Primary Site >> Colorectal Cancer
Gene >> MACC1
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Ref: MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. PMID: 19098908 Ref: Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer. PMID: 19341507 Ref: Unexpected domain composition of MACC1 links MET signaling and apoptosis. PMID: 19499089 Ref: Colon cancer metastasis: MACC1 and Met as metastatic pacemakers. PMID: 19666136 |
Ref: MACC1 - more than metastasis? Facts and predictions about a novel gene. PMID: 19787327 Ref: MACC1 as a marker for advanced colorectal carcinoma. PMID: 20682999 Ref: MACC 1 as a marker for peritoneal-disseminated gastric carcinoma. PMID: 20944120 |
Ref: Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence. PMID: 21093878 Ref: Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations. PMID: 21447729 Ref: MACC 1 as a marker for vascular invasive hepatocellular carcinoma. PMID: 21498695 Ref: Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis. PMID: 21508357 Ref: High recovery FASP applied to the proteomic analysis of microdissected formalin fixed paraffin embedded cancer tissues retrieves known colon cancer markers. PMID: 21526778 Ref: Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells. PMID: 21923915 Ref: [Expressions of MACC1, HGF, and C-met protein in epithelial ovarian cancer and their significance]. PMID: 21945764 Ref: Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. PMID: 21955323 Ref: Over-expression of Metastasis-associated in Colon Cancer-1 (MACC1) Associates with Better Prognosis of Gastric Cancer Patients. PMID: 23483020 |
Ref: MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer. PMID: 22179665 Ref: A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients. PMID: 22251819 Ref: [Establishment of BGC-823/pBaBb-puro-MACC1 gastric cancer cell line stably expressing MACC1 and its tumor-related gene expression profiles]. PMID: 22445973 Ref: In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice. PMID: 22484916 Ref: Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22493396 Ref: MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer. PMID: 22533346 Ref: Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma. PMID: 22736924 Ref: [Prognostic value of MACC1 and c-met expressions in non-small cell lung cancer]. PMID: 22814258 Ref: SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer. PMID: 22838389 Ref: Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer. PMID: 23095620 Ref: Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis. PMID: 23166620 Ref: The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment. PMID: 23173124 Ref: MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance. PMID: 23205101 Ref: [Expression and clinical significance of metastasis-associated in colon cancer 1 (MACC1) in HBV-related hepatocellular carcinoma]. PMID: 23291068 |
Ref: Knockdown of MACC1 expression suppressed hepatocellular carcinoma cell migration and invasion and inhibited expression of MMP2 and MMP9. PMID: 23232575 Ref: High intratumoral metastasis-associated in colon cancer-1 expression predicts poor outcomes of cryoablation therapy for advanced hepatocellular carcinoma. PMID: 23414367 Ref: Metastasis-associated in colon cancer-1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion. PMID: 23457029 Ref: Overexpression of MACC1 and Its significance in human Breast Cancer Progression. PMID: 23497677 Ref: Novel biomarkers for the prediction of metastasis in colorectal cancer. PMID: 23530884 Ref: MACC1 down-regulation inhibits proliferation and tumourigenicity of nasopharyngeal carcinoma cells through Akt/beta-catenin signaling pathway. PMID: 23573286 Ref: MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases. PMID: 23665971 Ref: Colon tumour secretopeptidome: insights into endogenous proteolytic cleavage events in the colon tumour microenvironment. PMID: 23684732 Ref: Overexpression of metastasis-associated in colon cancer-1 associated with poor prognosis in patients with esophageal cancer. PMID: 23737034 Ref: Promoter identification and transcriptional regulation of the metastasis gene MACC1 in colorectal cancer. PMID: 23800415 Ref: MACC1 - a novel target for solid cancers. PMID: 23815185 Ref: MACC1 is related to colorectal cancer initiation and early-stage invasive growth. PMID: 24124150 Ref: Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis. PMID: 24220141 Ref: [Significance of MACC1 protein expression in esophageal carcinoma]. PMID: 24351603 |
Ref: Overexpression of MACC1 protein and its clinical implications in patients with glioma. PMID: 23982875 Ref: High expression of MACC1 predicts poor prognosis in patients with osteosarcoma. PMID: 24065195 Ref: MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma. PMID: 24163085 Ref: MACC1 overexpression predicts a poor prognosis for non-small cell lung cancer. PMID: 24310811 Ref: Effects of MACC1 siRNA on biological behaviors of HeLa. PMID: 24346124 Ref: Downregulated expression of metastasis associated in colon cancer 1 (MACC1) reduces gallbladder cancer cell proliferation and invasion. PMID: 24425103 Ref: Single nucleotide polymorphisms in the metastasis-associated in colon cancer-1 gene predict the recurrence of hepatocellular carcinoma after transplantation. PMID: 24465159 Ref: Role of overexpression of MACC1 and/or FAK in predicting prognosis of hepatocellular carcinoma after liver transplantation. PMID: 24516351 Ref: Expression of MACC1 and MET in inflammatory bowel disease-associated colonic neoplasia. PMID: 24518605 Ref: [Expression of metastasis-associated in colon cancer-1 in different stages of epithelial ovarian cancer]. PMID: 24581128 Ref: Significant survival impact of MACC1 polymorphisms in HER2 positive breast cancer patients. PMID: 24910416 Ref: Metastasis-associated in colon cancer 1 is a novel survival-related biomarker for human patients with renal pelvis carcinoma. PMID: 24949951 Ref: MACC1 promotes carcinogenesis of colorectal cancer via beta-catenin signaling pathway. PMID: 25003996 Ref: MACC1 induces metastasis in ovarian carcinoma by upregulating hepatocyte growth factor receptor c-MET. PMID: 25009663 Ref: Metastasis-associated colon cancer-1 is a novel prognostic marker for cervical cancer. PMID: 25120795 Ref: MACC1 expression levels as a novel prognostic marker for colorectal cancer. PMID: 25295116 Ref: [Effects of small interfering RNA silencing MACC-1 expression on cell proliferation, cell cycle and invasion ability of cervical cancer SiHa cells]. PMID: 25327653 Ref: Prognostic significance of metastasis associated in colon cancer 1 (MACC1) expression in patients with gallbladder cancer. PMID: 25579553 |
Ref: MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect. PMID: 25043301 Ref: MACC1 overexpression and survival in solid tumors: a meta-analysis. PMID: 25326812 Ref: Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma. PMID: 25421538 Ref: Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer. PMID: 25444928 Ref: Circulating MACC1 as a novel diagnostic and prognostic biomarker for nonsmall cell lung cancer. PMID: 25544672 Ref: Circulating Metastasis Associated in Colon Cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker. PMID: 25574109 Ref: The expression of MACC1 and its role in the proliferation and apoptosis of salivary adenoid cystic carcinoma. PMID: 25640194 Ref: Differential role of MACC1 expression and its regulation of the HGF/cMet pathway between breast and colorectal cancer. PMID: 25738887 Ref: Metastasis-associated in colon cancer-1 is associated with poor prognosis in hepatocellular carcinoma, partly by promoting proliferation through enhanced glucose metabolism. PMID: 25738944 Ref: High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients. PMID: 25742883 Ref: Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer. PMID: 25785098 Ref: Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study. PMID: 25884643 Ref: Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2. PMID: 25895023 Ref: MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling. PMID: 25945841 Ref: Metastasis-associated in colon cancer 1 is an independent prognostic biomarker for survival in Klatskin tumor patients. PMID: 25953673 Ref: Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells. PMID: 26043756 Ref: Metastasis associated in colon cancer 1 predicts poor outcomes in patients with breast cancer. PMID: 26065229 Ref: Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis. PMID: 26090393 Ref: Increased expression of metastasis-associated in colon cancer-1 in renal cell carcinoma is associated with poor prognosis. PMID: 26097569 Ref: Molecular targets and pathways involved in liver metastasis of colorectal cancer. PMID: 26104118 Ref: Prognostic and clinicopathological significance of MACC1 expression in hepatocellular carcinoma patients: a meta-analysis. PMID: 26131051 Ref: Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line. PMID: 26133168 Ref: Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer. PMID: 26137000 Ref: Metastasis-Associated in Colon Cancer-1 Associates With Poor Prognosis and Promotes Cell Invasion and Angiogenesis in Human Cervical Cancer. PMID: 26332389 Ref: [Expression of MACC1 protein in colorectal cancer and its relationship with clinicopathological characteristics]. PMID: 26499151 |
Ref: SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival. PMID: 26686083 Ref: Increased MACC1 expression indicates a poor prognosis independent of MET expression in gastric adenocarcinoma. PMID: 26719224 Ref: MACC1 Induces Tumor Progression in Transgenic Mice and Colorectal Cancer Patients via Increased Pluripotency Markers Nanog and Oct4. PMID: 26758557 Ref: Knockdown of MACC1 expression increases cisplatin sensitivity in cisplatin-resistant epithelial ovarian cancer cells. PMID: 26794135 Ref: Genetic Variation in Metastasis-Associated in Colon Cancer-1 and the Risk of Breast Cancer Among the Chinese Han Population: A STROBE-Compliant Observational Study. PMID: 26871844 Ref: MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells. PMID: 26919111 Ref: MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis. PMID: 27143263 Ref: MACC-1 Promotes Endothelium-Dependent Angiogenesis in Gastric Cancer by Activating TWIST1/VEGF-A Signal Pathway. PMID: 27280289 Ref: Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer. PMID: 27431311 Ref: Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk. PMID: 27439755 Ref: MACC1 is post-transcriptionally regulated by miR-218 in colorectal cancer. PMID: 27462788 Ref: Loss of ZFP36 expression in colorectal cancer correlates to wnt/ ss-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of ZEB1, SOX9 and MACC1. PMID: 27463018 Ref: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT. PMID: 27488539 Ref: MicroRNA target for MACC1 and CYR61 to inhibit tumor growth in mice with colorectal cancer. PMID: 27492459 Ref: Voltage-gated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1-mediated upregulation of NHE1. PMID: 27529686 Ref: Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 (MACC1) overexpression in colorectal cancer: a meta-analysis. PMID: 27542234 Ref: Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis. PMID: 27547006 Ref: A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway. PMID: 27581375 Ref: Targeting H19 by lentivirus-mediated RNA interference increases A549 cell migration and invasion. PMID: 27607135 Ref: The potential therapeutic applications and prognostic significance of metastasis-associated in colon cancer-1 (MACC1) in cancers. PMID: 27688722 Ref: Diagnostic and prognostic value of serum MACC1 in breast cancer patients. PMID: 27793048 Ref: The expression of metastasis-associated in colon cancer-1 and KAI1 in gastric adenocarcinoma and their clinical significance. PMID: 27793161 Ref: Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer. PMID: 27832750 Ref: Investigation of MACC1 Gene Expression in Head and Neck Cancer and Cancer Stem Cells. PMID: 27917797 Ref: [Expressions of MACC1, Snail, and KISS-1 Proteins in Infiltrating Breast Carcinoma and Its Clinicopathological Features]. PMID: 28598089 |
Ref: The MACC1-SPON2 axis: a new biomarker and therapeutic target in colorectal cancer. PMID: 27669439 Ref: The role of metastasis-associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression. PMID: 27991682 Ref: miR-433 reduces cell viability and promotes cell apoptosis by regulating MACC1 in colorectal cancer. PMID: 28123526 Ref: MACC1 mediates chemotherapy sensitivity of 5-FU and cisplatin via regulating MCT1 expression in gastric cancer. PMID: 28235486 Ref: MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression. PMID: 28339092 Ref: The significance of DNA methylation profile in metastasis-related genes for the progression of colorectal cancer. PMID: 28364795 Ref: Prognostic value of MACC1 and proficient mismatch repair status for recurrence risk prediction in stage II colon cancer patients: the BIOGRID studies. PMID: 28460000 Ref: miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer. PMID: 28498456 Ref: Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. PMID: 28570591 Ref: YB-1 regulates tumor growth by promoting MACC1/c-Met pathway in human lung adenocarcinoma. PMID: 28624808 Ref: Single Nucleotide Polymorphisms in Genes MACC1, RAD18, MMP7 and SDF-1a As Prognostic Factors in Resectable Colorectal Cancer. PMID: 28740450 Ref: MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma. PMID: 28791376 Ref: Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer. PMID: 28943898 Ref: MACC1 facilitates chemoresistance and cancer stem celllike properties of colon cancer cells through the PI3K/AKT signaling pathway. PMID: 28990068 Ref: MiRNA-338-3p regulates cervical cancer cells proliferation by targeting MACC1 through MAPK signaling pathway. PMID: 29243777 |
Ref: MACC1 and HGF are associated with survival in patients with gastric cancer. PMID: 29435059 Ref: MicroRNA-598 Inhibits Cell Proliferation and Invasion of Glioblastoma by Directly Targeting Metastasis Associated in Colon Cancer-1 (MACC1). PMID: 29444745 Ref: The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer. PMID: 29678846 Ref: Coexistence of MACC1 and NM23-H1 dysregulation and tumor budding promise early prognostic evidence for recurrence risk of early-stage colon cancer. PMID: 29700912 Ref: [Expression of AXIN and MACC1 in Gastric Carcinoma and Its Clinical Significance]. PMID: 29737091 Ref: Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence. PMID: 29937183 Ref: MACC1 silencing inhibits cell proliferation and induces cell apoptosis of lung adenocarcinoma cells through the beta-catenin pathway. PMID: 29940751 Ref: Evaluation of the correlation of MACC1, CD44, Twist1, and KiSS-1 in the metastasis and prognosis for colon carcinoma. PMID: 30021598 Ref: DBC1 regulates Wnt/beta-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer. PMID: 30082743 Ref: Genetic and immunological biomarkers predict metastatic disease recurrence in stage III colon cancer. PMID: 30340556 Ref: Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer. PMID: 30370603 |