Primary Site >> Colorectal Cancer
Gene >> IL2
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Ref: Lymphokine-activated killer (LAK) cell phenomenon. IV. Lysis by LAK cell clones of fresh human tumor cells from autologous and multiple allogeneic tumors. PMID: 2989604 Ref: Lymphokine-activated killer (LAK) cells. Analysis of factors relevant to the immunotherapy of human cancer. PMID: 3871657 Ref: Interleukin generation in experimental colon cancer of rats: effects of tumor growth and tumor therapy. PMID: 3872959 Ref: Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. PMID: 3903508 Ref: Leu-11+ lymphocytes with natural killer (NK) activity are precursors of recombinant interleukin 2 (rIL 2)-induced activated killer (AK) cells. PMID: 3917475 Ref: Lymphokine-activated and natural killer cell activity in human intestinal mucosa. PMID: 3926882 |
Ref: [In vitro enhancement of cytotoxicity of human peripheral blood lymphocytes with recombinant interleukin 2 and an interferon mixture (alpha + beta + gamma) against human colon carcinoma cell line SW1116]. PMID: 3098183 Ref: Production of and response to interleukin-2 in peripheral blood lymphocytes of cancer patients. PMID: 3484660 Ref: A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2. PMID: 3526604 |
Ref: Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies. PMID: 2437198 Ref: Characterization of an immunosuppressive factor derived from colon cancer cells. PMID: 3104453 Ref: Therapy of cancer using the adoptive transfer of activated killer cells and interleukin-2. PMID: 3124451 Ref: Reduced incidence of hepatic metastases by perioperative treatment with recombinant human interleukin-2. PMID: 3496196 Ref: Human tumor cell lines with pleiotropic drug resistance are efficiently killed by interleukin-2 activated killer cells and by activated monocytes. PMID: 3496283 Ref: Severe hypovitaminosis C occurring as the result of adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells. PMID: 3496958 Ref: In vivo antitumor activity of tumor-infiltrating lymphocytes expanded in recombinant interleukin-2. PMID: 3500355 |
Ref: In vivo antitumor activity of multiple injections of recombinant interleukin 2, alone and in combination with three different types of recombinant interferon, on various syngeneic murine tumors. PMID: 2446744 Ref: An 80 to 85 kilodalton human phosphoglycoprotein associated with cell activation. PMID: 3183379 Ref: Susceptibility of chemoresistant murine and human tumor cells to lysis by interleukin 2-activated lymphocytes. PMID: 3258541 Ref: Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study. PMID: 3259261 Ref: [Adoptive immunotherapy of malignant disease using LAK cells]. PMID: 3260466 Ref: Laboratory correlates of adoptive immunotherapy with recombinant interleukin-2 and lymphokine-activated killer cells in humans. PMID: 3260537 Ref: Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells. PMID: 3262629 Ref: The hemodynamic effects of treatment with interleukin-2 and lymphokine-activated killer cells. PMID: 3264128 Ref: Lymphokine-activated killer (LAK) cells from human intestinal mucosa: cytotoxic activity against tumor cell lines and modified self but not autologous and allogeneic colon cancer cells. PMID: 3361887 |
Ref: Inhibition of lymphokine-activated killer cell generation by cultured tumor cell lines in vitro. PMID: 2462468 Ref: [Adoptive immunotherapy of advanced cancer patients with immune RNA-sensitized lymphocytes]. PMID: 2479817 Ref: Cytostatic and cytotoxic activity of lymphokine-activated killer cell supernatants. PMID: 2480843 Ref: Combination therapy of colon carcinoma 26 in mice with recombinant human interleukin-2 and interferon-alpha A/D: occurrence of large granular cells in the tumor. PMID: 2513305 Ref: Interleukin-2 and lymphokine-activated killer cell therapy of solid tumors: analysis of toxicity and management guidelines. PMID: 2647914 Ref: A monoclonal antibody (D612) with selective reactivity for malignant and normal gastro-intestinal epithelium. PMID: 2649441 Ref: Recombinant interleukin-2 by continuous infusion and adoptive transfer of recombinant interleukin-2-activated cells in patients with advanced cancer. PMID: 2661733 Ref: A phase-II trial of recombinant interleukin-2 and 5-FU chemotherapy in patients with metastatic colorectal carcinoma. PMID: 2670212 Ref: Experience with the use of high-dose interleukin-2 in the treatment of 652 cancer patients. PMID: 2679456 Ref: Influence of schedule of interleukin 2 administration on therapy with interleukin 2 and lymphokine activated killer cells. PMID: 2783243 Ref: Phase II trial of outpatient interleukin-2 in malignant lymphoma, chronic lymphocytic leukemia, and selected solid tumors. PMID: 2783339 Ref: Characterization of activated lymphocytes in colon cancer. PMID: 2783402 Ref: A phase I clinical trial of recombinant interleukin-2 by periodic 24-hour intravenous infusions. PMID: 2783732 Ref: Influence of the donors' clinical status on in vitro and in vivo tumor-cytotoxic activation of interleukin-2-exposed lymphocytes and their circulation in different organs. PMID: 2783888 Ref: Murine monoclonal IgG3 to human colorectal tumor-associated antigens: enhancement of antibody-dependent cell-mediated cytotoxicity by interleukin 2. PMID: 2785437 Ref: Phase I trial of recombinant interleukin-2 and recombinant beta-interferon in refractory neoplastic diseases. PMID: 2786553 Ref: Adriamycin-induced resistance to natural killer (NK)-mediated cytotoxicity. PMID: 2786743 Ref: Tolerance and effectiveness of recombinant interleukin-2 (r-met Hu IL-2 [ala-125]) and lymphokine-activated killer cells in patients with metastatic solid tumors. PMID: 2787749 Ref: Treatment of patients with advanced cancer using multiple long-term cultured lymphokine-activated killer (LAK) cell infusions and recombinant human interleukin-2. PMID: 2795092 Ref: Lymphokine-activated killer cell induction in tumor-infiltrating leukocytes from colon cancer patients. PMID: 2804913 |
Ref: Selective immunosuppressive action of a factor produced by colon cancer cells. PMID: 1698119 Ref: The clinical significance of interleukin-2. PMID: 2092277 Ref: Swainsonine, an inhibitor of glycoprotein processing, enhances cytotoxicity of large granular lymphocytes. PMID: 2108487 Ref: Lymphokine-activated killer cell cytotoxicity against human colon carcinomas enhanced by monoclonal antibody D612. PMID: 2123477 Ref: Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. PMID: 2137372 Ref: Granulocyte-monocyte colony-stimulating-factor augments the interleukin-2-induced cytotoxic activity of human lymphocytes in the absence and presence of mouse or chimeric monoclonal antibodies (mAb 17-1A). PMID: 2199042 Ref: Intraperitoneal lymphokine-activated killer-cell and interleukin-2 therapy for malignancies limited to the peritoneal cavity. PMID: 2213099 Ref: Phase I study of interleukin-2 and interferon alfa-2a as outpatient therapy for patients with advanced malignancy. PMID: 2213102 Ref: Paradoxical effects of 5-FU/folinic acid on lymphokine-activated killer (LAK) cell induction in patients with colorectal cancer. PMID: 2257211 Ref: Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine. PMID: 2290126 Ref: Tumor-infiltrating lymphocytes from human colon carcinomas. Functional and phenotypic characteristics after long-term culture in recombinant interleukin 2. PMID: 2295382 Ref: Adoptive immunotherapy of a mouse colon carcinoma with recombinant interleukin-2 alone or combined with lymphokine-activated killer cells or tumor-immune lymphocytes. Survival benefit of adjuvant post-surgical treatments and comparison with experimental m PMID: 2306753 Ref: Low-dose subcutaneous recombinant interleukin-2 in advanced human malignancy: a phase II outpatient study. PMID: 2334534 Ref: Evaluation of tetrazolium-based semiautomatic colorimetric assay for measurement of human antitumor cytotoxicity. PMID: 2340518 Ref: Time course of changes in phenotypes of cultured tumor-infiltrating lymphocytes isolated from human colorectal cancer. PMID: 2347471 Ref: Chimeric B72.3 mouse/human (IgG1) antibody directs the lysis of tumor cells by lymphokine-activated killer cells. PMID: 2386980 |
Ref: Natural killer cell stimulatory factor (NKSF) augments natural killer cell and antibody-dependent tumoricidal response against colon carcinoma cell lines. PMID: 1673486 Ref: The high lysability by LAK cells of colon-carcinoma cells resistant to doxorubicin is associated with a high expression of ICAM-1, LFA-3, NCA and a less-differentiated phenotype. PMID: 1706327 Ref: Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56). PMID: 1710251 Ref: Cell surface expression of ICAM-1 (CD54) and LFA-3 (CD58), two adhesion molecules, is up-regulated on bone marrow leukemic blasts after in vivo administration of high-dose recombinant interleukin-2. PMID: 1722705 Ref: Lymphokine-activated killer-cell-mediated killing of WiDr colon carcinoma cells is inhibited by K562 erythroleukemia cells. PMID: 1756146 Ref: Therapeutic use of a long-term cytotoxic T cell line recognizing a common tumour-associated antigen: the pattern of in vitro reactivity predicts the in vivo effect on different tumours. PMID: 1760812 Ref: Adjuvant adoptive immunotherapy with IL2 and lymphocytes from tumor-bearing mice: in vitro tumor-stimulated lymphocytes are more effective than LAK cells. PMID: 1787836 Ref: Immunological effects of levamisole in vitro. PMID: 1790137 Ref: Relapse after response to interleukin-2-based immunotherapy: patterns of progression and response to retreatment. PMID: 1790145 Ref: Factors influencing the establishment of tumour-infiltrating lymphocyte cultures from human breast carcinoma and colon carcinoma tissue. PMID: 1827279 Ref: Immunotherapy with IL2 by constant infusion and weekly doxorubicin. PMID: 1830717 Ref: Human recombinant interleukin-6 enhances antibody-dependent cellular cytotoxicity of human tumor cells mediated by human peripheral blood mononuclear cells. PMID: 1836975 Ref: Effects of cytokines on in vitro growth of tumor-infiltrating lymphocytes obtained from human primary and metastatic liver tumors. PMID: 1847844 Ref: Treatment of chemically induced autochthonous rat mammary and colorectal carcinomas with interleukin-2. PMID: 1868493 Ref: Immunotherapy of cancer with lymphokines and lymphokine-activated killer cells. PMID: 1925249 Ref: Decrease in cholesterol levels during the immunotherapy of cancer with interleukin-2. PMID: 1931624 Ref: Intestinal lymphokine-activated killer cells in inflammatory bowel disease. PMID: 1932665 Ref: Biological monitoring of low-dose interleukin 2 in humans: soluble interleukin 2 receptors, cytokines, and cell surface phenotypes. PMID: 1933892 Ref: [Splenic or hepatic arterial injections of interleukin-2 with chemotherapeutic agents for hepatic metastases]. PMID: 1944193 Ref: Hypovitaminosis C in patients treated with high-dose interleukin 2 and lymphokine-activated killer cells. PMID: 1962585 Ref: Characterization of the colorectal carcinoma-associated antigen defined by monoclonal antibody D612. PMID: 1988133 Ref: Recombinant interleukin-2: a biological response modifier. PMID: 2009728 Ref: Human lymphokine-activated killer cells augment immunotherapy of human colon carcinoma xenografts with monoclonal antibody D612. PMID: 2012797 |
Ref: Substance P increases in vitro lymphokine-activated-killer (LAK) cell cytotoxicity against fresh colorectal cancer cells. PMID: 1279274 Ref: Neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin as a second-line treatment in metastatic colorectal carcinoma. PMID: 1297233 Ref: Human c-erbB-2 proto-oncogene product as a target for bispecific-antibody-directed adoptive tumor immunotherapy. PMID: 1347516 Ref: Establishment of cytotoxic CD4+ T cell clones from cancer patients treated by local immunotherapy. PMID: 1363274 Ref: Effect of anti-CD3 antibody on the generation of interleukin-2-activated lymphocytes from tumor tissues of gastrointestinal cancer. PMID: 1386555 Ref: Perioperative immunotherapy with recombinant interleukin 2 in patients undergoing surgery for colorectal cancer. PMID: 1394200 Ref: Impaired cytokine production in whole blood cell cultures from patients with colorectal carcinomas as compared to benign colorectal tumors and controls. PMID: 1403351 Ref: Effects of a preoperative therapy with interleukin-2 on surgery-induced lymphocytopenia in cancer patients. PMID: 1495748 Ref: Immunotherapy of colorectal cancer. PMID: 1511394 Ref: Interleukin-2 increases the antibody response in patients receiving autologous intralymphatic tumor cell vaccine immunotherapy. PMID: 1515096 Ref: Immunopathological changes in the skin following recombinant interleukin-2 treatment. PMID: 1517903 Ref: Resident research award: tumor necrosis factor alpha selectively enhances growth and cytotoxic activity of tumor infiltrating lymphocytes from human colorectal cancer. PMID: 1548866 Ref: Interleukin-2 followed by fluorouracil and folinic acid in refractory colorectal cancer--results of a clinical phase II study. PMID: 1557653 Ref: IL-2 production by intestinal lamina propria cells in normal inflamed and cancer-bearing colons. PMID: 1563100 Ref: Chemo-adoptive immunotherapy of nude mice implanted with human colorectal carcinoma and melanoma cell lines. PMID: 1596937 Ref: Phase I study of low-dose cyclophosphamide and recombinant interleukin-2 for the treatment of advanced cancer. PMID: 1599914 Ref: Clinical trials of intrasplenic arterial infusion of interleukin-2 (IS-IL-2) to patients with advanced cancer. PMID: 1622739 Ref: Cytotoxic activity of intestinal lamina propria lymphocytes on human immunodeficiency virus (HIV)-infected cells. PMID: 1628889 Ref: Shared human melanoma antigens. Recognition by tumor-infiltrating lymphocytes in HLA-A2.1-transfected melanomas. PMID: 1729379 Ref: The treatment of colorectal hepatic metastases by continuous local infusion of interleukin-2. PMID: 21584588 |
Ref: Immunogenicity of recombinant human interleukin-2: biological features and clinical relevance. PMID: 7517168 Ref: Low-dose interleukin-2 in combination with interferon-alpha effectively modulates biological response in vivo. PMID: 7683166 Ref: Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer. PMID: 7693434 Ref: Enhanced activity against syngeneic murine tumors by intrasplenic injection of recombinant interleukin-2 (IL-2) and interleukin-1 (IL-1). PMID: 7804373 Ref: [Treatment with butyrate/IL-2 combination in peritoneal carcinomatosis of colonic origin]. PMID: 8019883 Ref: Cancer immunotherapy with low-dose interleukin-2 subcutaneous administration: potential efficacy in most solid tumor histotypes by a concomitant treatment with the pineal hormone melatonin. PMID: 8023699 Ref: Immunotherapy with low-dose subcutaneous interleukin-2 plus beta-interferon as a second-line therapy for metastatic colorectal carcinoma. PMID: 8116079 Ref: Expansion of tumor-infiltrating lymphocytes from human tumors using the T-cell growth factors interleukin-2 and interleukin-4. PMID: 8280717 Ref: A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin. PMID: 8314773 Ref: T-cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model: III. Activation of resting T cells and tumor neutralization induced by bispecific antibodies. PMID: 8334106 Ref: Synergetic effect of interleukin-2 and cellular cytotoxicity against a novel tumor-associated carbohydrate antigen Le(a)/Le(a) (dimeric Le(a)) mediated by monoclonal antibody NCC-ST-421 in adoptive immunization using SCID mice. PMID: 8348564 Ref: Therapeutic effect of neuraminidase-treated LAK cells on liver metastasis of Colon 26. PMID: 8379346 Ref: Short-duration in vitro interleukin-2-activated mononuclear cells for advanced cancer. A Hong Kong biotherapy pilot study trial. PMID: 8387882 Ref: T-cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model: IV. Tumor neutralization in Winn type assays. PMID: 8399065 Ref: Peri-operative modulation of cellular immunity in patients with colorectal cancer. PMID: 8403515 Ref: Specific immune recognition of autologous tumor by lymphocytes infiltrating colon carcinomas: analysis by cytokine secretion. PMID: 8422663 Ref: T cell killing of human colon carcinomas by monoclonal-antibody-targeted superantigens. PMID: 8439985 Ref: T cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. II. Syngeneic colon carcinoma CC531 is efficiently killed by retargeted cytotoxic T lymphocytes in vitro despite limited lysis in 51Cr release assays. PMID: 8450213 Ref: Inpatient continuous-infusion interleukin-2 in 788 patients with cancer. The National Biotherapy Study Group experience. PMID: 8453558 Ref: [Characterization of autologous-tumor specific cytotoxic T cells induced by means of butanol-extracted soluble antigen from T lymphocytes in colon cancer patients]. PMID: 8464410 Ref: Renal toxicity mediated by continuous infusion of recombinant interleukin-2. PMID: 8502315 Ref: The expression and biological activity of IL-2 receptor on a human pancreas cancer cell line. PMID: 8507543 Ref: Superantigen-induced cytokines suppress growth of human colon-carcinoma cells. PMID: 8509223 Ref: Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract. PMID: 8512825 Ref: Inhibition of proliferation, activation and function of human natural-killer-cells in-vitro by secreted products of lovo, a colorectal-cancer cell-line. PMID: 21573430 |
Ref: [Observation of the effects of LAK/IL-2 therapy combining with Lycium barbarum polysaccharides in the treatment of 75 cancer patients]. PMID: 7720497 Ref: Growth inhibition of human gastrointestinal cancer cells by cyclosporin A. PMID: 7798292 Ref: Single-chain antibody variable region-targeted interleukin-2 stimulates T cell killing of human colorectal carcinoma cells. PMID: 7806260 Ref: The clinical experience with interleukin-2 in cancer therapy. PMID: 7820182 Ref: A phase II study of advanced colorectal cancer patients treated with combination 5-fluorouracil plus leucovorin and subcutaneous interleukin-2 plus alpha interferon. PMID: 7830105 Ref: Phase II trials of high-dose interleukin-2 and lymphokine-activated killer cells in advanced breast carcinoma and carcinoma of the lung, ovary, and pancreas and other tumors. PMID: 7834121 Ref: Chimeric (mouse/human) anti-colon cancer antibody c30.6 inhibits the growth of human colorectal cancer xenografts in scid/scid mice. PMID: 7954462 Ref: An interleukin 2/sodium butyrate combination as immunotherapy for rat colon cancer peritoneal carcinomatosis. PMID: 7958681 Ref: The decreased expression of CD3 zeta chains in cancer patients is not reversed by IL-2 administration. PMID: 7989113 Ref: Interleukin 2 treatment in colorectal cancer: current results and future prospects. PMID: 7995410 Ref: Complete remission of liver metastases from colorectal cancer by treatment with a hepatic artery infusion (HAI) of interleukin-2-based immunochemotherapy: reports of three cases. PMID: 8054783 Ref: Enhanced cell-mediated tumor killing in patients immunized with human monoclonal antiidiotypic antibody 105AD7. PMID: 8069847 Ref: A phase II clinical trial of interleukin-2 and lymphokine-activated killer cells in advanced colorectal carcinoma. PMID: 8110733 Ref: The infiltration of experimentally induced lung metastases of colon carcinoma CC531 by adoptively transferred interleukin-2-activated natural killer cells in Wag rats. PMID: 8112894 Ref: Colon adenocarcinoma cells inhibit anti-CD3-activated killer cell induction. PMID: 8124689 Ref: Impaired left ventricular filling rate induced by treatment with recombinant interleukin 2 for advanced cancer. PMID: 8130026 Ref: Effects of oral administration of Lactobacillus casei on antitumor responses induced by tumor resection in mice. PMID: 8150553 Ref: Functional role of IL-2 receptors on tumour-infiltrating lymphocytes. PMID: 8198969 Ref: In vivo cytokine production and recombinant interleukin 2 immunotherapy: an insight into the possible mechanisms underlying clinical responses. PMID: 8198981 Ref: Influence of cytokines on mdr1 expression in human colon carcinoma cell lines: increased cytotoxicity of MDR relevant drugs. PMID: 8207045 Ref: Growth inhibition of a colonic adenocarcinoma cell line (HT29) by T cells specific for mutant p21 ras. PMID: 8306368 Ref: Perioperative immunomodulation in cancer surgery. PMID: 8311130 |
Ref: Antibody-targeted lymphokine-activated killer cells inhibit liver micrometastases in severe combined immunodeficient mice. PMID: 7498661 Ref: Acute phase proteins and recombinant IL-2 therapy: prediction of response and survival in patients with colorectal cancer. PMID: 7531626 Ref: Human anti-idiotypic antibodies induced a humoral and cellular immune response against a colorectal carcinoma-associated antigen in patients. PMID: 7539133 Ref: Phase I-II randomized study on prehepatectomy recombinant interleukin-2 immunotherapy in patients with metastatic carcinoma of the colon and rectum. PMID: 7551323 Ref: Immunization against a rat colon carcinoma by sodium butyrate-treated cells but not by interleukin 2-secreting cells. PMID: 7557139 Ref: Cytokine gene therapy with interleukin-2-transduced fibroblasts: effects of IL-2 dose on anti-tumor immunity. PMID: 7578396 Ref: Comparison of gene therapy with interleukin-2 gene modified fibroblasts and tumor cells in the murine CT-26 model of colorectal carcinoma. PMID: 7582256 Ref: Effect of splenectomy on hepatic metastasis of colon carcinoma and natural killer activity in the liver. PMID: 7587821 Ref: Effect of ranitidine and low-dose interleukin-2 in vitro on NK-cell activity in peripheral blood from patients with liver metastases from colorectal cancer. PMID: 7589599 Ref: The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells. PMID: 7600527 Ref: Generation of lymphokine-activated killer (LAK) cell activity from malignant peritoneal effusions. PMID: 7624448 Ref: Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine. PMID: 7629885 Ref: Lymphocytes infiltrating colorectal cancer have low proliferative capacity but can secrete normal levels of interferon gamma. PMID: 7641220 Ref: Morphological and functional characteristics of tumor-infiltrating lymphocytes from human colorectal cancers after stimulation with rIL-2. PMID: 7649213 Ref: Expansion of mucin-reactive T-helper lymphocytes from patients with colorectal cancer. PMID: 7663570 Ref: Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth. PMID: 7674335 Ref: Tumor-associated glycoantigen, sialyl Lewis(a) as a target for bispecific antibody-directed adoptive tumor immunotherapy. PMID: 7721341 Ref: Polysaccharide preparation PSK augments the proliferation and cytotoxicity of tumor-infiltrating lymphocytes in vitro. PMID: 7762991 Ref: Identification of a monoclonal antibody, TV-1, directed against the basement membrane of tumor vessels, and its use to enhance the delivery of macromolecules to tumors after conjugation with interleukin 2. PMID: 7780984 Ref: Induction of tumor-specific cytotoxic T lymphocytes and natural killer cells by tumor cells transfected with the interleukin-2 gene. PMID: 7828164 Ref: Superantigen-induced human CD4+ helper/killer T cell phenomenon. Selective induction of Th1 helper/killer T cells and application to tumor immunotherapy. PMID: 7836762 Ref: Tumour-infiltrating lymphocytes bear the 75 kDa tumour necrosis factor receptor. PMID: 7841036 Ref: Phase I trial of escalating doses of interleukin-1 beta in combination with a fixed dose of interleukin-2. PMID: 7844609 Ref: Modulation of the cytokine and acute-phase response to major surgery by recombinant interleukin-2. PMID: 7881967 Ref: The involvement of transforming growth factor beta in the impaired antitumor T-cell response at the gut-associated lymphoid tissue (GALT). PMID: 8521406 Ref: Pre-operative interleukin-2 immunotherapy induces eosinophilic infiltration in colorectal neoplastic stroma. PMID: 8532404 Ref: Culture of tumour-infiltrating lymphocytes from melanoma and colon carcinoma: removal of tumour cells does not affect tumour-specificity. PMID: 8536275 Ref: Human, recombinant interleukin-2 induces in vitro histamine release in a dose-dependent manner. PMID: 8590893 Ref: Development of immunogenic colorectal cancer cell lines for vaccination: expression of CD80 (B7.1) is not sufficient to restore impaired primary T cell activation in vitro. PMID: 8652275 Ref: A phase II trial of interleukin-2 and interferon-alpha in the treatment of metastatic colorectal carcinoma. PMID: 8680653 Ref: Sequential biochemotherapy for metastatic colorectal cancer using fluorouracil, folinic acid, thymopentin and interleukin-2: clinical and immunological effects. PMID: 8750154 Ref: Efficacy and tolerability of cancer neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin - a progress report of 200 patients with advanced solid neoplasms. PMID: 21597854 |
Ref: Antibody-targeted superantigen therapy induces tumor-infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma. PMID: 8566049 Ref: Murine colon carcinoma cells engineered to produce human interleukin-2 induce tumor-specific anti-tumor response. PMID: 8608957 Ref: Growth of tumor-infiltrating lymphocytes from human solid cancers: summary of a 5-year experience. PMID: 8621219 Ref: Improved immunotherapy of a recombinant carcinoembryonic antigen vaccinia vaccine when given in combination with interleukin-2. PMID: 8625312 Ref: Disregulation in TH1 and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. PMID: 8625361 Ref: Interleukin-12 increases bispecific-antibody-mediated natural killer cell cytotoxicity against human tumors. PMID: 8625370 Ref: Cytokine regulation of ezrin expression in the human colon cancer cell line HT29. PMID: 8687142 Ref: Preoperative interleukin-2 subcutaneous immunotherapy may prolong the survival time in advanced colorectal cancer patients. PMID: 8692528 Ref: [Vaccination with genetically modified IL-2 secreting cells in a rat model of colonic carcinoma]. PMID: 8695924 Ref: Adjuvant hepatic arterial IL-2 and MMC, 5-FU after curative resection of colorectal liver metastases. PMID: 8799416 Ref: Subcutaneous low-dose interleukin-2 and intravenous 5-fluorouracil plus high-dose levofolinic acid as salvage treatment for metastatic colorectal carcinoma. PMID: 8826605 Ref: Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells. PMID: 8827016 Ref: [Diagnosis and therapy for metastatic liver cancer]. PMID: 8831736 Ref: Immune reactions induced by interleukin-2 transfected colorectal cancer cells in vitro: predominant induction of lymphokine-activated killer cells. PMID: 8834769 Ref: Structure and function of sinusoidal lining cells in the liver. PMID: 8839287 Ref: [Locoregional therapy for liver metastases of colorectal cancer]. PMID: 8854772 Ref: [Regional adoptive immunotherapy using activated lymphocytes]. PMID: 8854802 Ref: Modulation of mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance. PMID: 8912533 Ref: Diabetes mellitus induced by low-dose interleukin-2. PMID: 8917637 Ref: Immunological and side effects of low sc recombinant interleukin-2 dose in addition to conventional treatment in relapsed breast and colorectal cancer patients. PMID: 8952853 Ref: Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines. PMID: 8955204 Ref: Interleukin 2 and interferon alpha-2a do not improve anti-tumour activity of 5-fluorouracil in advanced colorectal cancer. PMID: 8980407 Ref: Release of cytokines by a fermented lectin-1 (ML-1) free mistletoe extract reflects differences in the reactivity of PBMC in healthy and allergic individuals and tumour patients. PMID: 9010693 Ref: Inhibition of peritoneal dissemination of colon carcinoma in syngeneic mice immunized with interleukin-2-producing cells. PMID: 9020917 Ref: The cognitive effects of recombinant interleukin-2 (rIL-2) therapy: a controlled clinical trial using computerised assessments. PMID: 9038610 Ref: [A retrospective view of tumor immunology]. PMID: 9224970 Ref: Development of tumor B-cell lymphocyte hybridoma (TBH) autovaccination. Results of a phase I-II clinical trial. PMID: 10168565 Ref: Prognostic significance of immunological evaluation in colorectal cancer. PMID: 10851496 Ref: Necessity of biotherapeutic treatments inducing TH1 cell functions in colorectal cancer. PMID: 10851498 Ref: Immunological directives for biotherapy improvement in the treatment of colorectal cancer. PMID: 10851527 Ref: Cell mediated cytotoxicity of human colon carcinoma cells by a monoclonal antibody (R4) recognizing the carcinoembryonic antigen (CEA) and CEA-related molecules. PMID: 21544473 |
Ref: Interleukin-7 (IL-7) in colorectal cancer: IL-7 is produced by tissues from colorectal cancer and promotes preferential expansion of tumour infiltrating lymphocytes. PMID: 9042431 Ref: Histocompatibility leukocyte antigen-A2402-restricted cytotoxic T lymphocytes recognizing adenocarcinoma in tumor-infiltrating lymphocytes of patients with colon cancer. PMID: 9119749 Ref: Cytotoxic T-cell clone against rectal carcinoma induced by stimulation of a patient's peripheral blood mononuclear cells with autologous cultured tumor cells. PMID: 9139862 Ref: [Preoperative subcutaneous immunotherapy with interleukin-2 in renal carcinoma with synchronous metastasis: randomized clinico-biological study. Preoperative use of Il-2 in renal carcinoma]. PMID: 9181906 Ref: Expression of beta-galactoside alpha 2,6-sialyltransferase does not alter the susceptibility of human colon cancer cells to NK-mediated cell lysis. PMID: 9184831 Ref: Modulations of the effector function and cytokine production of human lymphocytes by secreted factors derived from colorectal-carcinoma cells. PMID: 9212235 Ref: Postoperative changes in serum interleukin-2 concentrations. PMID: 9248982 Ref: Tumor-infiltrating dendritic cells are defective in their antigen-presenting function and inducible B7 expression in rats. PMID: 9259401 Ref: Trefoil peptide expression and secretion is regulated by neuropeptides and acetylcholine. PMID: 9277413 Ref: Interleukin-2-activated killer cell activity in colorectal tumor patients: evaluation of in vitro effects by prothymosin alpha1. PMID: 9292704 Ref: Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy. PMID: 9336744 Ref: Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy. PMID: 9354462 Ref: 5-Fluorouracil-resistant colonic tumors are highly responsive to sodium butyrate/interleukin-2 bitherapy in rats. PMID: 9399677 Ref: Long-term survival of immunocompetent rats with intraperitoneal colon carcinoma tumors using herpes simplex thymidine kinase/ganciclovir and IL-2 treatments. PMID: 9425438 Ref: The psychological and psychiatric effects of rIL-2 therapy: a controlled clinical trial. PMID: 9451748 Ref: Anticancer neuroimmunomodulation by pineal hormones other than melatonin: preliminary phase II study of the pineal indole 5-methoxytryptophol in association with low-dose IL-2 and melatonin. PMID: 9498162 Ref: Preclinical studies with prothymosin alpha1 on mononuclear cells from tumor patients. PMID: 9637344 Ref: Various functions of PBMC from colon cancer patients are not decreased compared to healthy blood donors. PMID: 10851450 Ref: The sCEA molecule suppressive role in NK and TH1 cell functions in colorectal cancer. PMID: 10851473 Ref: The role of the soluble CD30 serum level in colorectal cancer: a possible marker for a patient subset which could benefit from IL-2 biotherapy. PMID: 10851480 Ref: IL-2-Activated Killer Cells and Native Cytokines in Treatment of Patients with Advanced Cancer. PMID: 12687071 Ref: Apoptosis induced by sodium butyrate treatment increases immunogenicity of a rat colon tumor cell line. PMID: 14646537 Ref: Effects of thymic peptides, in vitro, on the impaired immunocytotoxicity of peripheral blood mononuclear cells from tumor patients. PMID: 21533400 Ref: Interleukin-2 (IL-2) gene therapy with allogeneic fibroblasts in the CT-26 model of murine colorectal carcinoma. PMID: 21590028 Ref: Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro. PMID: 21590251 |
Ref: The significance of an increase in soluble interleukin-2 receptor level in colorectal cancer and its biological regulating role in the physiological switching of the immune response cytokine network from TH1 to TH2 and back. PMID: 9439647 Ref: Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration. PMID: 9462713 Ref: Docetaxel treatment of HT-29 colon carcinoma cells reinforces the adhesion and immunocytotoxicity of peripheral blood lymphocytes in vitro. PMID: 9499461 Ref: Molecular mimicry of carcinoembryonic antigen by peptides derived from the structure of an anti-idiotype antibody. PMID: 9515808 Ref: Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+ CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene. PMID: 9536262 Ref: Interleukin 15 protects against toxicity and potentiates antitumor activity of 5-fluorouracil alone and in combination with leucovorin in rats bearing colorectal cancer. PMID: 9563485 Ref: Immune response of rat spleen cells to a carcinogen and to vaccination with anti-p53 polyclonal antibodies. PMID: 9568090 Ref: Interleukin 2 restores CD3-zeta chain expression but fails to generate tumour-specific lytic activity in tumour-infiltrating lymphocytes derived from human colorectal hepatic metastases. PMID: 9569042 Ref: Inhibition of experimental lung metastasis of murine colon carcinoma cells depends on the amount of interleukin-2 secreted from the transduced cells. PMID: 9615724 Ref: Gene therapy for hepatic micrometastasis of murine colon carcinoma. PMID: 9625325 Ref: Tumour necrosis factor-alpha enhances intraepithelial lymphocyte proliferation and migration. PMID: 9659158 Ref: Recombinant immunocytokines targeting the mouse transferrin receptor: construction and biological activities. PMID: 9667950 Ref: Colon cancer cell vaccine prepared with replication-deficient vaccinia viruses encoding B7.1 and interleukin-2 induce antitumor response in syngeneic mice. PMID: 9690454 Ref: [Clinical evaluation of intermittent hepatic arterial infusion therapy for metastatic liver tumor of gastric and colorectal cancer]. PMID: 9703838 Ref: Induction of persistent tumor-protective immunity in mice cured of established colon carcinoma metastases. PMID: 9731503 Ref: Identification of a human CD8+ T lymphocyte neo-epitope created by a ras codon 12 mutation which is restricted by the HLA-A2 allele. PMID: 9732698 Ref: Selective suppression of cytokine secretion in whole blood cell cultures of patients with colorectal cancer. PMID: 9792144 Ref: Introduction of adhesive and costimulatory immune functions into tumor cells by infection with Newcastle Disease Virus. PMID: 9824618 Ref: Induction of antigen presentation by macrophages after phagocytosis of tumour apoptotic cells. PMID: 9851522 Ref: Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds. PMID: 9853404 Ref: Immunocytokines: a promising approach to cancer immunotherapy. PMID: 9888698 Ref: Comparison of the effects of various clinically applied mistletoe preparations on peripheral blood leukocytes. PMID: 9893935 Ref: Inhibition of peritoneal dissemination of murine colon carcinoma cells by administrating retrovirus harboring IL-2 gene. PMID: 9917087 Ref: IL-2 gene transfer for chemosensitization of multidrug-resistant human colon carcinoma cells. PMID: 10026864 |
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Ref: 105Ad7 cancer vaccine stimulates anti-tumour helper and cytotoxic T-cell responses in colorectal cancer patients but repeated immunisations are required to maintain these responses. PMID: 10585589 Ref: Comparison of the effects of immunosuppressive factors from newly established colon carcinoma cell cultures on human lymphocyte proliferation and cytokine secretion. PMID: 10601837 Ref: Construction of new amplifier expression vectors for high levels of IL-2 gene expression. PMID: 10677573 Ref: Potentiation of immunologic responsiveness to dendritic cell-based tumor vaccines by recombinant interleukin-2. PMID: 10685663 Ref: IL-10 enhances IL-2-induced proliferation and cytotoxicity by human intestinal lymphocytes. PMID: 10691913 Ref: Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma. PMID: 10694814 Ref: Interleukin-18 in combination with IL-2 enhances natural killer cell activity without inducing large amounts of IFN-gamma in vivo. PMID: 10714558 Ref: Combinations of the cytokines IL-12, IL-2 and IFN-alpha significantly augment whereas the cytokine IL-4 suppresses the cytokine-induced antibody-dependent cellular cytotoxicity of monoclonal antibodies 17-1A and BR55-2. PMID: 10843759 Ref: Augmentation of 17-1A-induced antibody-dependent cellular cytotoxicity by the triple cytokine combination of interferon-alpha, interleukin-2, and interleukin-12. PMID: 10916758 Ref: Recombinant adenoviral vectors have adjuvant activity and stimulate T cell responses against tumor cells. PMID: 10981668 Ref: Cytokines secreted by lymphokine-activated killer cells induce endogenous nitric oxide synthesis and apoptosis in DLD-1 colon cancer cells. PMID: 11006006 Ref: Prestimulation of monocytes by the cytokines GM-CSF or IL-2 enhances the antibody dependent cellular cytotoxicity of monoclonal antibody 17-1A. PMID: 11031784 Ref: Abrogation of surgery-induced decline in circulating dendritic cells by subcutaneous preoperative administration of IL-2 in operable cancer patients. PMID: 11037053 Ref: Interleukin-2 enhances susceptibility of colon cancer cells to FasR mediated apoptosis by up-regulating Fas receptor level and down-regulating FAP-1 expression. PMID: 12657200 Ref: What to do with targeted IL-2. PMID: 12861355 |
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Ref: Therapeutic effect of colon tumor cells expressing FLT-3 ligand plus systemic IL-2 in mice with syngeneic colon cancer. PMID: 11904730 Ref: Recombinant interleukin-2 treatment decreases P-glycoprotein activity and paclitaxel metabolism in mice. PMID: 11914641 Ref: Secretion of interleukin-10 from murine colon carcinoma cells suppresses systemic antitumor immunity and impairs protective immunity induced against the tumors. PMID: 11916240 Ref: Effects of IL-2 preoperative immunotherapy on surgery-induced changes in angiogenic regulation and its prevention of VEGF increase and IL-12 decline. PMID: 11995457 Ref: Low-dose recombinant IL-2 induces psychological changes: monitoring by Minnesota Multiphasic Personality Inventory (MMPI). PMID: 12014643 Ref: Treatment with GM-CSF and IL-2 in patients with metastatic colorectal carcinoma induced high serum levels of neopterin and sIL-2R, an indicator of immune suppression. PMID: 12070712 Ref: Efficacy of intraperitoneal thermochemotherapy and immunotherapy in intraperitoneal recurrence after gastrointestinal cancer resection. PMID: 12439917 Ref: Adjuvant effect of a Flt3 ligand (FL) gene-transduced xenogeneic cell line in a murine colon cancer model. PMID: 12443727 Ref: [Hepatic arterial infusion of IL-2 and chemotherapy for unresectable liver metastasis from colorectal cancer]. PMID: 12484016 Ref: [Cytokines and soluble cytokine receptors in the perioperative period]. PMID: 12688152 Ref: Cytokine associated sensitivity of colon carcinoma cells to FasR-mediated cytotoxicity of CTL. PMID: 17585452 |
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Ref: Vgamma9Vdelta2 T cell-mediated recognition of human solid tumors. Potential for immunotherapy of hepatocellular and colorectal carcinomas. PMID: 17764010 Ref: Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity. PMID: 18422755 Ref: Occurrence of autoimmunity in a long-term survivor with metastatic colon carcinoma treated with a new chemo-immunotherapy regimen. PMID: 18467257 Ref: A study of immunoendocrine strategies with pineal indoles and interleukin-2 to prevent radiotherapy-induced lymphocytopenia in cancer patients. PMID: 18610754 Ref: Free-from-progression period and overall short preoperative immunotherapy with IL-2 increases the survival of pancreatic cancer patients treated with macroscopically radical surgery. PMID: 18630487 Ref: Influence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide-activated human natural killer (NK) cells. PMID: 18759005 Ref: Cytokine adjuvanation of therapeutic anti-tumor immunity targeted to cancer mucosa antigens. PMID: 19956776 |
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