Primary Site >> Esophagus Cancer

Gene >> MAPK1

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Ref: Suppression of Erk activation and in vivo growth in esophageal cancer cells by the dominant negative Ras mutant, N116Y.
PMID: 9766573
 Ref: Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway.
PMID: 10763823
 Ref: Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent.
PMID: 11297525
 Ref: Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways.
PMID: 14586407
 Ref: Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.
PMID: 15081869
Ref: The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation.
PMID: 15375172
 Ref: Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells.
PMID: 15718251
 Ref: Gefitinib, an epidermal growth factor receptor blockade agent, shows additional or synergistic effects on the radiosensitivity of esophageal cancer cells in vitro.
PMID: 16508686
 Ref: Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines.
PMID: 17143494
 Ref: Statins in esophageal cancer cell lines: promising lead?
PMID: 18371147
Ref: Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.
PMID: 18426913
Ref: Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway.
PMID: 18452159
Ref: Pilot study of gefitinib, oxaliplatin, and radiotherapy for esophageal adenocarcinoma: tissue effect predicts clinical response.
PMID: 18845990
 Ref: Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells.
PMID: 19164283
Ref: Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells.
PMID: 19534809
 Ref: A novel pharmacodynamic approach to assess and predict tumor response to the epidermal growth factor receptor inhibitor gefitinib in patients with esophageal cancer.
PMID: 19956829
Ref: shRNA interference for extracellular signal-regulated kinase 2 can inhibit the growth of esophageal cancer cell line Eca109.
PMID: 20415541
 Ref: The expression and activation of ERK/MAPK pathway in human esophageal cancer cell line EC9706.
PMID: 20464500
Ref: A novel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma.
PMID: 21707510
Ref: [Expression of ERK1/2 MAPK signaling transduction pathway in esophageal cancers in Kazakh patients].
PMID: 21875481
Ref: BRAF mutations in advanced cancers: clinical characteristics and outcomes.
PMID: 22039425
 Ref: pERK activation in esophageal carcinomas: clinicopathological associations.
PMID: 22658382
Ref: Gene silencing of beta-catenin by RNAi inhibits proliferation of human esophageal cancer cells by inducing G0/G1 cell cycle arrest.
PMID: 22938416
Ref: Downregulation of tropomyosin-1 in squamous cell carcinoma of esophagus, the role of Ras signaling and methylation.
PMID: 22965424
Ref: Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer.
PMID: 22992863
 Ref: Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer.
PMID: 23064324
Ref: The radiation-sensitizing effect of flavopiridol in the esophageal cancer cell line Eca109.
PMID: 23833659
Ref: [Roles of targeting Ras/Raf/MEK/ERK signaling pathways in the treatment of esophageal carcinoma].
PMID: 23888683
Ref: Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells.
PMID: 24024333
Ref: Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression.
PMID: 24130695
 Ref: Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells.
PMID: 24788582
Ref: DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways.
PMID: 25026173
 Ref: Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells.
PMID: 25333998
Ref: Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy.
PMID: 25595897
Ref: Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair.
PMID: 25750543
Ref: Marsdenia tenacissima extract induces G0/G1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase (MAPK) signaling pathway.
PMID: 26073339
Ref: High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis.
PMID: 26124180
Ref: Over-expression of Orai1 mediates cell proliferation and associates with poor prognosis in human non-small cell lung carcinoma.
PMID: 26191202
 Ref: Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.
PMID: 26646323
Ref: [Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice].
PMID: 27188603
Ref: Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation.
PMID: 27602169
 Ref: Solute Carrier Family 39 Member 6 Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-Kinase Signaling, and Up-regulating Genes That Regulate Metastasis.
PMID: 28209530
Ref: GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways.
PMID: 29019267
 Ref: HER2 Confers Resistance to Foretinib Inhibition of MET-Amplified Esophageal Adenocarcinoma Cells.
PMID: 29223420
Ref: Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma.
PMID: 29331417
Ref: Cullin7 promotes epithelialmesenchymal transition of esophageal carcinoma via the ERKSNAI2 signaling pathway.
PMID: 29393450
Ref: Progranulin promotes lymphangiogenesis through VEGF-C and is an independent risk factor in human esophageal cancers.
PMID: 29452214
Ref: Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma.
PMID: 29454790
Ref: Glucose-regulated protein 94 mediates progression and metastasis of esophageal squamous cell carcinoma via mitochondrial function and the NF-kB/COX-2/VEGF axis.
PMID: 29507700
Ref: Chemoresistance to Cancer Treatment: Benzo-alpha-Pyrene as Friend or Foe?
PMID: 29673198
Ref: Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the AktGSK3beta and MAPK/ERK signaling cascades.
PMID: 29693162
Ref: IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment.
PMID: 29976575
Ref: Ricolinostat (ACY-1215) suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways.
PMID: 30050135
Ref: Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
PMID: 30113849
Ref: RUNX2 Plays An Oncogenic Role in Esophageal Carcinoma by Activating the PI3K/AKT and ERK Signaling Pathways.
PMID: 30138923