Primary Site >> Colorectal Cancer
Gene >> KL
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Ref: Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. PMID: 21523445 Ref: [DNA methylation of ZIC1 and KLOTHO gene promoters in colorectal carcinomas and its clinicopathological significance]. PMID: 21671493 |
Ref: Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway. PMID: 24818842 |
Ref: Hypothesis: cell signalling influences age-related risk of colorectal cancer. PMID: 25388238 Ref: Klotho gene polymorphisms are related to colorectal cancer susceptibility. PMID: 26261651 |
Ref: Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1alpha axis. PMID: 29884183 |