Primary Site >> Colorectal Cancer
Gene >> IL6
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Ref: Pathogenesis of rat colon carcinomas induced by N-methyl-N-nitrosourea. PMID: 278854 |
Ref: The effect of disulfiram on the carcinogenicity of 3,2'dimethyl-4-aminopbiphenyl in Syrian golden hamsters and rats. PMID: 7197594 |
Ref: Role of administration route in the therapeutic efficacy of doxifluridine. PMID: 2950266 |
Ref: Interleukin-6 and its receptor are expressed in human intestinal epithelial cells. PMID: 1970694 Ref: Characterization of the synergistic antiproliferative effects of interferon-gamma and tumor necrosis factor on human colon carcinoma cell lines. PMID: 2111352 Ref: Investigation of cytokine gene expression in human colorectal cancer. PMID: 2114216 |
Ref: Adjuvant adoptive immunotherapy with IL2 and lymphocytes from tumor-bearing mice: in vitro tumor-stimulated lymphocytes are more effective than LAK cells. PMID: 1787836 Ref: Human recombinant interleukin-6 enhances antibody-dependent cellular cytotoxicity of human tumor cells mediated by human peripheral blood mononuclear cells. PMID: 1836975 Ref: Elevated circulating interleukin-6 is associated with an acute-phase response but reduced fixed hepatic protein synthesis in patients with cancer. PMID: 1898691 Ref: Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines. PMID: 1918946 Ref: Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients. PMID: 2021932 |
Ref: Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. PMID: 1321338 Ref: Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1. PMID: 1389533 Ref: Hepatic metastasis alters the immune function of murine liver nonparenchymal cells. PMID: 1444795 Ref: Identification of a protein factor secreted by 3T3-L1 preadipocytes inhibitory for the human MCF-7 breast cancer cell line. PMID: 1458474 Ref: Interleukin-6 increases carcinoembryonic antigen and histocompatibility leukocyte antigen expression on the surface of human colorectal carcinoma cells. PMID: 1477074 Ref: [Clinical studies on locoregional immunochemotherapy of peritonitis carcinomatosa]. PMID: 1530341 Ref: Mechanisms of experimental cancer cachexia. Interaction between mononuclear phagocytes and colon-26 carcinoma and its relevance to IL-6-mediated cancer cachexia. PMID: 1534101 |
Ref: Transfer of the IL-6 gene into a human colorectal carcinoma cell line and consequent enhancement of tumor antigen expression. PMID: 8102353 Ref: Homoharringtonine induces heat protection and facilitates dissociation of heat shock transcription factor and heat shock element complex. PMID: 8267568 Ref: Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression. PMID: 8344757 Ref: Mechanisms of experimental cancer cachexia. Local involvement of IL-1 in colon-26 tumor. PMID: 8450216 Ref: Effect of cytokines on the epithelial function of the human colon carcinoma cell line HT29 cl 19A. PMID: 8504961 Ref: Superantigen-induced cytokines suppress growth of human colon-carcinoma cells. PMID: 8509223 |
Ref: Mechanism of quercetin-induced suppression and delay of heat shock gene expression and thermotolerance development in HT-29 cells. PMID: 7845388 Ref: Multifocal inflammatory leukoencephalopathy associated with levamisole and 5-fluorouracil: case report. PMID: 7885561 Ref: Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. PMID: 8011699 Ref: Effect of staurosporine on the transcription of HSP70 heat shock gene in HT-29 cells. PMID: 8037750 Ref: Inhibition of CT-26 murine adenocarcinoma growth in the rectum of mice treated with recombinant human interleukin-6. PMID: 8061898 Ref: Correlation between the capacity to activate macrophages in vitro and the antitumor activity in vivo of lipopolysaccharides from different bacterial species. PMID: 8088853 Ref: Effect of human bowel wall distension on translocation of indigenous bacteria and endotoxins. PMID: 8131684 Ref: In vivo cytokine production and recombinant interleukin 2 immunotherapy: an insight into the possible mechanisms underlying clinical responses. PMID: 8198981 Ref: Hepatocyte growth factor stimulates invasion across reconstituted basement membranes by a new human small intestinal cell line. PMID: 8306528 |
Ref: The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells. PMID: 7600527 Ref: Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth. PMID: 7674335 Ref: Establishment and characterization of cachexia-inducing and -non-inducing clones of murine colon 26 carcinoma. PMID: 7759158 Ref: Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic antigen (CEA) and HLA expression by human colorectal carcinoma cells: role for endogenous IFN-beta. PMID: 7780031 Ref: Phase I trial of escalating doses of interleukin-1 beta in combination with a fixed dose of interleukin-2. PMID: 7844609 Ref: Modulation of the cytokine and acute-phase response to major surgery by recombinant interleukin-2. PMID: 7881967 |
Ref: Antibody-targeted superantigen therapy induces tumor-infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma. PMID: 8566049 Ref: Antitumor effect induced by the expression of granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells. PMID: 8620478 Ref: Disregulation in TH1 and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. PMID: 8625361 Ref: [Prolongation of survival and antitumor activity of antitumor drugs in murine cancer cachexia model]. PMID: 8678537 Ref: Murine interleukin-12 prevents the development of cancer cachexia in a murine model. PMID: 8824558 Ref: Modulation of the plasminogen activation system by inflammatory cytokines in human colon carcinoma cells. PMID: 8826848 Ref: Structure and function of sinusoidal lining cells in the liver. PMID: 8839287 Ref: Carcinoembryonic antigen induces cytokine expression in Kuppfer cells: implications for hepatic metastasis from colorectal cancer. PMID: 8841002 Ref: Elevated serum interleukin-6 and decreased thyroid hormone levels in postoperative patients and effects of IL-6 on thyroid cell function in vitro. PMID: 9001195 Ref: Release of cytokines by a fermented lectin-1 (ML-1) free mistletoe extract reflects differences in the reactivity of PBMC in healthy and allergic individuals and tumour patients. PMID: 9010693 Ref: Lentinan enhances sensitivity of mouse colon 26 tumor to cis-diamminedichloroplatinum (II) and decreases glutathione transferase expression. PMID: 9045947 Ref: Development of tumor B-cell lymphocyte hybridoma (TBH) autovaccination. Results of a phase I-II clinical trial. PMID: 10168565 Ref: Prognostic significance of immunological evaluation in colorectal cancer. PMID: 10851496 Ref: Necessity of biotherapeutic treatments inducing TH1 cell functions in colorectal cancer. PMID: 10851498 |
Ref: Preoperative total parenteral nutrition influences postoperative systemic cytokine responses after colorectal surgery. PMID: 9058440 Ref: The anti-human tumor effect and generation of human cytotoxic T cells in SCID mice given human peripheral blood lymphocytes by the in vivo transfer of the Interleukin-6 gene using adenovirus vector. PMID: 9102222 Ref: Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy. PMID: 9336744 Ref: Plasma interleukin-6 is not a mediator of changes in lipoprotein lipase activity in cancer patients. PMID: 9356883 Ref: In vitro toxicity studies with mitomycins and bleomycin on endothelial cells. PMID: 9402313 Ref: Construction and biological activity of a recombinant bispecific single-chain antibody designed for therapy of minimal residual colorectal cancer. PMID: 9435872 Ref: IL-10 and sIL-2R serum levels as possible peripheral blood prognostic markers in the passage from adenoma to colorectal cancer. PMID: 10851474 Ref: The role of the soluble CD30 serum level in colorectal cancer: a possible marker for a patient subset which could benefit from IL-2 biotherapy. PMID: 10851480 |
Ref: The significance of an increase in soluble interleukin-2 receptor level in colorectal cancer and its biological regulating role in the physiological switching of the immune response cytokine network from TH1 to TH2 and back. PMID: 9439647 Ref: Interleukin-6 levels in colorectal cancer tissues. PMID: 9673566 Ref: Laparoscopic-assisted vs. open surgery for colorectal cancer: comparative study of immune effects. PMID: 9678378 Ref: Serum hepatocyte growth factor as an index of disease status of patients with colorectal carcinoma. PMID: 9716026 Ref: Blood transfusion and postoperative serum interleukin-6 levels in colorectal cancer patients. PMID: 9755998 Ref: Relation between depression and circulating immune products in patients with advanced colorectal cancer. PMID: 9816354 Ref: Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosis in colorectal cancer. PMID: 9817250 Ref: Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. PMID: 9876070 Ref: Comparison of the effects of various clinically applied mistletoe preparations on peripheral blood leukocytes. PMID: 9893935 Ref: Adhesion of colorectal carcinoma cells to the endothelium is mediated by cytokines from CEA stimulated Kupffer cells. PMID: 10211983 |
Ref: Local expression of cytokines in human colorectal carcinoma: evidence of specific interleukin-6 gene expression. PMID: 9924696 Ref: Tumour inoculation site-dependent induction of cachexia in mice bearing colon 26 carcinoma. PMID: 10070867 Ref: Enhancement of antibody dependent cellular cytotoxicity (ADCC) by combination of cytokines. PMID: 10211790 Ref: Significance of pre-treatment immunological parameters in colorectal cancer patients with unresectable metastases to the liver. PMID: 10228796 Ref: pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis. PMID: 10328217 Ref: Serum interleukin-6 level reflects the tumor proliferative activity in patients with colorectal carcinoma. PMID: 10375098 Ref: Control of tumor development by intratumoral cytokines. PMID: 10397168 Ref: A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway. PMID: 10444430 Ref: Profile of circulating levels of interleukin-1 receptor antagonist and interleukin-6 in colorectal cancer patients. PMID: 10582766 Ref: Enhanced cytokine response to surgical trauma in patients with colorectal cancer. PMID: 11341603 |
Ref: The role of interleukin-6 in inhibition of lung metastasis in subcutaneous tumor-bearing mice. PMID: 10601594 Ref: Molecular pathology of cyclooxygenase-2 in neoplasia. PMID: 10678579 Ref: How should patients 80 years of age or older with colorectal carcinoma be treated? Long-term and short-term outcome and postoperative cytokine levels. PMID: 10696898 Ref: CRP, TNF-alpha, IL-1ra, IL-6, IL-8 and IL-10 in blood serum of colorectal cancer patients. PMID: 10749586 Ref: Systemic cytokine response after laparoscopic-assisted resection of rectosigmoid carcinoma: A prospective randomized trial. PMID: 10749610 Ref: Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer. PMID: 10761792 Ref: Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells. PMID: 10766420 Ref: Combinations of the cytokines IL-12, IL-2 and IFN-alpha significantly augment whereas the cytokine IL-4 suppresses the cytokine-induced antibody-dependent cellular cytotoxicity of monoclonal antibodies 17-1A and BR55-2. PMID: 10843759 Ref: Laparoscopic surgery preserves monocyte-mediated tumor cell killing in contrast to the conventional approach. PMID: 10858471 Ref: Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line. PMID: 10903137 Ref: Lens culinaris, Phaseolus vulgaris and vicia faba lectins specifically trigger IL-8 production by the human colon carcinoma cell line CACO-2. PMID: 10930314 Ref: Nutritional status and postoperative cytokine response in colorectal cancer patients. PMID: 10975992 Ref: Effect of colon carcinoma cell supernatants on cytokine production and phagocytic capacity. PMID: 10996732 Ref: Oxaliplatin-induced fever and release of IL-6. PMID: 11053984 Ref: Effect of laparotomy and laparoscopy on the establishment of lung metastasis in a murine model. PMID: 11056443 Ref: Tumor growth inhibition effect of hIL-6 on colon cancer cells transfected with the target gene by retroviral vector. PMID: 11819530 |
Ref: Influence of cytokines, monoclonal antibodies and chemotherapeutic drugs on epithelial cell adhesion molecule (EpCAM) and LewisY antigen expression. PMID: 11167991 Ref: IL-6 and IFN-gamma regulation of IL-10 production by human colon carcinoma cells. PMID: 11179490 Ref: Effect of inflammatory cytokines and growth factors on tumour cell adhesion to the peritoneum. PMID: 11276014 Ref: Immune-stimulating effects of low-dose perioperative recombinant granulocyte-macrophage colony-stimulating factor in patients operated on for primary colorectal carcinoma. PMID: 11298622 Ref: Role of tumor necrosis factor on toxicity and cytokine production after isolated hepatic perfusion. PMID: 11309322 Ref: Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. PMID: 11322385 Ref: Induction of alpha1-acid glycoprotein mRNA by cytokines and differentiation in human colon carcinoma cell. PMID: 11355696 Ref: Acute phase response in laparoscopic and open colectomy in colon cancer: randomized study. PMID: 11357021 Ref: [Dynamics of leptin plasma levels after abdominal surgical procedures]. PMID: 11482152 Ref: Pharmacokinetic study of a gallium-porphyrin photo- and sono-sensitizer, ATX-70, in tumor-bearing mice. PMID: 11572768 Ref: Serum factors attenuating the anti-tumor activity of 5-fluorouracil. PMID: 11603002 Ref: Autoreactivity against interleukin 6 as a risk factor in elderly patients with colorectal carcinoma. PMID: 11695972 Ref: Bacterial lipopolysaccharide induces transforming growth factor beta and hepatocyte growth factor through toll-like receptor 2 in cultured human colon cancer cells. PMID: 11725828 Ref: Changes in T cell subsets, interleukin-6 and C-reactive protein after laparoscopic and open colorectal resection for malignancy. PMID: 11727135 Ref: [The levels of selected cytokines in patients with colorectal cancer--a preliminary report]. PMID: 11770312 Ref: Abrogation of surgery-induced IL-6 hypersecretion by presurgical immunotherapy with IL-2 and its importance in the prevention of postoperative complications. PMID: 11860226 |
Ref: Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery. PMID: 11846459 Ref: Chronic immune activation and inflammation in the pathogenesis of AIDS and cancer. PMID: 11883529 Ref: Decreased production of interleukin-12 and type 2 immune responses are marked in cachectic patients with colorectal and gastric cancer. PMID: 11907352 Ref: Intra-tumoral interleukin-6 down-regulation system and genetic mutations of tumor suppressor genes in colorectal carcinoma. PMID: 11920517 Ref: [Dynamic of IL-6 and IL-8 concentrations in patients after surgery treated with total parenteral nutrition]. PMID: 11957802 Ref: Anticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26/clone 20 adenocarcinoma. PMID: 11979446 Ref: Immunomodulatory changes in patients with colorectal cancer. PMID: 12018452 Ref: Circulating levels of interleukin-10 and interleukin-6 in gastric and colon cancer patients before and after surgery: relationship with radicality and outcome. PMID: 12034030 Ref: Systemic interleukin-6 response to colorectal surgery originates from the bowel. PMID: 12119524 Ref: Oxaliplatin may induce cytokine-release syndrome in colorectal cancer patients. PMID: 12144121 Ref: Cell surface phenotyping and cytokine production of Epstein-Barr Virus (EBV)-transformed lymphoblastoid cell lines (LCLs). PMID: 12191505 Ref: Molecular analysis of lipid-depleting factor in a colon-26-inoculated cancer cachexia model. PMID: 12209586 Ref: Raltitrexed treatment promotes systemic inflammatory reaction in patients with colorectal carcinoma. PMID: 12237767 Ref: Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes. PMID: 12349828 Ref: Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: a mechanism for metastatic initiation? PMID: 12384057 Ref: The soluble tumor necrosis factor receptor I is an early predictor of local infective complications after colorectal surgery. PMID: 12405162 Ref: Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints. PMID: 12414631 Ref: Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer. PMID: 12454774 Ref: [Cytokines and soluble cytokine receptors in the perioperative period]. PMID: 12688152 |
Ref: Circulating interleukin-6 predicts survival in patients with metastatic breast cancer. PMID: 12494472 Ref: Serum C-reactive protein correlates with survival in colorectal cancer patients but is not an independent prognostic indicator. PMID: 12655256 Ref: Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. PMID: 12727794 Ref: Peritoneal release of TNFalpha and IL-6 after elective colorectal surgery and anastomotic leakage. PMID: 12746189 Ref: Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer. PMID: 12753152 Ref: Expression of interleukin 6 and its receptor in human gastric and colorectal cancers. PMID: 12760309 Ref: -174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. PMID: 12796383 Ref: Intensification of antitumor effect by T helper 1-dominant adoptive immunogene therapy for advanced orthotopic colon cancer. PMID: 12796406 Ref: Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. PMID: 12839942 Ref: Detrimental immunologic effects of preoperative chemoradiotherapy in advanced rectal cancer. PMID: 12847360 Ref: Persistence of epidermal growth factor receptor and interleukin 10 in blood of colorectal cancer patients after surgery identifies patients with high risk to relapse. PMID: 12855647 Ref: Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. PMID: 12856716 Ref: Serum interleukin-6 levels reflect the disease status of colorectal cancer. PMID: 12884234 Ref: Association between serum carcinoembryonic antigen and endothelial cell adhesion molecules in colorectal cancer. PMID: 12931019 Ref: [Intra-tumoral IL-6 down-regulation system as a new therapeutic target to control tumor growth in colorectal carcinoma]. PMID: 14574939 Ref: Identification of a carcinoembryonic antigen binding protein on monocytes. PMID: 14592416 Ref: Minilaparotomy may be independently associated with reduction in inflammatory responses after resection for colorectal cancer. PMID: 14593231 Ref: Effects of major liver resection, with or without recombinant bactericidal/permeability-increasing protein (rBPI21), on the angiogenic profile of patients with metastatic colorectal carcinoma. PMID: 14598357 Ref: Locoregional immunotherapy of malignant effusion from colorectal cancer using the streptococcal preparation OK-432 plus interleukin-2: induction of autologous tumor-reactive CD4+ Th1 killer lymphocytes. PMID: 14612896 Ref: Treatment of human solid malignancies with autologous activated lymphocytes and cimetidine: a phase II trial of the cancer biotherapy research group. PMID: 14629821 Ref: Interleukin-1beta (IL-1beta) and IL-6 modulate insulin-like growth factor-binding protein (IGFBP) secretion in colon cancer epithelial (Caco-2) cells. PMID: 14656210 Ref: Comparative evaluation of immune response after laparoscopical and open total mesorectal excisions with anal sphincter preservation in patients with rectal cancer. PMID: 14669314 |
Ref: The effects of surgery, with or without rhGM-CSF, on the angiogenic profile of patients treated for colorectal carcinoma. PMID: 14693162 Ref: Serum monocyte chemoattractant protein-1 in patients with postoperative infectious complications from gastrointestinal surgery for cancer. PMID: 14708051 Ref: Breast cancer cells induce osteoclast formation by stimulating host IL-11 production and downregulating granulocyte/macrophage colony-stimulating factor. PMID: 14999770 Ref: Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs. PMID: 15010828 Ref: Recruitment of STAT3 for production of IL-10 by colon carcinoma cells induced by macrophage-derived IL-6. PMID: 15034082 Ref: Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes. PMID: 15077188 Ref: Regulation of cytokine production in carcinoembryonic antigen stimulated Kupffer cells by beta-2 adrenergic receptors: implications for hepatic metastasis. PMID: 15159029 Ref: The traditional diet of Greece and cancer. PMID: 15167223 Ref: The pattern of cytokine gene expression in human colorectal carcinoma. PMID: 15188028 Ref: Carcinoembryonic antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal carcinoma cells. PMID: 15221959 Ref: Decreased interleukin-1 receptor antagonist response following moderate exercise in patients with colorectal carcinoma after primary treatment. PMID: 15225901 Ref: IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. PMID: 15284182 Ref: C-reactive protein as a prognostic variable that reflects uncontrolled up-regulation of the IL-1-IL-6 network system in colorectal carcinoma. PMID: 15309885 Ref: Adequate nourishment through total parenteral nutrition treatment may augment immune function in patients with colon cancer. PMID: 15325502 Ref: Effects of G-CSF and antibiotic prophylaxis in a 2 x 2 factorial design on outcome in septic rats. PMID: 15338063 Ref: Suppression of cancer cachexia by 20S,21-epoxy-resibufogenin-3-acetate-a novel nonpeptide IL-6 receptor antagonist. PMID: 15381112 Ref: Influence of proinflammatory cytokines on the adhesion of human colon carcinoma cells to lung microvascular endothelium. PMID: 15386356 Ref: Dependence of positive effects of granulocyte colony-stimulating factor on the antibiotic regimen: evaluation in rats with polymicrobial peritonitis. PMID: 15457367 Ref: TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. PMID: 15485627 Ref: Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery. PMID: 15502050 Ref: [Variation of cytokines with administration of chemotherapeutic and immuno-therapeutic drugs for colorectal cancer]. PMID: 15553673 Ref: [Complex forms of immune insufficiency to some cytokines (TNF-alpha, interferons) in colorectal cancers as exemplified by the COLO 205 cell line. Mechanism of resistance with special reference to signaling proteins and cytokines]. PMID: 15577750 Ref: Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines. PMID: 15630177 Ref: The effect of Edrecolomab (Mo17-1A) or fluorouracil-based chemotherapy on specific immune parameters in patients with colorectal cancer. A comparative study. PMID: 15713997 Ref: Carcinoembryonic antigen promotes tumor cell survival in liver through an IL-10-dependent pathway. PMID: 16035616 |
Ref: No inhibition of IL-27 signaling by soluble gp130. PMID: 15607729 Ref: Deficiency in systemic interleukin-1 receptor antagonist production as an operative risk factor in malnourished elderly patients with colorectal carcinoma. PMID: 15644666 Ref: IL-6 signaling promotes tumor growth in colorectal cancer. PMID: 15655344 Ref: MET signalling in primary colon epithelial cells leads to increased transformation irrespective of aberrant Wnt signalling. PMID: 15785735 Ref: Intraperitoneal cytokine productions and their relationship to peritoneal sepsis and systemic inflammatory markers in patients with inflammatory bowel disease. PMID: 15785898 Ref: Serum IL-6, TNFalpha and CRP levels in Greek colorectal cancer patients: prognostic implications. PMID: 15786541 Ref: IL-6 transsignaling: the in vivo consequences. PMID: 15871661 Ref: Possible role of REG Ialpha protein in ulcerative colitis and colitic cancer. PMID: 15914572 Ref: Interleukin-5 potentiates the growth response of Caco-2 cells to IGF-II: a role in colonic carcinogenesis complicating ulcerative colitis? PMID: 15935984 Ref: The effect of granulocyte macrophage-colony stimulating factor on bacterial translocation after administration of 5-fluorouracil in rats. PMID: 15975592 Ref: Clinical significance of serum cytokine measurements in untreated colorectal cancer patients: soluble tumor necrosis factor receptor type I--an independent prognostic factor. PMID: 16006772 Ref: Chinese herbal formula, Bing De Ling, enhances antitumor effects and ameliorates weight loss induced by 5-fluorouracil in the mouse CT26 tumor model. PMID: 16008516 Ref: Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis. PMID: 16012947 Ref: Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. PMID: 16036105 Ref: Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. PMID: 16129903 Ref: Enhanced production of interleukin 6 in peripheral blood monocytes stimulated with mucins secreted into the bloodstream. PMID: 16144911 Ref: [Effect of immune-enhanced enteral diet on postoperative immunological function in patients with colorectal cancer]. PMID: 16167254 Ref: Differentiation-dependent expression and mitogenic action of interleukin-6 in human colon carcinoma cells: relevance for tumour progression. PMID: 16176872 Ref: Suppression of progression and metastasis of established colon tumors in mice by intravenous delivery of short interfering RNA targeting KITENIN, a metastasis-enhancing protein. PMID: 16204073 Ref: Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. PMID: 16214925 Ref: [Evaluation of the minimal invasiveness of laparoscopic operation for colorectal carcinoma]. PMID: 16224652 Ref: [Usefulness in predicting parameters for the selection of responders who received immunochemotherapy with PSK in patients with colorectal cancer]. PMID: 16315871 Ref: [Dendritic cells reduce the number and function of CD4+CD25+ cells in cytokine-induced killer cells]. PMID: 16405818 |
Ref: Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs. PMID: 16395669 Ref: Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice. PMID: 16424015 Ref: Interleukin-6 level in patients with colorectal cancer. PMID: 16442710 Ref: Perioperative allogeneic blood transfusion, the related cytokine response and long-term survival after potentially curative resection of colorectal cancer. PMID: 16477921 Ref: Genomic instability and tissue expression of angiogenic growth factors in sporadic colorectal cancer. PMID: 16546493 Ref: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line. PMID: 16597643 Ref: Influence of major surgery on the mannan-binding lectin pathway of innate immunity. PMID: 16634797 Ref: Interleukin-6 trans-signalling in chronic inflammation and cancer. PMID: 16640655 Ref: Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling. PMID: 16716147 Ref: Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness. PMID: 16774945 Ref: Inflammation-related gene polymorphisms and colorectal adenoma. PMID: 16775170 Ref: Profiling adipocytokine secretion from creeping fat in Crohn's disease. PMID: 16775490 Ref: Effect of milk fermented with a Lactobacillus helveticus R389(+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice. PMID: 16831211 Ref: Molecular responses of rectal cancer to preoperative chemoradiation. PMID: 16905208 Ref: Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer. PMID: 16937502 Ref: Clinical significance of tissue expression of interleukin-6 in colorectal carcinoma. PMID: 17094421 Ref: Site-specific patterns of surgical site infections and their early indicators after elective colorectal cancer surgery. PMID: 17106815 Ref: Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. PMID: 17178849 Ref: Study of interleukin-6 in the spread of colorectal cancer: the diagnostic significance of IL-6. PMID: 17189976 Ref: Influence of interleukin-6 on the invasiveness of human colorectal carcinoma. PMID: 17201185 |
Ref: Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models. PMID: 17009035 Ref: Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial. PMID: 17021855 Ref: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. PMID: 17143621 Ref: Relationship between soluble P-selectin and inflammatory factors (interleukin-6 and C-reactive protein) in colorectal cancer. PMID: 17169411 Ref: Prevention of cancer cachexia by pyrrolidine dithiocarbamate (PDTC) in colon 26 tumor-bearing mice. PMID: 17202436 Ref: Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells. PMID: 17210703 Ref: Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, WXC-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases. PMID: 17242699 Ref: Activation of human peritoneal immune cells in early stages of gastric and colon cancer. PMID: 17263978 Ref: Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. PMID: 17297444 Ref: Preoperative interleukin-6 production by mononuclear blood cells predicts survival after radical surgery for colorectal carcinoma. PMID: 17345614 Ref: Cytotoxic activity and absence of tumor growth stimulation of standardized mistletoe extracts in human tumor models in vitro. PMID: 17352237 Ref: Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. PMID: 17394066 Ref: Lack of association between genetic polymorphisms in cytokine genes and disease expression in patients with hereditary non-polyposis colorectal cancer. PMID: 17454884 Ref: Metabolic syndrome and gastrointestinal diseases. PMID: 17464454 Ref: Distinct changes of dendritic cell number and IL-12 mRNA level in adjacent mucosa throughout the colorectal adenoma-carcinoma sequence. PMID: 17579859 Ref: Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid hormone-related protein in colon 26 carcinoma. PMID: 17645771 Ref: Effect of perioperative allogeneic red blood cell transfusion on the immune-inflammatory response after colorectal cancer resection. PMID: 17671807 Ref: IL6 genotypes and colon and rectal cancer. PMID: 17694420 Ref: Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. PMID: 17724375 Ref: Inhibitory effect of phytoglycoprotein on tumor necrosis factor-alpha and interleukin-6 at initiation stage of colon cancer in 1,2-dimethylhydrazine-treated ICR mice. PMID: 17868752 Ref: [Clinical significance of interleukin-6 (IL-6) as a prognostic factor of cancer disease]. PMID: 18030875 Ref: How relevant are cytokines in colorectal cancer wasting? PMID: 18032977 Ref: [Anticancer immunotherapy using inactivated Sendai virus particles]. PMID: 18040151 Ref: Obesity, metabolic syndrome, and prostate cancer. PMID: 18265478 |
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PMID: 28348483 Ref: Strong association of interleukin-6 -174G/C promoter single nucleotide polymorphism with a decreased risk of colorectal cancer in ethnic Kashmiri population: A case control study. PMID: 28349833 Ref: Ameliorative effects of pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma. PMID: 28358223 Ref: Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells. PMID: 28386381 Ref: EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients. PMID: 28400195 Ref: Cytokine-induced killer cells/dendritic cells-cytokine induced killer cells immunotherapy combined with chemotherapy for treatment of colorectal cancer in China: a meta-analysis of 29 trials involving 2,610 patients. PMID: 28404886 Ref: Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice. PMID: 28420165 Ref: Expression of A-kinase anchor protein 13 and Rho-associated coiled-coil containing protein kinase in restituted and regenerated mucosal epithelial cells following mucosal injury and colorectal cancer cells in mouse models. PMID: 28434818 Ref: Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan. PMID: 28454924 Ref: Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice. PMID: 28468928 Ref: Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors. PMID: 28475119 Ref: Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer. PMID: 28476816 Ref: Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice. PMID: 28481246 Ref: Z-505 hydrochloride, an orally active ghrelin agonist, attenuates the progression of cancer cachexia via anabolic hormones in Colon 26 tumor-bearing mice. PMID: 28529141 Ref: Expression of pattern recognition receptor genes and mortality in patients with colorectal adenocarcinoma. PMID: 28533893 Ref: Reelin protects from colon pathology by maintaining the intestinal barrier integrity and repressing tumorigenic genes. PMID: 28572005 Ref: FOLFOX regimen plus dendritic cells-cytokine-induced killer cells immunotherapy for the treatment of colorectal cancer: a meta-analysis. PMID: 28572734 Ref: Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance. PMID: 28576788 Ref: Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors. PMID: 28584401 Ref: Prognostic significance of SOCS3 and its biological function in colorectal cancer. PMID: 28603075 Ref: Potentially probiotic Lactobacillus strains with anti-proliferative activity induce cytokine/chemokine production and neutrophil recruitment in mice. PMID: 28618861 Ref: Visfatin mediates doxorubicin resistance in human colorectal cancer cells via up regulation of multidrug resistance 1 (MDR1). PMID: 28667355 Ref: Proinflammatory Cytokines IL-6 and TNF-alpha Increased Telomerase Activity through NF-kappaB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells. PMID: 28676732 Ref: Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression. PMID: 28680090 Ref: Cytotoxicity against tumor cell lines and anti-inflammatory properties of chitinases from Calotropis procera latex. PMID: 28698893 Ref: CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis. PMID: 28700533 Ref: Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista. PMID: 28711499 Ref: Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling. PMID: 28725043 Ref: Curcumin and Salsalate Suppresses Colonic Inflammation and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated Mice. PMID: 28745498 Ref: Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy. PMID: 28749573 Ref: Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. PMID: 28759012 Ref: Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. PMID: 28759385 Ref: Septic Complications after Resection for Middle or Low Rectal Cancer: Role of Gut Barrier Function and Inflammatory Serum Markers. PMID: 28768258 Ref: Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/beta-catenin signaling. PMID: 28783170 Ref: Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis. PMID: 28784136 Ref: Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis. PMID: 28826099 Ref: Upregulation of Treg-Related Genes in Addition with IL6 Showed the Significant Role for the Distant Metastasis in Colorectal Cancer. PMID: 28868572 Ref: Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice. PMID: 28881611 Ref: [Early versus traditional postoperative oral feeding in patients undergoing elective colorectal surgery: a meta-analysis of safety and efficacy]. PMID: 28901001 Ref: Tumor location impacts immune response in mouse models of colon cancer. PMID: 28903381 Ref: Gut Microbe-Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. PMID: 28917668 Ref: Pro-inflammatory chitosan/poly(gamma-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity. PMID: 28919508 Ref: The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-Derived IL6. PMID: 28928161 Ref: Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. PMID: 28928376 Ref: IL-8 Is Involved in Estrogen-Related Receptor alpha-Regulated Proliferation and Migration of Colorectal Cancer Cells. PMID: 28993941 Ref: S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. PMID: 29108270 Ref: TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis. PMID: 29118756 Ref: High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer. PMID: 29131521 Ref: Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Inflammatory Markers in Colorectal Cancer Surgery: A Prospective Cohort Study. PMID: 29133757 Ref: Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-kappaB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis. PMID: 29198745 Ref: MiR-92a promotes stem cell-like properties by activating Wnt/beta-catenin signaling in colorectal cancer. PMID: 29254202 Ref: Autophagy-related gene expression in colorectal cancer patients. PMID: 29254294 Ref: Quick rehabilitation nursing improves the recovery of colon cancer patients after laparoscopy. PMID: 29254317 Ref: Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice. PMID: 29326691 Ref: Phosphorylation of STAT3 Promotes Vasculogenic Mimicry by Inducing Epithelial-to-Mesenchymal Transition in Colorectal Cancer. PMID: 29333928 Ref: Association of Ozone with 5-Fluorouracil and Cisplatin in Regulation of Human Colon Cancer Cell Viability: In Vitro Anti-Inflammatory Properties of Ozone in Colon Cancer Cells Exposed to Lipopolysaccharides. PMID: 29721026 |
Ref: Discovery of Novel 2-Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment. PMID: 28425852 Ref: Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines. PMID: 28438053 Ref: Strain-specific probiotic (microbial cell preparation) and omega-3 fatty acid in modulating quality of life and inflammatory markers in colorectal cancer patients: a randomized controlled trial. PMID: 28857425 Ref: Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy. PMID: 28969939 Ref: CCL26 Participates in the PRL-3-Induced Promotion of Colorectal Cancer Invasion by Stimulating Tumor-Associated Macrophage Infiltration. PMID: 29051319 Ref: Identification of PMN-released mutagenic factors in a co-culture model for colitis-associated cancer. PMID: 29106440 Ref: Wake-up Call to Clinicians: The Impact of Sleep Dysfunction on Gastrointestinal Health and Disease. PMID: 29189428 Ref: Inhibition of MK2 suppresses IL-1beta, IL-6, and TNF-alpha-dependent colorectal cancer growth. PMID: 29197088 Ref: Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis. PMID: 29203393 Ref: MicroRNA-6869-5p acts as a tumor suppressor via targeting TLR4/NF-kappaB signaling pathway in colorectal cancer. PMID: 29206292 Ref: The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells. PMID: 29222016 Ref: Colonic aberrant crypt formation accompanies an increase of opportunistic pathogenic bacteria in C57BL/6 mice fed a high-fat diet. PMID: 29223827 Ref: Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. PMID: 29229353 Ref: mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. PMID: 29275959 Ref: Protein Expression and Genetic Variation of IL32 and Association with Colorectal Cancer in Swedish Patients. PMID: 29277790 Ref: Effect of immunonutrition on colorectal cancer patients undergoing surgery: a meta-analysis. PMID: 29335838 Ref: Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning. PMID: 29338749 Ref: 133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. PMID: 29343721 Ref: Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling. 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