Primary Site >> Colorectal Cancer

Gene >> IL4R

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Ref: Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.
PMID: 1419612
 Ref: Growth inhibition of human colorectal-carcinoma cells by interleukin-4 and expression of functional interleukin-4 receptors.
PMID: 7927955
 Ref: Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells.
PMID: 8530527
 Ref: Inhibition of growth and enhancement of differentiation of colorectal carcinoma cell lines by MAb MR6 and IL-4.
PMID: 9178815
Ref: Regulation of 15-lipoxygenase expression by cytokines.
PMID: 9547609
 Ref: Regulatory effect of interleukin-4 and interleukin-13 on colon cancer cell adhesion.
PMID: 10817509
Ref: Enzymatic mutation detection in the P53 gene.
PMID: 11017933
 Ref: Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate.
PMID: 12503617
 Ref: Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk.
PMID: 17258448
 Ref: Lack of interleukin-4 receptor alpha chain-dependent signalling promotes azoxymethane-induced colorectal aberrant crypt focus formation in Balb/c mice.
PMID: 18220315
Ref: Interleukin promoter polymorphisms and prognosis in colorectal cancer.
PMID: 18448485
 Ref: Epithelial interleukin-4 receptor expression promotes colon tumor growth.
PMID: 20176658
 Ref: Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma.
PMID: 23437326
Ref: Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations.
PMID: 23784081
 Ref: Interleukin-4 receptor-targeted liposomal doxorubicin as a model for enhancing cellular uptake and antitumor efficacy in murine colorectal cancer.
PMID: 26436767