Primary Site >> Liver Cancer
Gene >> KLRK1
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Ref: Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid. PMID: 12569559 |
Ref: Antitumor activity of eosinophils activated by IL-5 and eotaxin against hepatocellular carcinoma. PMID: 15383175 |
Ref: Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate. PMID: 16024634 Ref: Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas. PMID: 16168521 |
Ref: STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. PMID: 17133483 |
Ref: Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease. PMID: 18025181 |
Ref: Vgamma9Vdelta2 T cell-mediated recognition of human solid tumors. Potential for immunotherapy of hepatocellular and colorectal carcinomas. PMID: 17764010 Ref: Direct and natural killer cell-mediated antitumor effects of low-dose bortezomib in hepatocellular carcinoma. PMID: 18519785 |
Ref: Inhibition of hepatitis B virus replication by small interference RNA induces expression of MICA in HepG2.2.15 cells. PMID: 18685862 Ref: Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. PMID: 19109155 Ref: DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vgamma9Vdelta2 T cells. PMID: 19404979 Ref: [Expression of NK cells receptor NKG2D from peripheral blood in patients with primary hepatic carcinoma and its clinical significance]. PMID: 19595184 Ref: Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. PMID: 19826051 |
Ref: Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. PMID: 19998387 |
Ref: Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells. PMID: 21106845 Ref: Combinatorial cytotoxicity of gemcitabine and cytokine-activated killer cells in hepatocellular carcinoma via the NKG2D-MICA/B system. PMID: 21873167 |
Ref: NKG2D and its ligands: key to immunotherapy of liver cancer? PMID: 21798219 Ref: Interleukin-1beta enhances the production of soluble MICA in human hepatocellular carcinoma. PMID: 22302133 Ref: Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro. PMID: 22396543 Ref: [Expression and significance of the NK cell receptors in primary hepatocellular carcinoma and paracancerous tissues]. PMID: 22558993 Ref: Interaction of Hepatitis C virus proteins with pattern recognition receptors. PMID: 22726246 |
Ref: Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions. PMID: 23225218 Ref: The combination therapy of alpha-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice. PMID: 23420533 Ref: Hepatitis B virus-induced hepatocellular carcinoma: functional roles of MICA variants. PMID: 24010643 Ref: p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. PMID: 24043758 Ref: Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs. PMID: 24061441 Ref: Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression. PMID: 24107450 |
Ref: Hepatitis B surface antigen inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells. PMID: 23917076 Ref: Alloimmune activation promotes anti-cancer cytotoxicity after rat liver transplantation. PMID: 24651497 Ref: hIL-15 gene-modified human natural killer cells (NKL-IL15) augments the anti-human hepatocellular carcinoma effect in vivo. PMID: 24721706 Ref: Loss of expression of MHC class I-related chain A (MICA) is a frequent event and predicts poor survival in patients with hepatocellular carcinoma. PMID: 25031731 Ref: MICA/B expression is inhibited by unfolded protein response and associated with poor prognosis in human hepatocellular carcinoma. PMID: 25228093 Ref: Granulin-epithelin precursor renders hepatocellular carcinoma cells resistant to natural killer cytotoxicity. PMID: 25315249 Ref: MICA polymorphism: biology and importance in cancer. PMID: 25330802 |
Ref: MICA SNPs and the NKG2D system in virus-induced HCC. PMID: 25270965 Ref: Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia. PMID: 25393931 Ref: Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment. PMID: 25626490 Ref: Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells. PMID: 25926643 Ref: Restoration of natural killer activity in hepatocellular carcinoma by treatment with antibody against granulin-epithelin precursor. PMID: 26140244 Ref: Development of a screening method to identify regulators of MICA shedding. PMID: 26299929 |
Ref: Impact of natural killer cells on chronic hepatitis C and hepatocellular carcinoma. PMID: 26574168 Ref: A bispecific protein rG7S-MICA recruits natural killer cells and enhances NKG2D-mediated immunosurveillance against hepatocellular carcinoma. PMID: 26791237 Ref: Failure recovery of circulating NKG2D(+)CD56(dim)NK cells in HBV-associated hepatocellular carcinoma after hepatectomy predicts early recurrence. PMID: 26942056 Ref: Scorpion venom activates natural killer cells in hepatocellular carcinoma via the NKG2D-MICA pathway. PMID: 27089390 Ref: Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype. PMID: 27091211 Ref: Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition. PMID: 27141341 Ref: Expanded and Activated Natural Killer Cells for Immunotherapy of Hepatocellular Carcinoma. PMID: 27197065 Ref: Enhancing NK cell cytotoxicity by miR-182 in hepatocellular carcinoma. PMID: 27262453 Ref: Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection. PMID: 27630638 |
Ref: The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma. PMID: 28128200 Ref: Augmented anti-tumor activity of NK-92 cells expressing chimeric receptors of TGF-betaR II and NKG2D. PMID: 28184969 Ref: Sunitinib Induces NK-kappaB-dependent NKG2D Ligand Expression in Nasopharyngeal Carcinoma and Hepatoma Cells. PMID: 28452850 Ref: Anti-hepatocarcinoma activity of TT-1, an analog of melittin, combined with interferon-alpha via promoting the interaction of NKG2D and MICA. PMID: 28585428 Ref: Oncolytic measles virus enhances antitumour responses of adoptive CD8(+)NKG2D(+) cells in hepatocellular carcinoma treatment. PMID: 28701757 Ref: Enhanced antitumor activity of gemcitabine by polysaccharide-induced NK cell activation and immune cytotoxicity reduction in vitro/vivo. PMID: 28732877 Ref: MiR-615-5p depresses natural killer cells cytotoxicity through repressing IGF-1R in hepatocellular carcinoma patients. PMID: 28747084 |
Ref: Nano-Pulse Stimulation Ablates Orthotopic Rat Hepatocellular Carcinoma and Induces Innate and Adaptive Memory Immune Mechanisms that Prevent Recurrence. PMID: 29533981 Ref: Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions. PMID: 29568203 Ref: Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cells. PMID: 29581297 Ref: Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells. PMID: 29713019 Ref: Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver cancer. PMID: 29725428 Ref: CD8(+) T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma. PMID: 29784005 Ref: IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction. PMID: 29867983 Ref: The Paradoxical Role of NKG2D in Cancer Immunity. PMID: 30150983 Ref: Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis. PMID: 30238080 Ref: MicroRNA-34a Promotes MICB Expression in Hepatocytes. PMID: 30256916 |