Primary Site >> Colorectal Cancer
Gene >> LGALS3
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Ref: Expression of a Mr 32,000 laminin-binding protein messenger RNA in human colon carcinoma correlates with disease progression. PMID: 2141294 |
Ref: Carbohydrate-binding protein 35 is the major cell-surface laminin-binding protein in colon carcinoma. PMID: 1842179 Ref: Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression. PMID: 1933952 |
Ref: Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation. PMID: 1339304 Ref: Inverse modulation of steady-state messenger RNA levels of two non-integrin laminin-binding proteins in human colon carcinoma. PMID: 1386115 Ref: [Cellular and molecular biological study of the laminin-binding protein and its clinical application]. PMID: 1470161 Ref: Anti-sense RNA of 32-kDa laminin-binding protein inhibits attachment and invasion of a human colon carcinoma cell line. PMID: 1534386 |
Ref: Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. PMID: 7682704 |
Ref: Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate. PMID: 7954433 Ref: [Expression of laminin-binding lectin CBP35 in colorectal cancer: correlation with liver metastasis]. PMID: 8065062 |
Ref: Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells. PMID: 7743523 Ref: The laminin alpha 1 chain Ile-Lys-Val-Ala-Val (IKVAV)-containing peptide promotes liver colonization by human colon cancer cells. PMID: 7758002 Ref: Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon. PMID: 7773932 |
Ref: Decreased expression of galectin-3 is associated with progression of human breast cancer. PMID: 8691344 Ref: Expression of 32-kDa laminin-binding protein mRNA in colon cancer tissues. PMID: 8769953 Ref: Colon cancer mucin: a new ligand for the beta-galactoside-binding protein galectin-3. PMID: 8813123 |
Ref: Association between sucrase-isomaltase and p53 expression in colorectal cancer. PMID: 9084856 Ref: Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. PMID: 9394730 |
Ref: Metastasis of human colon cancer is altered by modifying expression of the beta-galactoside-binding protein galectin 3. PMID: 9679034 |
Ref: Involvement of galectin-3 expression in colorectal cancer progression and metastasis. PMID: 10375607 Ref: Galectins-1 and -3 and their ligands in tumor biology. Non-uniform properties in cell-surface presentation and modulation of adhesion to matrix glycoproteins for various tumor cell lines, in biodistribution of free and liposome-bound galectins and in thei PMID: 10480338 |
Ref: Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands. PMID: 10961987 |
Ref: Role of galectin-3 in adenocarcinoma liver metastasis. PMID: 11604988 |
Ref: Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor. PMID: 11839721 Ref: The constitutive expression of galectin-3 is downregulated in the intestinal epithelia of Crohn's disease patients, and tumour necrosis factor alpha decreases the level of galectin-3-specific mRNA in HCT-8 cells. PMID: 11981338 Ref: Primary colorectal carcinomas and their intrapulmonary metastases: clinical, glyco-, immuno- and lectin histochemical, nuclear and syntactic structure analysis with emphasis on correlation with period of occurrence of metastases and survival. PMID: 12193204 Ref: Expression of human intestinal mucin is modulated by the beta-galactoside binding protein galectin-3 in colon cancer. PMID: 12198708 Ref: Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. PMID: 12488479 |
Ref: Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration. PMID: 12471620 Ref: Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting. PMID: 12673710 Ref: Prognostic values of galectin-3 and the macrophage migration inhibitory factor (MIF) in human colorectal cancers. PMID: 12748256 |
Ref: Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells. PMID: 14687799 Ref: Mucins and mucin binding proteins in colorectal cancer. PMID: 15000151 Ref: Cell surface overexpression of galectin-3 and the presence of its ligand 90k in the blood plasma as determinants in colon neoplastic lesions. PMID: 15140826 Ref: A circulating ligand for galectin-3 is a haptoglobin-related glycoprotein elevated in individuals with colon cancer. PMID: 15362030 |
Ref: Galectin-3 expression is a potent prognostic marker in colorectal cancer. PMID: 16080575 Ref: Gefitinib-responsive EGFR-positive colorectal cancers have different proteome profiles from non-responsive cell lines. PMID: 16115757 Ref: Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation. PMID: 16285957 |
Ref: Tumor-associated antigen 90K/Mac-2-binding protein: possible role in colon cancer. PMID: 16518858 Ref: [Association of galectin-3 expression with biological behaviors of human colorectal carcinoma]. PMID: 17259097 Ref: Galectin-4 expression in carcinoid tumors. PMID: 17308361 |
Ref: Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. PMID: 17534895 Ref: Galectin-3 expression in colorectal cancer: relation to invasion and metastasis. PMID: 17695516 Ref: [Association of galectin-3 and E-cadherin expressions with lymph node metastasis of colon cancer]. PMID: 18024302 Ref: Toxicity assessment of wastewater by proteomics analysis. PMID: 18382413 |
Ref: Varied expression and localization of multiple galectins in different cancer cell lines. PMID: 18288388 Ref: Expression of galectin-3 in the tumor immune response in colon cancer. PMID: 18542048 Ref: Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis. PMID: 18676377 Ref: [Expression of galectin-3 in liver metastasis of colon cancer and the inhibitory effect of modified citrus pectin]. PMID: 18753060 Ref: Tumor-associated galectin-3 modulates the function of tumor-reactive T cells. PMID: 18757439 Ref: Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells. PMID: 19016746 Ref: Lectin-epithelial interactions in the human colon. PMID: 19021580 Ref: Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model. PMID: 19109874 |
Ref: Galectin-3 stabilizes heterogeneous nuclear ribonucleoprotein Q to maintain proliferation of human colon cancer cells. PMID: 19137262 Ref: Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. PMID: 19190323 |
Ref: The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic clea PMID: 19665518 Ref: Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients. PMID: 19686089 Ref: Chemical characterization, antiproliferative and antiadhesive properties of polysaccharides extracted from Pleurotus pulmonarius mycelium and fruiting bodies. PMID: 19830415 Ref: Implication of the Galectin-3 in colorectal cancer development (about 325 Tunisian patients). PMID: 20080461 Ref: [Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)]. PMID: 20415207 Ref: Circulating galectin-3 in the bloodstream: An emerging promoter of cancer metastasis. PMID: 21160594 |
Ref: Immunoexpression of galectin-3 in colorectal cancer and its relationship with survival. PMID: 20635166 Ref: Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5. PMID: 21094132 Ref: The role of galectins in colorectal cancer progression. PMID: 21520033 Ref: Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium. PMID: 21933892 Ref: Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. PMID: 22074249 |
Ref: Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention. PMID: 21516492 Ref: Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients. PMID: 21823122 Ref: Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. PMID: 21941373 Ref: Galectin-1 and Galectin-3 Mediate Protocadherin-24-Dependent Membrane Localization of beta-catenin in Colon Cancer Cell Line HCT116. PMID: 23115611 Ref: Galectin-3-independent Down-regulation of GABABR1 due to Treatment with Korean Herbal Extract HAD-B Reduces Proliferation of Human Colon Cancer Cells. PMID: 25780644 |
Ref: Simultaneous determination of serum galectin-3 and -4 levels detects metastases in colorectal cancer patients. PMID: 23117840 Ref: Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium. PMID: 23401226 Ref: Dendritic cell-based immunotherapy for colon cancer using an HLA-A*0201-restricted cytotoxic T-lymphocyte epitope from tumor-associated antigen 90K. PMID: 23524651 Ref: Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells. PMID: 23580446 Ref: The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity. PMID: 23898060 Ref: Aberrant O-GlcNAc-modified proteins expressed in primary colorectal cancer. PMID: 24126823 Ref: Characterization of dextran sodium sulfate-induced inflammation and colonic tumorigenesis in Smad3(-/-) mice with dysregulated TGFbeta. PMID: 24244446 Ref: Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via beta-catenin/GSK-3beta modulation in colorectal carcinoma. PMID: 24303084 |
Ref: Revealing the molecular mechanism of colorectal cancer by establishing LGALS3-related protein-protein interaction network and identifying signaling pathways. PMID: 24398765 Ref: Increased expression of colonic Wnt9A through Sp1-mediated transcriptional effects involving arylsulfatase B, chondroitin 4-sulfate, and galectin-3. PMID: 24778176 Ref: Expression of APC protein during tongue malignant transformation in galectin-3-deficient mice challenged by the carcinogen 4-nitroquniline-n-oxide. PMID: 25031746 Ref: Effects of metabolic acidosis on intracellular pH responses in multiple cell types. PMID: 25209413 Ref: Impact of sodium butyrate on the network of adhesion/growth-regulatory galectins in human colon cancer in vitro. PMID: 25275038 |
Ref: Atractylochromene Is a Repressor of Wnt/beta-Catenin Signaling in Colon Cancer Cells. PMID: 25593640 Ref: Inhibition of Wnt/beta-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells. PMID: 25625870 Ref: Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. PMID: 26160844 Ref: The expression and significance of Gal-3 and MUC1 in colorectal cancer and colon cancer. PMID: 26251612 Ref: Chemoprevention of Azoxymethane-induced Colonic Carcinogenesis in Balb/c mice Using a Modified Pectin Alginate Probiotic. PMID: 26254367 Ref: Senescent mesenchymal stem cells promote colorectal cancer cells growth via galectin-3 expression. PMID: 26273429 Ref: Circulating Galectin-1 and 90K/Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal Cancer. PMID: 26448934 Ref: Eudragit S100 Coated Citrus Pectin Nanoparticles for Colon Targeting of 5-Fluorouracil. PMID: 28787974 |
Ref: LGALS3 and AXIN1 gene variants playing role in the Wnt/ beta-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer. PMID: 26894286 Ref: The expression profiles of the galectin gene family in colorectal adenocarcinomas. PMID: 27001434 Ref: Knockdown of LI-cadherin alters expression of matrix metalloproteinase-2 and -9 and galectin-3. PMID: 27035870 Ref: Continuous administration of bevacizumab plus capecitabine, even after acquired resistance to bevacizumab, restored anti-angiogenic and antitumor effect in a human colorectal cancer xenograft model. PMID: 27350037 Ref: Association between circulating galectin-3 levels and the immunological, inflammatory and nutritional parameters in patients with colorectal cancer. PMID: 27446542 Ref: Circulating and tissue galectin-1 and galectin-3 in colorectal carcinoma: association with clinicopathological parameters, serum CEA, IL-17 and IL23. PMID: 27685917 Ref: Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer PMID: 28032729 Ref: Over expression of galectin-3 associates with short-term poor prognosis in stage II colon cancer. PMID: 28085015 |
Ref: Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression. PMID: 28146425 Ref: Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells. PMID: 28731466 Ref: Galectin-3 Expression in Colorectal Cancer and its Correlation with Clinical Pathological Characteristics and Prognosis. PMID: 28744489 Ref: Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PMID: 28968471 Ref: ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway. PMID: 29348846 |
Ref: Correction: Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression. PMID: 29552332 Ref: Fecal Galectin-3: A New Promising Biomarker for Severity and Progression of Colorectal Carcinoma. PMID: 29849497 Ref: Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers? PMID: 29872358 Ref: Expression of Galectins-1 and Galectin-3 in Stomach and Colorectal Cancer with Tissue Eosinophilia. PMID: 29926280 Ref: Colon cancer-derived conditioned medium induces differentiation of THP-1 monocytes into a mixed population of M1/M2 cells. PMID: 30183516 Ref: Extracellular galectin-3 facilitates colon cancer cell migration and is related to the epidermal growth factor receptor. PMID: 30210679 |