Primary Site >> Colorectal Cancer
Gene >> KIT
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Ref: Expression of c-kit and kit ligand in human colon carcinoma cells. PMID: 7694350 |
Ref: Complementary DNA cloning and characterization of truncated form of c-kit in human colon carcinoma cells. PMID: 7505199 Ref: Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. PMID: 8011699 |
Ref: Interleukin 4 down-regulates expression of c-kit and autocrine stem cell factor in human colorectal carcinoma cells. PMID: 8519688 |
Ref: Expression and identification of aberrant c-kit transcripts in human cancer cells. PMID: 9149133 Ref: Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-beta 1. PMID: 9207920 |
Ref: Distribution of the interstitial cells of Cajal in the human anorectum. PMID: 9862380 |
Ref: Clinical and histopathological features of colonic stromal tumor in a child. PMID: 10864354 Ref: Gastrointestinal stromal tumor of the rectum with activating mutation of c-kit: report of a case. PMID: 11005505 Ref: Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases. PMID: 11023095 Ref: Specific mutation in exon 11 of c-kit proto-oncogene in a malignant gastrointestinal stromal tumor of the rectum. PMID: 11063223 |
Ref: Aberrant activation of c-kit protects colon carcinoma cells against apoptosis and enhances their invasive potential. PMID: 11280787 Ref: Schwannomas in the colon and rectum: a clinicopathologic and immunohistochemical study of 20 cases. PMID: 11420455 Ref: Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors--a clinicopathologic and immunohistochemical study of eighty-eight cases. PMID: 11598163 |
Ref: Protein kinase A: regulation and receptor-mediated delivery of antisense oligonucleotides and cytotoxic drugs. PMID: 12119275 Ref: Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease. PMID: 12135029 Ref: The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy. PMID: 12208734 Ref: Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. PMID: 12235070 Ref: Immunohistochemical staining for c-Kit (CD117) is a rare event in human colorectal carcinoma. PMID: 12453327 |
Ref: Gastrointestinal stromal tumor of rectum: a report of 2 cases. PMID: 12886152 Ref: Analysis of protein expression and gene mutation of c-kit in colorectal neuroendocrine carcinomas. PMID: 14657715 Ref: [The c-kit/Stem Cell Factor in the cancerogenetic process of colon-rectal carcinoma. Biological and clinical aspects]. PMID: 14663421 |
Ref: Inhibition of cell survival and invasive potential of colorectal carcinoma cells by the tyrosine kinase inhibitor STI571. PMID: 14726674 Ref: Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor. PMID: 14985702 Ref: [Expression of leucocyte cell-surface antigens on colon cancer cell line HR8348]. PMID: 15067730 Ref: Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients. PMID: 15133698 Ref: Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo. PMID: 15322124 Ref: Identification of interstitial cells of Cajal in the human rectum. PMID: 15353319 Ref: Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors. PMID: 15613459 Ref: Evaluation of prognosis for malignant rectal gastrointestinal stromal tumor by clinical parameters and immunohistochemical staining. PMID: 15622586 |
Ref: COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? PMID: 15589595 Ref: Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation. PMID: 15688149 Ref: Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor. PMID: 15727903 Ref: Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas. PMID: 15743179 Ref: [Activity of the National Oncology R&D Consortium in 2004]. PMID: 15902326 Ref: Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass. PMID: 16018942 Ref: Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. PMID: 16048580 Ref: Desmoplastic fibroma of bone: an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin. PMID: 16153468 |
Ref: The identification of specialized pacemaking cells in the anal sphincters. PMID: 16088385 Ref: Malignant peripheral nerve sheath tumor arising from the colon in a newborn: report of a case and review of the literatures. PMID: 16481232 Ref: Interstitial cells of cajal in patients with constipation due to total colonic inertia. PMID: 16809224 Ref: KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomes. PMID: 16964380 Ref: Benign hybrid perineurioma-schwannoma in the colon. A case report. PMID: 17126257 |
Ref: Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor (GIST). PMID: 16639561 Ref: Different matrix micro-environments in colon cancer and diverticular disease. PMID: 17021746 Ref: Gastrointestinal stromal tumor of the anal canal: an unusual presentation. PMID: 17306018 Ref: Sunitinib: from rational design to clinical efficacy. PMID: 17327610 Ref: Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway. PMID: 17410437 Ref: Coexistence of gastrointestinal stromal tumor (GIST) and colorectal adenocarcinoma: A case report. PMID: 17708776 Ref: Case of rectal malignant melanoma showing immunohistochemical variability in a tumor. PMID: 17965534 Ref: Poorly differentiated carcinoma of the rectum with aberrant immunophenotype: a case report. PMID: 17990362 |
Ref: Neoadjuvant imatinib in a gastrointestinal stromal tumor of the rectum: report of a case. PMID: 18239881 Ref: Assessing interstitial cells of Cajal in slow transit constipation using CD117 is a useful diagnostic test. PMID: 18460978 Ref: Elevated p21 expression is associated with poor prognosis of rectal stromal tumors after resection. PMID: 18521824 Ref: Prognostic analysis of rectal stromal tumors by reference of National Institutes of Health risk categories and immunohistochemical studies. PMID: 18633679 Ref: Recurrent rectal GIST resected successfully after preoperative chemotherapy with imatinib mesylate. PMID: 18704638 Ref: Colorectal mesenchymal tumors - from smooth muscle tumors to stromal tumors. PMID: 18949416 Ref: mRNA expression of platelet-derived growth factor receptor-beta and C-KIT: correlation with pathologic response to cetuximab-based chemoradiotherapy in patients with rectal cancer. PMID: 19028276 |
Ref: Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. PMID: 19579873 Ref: Gastrointestinal stromal tumors of the rectum: report of five cases. PMID: 19637785 Ref: Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PMID: 20027224 Ref: Gastrointestinal stromal tumor of the digestive organs: a histopathologic study of 31 cases in a single Japanese institute. PMID: 20126584 |
Ref: Immunohistochemical detection of receptor tyrosine kinases c-kit, EGF-R, and PDGF-R in colorectal adenocarcinomas. PMID: 19280218 Ref: Hereditary gastrointestinal stromal tumors sharing the KIT Exon 17 germline mutation p.Asp820Tyr develop through different cytogenetic progression pathways. PMID: 19847891 Ref: Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review. PMID: 19940466 Ref: c-kit (CD117) expression in human tumors and its prognostic value: an immunohistochemical analysis. PMID: 20177846 Ref: [Insulin protects the loss of colonic interstitial cells of Cajal and acetylcholine in patients with type 2 diabetes mellitus]. PMID: 20450658 Ref: A large cystic gastrointestinal stromal tumor of the rectum in the retrorectal space. PMID: 20455085 Ref: The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer. PMID: 20652953 Ref: [Current options and principles of pathomorphology-based tumour diagnostics]. PMID: 20842917 Ref: Colorectal gastrointestinal stromal tumor. PMID: 20967481 Ref: Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of 2-indolinone derivatives. PMID: 21028894 Ref: Differential expression of aldehyde dehydrogenase 1a1 (ALDH1) in normal ovary and serous ovarian tumors. PMID: 21176222 Ref: [Curative resection for bulky rectal gastrointestinal stromal tumor after neoadjuvant imatinib mesylate]. PMID: 21224658 |
Ref: Dasatinib: an anti-tumour agent via Src inhibition. PMID: 21226671 Ref: Apoptotic effect of imatinib on human colon adenocarcinoma cells: influence on actin cytoskeleton organization and cell migration. PMID: 21658383 Ref: Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. PMID: 21670084 Ref: Cathepsin L is highly expressed in gastrointestinal stromal tumors. PMID: 21769426 Ref: Rectal hemangiopericytoma in a 37-year-old woman: a case report and review of the literature. PMID: 21819590 Ref: Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling. PMID: 21949247 Ref: Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors. PMID: 22174910 Ref: [A case of amelanotic anorectal malignant melanoma mimicking gastrointestinal stromal tumor]. PMID: 22189238 |
Ref: Perivascular epithelioid cell tumor of the sigmoid colon with transcription factor E3 expression. PMID: 21546294 Ref: Critical comments for roles of biomarkers in the diagnosis and treatment of cancer. PMID: 21652149 Ref: Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1. PMID: 21977032 Ref: Role of ancillary studies in fine-needle aspiration from selected tumors. PMID: 22045615 Ref: A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors. PMID: 22421192 Ref: Regorafenib for cancer. PMID: 22577890 Ref: High-risk CD117-positive gastrointestinal stromal tumor of the colon in a 12-year-old girl: adjuvant treatment with imatinib mesylate. PMID: 22678007 Ref: The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment. PMID: 23173124 Ref: Is there currently an established role for the use of predictive or prognostic molecular markers in the management of colorectal cancer? A point/counterpoint. PMID: 24451733 |
Ref: Clinicopathological features and prognostic factors of rectal gastrointestinal stromal tumors. PMID: 23288714 Ref: Clinical and endoscopic features of angiosarcoma of the colon: two case reports and a review of the literature. PMID: 23397573 Ref: Histopathologic study of the rectum in 1,464 consecutive rectal specimens in a single Japanese hospital: II. malignant lesions. PMID: 23412998 Ref: Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma. PMID: 23437326 Ref: Prognostic value of changes in the expression of stem cell markers in the peripheral blood of patients with colon cancer. PMID: 23545848 Ref: Critical appraisal of the use of regorafenib in the management of colorectal cancer. PMID: 23610528 Ref: Protein kinase C-delta-mediated recycling of active KIT in colon cancer. PMID: 23881925 Ref: Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells. PMID: 23900414 Ref: c-Kit is suppressed in human colon cancer tissue and contributes to L1-mediated metastasis. PMID: 24008320 Ref: Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. PMID: 24009080 |
Ref: Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update. PMID: 23852704 Ref: Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. PMID: 24584270 Ref: High-mobility group AT-hook 2: an independent marker of poor prognosis in intrahepatic cholangiocarcinoma. PMID: 25245603 Ref: A case of a gastrointestinal stromal tumor with skeinoid fibers of the sigmoid colon. PMID: 25408627 |
Ref: Fluorescence virus-guided capturing system of human colorectal circulating tumour cells for non-invasive companion diagnostics. PMID: 24870621 Ref: Novel molecular insights from routine genotyping of colorectal carcinomas. PMID: 25683705 Ref: 3-(Benzo[d][1,3]dioxol-5-ylamino)-N-(4-fluorophenyl)thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P-glycoprotein efflux pump activity. PMID: 25758415 Ref: Laparoscopic resection of schwannoma of the ascending colon. PMID: 25759634 Ref: Established and Potential Predictive Biomarkers in Gastrointestinal Cancer--c-Kit, Her2, Ras and Beyond. PMID: 25924988 Ref: Maintenance of Clonogenic KIT(+) Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells. PMID: 25962936 Ref: KIT Signaling Promotes Growth of Colon Xenograft Tumors in Mice and Is Up-Regulated in a Subset of Human Colon Cancers. PMID: 26026391 Ref: Synchronous occurrence of ileal stromal tumor (GIST) and colonic adenocarcinoma: a case report. PMID: 26076794 Ref: Clinical Validation of a Multiplex Kit for RAS Mutations in Colorectal Cancer: Results of the RASKET (RAS KEy Testing) Prospective, Multicenter Study. PMID: 26137573 Ref: LIVER METASTASIS OF A GASTROINTESTINAL STROMAL TUMOR OF LARGE BOWEL: CASE REPORT. PMID: 26204643 Ref: Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia. PMID: 26206183 Ref: [Expression of TMEM16A in the colon of intractable functional constipation patients and its clinical implications]. PMID: 26211778 Ref: c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer. PMID: 26226570 Ref: Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach. PMID: 26227479 Ref: Aberrant expressions of c-KIT and DOG-1 in mucinous and nonmucinous colorectal carcinomas and relation to clinicopathologic features and prognosis. PMID: 26272691 Ref: C-kit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model. PMID: 26356816 Ref: Tryptase-positive and CD117 Positive Mast Cells Correlate with Survival in Patients with Liver Metastasis. PMID: 26408693 Ref: Perivascular Interstitial Cells of Cajal in Human Colon. PMID: 28247865 |
Ref: Involvement of Notch-1 in Resistance to Regorafenib in Colon Cancer Cells. PMID: 26419617 Ref: Targeting c-kit receptor in neuroblastomas and colorectal cancers using stem cell factor (SCF)-based recombinant bacterial toxins. PMID: 26428235 Ref: EBI-907, a novel BRAF(V600E) inhibitor, has potent oral anti-tumor activity and a broad kinase selectivity profile. PMID: 26810733 Ref: Multikinase inhibitor regorafenib inhibits the growth and metastasis of colon cancer with abundant stroma. PMID: 26865419 Ref: Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology. PMID: 26968814 Ref: Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. PMID: 27218826 Ref: [Rectal gastrointestinal stromal tumor: a clinical and pathologic analysis]. PMID: 27430691 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Targeted ultra-deep sequencing unveils a lack of driver-gene mutations linking non-hereditary gastrointestinal stromal tumors and highly prevalent second primary malignancies: random or nonrandom, that is the question. PMID: 27806309 Ref: Perivascular epithelioid cell tumor of the descending colon mimicking a gastrointestinal stromal tumor: a case report. PMID: 27842558 |
Ref: Development of a gene panel for next-generation sequencing of clinically relevant mutations in cell-free DNA from cancer patients. PMID: 28170370 Ref: Subepithelial rectal gastrointestinal stromal tumor - the use of endoscopic ultrasound-guided fine needle aspiration to establish a definitive cytological diagnosis: a case report. PMID: 28259173 Ref: Rational drug design of indazole-based diarylurea derivatives as anticancer agents. PMID: 28338292 Ref: A Novel Diagnostic Tool for Selecting Patients With Mesenchymal-Type Colon Cancer Reveals Intratumor Subtype Heterogeneity. PMID: 28376187 Ref: Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. PMID: 28377632 Ref: SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal Carcinoma. PMID: 28383479 Ref: Clinicopathological characteristics of KIT and protein kinase C-delta expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour. PMID: 28561935 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Altered expression of cytokeratin 7 and CD117 in transitional mucosa adjacent to human colorectal cancer. PMID: 28693143 Ref: Rectal carcinoma and multiple gastrointestinal stromal tumors (GIST) of the small intestine in a patient with neurofibromatosis type 1: a case report. PMID: 28835241 Ref: A transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers. PMID: 29147625 |
Ref: Expanding the Spectrum of Colonic Manifestations in Tuberous Sclerosis: L-Cell Neuroendocrine Tumor Arising in the Background of Rectal PEComa. PMID: 28733877 Ref: A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. PMID: 29194591 Ref: Design, synthesis, biological assessment and molecular docking studies of new 2-aminoimidazole-quinoxaline hybrids as potential anticancer agents. PMID: 29310028 Ref: MicroRNA hsa-let-7e-5p as a potential prognosis marker for rectal carcinoma with liver metastases. PMID: 29731866 Ref: Implementation of next generation sequencing technology for somatic mutation detection in routine laboratory practice. PMID: 29752127 Ref: SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma. PMID: 29786668 Ref: Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers. PMID: 30032643 Ref: SCF/c-KIT signaling promotes mucus secretion of colonic goblet cells and development of mucinous colorectal adenocarcinoma. PMID: 30034943 Ref: Management of a case of high-risk gastrointestinal stromal tumor in rectum by transanal minimal invasive surgery. PMID: 30098596 Ref: The gene mutational discrepancies between primary and paired metastatic colorectal carcinoma detected by next-generation sequencing. PMID: 30171333 Ref: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases. PMID: 30202242 Ref: [Relationship between c-kit mRNA expression and prognosis in patients with rectal carcinoma]. PMID: 30293390 Ref: (+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer. PMID: 30298093 Ref: Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer. PMID: 30336768 |