 10 augments apoptotic cell death induced by 5-fluorouracil in human colon cancer cells. PMID: 25688504 Ref: Transcriptome profiling of LGR5 positive colorectal cancer cells. PMID: 26484096 |
Ref: Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling. PMID: 24497447 Ref: Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy. PMID: 24928309 Ref: 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. PMID: 25178491 Ref: Steroidal constituents from the edible sea urchin Diadema savignyi Michelin induce apoptosis in human cancer cells. PMID: 25211186 Ref: Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF and matrix metallopeptidase-9. PMID: 25326806 Ref: A novel pyrido-thieno-pyrimidine derivative activates p53 through induction of phosphorylation and acetylation in colorectal cancer cells. PMID: 25338966 Ref: Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. PMID: 25383957 Ref: Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer. PMID: 25500543 Ref: MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation. PMID: 25603978 Ref: Tanshinone I induces cyclin D1 proteasomal degradation in an ERK1/2 dependent way in human colorectal cancer cells. PMID: 25615593 Ref: PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer. PMID: 25617799 Ref: HGF-activated colonic fibroblasts mediates carcinogenesis of colonic epithelial cancer cells via PKC-cMET-ERK1/2-COX-2 signaling. PMID: 25643632 Ref: Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. PMID: 25644809 Ref: MiR-21/RASA1 axis affects malignancy of colon cancer cells via RAS pathways. PMID: 25663768 Ref: AZD-4547 exerts potent cytostatic and cytotoxic activities against fibroblast growth factor receptor (FGFR)-expressing colorectal cancer cells. PMID: 25691251 Ref: Heterozygous deletion of ATG5 in Apc(Min/+) mice promotes intestinal adenoma growth and enhances the antitumor efficacy of interferon-gamma. PMID: 25695667 Ref: Clinicopathologic Significance of BRAF Mutation and Extracellular Signal Regulated Kinase 1/2 Expression in Patients With a Colorectal Adenocarcinoma. PMID: 25745621 Ref: PCK3145 inhibits proliferation and induces apoptosis in breast and colon cancer cells. PMID: 25750288 Ref: HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. PMID: 25800793 Ref: Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways. PMID: 25816245 Ref: Effects of dose rates on radiation-induced replenishment of intestinal stem cells determined by Lgr5 lineage tracing. PMID: 25832104 Ref: Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses. PMID: 25834404 Ref: Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer. PMID: 25879875 Ref: Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer. PMID: 25884313 Ref: HGUE-C-1 is an atypical and novel colon carcinoma cell line. PMID: 25885658 Ref: KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells. PMID: 25933688 Ref: gamma-Synuclein confers both pro-invasive and doxorubicin-mediated pro-apoptotic properties to the colon adenocarcinoma LS 174T cell line. PMID: 25956278 Ref: Prominin-1 (CD133, AC133) and dipeptidyl-peptidase IV (CD26) are indicators of infinitive growth in colon cancer cells. PMID: 25973297 Ref: Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation. PMID: 25987127 Ref: Tumor promotion by gamma and suppression by beta non-muscle actin isoforms. PMID: 26008973 Ref: [Role of CTHRC1 in proliferation, migration and invasion of human colorectal cancer cells]. PMID: 26018280 Ref: Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation. PMID: 26026836 Ref: Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway. PMID: 26028667 Ref: Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth. PMID: 26029998 Ref: Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour. PMID: 26043921 Ref: Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRalpha/c-SRC/ERK1/2/NFkappaB/TP53 pathway: in vitro and in vivo studies. PMID: 26056802 Ref: St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling. PMID: 26069204 Ref: Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts. PMID: 26070816 Ref: Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. PMID: 26096612 Ref: SP1-mediated microRNA-520d-5p suppresses tumor growth and metastasis in colorectal cancer by targeting CTHRC1. PMID: 26101709 Ref: Gene expression in colon cancer: A focus on tumor site and molecular phenotype. PMID: 26171582 Ref: Screening of potential diagnostic markers and therapeutic targets against colorectal cancer. PMID: 26185457 Ref: Up-regulation of microRNA-302a inhibited the proliferation and invasion of colorectal cancer cells by regulation of the MAPK and PI3K/Akt signaling pathways. PMID: 26191138 Ref: Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia. PMID: 26206183 Ref: Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells. PMID: 26236156 Ref: Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. PMID: 26261008 Ref: Implication of Akt, ERK1/2 and alternative p38MAPK signalling pathways in human colon cancer cell apoptosis induced by green tea EGCG. PMID: 26303273 Ref: E-cadherin knockdown increases beta-catenin reducing colorectal cancer chemosensitivity only in three-dimensional cultures. PMID: 26316041 Ref: Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells. PMID: 26318418 Ref: Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway. PMID: 26318998 Ref: Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment. PMID: 26397137 Ref: Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers. PMID: 26404261 Ref: Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo. PMID: 26404630 Ref: Synergistic Effect of SN-38 in Combination with Cetuximab on Angiogenesis and Cancer Cell Invasion. PMID: 26504021 Ref: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes. PMID: 26625825 Ref: Bioinformatic analysis of potential candidates for therapy of inflammatory bowel disease. PMID: 26636514 Ref: Epieriocalyxin A Induces Cell Apoptosis Through JNK and ERK1/2 Signaling Pathways in Colon Cancer Cells. PMID: 27352353 |
Ref: PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition. PMID: 25641341 Ref: DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis. PMID: 25772234 Ref: UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients. PMID: 25917796 Ref: Selective beta2-AR Blockage Suppresses Colorectal Cancer Growth Through Regulation of EGFR-Akt/ERK1/2 Signaling, G1-Phase Arrest, and Apoptosis. PMID: 26189563 Ref: Bioinformatic analyses revealed underlying biological functions correlated with oxaliplatin responsiveness. PMID: 26232912 Ref: Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway. PMID: 26530054 Ref: Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53. PMID: 26636733 Ref: Up-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk. PMID: 26646797 Ref: Exosomes derived from SW480 colorectal cancer cells promote cell migration in HepG2 hepatocellular cancer cells via the mitogen-activated protein kinase pathway. PMID: 26647805 Ref: Enhancement of CD3AK cell proliferation and killing ability by alpha-Thujone. PMID: 26655741 Ref: Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells. PMID: 26677729 Ref: Pristimerin demonstrates anticancer potential in colorectal cancer cells by inducing G1 phase arrest and apoptosis and suppressing various pro-survival signaling proteins. PMID: 26718323 Ref: MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer. PMID: 26718987 Ref: Nanoproteomic analysis of ischemia-dependent changes in signaling protein phosphorylation in colorectal normal and cancer tissue. PMID: 26742633 Ref: Upregulation of CD44v6 contributes to acquired chemoresistance via the modulation of autophagy in colon cancer SW480 cells. PMID: 26747179 Ref: Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer. PMID: 26754532 Ref: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice. PMID: 26774139 Ref: Knockdown of MACC1 expression increases cisplatin sensitivity in cisplatin-resistant epithelial ovarian cancer cells. PMID: 26794135 Ref: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation. PMID: 26804170 Ref: KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway. PMID: 26847701 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24. PMID: 26867566 Ref: Biphasic activation of extracellular signal-regulated kinase (ERK) 1/2 in epidermal growth factor (EGF)-stimulated SW480 colorectal cancer cells. PMID: 26879318 Ref: The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus. PMID: 26901856 Ref: AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin. PMID: 26918349 Ref: PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth. PMID: 26936995 Ref: Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation. PMID: 26959608 Ref: Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells. PMID: 26988990 Ref: Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. PMID: 27028006 Ref: Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations. PMID: 27036313 Ref: Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells. PMID: 27086143 Ref: Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells. PMID: 27112151 Ref: Claudin-7 indirectly regulates the integrin/FAK signaling pathway in human colon cancer tissue. PMID: 27121327 Ref: Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model. PMID: 27133199 Ref: The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells. PMID: 27167250 Ref: ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. PMID: 27187615 Ref: The Antitumor Effect of Gekko Sulfated Glycopeptide by Inhibiting bFGF-Induced Lymphangiogenesis. PMID: 27190997 Ref: SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway. PMID: 27220321 Ref: Actions of l-thyroxine and Nano-diamino-tetrac (Nanotetrac) on PD-L1 in cancer cells. PMID: 27221508 Ref: Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects. PMID: 27224059 Ref: Progesterone receptor activation is required for folic acid-induced anti-proliferation in colorectal cancer cell lines. PMID: 27233474 Ref: Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs. PMID: 27259276 Ref: Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer. PMID: 27304964 Ref: Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer. PMID: 27312529 Ref: EphA4-mediated signaling regulates the aggressive phenotype of irradiation survivor colorectal cancer cells. PMID: 27323967 Ref: Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. PMID: 27347133 Ref: Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody. PMID: 27364553 Ref: Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer. PMID: 27409167 Ref: Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and beta-catenin signaling pathways. PMID: 27422337 Ref: The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3beta-dependent threonine-286 phosphorylation in human colorectal cancer cells. PMID: 27424123 Ref: Flagellin Induces beta-Defensin 2 in Human Colonic Ex vivo Infection with Enterohemorrhagic Escherichia coli. PMID: 27446815 Ref: Anticancer Activity of Buttermilk Against SW480 Colon Cancer Cells is Associated with Caspase-Independent Cell Death and Attenuation of Wnt, Akt, and ERK Signaling. PMID: 27472445 Ref: Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer. PMID: 27472952 Ref: DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling. PMID: 27517319 Ref: High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer. PMID: 27562229 Ref: All-Trans Retinoic Acid Inhibits Human Colorectal Cancer Cells RKO Migration via Downregulating Myosin Light Chain Kinase Expression through MAPK Signaling Pathway. PMID: 27564600 Ref: Targeting H19 by lentivirus-mediated RNA interference increases A549 cell migration and invasion. PMID: 27607135 Ref: Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways. PMID: 27634156 Ref: The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells. PMID: 27668882 Ref: Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells. PMID: 27670681 Ref: Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. PMID: 27698814 Ref: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model. PMID: 27729020 Ref: Claudin-1 promotes TNF-alpha-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells. PMID: 27742576 Ref: Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase. PMID: 27746693 Ref: Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells. PMID: 27773818 |
Ref: Inhibition of NF-kappaB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38. PMID: 27060453 Ref: Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation. PMID: 27293079 Ref: Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib. PMID: 27321184 Ref: RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis. PMID: 27511199 Ref: The Role of EphA4 Signaling in Radiation-Induced EMT-Like Phenotype in Colorectal Cancer Cells. PMID: 27632701 Ref: Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APC(min/+) Mouse Models of Experimental Colon Cancer. PMID: 27730672 Ref: Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells. PMID: 27832659 Ref: TGF-beta1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells. PMID: 27840994 Ref: Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells. PMID: 27871156 Ref: SN38 increases IL-8 expression through the MAPK pathways in HCT8 cells. PMID: 27878250 Ref: Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer. PMID: 27890432 Ref: Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. PMID: 28008134 Ref: Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer. PMID: 28026024 Ref: Butyrate Inhibits Cancerous HCT116 Colon Cell Proliferation but to a Lesser Extent in Noncancerous NCM460 Colon Cells. PMID: 28045428 Ref: Long non-coding RNA growth arrest specific transcript 5 acts as a tumour suppressor in colorectal cancer by inhibiting interleukin-10 and vascular endothelial growth factor expression. PMID: 28099146 Ref: Knockdown of NIK and IKKbeta-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-kappaBeta Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK. PMID: 28125661 Ref: Adamts18 deficiency promotes colon carcinogenesis by enhancing beta-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer. PMID: 28145888 Ref: Biased Signaling by Agonists of Protease Activated Receptor 2. PMID: 28169521 Ref: Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. PMID: 28179995 Ref: Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK. PMID: 28188228 Ref: Inflammatory cytokines IL-17 and TNF-alpha up-regulate PD-L1 expression in human prostate and colon cancer cells. PMID: 28223102 Ref: Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity. PMID: 28247965 Ref: Enhancement of NK cells proliferation and function by Shikonin. PMID: 28303727 Ref: Exendin-4 does not modify growth or apoptosis of human colon cancer cells. PMID: 28318339 Ref: Sulfatase-2 promotes the growth and metastasis of colorectal cancer by activating Akt and Erk1/2 pathways. PMID: 28320104 Ref: Antiproliferation effect of guanosine on HCT 116 cells involves MAPK and AMPK pathways. PMID: 28323520 Ref: Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1alpha via the mTOR/p70S6K/4E-BP1 and MAPK pathways. PMID: 28341244 Ref: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism]. PMID: 28377354 Ref: RSK activation via ERK modulates human colon cancer cells response to PTHrP. PMID: 28385776 Ref: Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels. PMID: 28420432 Ref: Study of the expression and function of ACY1 in patients with colorectal cancer. PMID: 28454420 Ref: ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers. PMID: 28465216 Ref: Vitex rotundifolia Fruit Extract Induces Apoptosis Through the Downregulation of ATF3-Mediated Bcl-2 Expression in Human Colorectal Cancer Cells. PMID: 28468511 Ref: The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation. PMID: 28472897 Ref: Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer. PMID: 28476123 Ref: Thioredoxin-1 promotes colorectal cancer invasion and metastasis through crosstalk with S100P. PMID: 28483515 Ref: Fas signaling induces stemness properties in colorectal cancer by regulation of Bmi1. PMID: 28543447 Ref: Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner. PMID: 28630428 Ref: BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity. PMID: 28655712 Ref: Effect of nonylphenol on the regulation of cell growth in colorectal cancer cells. PMID: 28656208 Ref: Cellular prion protein (PrP(C)) in the development of Merlin-deficient tumours. PMID: 28692055 Ref: Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth. PMID: 28708871 Ref: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling. PMID: 28726723 Ref: miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. PMID: 28739727 Ref: An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer. PMID: 28811578 Ref: Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cgamma-mediated FAK/ERK signaling pathway in colon cancer. PMID: 28821612 Ref: Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells. PMID: 28870200 Ref: Grape seed extracts modify the outcome of oxaliplatin in colon cancer cells by interfering with cellular mechanisms of drug cytotoxicity. PMID: 28881609 Ref: Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways. PMID: 28970726 Ref: Hijiki and sodium arsenite stimulate growth of human colorectal adenocarcinoma cells through ERK1/2 activation. PMID: 28974440 Ref: IL-8 Is Involved in Estrogen-Related Receptor alpha-Regulated Proliferation and Migration of Colorectal Cancer Cells. PMID: 28993941 Ref: L290P/V mutations increase ERK3's cytoplasmic localization and migration/invasion-promoting capability in cancer cells. PMID: 29101390 Ref: Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro. PMID: 29110726 Ref: HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation. PMID: 29152115 Ref: Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner. PMID: 29233468 Ref: Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma. PMID: 29262609 |
Ref: Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines. PMID: 28438053 Ref: Simvastatin enhances radiation sensitivity of colorectal cancer cells. PMID: 28916945 Ref: Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells. PMID: 28933585 Ref: Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation. PMID: 29074106 Ref: MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells. PMID: 29084209 Ref: Wnt/beta-Catenin Pathway Activation Mediates Adaptive Resistance to BRAF Inhibition in Colorectal Cancer. PMID: 29167314 Ref: Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. PMID: 29255136 Ref: Vitex rotundifolia Fruit Suppresses the Proliferation of Human Colorectal Cancer Cells through Down-regulation of Cyclin D1 and CDK4 via Proteasomal-Dependent Degradation and Transcriptional Inhibition. PMID: 29298515 Ref: A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer. PMID: 29329541 Ref: PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway. PMID: 29368606 Ref: BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury. PMID: 29394953 Ref: Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue. PMID: 29423057 Ref: Construction of key signal regulatory network in metastatic colorectal cancer. PMID: 29464057 Ref: TNF-alpha promotes colon cancer cell migration and invasion by upregulating TROP-2. PMID: 29467899 Ref: beta-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. PMID: 29551770 Ref: Expression of factors and key components associated with the PI3K signaling pathway in colon cancer. PMID: 29552187 Ref: The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs. PMID: 29636593 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. PMID: 29645049 Ref: Andrographolide Antagonizes TNF-alpha-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-kappaB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells. PMID: 29672044 Ref: Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells. PMID: 29724012 Ref: Simultaneous stimulation with tumor necrosis factor-alpha and transforming growth factor-beta1 induces epithelial-mesenchymal transition in colon cancer cells via the NF-kappaB pathway. PMID: 29725419 Ref: LIM and SH3 protein 1 knockdown suppresses proliferation and metastasis of colorectal carcinoma cells via inhibition of the mitogen-activated protein kinase signaling pathway. PMID: 29731863 Ref: Metformin increases the cytotoxicity of oxaliplatin in human DLD-1 colorectal cancer cells through down-regulating HMGB1 expression. PMID: 29737584 Ref: shRNAinduced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells. PMID: 29845259 Ref: AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells. PMID: 29846015 Ref: NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway. PMID: 29857489 Ref: Dioscorea bulbifera induced apoptosis through inhibition of ERK 1/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells. PMID: 29860114 Ref: Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. PMID: 29872506 Ref: 3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation. PMID: 29887940 Ref: FOXD1 predicts prognosis of colorectal cancer patients and promotes colorectal cancer progression via the ERK 1/2 pathway. PMID: 29887965 Ref: The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids. PMID: 29915160 Ref: Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells. PMID: 29928348 Ref: Activating HER3 mutations in breast cancer. PMID: 29963236 Ref: Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells. PMID: 29981429 Ref: Korean Red Ginseng extract reduces hypoxia-induced epithelial-mesenchymal transition by repressing NF-kappaB and ERK1/2 pathways in colon cancer. PMID: 29983610 Ref: Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP. PMID: 30009852 Ref: Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. PMID: 30056083 Ref: Follistatin-like protein 1 sustains colon cancer cell growth and survival. PMID: 30131854 Ref: Methyl-beta-cyclodextrin potentiates the BITC-induced anti-cancer effect through modulation of the Akt phosphorylation in human colorectal cancer cells. PMID: 30200817 Ref: Extracellular galectin-3 facilitates colon cancer cell migration and is related to the epidermal growth factor receptor. PMID: 30210679 Ref: Sorcin a Potential Molecular Target for Cancer Therapy. PMID: 30216763 Ref: Enah overexpression is correlated with poor survival and aggressive phenotype in gastric cancer. PMID: 30250066 Ref: HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer. PMID: 30258050 Ref: miR124 inhibits cell growth through targeting IQGAP1 in colorectal cancer. PMID: 30272357 Ref: Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis. PMID: 30273442 Ref: Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance. PMID: 30275173 Ref: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol. PMID: 30333251 Ref: PAR4 overexpression promotes colorectal cancer cell proliferation and migration. PMID: 30333860 Ref: EPA significantly improves anti-EGFR targeted therapy by regulating miR-378 expression in colorectal cancer. PMID: 30333883 Ref: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. PMID: 30382763 |