Primary Site >> Stomach Cancer
Gene >> KRAS
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Ref: A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogene. PMID: 3951985 |
Ref: Preparation of anti-ras Mr 21,000 protein monoclonal antibodies and immunohistochemical analyses on expression of ras genes in human stomach and thyroid cancers. PMID: 3046740 Ref: [ret gene from a human stomach cancer]. PMID: 3248771 |
Ref: Expression of c-myc oncogene in colorectal polyps as a biological marker for monitoring malignant potential. PMID: 2743265 Ref: [Proto-oncogene expression in human carcinomas of the stomach and in the gastric mucosa of rats exposed to N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis]. PMID: 2924705 |
Ref: [Molecular pathological diagnosis of cancer]. PMID: 1973345 Ref: Heterogeneous protooncogene amplification correlates with tumor progression and presence of metastases in gastric cancer patients. PMID: 2253224 Ref: Glycine to aspartic acid mutations at codon 13 of the c-Ki-ras gene in human gastrointestinal cancers. PMID: 2404571 |
Ref: Evidence for a common molecular pathogenesis in colorectal, gastric, and pancreatic cancer. PMID: 1663781 Ref: Analysis of ras gene mutations in gastrointestinal cancers. PMID: 1686883 Ref: K-ras activation in gastric epithelial tumors in Japanese. PMID: 2049776 |
Ref: Genetic changes in multi-step development of colorectal cancer. PMID: 1453686 |
Ref: Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method. PMID: 8249918 Ref: Advanced gastroduodenal polyposis with ras mutations in a patient with familial adenomatous polyposis. PMID: 8387955 Ref: Loss of heterozygosity and K-ras gene mutations in gastric cancer. PMID: 8406432 Ref: Infrequent ras mutation in human stomach cancers. PMID: 8463133 |
Ref: Ki-ras and c-myc oncogene expression measured by coamplification polymerase chain reaction. PMID: 8002989 |
Ref: Using biopsy materials to detect mutations in gastrointestinal tumors. PMID: 7665812 Ref: The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma. PMID: 7674088 Ref: Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases. PMID: 7773929 |
Ref: [Detection of c-Ki-ras oncogene codon 12 point mutations in lung carcinoma, gastric carcinoma and hepatic carcinoma]. PMID: 9208596 |
Ref: Establishment and characterization of human gastric carcinoma cell lines. PMID: 9033653 Ref: Mutation of ras oncogene in gastric adenocarcinoma: association with histological phenotype. PMID: 9137494 Ref: Low epithelial cell proliferation and absence of oncoprotein expression in juvenile polyposis of the stomach, with or without tumors. PMID: 9260812 Ref: [Findings of genetic changes in small intestinal carcinomas]. PMID: 9263525 Ref: Telomerase activity and its clinicopathological significance in gastric cancer. PMID: 9301460 Ref: Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells. PMID: 9376258 |
Ref: Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy. PMID: 9587115 Ref: Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination. PMID: 9620027 Ref: Different genome organization in two new cell lines established from human gastric carcinoma. PMID: 9723033 Ref: Multiple early gastric stump carcinomas after gastrectomy for peptic ulcer. PMID: 9732951 Ref: Infrequent frameshift mutations of polynucleotide repeats in multiple primary cancers affecting the esophagus and other organs. PMID: 9824204 Ref: Farnesylcysteine methyltransferase activity and Ras protein expression in human stomach tumor tissue. PMID: 9875463 |
Ref: KRAS mutations predict progression of preneoplastic gastric lesions. PMID: 10067815 Ref: Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization. PMID: 10092127 Ref: K-ras mutations in gastric stump carcinomas and in carcinomas from the non-operated stomach. PMID: 10430398 Ref: Multiple APC mutations in sporadic flat colorectal adenomas. PMID: 10602369 |
Ref: Transduction effect of antisense K-ras on malignant phenotypes in gastric cancer cells. PMID: 10893435 Ref: [Characteristics of plasma DNA and its application for detection of K-ras gene mutation]. PMID: 10897674 |
Ref: C-myc amplification and cluster analysis in human gastric carcinoma. PMID: 11299830 |
Ref: Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma. PMID: 12163385 |
Ref: BRAF and KRAS mutations in stomach cancer. PMID: 14534542 Ref: Alterations of chromosomal copy number during progression of diffuse-type gastric carcinomas: metaphase- and array-based comparative genomic hybridization analyses of multiple samples from individual tumours. PMID: 14595756 |
Ref: Mutations of BRAF and KRAS in gastric cancer and their association with microsatellite instability. PMID: 14618633 |
Ref: Mutations of PIK3CA in gastric adenocarcinoma. PMID: 15784156 Ref: The prevalence of PIK3CA mutations in gastric and colon cancer. PMID: 15994075 Ref: Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer. PMID: 16007118 Ref: [Evaluation of K-ras 12 oncogene mutations in Venezuelan patients with Helicobacter pylori infection]. PMID: 16353541 |
Ref: Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study. PMID: 17267619 Ref: Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns. PMID: 17693665 Ref: No duplicate KRAS mutation is identified on the same allele in gastric or colorectal cancer cells with multiple KRAS mutations. PMID: 17697521 |
Ref: Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells. PMID: 18627290 Ref: Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression. PMID: 18781563 Ref: Molecular targets and biological modifiers in gastric cancer. PMID: 19013893 Ref: Total number of genome alterations in sporadic gastrointestinal cancer inferred from pooled analyses in the literature. PMID: 19023234 |
Ref: Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. PMID: 19142899 Ref: Updates in Gastrointestinal Oncology - insights from the 2008 44th annual meeting of the American Society of Clinical Oncology. PMID: 19236713 Ref: Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene. PMID: 19318583 Ref: Significant association between EGFR-mutated lung adenocarcinoma and past illness from gastric cancer or uterine myoma: its implication in carcinogenesis. PMID: 19362747 Ref: A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. PMID: 19545448 Ref: Down-regulation of epidermal growth factor receptor by selective expansion of a 5'-end regulatory dinucleotide repeat in colon cancer with microsatellite instability. PMID: 19584170 Ref: Mutation detection of KRAS by high-resolution melting analysis in Chinese with gastric cancer. PMID: 19639197 Ref: Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. PMID: 19755509 Ref: Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen. PMID: 19938198 |
Ref: Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: a phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). PMID: 20068568 Ref: Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. PMID: 20080834 Ref: KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach. PMID: 20358631 Ref: Fulminant plasmapheresis-refractory thrombotic microangiopathy associated with advanced gastric cancer. PMID: 20438546 Ref: Progress in cancer chemotherapy with special stress on molecular-targeted therapy. PMID: 20651047 Ref: Cytogenetic characterization and evaluation of c-MYC gene amplification in PG100, a new Brazilian gastric cancer cell line. PMID: 20658094 |
Ref: Oncogenic mutations in gastric cancer with microsatellite instability. PMID: 20937558 Ref: Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China. PMID: 21080251 Ref: Epidermal growth factor receptor mutation in gastric cancer. PMID: 21436633 Ref: Correlation between genomic alterations assessed by array comparative genomic hybridization, prognostically informative histologic subtype, stage, and patient survival in gastric cancer. PMID: 21676433 Ref: Gastric cancer and concomitant renal cancer: a systematic immunohistochemical and molecular analysis. PMID: 21687951 Ref: Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction. PMID: 21811258 Ref: Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). PMID: 22152101 Ref: Oxaliplatin, irinotecan and cetuximab in advanced gastric cancer. A multicenter phase II trial (Gastric-2) of the Arbeitsgemeinschaft Medikamentose Tumortherapie (AGMT). PMID: 22199312 |
Ref: NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. PMID: 22159814 Ref: Targeted therapies and predictive markers in epithelial malignancies of the gastrointestinal tract. PMID: 22229849 Ref: Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines. PMID: 22290393 Ref: A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. PMID: 22315472 Ref: Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines. PMID: 22614881 Ref: Molecular diagnosis on tissues and cells: how it affects training and will affect practice in the future. PMID: 22846108 Ref: Frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer. PMID: 23152928 Ref: Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India. PMID: 23168708 Ref: [Genetic and epigenetic alterations in gastric carcinogenesis]. PMID: 23198549 Ref: Whole-genome reconstruction and mutational signatures in gastric cancer. PMID: 23237666 Ref: Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori. PMID: 23326126 Ref: ABO and Rh blood groups and risk of colorectal adenocarcinoma. PMID: 23464411 |
Ref: Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. PMID: 23196062 Ref: MicroRNAs in Cancer: the 22nd Hiroshima Cancer Seminar/the 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima. PMID: 23487440 Ref: KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: results from a large international multicentre study. PMID: 23511561 Ref: Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer. PMID: 23667495 Ref: A let-7 binding site polymorphism rs712 in the KRAS 3' UTR is associated with an increased risk of gastric cancer. PMID: 23729275 Ref: Towards the goal of personalized medicine in gastric cancer--time to move beyond HER2 inhibition. Part I: Targeting receptor tyrosine kinase gene amplification. PMID: 23819947 Ref: Prognostic and putative predictive biomarkers of gastric cancer for personalized medicine. PMID: 23846438 Ref: The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. PMID: 23880861 Ref: Towards the goal of personalized medicine in gastric cancer--time to move beyond HER2 inhibition. Part II: Targeting gene mutations and gene amplifications and the angiogenesis pathway. PMID: 23911227 Ref: HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab. PMID: 24146218 Ref: Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study. PMID: 24196786 |
Ref: Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma. PMID: 24122810 Ref: EGFR, HER-2 and KRAS in canine gastric epithelial tumors: a potential human model? PMID: 24454858 Ref: Cetuximab inhibits gastric cancer growth in vivo, independent of KRAS status. PMID: 24467518 Ref: SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review. PMID: 24503755 Ref: Comparison of HER2 expression between primary colorectal cancer and their corresponding metastases. PMID: 24668895 Ref: DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach. PMID: 24674026 Ref: Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer. PMID: 24774510 Ref: Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer. PMID: 24861525 Ref: Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets. PMID: 24935174 Ref: The mutational burdens and evolutionary ages of early gastric cancers are comparable to those of advanced gastric cancers. PMID: 25042771 Ref: Mutually exclusive FGFR2, HER2, and KRAS gene amplifications in gastric cancer revealed by multicolour FISH. PMID: 25086186 Ref: MEK inhibitor for gastric cancer with MEK1 gene mutations. PMID: 25253779 Ref: GNAS mutation as an alternative mechanism of activation of the Wnt/beta-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type. PMID: 25288233 Ref: High-throughput sequencing and copy number variation detection using formalin fixed embedded tissue in metastatic gastric cancer. PMID: 25372287 Ref: [Application of molecular targeted agents in comprehensive treatment of gastrointestinal cancer]. PMID: 25421761 |
Ref: Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. PMID: 24510342 Ref: Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing. PMID: 25427437 Ref: Cetuximab-induced insulin-like growth factor receptor I activation mediates cetuximab resistance in gastric cancer cells. PMID: 25625229 Ref: Tumor profiling of gastric and esophageal carcinoma reveal different treatment options. PMID: 25778705 Ref: Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer. PMID: 25815786 Ref: Prospective comprehensive genomic profiling of advanced gastric carcinoma cases reveals frequent clinically relevant genomic alterations and new routes for targeted therapies. PMID: 25882375 Ref: Cancer mutation screening: Comparison of high-resolution melt analysis between two platforms. PMID: 25932046 Ref: Anti-tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC-803 proliferation via phospho-extracellular signal-regulated kinase-, Src-, c-Jun N-terminal kinase- and phosphoinositide 3-kinase-associated pathways. PMID: 26063313 Ref: Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer. PMID: 26121593 Ref: Bioresponsive antisense DNA gold nanobeacons as a hybrid in vivo theranostics platform for the inhibition of cancer cells and metastasis. PMID: 26189409 Ref: Comparison of variations detection between whole-genome amplification methods used in single-cell resequencing. PMID: 26251698 Ref: KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity. PMID: 26318594 Ref: Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer. PMID: 26401016 Ref: Pyloric gland adenoma: a histologic, immunohistochemical and molecular genetic study of 23 cases. PMID: 26421956 Ref: Assessment of a HER2 scoring system for colorectal cancer: results from a validation study. PMID: 26449765 Ref: Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer. PMID: 26567773 |
Ref: MET in gastric cancer--discarding a 10% cutoff rule. PMID: 26033401 Ref: Clinicopathological characteristics of RHOA mutations in a Central European gastric cancer cohort. PMID: 26251521 Ref: Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer. PMID: 26489445 Ref: Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype. PMID: 26538087 Ref: Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. PMID: 26677984 Ref: HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials. PMID: 26690310 Ref: Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model. PMID: 26837764 Ref: Comprehensive molecular portrait using next generation sequencing of resected intestinal-type gastric cancer patients dichotomized according to prognosis. PMID: 26961069 Ref: Prognostic impact of KRAS mutant type and MET amplification in metastatic and recurrent gastric cancer patients treated with first-line S-1 plus cisplatin chemotherapy. PMID: 27014419 Ref: Braf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer. PMID: 27116958 Ref: The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas. PMID: 27175599 Ref: Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers. PMID: 27275783 Ref: Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation. PMID: 27437872 Ref: Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells. PMID: 27699948 Ref: MicroRNA-134 functions as a tumor suppressor gene in gastric cancer. PMID: 27830015 Ref: [Molecular Pathogenesis of Colorectal Cancer]. PMID: 27951718 |
Ref: Gene amplification of CCNE1, CCND1, and CDK6 in gastric cancers detected by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization. PMID: 27864121 Ref: Molecular Testing for Gastrointestinal Cancer. PMID: 28219002 Ref: Tumor and serum gamma-glutamyl transpeptidase, new prognostic and molecular interpretation of an old biomarker in gastric cancer. PMID: 28404903 Ref: Erratum to: Braf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer. PMID: 28444545 Ref: The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy? PMID: 28507801 Ref: Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers. PMID: 28522256 Ref: Genomic Profiling of Small-Bowel Adenocarcinoma. PMID: 28617917 Ref: Liver metastases from gastric carcinoma: A Case report and review of the literature. PMID: 28625333 Ref: Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma. PMID: 28738329 Ref: Genomic alterations in advanced gastric cancer endoscopic biopsy samples using targeted next-generation sequencing. PMID: 28744403 Ref: Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression. PMID: 28760854 Ref: Apatinib in the treatment of advanced lung adenocarcinoma with KRAS mutation. PMID: 28894382 Ref: Hepatoid Adenocarcinoma of the Stomach: A Challenging Diagnostic and Therapeutic Disease through a Case Report and Review of the Literature. PMID: 29034239 Ref: Actionable gene-based classification toward precision medicine in gastric cancer. PMID: 29089060 Ref: KRAS Mutation in Gastric Cancer and Prognostication Associated with Microsatellite Instability Status. PMID: 29116623 Ref: ITGBL1 Predicts a Poor Prognosis and Correlates EMT Phenotype in Gastric Cancer. PMID: 29151964 Ref: Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis. PMID: 29237412 Ref: Correlation between MEK signature and Ras gene alteration in advanced gastric cancer. PMID: 29296181 Ref: Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing. PMID: 29307989 |
Ref: Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis. PMID: 27779515 Ref: Gastric poorly cohesive carcinoma: a correlative study of mutational signatures and prognostic significance based on histopathological subtypes. PMID: 28873240 Ref: Gastric Carcinomas With Lymphoid Stroma: An Evaluation of the Histopathologic and Molecular Features. PMID: 29438172 Ref: Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status. PMID: 29468422 Ref: Human gastric cancer modelling using organoids. PMID: 29703791 Ref: Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer. PMID: 29725898 Ref: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. PMID: 29808010 Ref: Pyloric Gland Adenoma (PGA) of the Gallbladder: A Unique and Distinct Tumor from PGAs of the Stomach, Duodenum, and Pancreas. PMID: 29975247 Ref: Development of Patient-Derived Gastric Cancer Organoids from Endoscopic Biopsies and Surgical Tissues. PMID: 30003451 Ref: Three types of metaplasia models through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium. PMID: 30168144 Ref: Landscape of somatic mutations in gastric cancer assessed using next-generation sequencing analysis. PMID: 30250552 Ref: Identification of Potential Biomarkers Involved in Gastric Cancer Through Integrated Analysis of Non-Coding RNA Associated Competing Endogenous RNAs Network. PMID: 30336538 |