Primary Site >> Colorectal Cancer
Gene >> KLRK1
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Ref: NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity. PMID: 12884870 Ref: Analysis of MICA gene transcripts in human rectal cancers. PMID: 12894536 Ref: Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. PMID: 14662896 |
Ref: Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. PMID: 15187109 |
Ref: Natural killer and NK-Like T-cell activation in colorectal carcinoma patients treated with autologous tumor-derived heat shock protein 96. PMID: 15867395 Ref: DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor. PMID: 16040807 Ref: V gamma 9V delta 2 T cell response to colon carcinoma cells. PMID: 16210656 |
Ref: Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients. PMID: 16184547 |
Ref: A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients. PMID: 17143612 |
Ref: Vgamma9Vdelta2 T cell-mediated recognition of human solid tumors. Potential for immunotherapy of hepatocellular and colorectal carcinomas. PMID: 17764010 Ref: Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese. PMID: 18174257 Ref: Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through Fas ligand. PMID: 18284469 Ref: Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma. PMID: 18398827 Ref: Influence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide-activated human natural killer (NK) cells. PMID: 18759005 |
Ref: TNK cells (NKG2D+ CD8+ or CD4+ T lymphocytes) in the control of human tumors. PMID: 19089424 Ref: Association of MICA-TM and MICB C1_2_A microsatellite polymorphisms with tumor progression in patients with colorectal cancer. PMID: 19353249 Ref: Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes. PMID: 19454726 Ref: Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells. PMID: 19569244 Ref: NKG2D ligand expression in human colorectal cancer reveals associations with prognosis and evidence for immunoediting. PMID: 19861434 Ref: Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity. PMID: 19915059 |
Ref: ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients. PMID: 20054857 Ref: Induction of a less aggressive phenotype in human colon carcinoma HCT116 cells by chronic exposure to HDAC inhibitor SAHA. PMID: 20878117 |
Ref: Lenalidomide enhances antibody-dependent cellular cytotoxicity of solid tumor cells in vitro: influence of host immune and tumor markers. PMID: 20848094 Ref: Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells. PMID: 21257710 Ref: Avitalized bacteria mediate tumor growth control via activation of innate immunity. PMID: 21463858 |
Ref: Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction. PMID: 21951556 Ref: Identification and functional analysis of ligands for natural killer cell activating receptors in colon carcinoma. PMID: 22189020 Ref: Possible association of decreased NKG2D expression levels and suppression of the activity of natural killer cells in patients with colorectal cancer. PMID: 22200673 Ref: The effect of photodynamic therapy on tumor cell expression of major histocompatibility complex (MHC) class I and MHC class I-related molecules. PMID: 22246985 Ref: Interleukin-1beta enhances the production of soluble MICA in human hepatocellular carcinoma. PMID: 22302133 |
Ref: The combination therapy of alpha-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice. PMID: 23420533 Ref: Epithelial-mesenchymal transition induces an antitumor immune response mediated by NKG2D receptor. PMID: 23509364 Ref: A high throughput method for enrichment of natural killer cells and lymphocytes and assessment of in vitro cytotoxicity. PMID: 23680234 Ref: Chemotherapy sensitizes colon cancer initiating cells to Vgamma9Vdelta2 T cell-mediated cytotoxicity. PMID: 23762301 Ref: Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA. PMID: 23902341 Ref: Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer. PMID: 24138752 Ref: Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation. PMID: 24190430 |
Ref: Augmenting the expression of NKp44 molecule and the natural killer activity in peripheral blood mononuclear cells from patients with malignant colorectal carcinoma. PMID: 24154937 Ref: The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma. PMID: 24242212 Ref: Treatment with a fusion protein of the extracellular domains of NKG2D to IL-15 retards colon cancer growth in mice. PMID: 24810637 Ref: Peripheral Foxp3+ regulatory T cells and natural killer group 2, member D expression levels in natural killer cells of patients with colorectal cancer. PMID: 24819058 Ref: Interleukin-18 synergism with interleukin-2 in cytotoxicity and NKG2D expression of human natural killer cells. PMID: 25292077 Ref: gammadelta T cells as a potential tool in colon cancer immunotherapy. PMID: 25341120 |
Ref: The narrow-spectrum HDAC inhibitor entinostat enhances NKG2D expression without NK cell toxicity, leading to enhanced recognition of cancer cells. PMID: 24203492 Ref: COX-2- and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon cancer cells. PMID: 25218028 Ref: Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia. PMID: 25393931 Ref: Metastatic colon cancer cell populations contain more cancer stem-like cells with a higher susceptibility to natural killer cell-mediated lysis compared with primary colon cancer cells. PMID: 25789015 Ref: The decrease in NKG2D+ Natural Killer cells in peripheral blood of patients with metastatic colorectal cancer. PMID: 25924638 Ref: Phenotypic analysis of T cells infiltrating colon cancers: Correlations with oncogenetic status. PMID: 26405567 |
Ref: IL-15 superagonist/IL-15RalphaSushi-Fc fusion complex (IL-15SA/IL-15RalphaSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas. PMID: 26910920 Ref: Resistance of novel mouse strains different in MHC class I and the NKC domain to the development of experimental tumors. PMID: 27279019 Ref: Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15. PMID: 27777574 |
Ref: A 15-gene signature for prediction of colon cancer recurrence and prognosis based on SVM. PMID: 27998790 Ref: Chitosan nanoparticle-based delivery of fused NKG2D-IL-21 gene suppresses colon cancer growth in mice. PMID: 28450784 |
Ref: Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models. PMID: 29342200 Ref: Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer. PMID: 29388200 Ref: Hemacytotoxicity and natural killer lytic index: New parameters to evaluate natural killer cell immunity for clinical use in cancer. PMID: 29391904 Ref: Decline in peripheral blood NKG2D+CD3+CD56+ NKT cells in metastatic colorectal cancer patients. PMID: 29405723 Ref: Sensing Bacterial-Induced DNA Damaging Effects via Natural Killer Group 2 Member D Immune Receptor: From Dysbiosis to Autoimmunity and Carcinogenesis. PMID: 29422899 Ref: Mucosa-associated invariant T cells in malignancies: a faithful friend or formidable foe? PMID: 29470597 Ref: NKG2D Immunoligand rG7S-MICA Enhances NK Cell-mediated Immunosurveillance in Colorectal Carcinoma. PMID: 29528990 Ref: Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer. PMID: 29763380 Ref: Diagnostic value of peripheral blood immune profiling in colorectal cancer. PMID: 29854709 Ref: Targeting the Epidermal Growth Factor Receptor Can Counteract the Inhibition of Natural Killer Cell Function Exerted by Colorectal Tumor-Associated Fibroblasts. PMID: 29910806 Ref: Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis. PMID: 30144974 |