Primary Site >> Colorectal Cancer
Gene >> IL18
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Ref: Control of tumor development by intratumoral cytokines. PMID: 10397168 |
Ref: Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper T cells. PMID: 10770633 Ref: Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. PMID: 11525597 |
Ref: Successful immunogene therapy using colon cancer cells (colon 26) transfected with plasmid vector containing mature interleukin-18 cDNA and the Igkappa leader sequence. PMID: 11219497 Ref: Expression and release of IL-18 binding protein in response to IFN-gamma. PMID: 11739524 Ref: Nitric oxide synthase inhibitor and IL-18 enhance the anti-tumor immune response of rats carrying an intrahepatic colon carcinoma. PMID: 11761444 |
Ref: Influence of 5-fluorouracil and folinic acid on interleukin-18 production in colorectal cancer patients. PMID: 11936589 Ref: Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease. PMID: 12135029 |
Ref: Intensification of antitumor effect by T helper 1-dominant adoptive immunogene therapy for advanced orthotopic colon cancer. PMID: 12796406 Ref: [Interleukin 18 expression in colon cancer and adenoma]. PMID: 12947707 Ref: Antitumor effects of interleukin-18 gene-modified hepatocyte cell line on implanted liver carcinoma. PMID: 14570604 |
Ref: Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity. PMID: 15298707 |
Ref: Low-dose combretastatin A4 phosphate enhances the immune response of tumor hosts to experimental colon carcinoma. PMID: 16899622 Ref: Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity. PMID: 16971136 |
Ref: Reduced expression of microenvironmental Th1 cytokines accompanies adenomas-carcinomas sequence of colorectum. PMID: 17160410 Ref: Distinct changes of dendritic cell number and IL-12 mRNA level in adjacent mucosa throughout the colorectal adenoma-carcinoma sequence. PMID: 17579859 Ref: [Changes of tumorigenicity induced by interleukin-18 gene transduction and its anti-tumor effect on human colon cancer SW480 cells]. PMID: 17645843 |
Ref: EGCG and Polyphenon E attenuate inflammation-related mouse colon carcinogenesis induced by AOM plus DDS. PMID: 21479417 |
Ref: Microsatellite and chromosomal stable colorectal cancers demonstrate poor immunogenicity and early disease recurrence. PMID: 18637931 Ref: IL-18 serum level and IL-18 promoter gene polymorphism in Iranian patients with gastrointestinal cancers. PMID: 19638090 |
Ref: Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. PMID: 20226691 Ref: Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. PMID: 20398056 Ref: IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. PMID: 20855874 Ref: [Killing effect of interleukin-18-enhanced FasL-expressing colon cancer cells on human hepatocytes in vitro]. PMID: 21122378 |
Ref: The Nlrp3 inflammasome: contributions to intestinal homeostasis. PMID: 21388882 Ref: A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. PMID: 21543645 Ref: Proteomic analysis identifies translationally controlled tumor protein as a mediator of phosphatase of regenerating liver-3-promoted proliferation, migration and invasion in human colon cancer cells. PMID: 22340241 |
Ref: Combined treatment with bevacizumab and standard chemotherapy restores abnormal immune parameters in advanced colorectal cancer patients. PMID: 20820907 Ref: Diet-induced obesity elevates colonic TNF-alpha in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. PMID: 22209007 Ref: [Association of the IL-18 gene polymorphism with susceptibility to colorectal cancer]. PMID: 22539392 Ref: Human IL18-IL2 fusion protein as a potential antitumor reagent by enhancing NK cell cytotoxicity and IFN-gamma production. PMID: 22699929 Ref: IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. PMID: 23075849 |
Ref: Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. PMID: 23696660 Ref: Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease. PMID: 23847622 Ref: IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. PMID: 24228233 |
Ref: Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. PMID: 24412617 Ref: Inflammasome: cancer's friend or foe? PMID: 24518102 Ref: NLRPs, microbiota, and gut homeostasis: unravelling the connection. PMID: 24740681 Ref: Preventive effects of the angiotensin-converting enzyme inhibitor, captopril, on the development of azoxymethane-induced colonic preneoplastic lesions in diabetic and hypertensive rats. PMID: 24959250 Ref: A novel cancer vaccine strategy with combined IL-18 and HSV-TK gene therapy driven by the hTERT promoter in a murine colorectal cancer model. PMID: 25051201 Ref: Interleukin-18 synergism with interleukin-2 in cytotoxicity and NKG2D expression of human natural killer cells. PMID: 25292077 Ref: Serum cytokine levels in patients with colorectal cancers according to tumor stages and VEGF gene polymorphism. PMID: 25713884 |
Ref: The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis. PMID: 25725098 Ref: Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. PMID: 26107252 Ref: IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1. PMID: 26216891 Ref: The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity. PMID: 26384545 Ref: Association between the -607 C > A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis. PMID: 26681034 Ref: CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors. PMID: 27081544 |
Ref: A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. PMID: 26037070 Ref: Endogenous conversion of omega-6 to omega-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/beta-catenin signaling or activating 15-PGDH/IL-18. PMID: 26650508 Ref: Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. PMID: 27059389 Ref: Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. PMID: 27234655 Ref: Ginsenoside Rh2 alleviates tumor-associated depression in a mouse model of colorectal carcinoma. PMID: 27347326 |
Ref: Effects of tumor vaccine expressing Granulocyte-Macrophage Colony Stimulating Factor and interleukin-18 fusion on cancer cells and its possible application for cancer immunotherapy. PMID: 26868088 Ref: NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury. PMID: 27353251 Ref: Hemidesmosome integrity protects the colon against colitis and colorectal cancer. PMID: 27371534 Ref: The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. PMID: 27524110 Ref: The multifaceted roles of inflammasome proteins in cancer. PMID: 27875342 Ref: Inflammasomes and Cancer. PMID: 28093447 Ref: NLRP3 Inhibitors as Potential Therapeutic Agents for Treatment of Inflammatory Bowel Disease. PMID: 28155620 Ref: HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis. PMID: 28428272 Ref: Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development. PMID: 28955343 Ref: IL-8 Is Involved in Estrogen-Related Receptor alpha-Regulated Proliferation and Migration of Colorectal Cancer Cells. PMID: 28993941 |
Ref: Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis. PMID: 29203393 Ref: SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer. PMID: 30231985 |