Primary Site >> Colorectal Cancer

Gene >> LRIG1

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Ref: LRIG1 expression in colorectal cancer.
PMID: 17851870
Ref: Lrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERalpha-positive breast cancer.
PMID: 21821674
Ref: Intestinal stem cells - types and markers.
PMID: 23471862
Ref: Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis.
PMID: 24833705
Ref: LRIG1 extracellular domain: structure and function analysis.
PMID: 25765764
Ref: LRIG1, a 3p tumor suppressor, represses EGFR signaling and is a novel epigenetic silenced gene in colorectal cancer.
PMID: 26159916
Ref: Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort.
PMID: 29212164
Ref: Expression of Lrig1, a negative regulator of EGFR, is dynamically altered during different stages of gastric carcinogenesis.
PMID: 30248341
Ref: A Unique Non-Saccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation.
PMID: 30337351