Primary Site >> Colorectal Cancer

Gene >> L1CAM

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Ref: Mutations in L1-CAM in two families with X linked complicated spastic paraplegia, MASA syndrome, and HSAS.
PMID: 7562969
Ref: Molecular changes during the genesis of human gliomas.
PMID: 9407626
Ref: Identification of cell surface and secreted proteins essential for tumor cell survival using a genetic suppressor element screen.
PMID: 15361835
Ref: L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.
PMID: 15716380
Ref: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.
PMID: 17030349
Ref: Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.
PMID: 17699774
Ref: L1-CAM in cancerous tissues.
PMID: 18847309
Ref: L1 cell adhesion molecule (L1CAM) in invasive tumors.
PMID: 19144458
Ref: The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells.
PMID: 19565570
Ref: DNA hypomethylation at the CpG island is involved in aberrant expression of the L1 cell adhesion molecule gene in colorectal cancer.
PMID: 19639167
Ref: Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells.
PMID: 20501702
Ref: L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers.
PMID: 21123622
Ref: Expression of l1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer.
PMID: 21685041
Ref: TGF-beta1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells.
PMID: 22349829
Ref: Molecular targets and pathways involved in liver metastasis of colorectal cancer.
PMID: 26104118
Ref: Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options.
PMID: 27074785
Ref: [Pancreatic acinar neoplasms : Comparative molecular characterization].
PMID: 27807633
Ref: Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System.
PMID: 29188232