Primary Site >> Colorectal Cancer
Gene >> IGFBP3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Insulin-like growth-factor-binding protein gene expression and protein production by human tumour cell lines. PMID: 1377187 |
Ref: Alterations in serum levels of insulin-like growth factors and insulin-like growth-factor-binding proteins in patients with colorectal cancer. PMID: 7514152 |
Ref: Expression of IGFBP-2, -3, and -4 mRNA during differentiation of Caco-2 colon epithelial cells. PMID: 8944682 |
Ref: Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers. PMID: 9218734 Ref: Insulin-like growth factor binding proteins as mediators of IGF-I effects on colon cancer cell proliferation. PMID: 9386991 |
Ref: Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) proteolysis in patients with colorectal cancer: possible association with the metastatic potential of the tumor. PMID: 9761113 Ref: Sequence alterations of insulin-like growth factor binding protein 3 in neoplastic and normal gastrointestinal tissues. PMID: 9809981 |
Ref: Growth inhibition and differentiation of the human colon carcinoma cell line, Caco-2, by constitutive expression of insulin-like growth factor binding protein-3. PMID: 10029281 Ref: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. PMID: 10203281 Ref: IGF-I and IGF-II in relation to colorectal cancer. PMID: 10449601 Ref: Re: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. PMID: 10580038 Ref: Insulin-like growth factor-I and binding protein-3 and risk of cancer. PMID: 10592442 Ref: IGFs and human cancer: implications regarding the risk of growth hormone therapy. PMID: 10592443 |
Ref: Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells. PMID: 10646845 Ref: Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. PMID: 10699960 Ref: A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. PMID: 10794477 Ref: IGFBP-3 mediates TGF beta 1 proliferative response in colon cancer cells. PMID: 10897042 Ref: Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. PMID: 11018095 Ref: Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer. PMID: 11044360 Ref: More about: prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. PMID: 11106691 Ref: Does the GH-IGF axis play a role in cancer pathogenesis? PMID: 11161960 |
Ref: High-risk colorectal adenomas and serum insulin-like growth factors. PMID: 11136321 Ref: Energy balance and cancer: the role of insulin and insulin-like growth factor-I. PMID: 11310428 Ref: Increased levels of insulin-like growth factor binding protein-2 in sera and tumours from patients with colonic neoplasia with and without acromegaly. PMID: 11318786 Ref: IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai. PMID: 11742490 |
Ref: Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. PMID: 11861378 Ref: Insulin-like growth factor-I has a biphasic effect on colon carcinoma cells through transient inactivation of forkhead1, initially mitogenic, then mediating growth arrest and differentiation. PMID: 11920634 Ref: Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden. PMID: 11950809 Ref: Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. PMID: 12096082 Ref: Plasma from patients undergoing major open surgery stimulates in vitro tumor growth: Lower insulin-like growth factor binding protein 3 levels may, in part, account for this change. PMID: 12219010 Ref: Insulin-like growth factor II and colorectal cancer risk in women. PMID: 12223436 Ref: Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30-50-year-old women. PMID: 12496050 |
Ref: Transcriptional upregulation of the insulin-like growth factor binding protein IGFBP-3 by sodium butyrate increases IGF-independent apoptosis in human colonic adenoma-derived epithelial cells. PMID: 12663497 Ref: Serum insulin-like growth factor I and subsequent risk of colorectal cancer among Japanese-American men. PMID: 12936897 Ref: Epidemiology and biology of insulin-like growth factor binding protein-3 (IGFBP-3) as an anti-cancer molecule. PMID: 14710351 |
Ref: Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis. PMID: 12970065 Ref: Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3. PMID: 14744783 Ref: Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. PMID: 15066917 Ref: A prospective study of plasma C-peptide and colorectal cancer risk in men. PMID: 15069117 Ref: Depletion of circulating insulin-like growth factor binding protein 3 after open surgery is associated with high interleukin-6 levels. PMID: 15085435 Ref: Cancer risk following growth hormone use in childhood: implications for current practice. PMID: 15144231 Ref: Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer. PMID: 15247132 Ref: Insulin-like growth factor-binding protein 3 inhibits growth of experimental colocarcinoma. PMID: 15300181 Ref: Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice. PMID: 15736405 |
Ref: Open surgery induces a dramatic decrease in circulating intact IGFBP-3 in patients with colorectal cancer not seen with laparoscopic surgery. PMID: 15531967 Ref: A new single nucleotide polymorphism in the insulin-like growth factor I regulatory region associates with colorectal cancer risk in singapore chinese. PMID: 15668488 Ref: Energy balance, insulin-related genes and risk of colon and rectal cancer. PMID: 15688407 Ref: A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. PMID: 15824155 Ref: Insulin-like growth factor polymorphisms and colorectal cancer risk. PMID: 15894673 Ref: Association of an exon 1 polymorphism in the IGFBP3 gene with circulating IGFBP-3 levels and colorectal cancer risk: the multiethnic cohort study. PMID: 15894694 Ref: [Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis]. PMID: 15921617 Ref: Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: genetic factors. PMID: 15941947 Ref: Associations between plasma insulin-like growth factor proteins and C-peptide and quality of life in patients with metastatic colorectal cancer. PMID: 15941948 Ref: EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. PMID: 16053920 Ref: Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. PMID: 16083703 Ref: Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: personal and lifestyle factors (United States). PMID: 16132801 Ref: Insulin resistance, apoptosis, and colorectal adenoma risk. PMID: 16172212 Ref: Differential expression of IGF-binding protein-3 in normal and malignant colon and its influence on apoptosis. PMID: 16322329 |
Ref: Physical activity, insulin-like growth factor 1, insulin-like growth factor binding protein 3, and survival from colorectal cancer. PMID: 16299029 Ref: Altered plasma matrix metalloproteinase-9/tissue inhibitor of matrix [corrected] metalloproteinase-1 concentration during the early postoperative period in patients with colorectal cancer. PMID: 16432654 Ref: Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer. PMID: 16448675 Ref: PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). PMID: 16489531 Ref: Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. PMID: 16675592 Ref: Insulin-like growth factors and cancer: no role in screening. Evidence from the BUPA study and meta-analysis of prospective epidemiological studies. PMID: 16804529 Ref: Unexpected abundance of HLA class II presented peptides in primary renal cell carcinomas. PMID: 16857787 Ref: Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells. PMID: 17016662 |
Ref: Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB. PMID: 16645643 Ref: Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers. PMID: 17096329 Ref: Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk. PMID: 17237315 Ref: Plasma C-peptide, insulin-like growth factor-I, insulin-like growth factor binding proteins and risk of colorectal cancer in a nested case-control study: the Japan public health center-based prospective study. PMID: 17266031 Ref: CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3. PMID: 17297462 Ref: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. PMID: 17372756 Ref: Insulin-like growth factor-I and risk of high-grade cervical intraepithelial neoplasia. PMID: 17416762 Ref: Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. PMID: 17418982 Ref: Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. PMID: 17991659 Ref: Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer. PMID: 18031946 Ref: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. PMID: 18084616 Ref: IGF-1 Gene Expression in Rat Colonic Mucosa After Different Exercise Volumes. PMID: 24149475 |
Ref: Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. PMID: 17620308 Ref: Assessing the potential usefulness of IGF-related peptides and adiponectin for predicting disease risk. PMID: 17928251 Ref: Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women. PMID: 18054929 Ref: Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. PMID: 18059035 Ref: Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women. PMID: 18172327 Ref: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. PMID: 18204436 Ref: Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas. PMID: 18498652 Ref: Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models. PMID: 18502161 Ref: Serum concentrations of insulin-like growth factor and insulin-like growth factor binding protein 3 and recurrent colorectal adenomas. PMID: 18559566 Ref: IGF-I, IGFBP-3, and IGF-I/IGFBP-3 ratio: no association with incident colorectal cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. PMID: 18628438 Ref: No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer. PMID: 18842999 Ref: Voluntary exercise inhibits intestinal tumorigenesis in Apc(Min/+) mice and azoxymethane/dextran sulfate sodium-treated mice. PMID: 18976499 Ref: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PMID: 19002263 Ref: Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741. PMID: 19073970 Ref: (-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice. PMID: 19138973 |
Ref: Expression of insulin-like growth factor system components in colorectal tissue and its relation with serum IGF levels. PMID: 18801683 Ref: CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. PMID: 18832519 Ref: Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. PMID: 19064975 Ref: Number of aberrant crypt foci associated with adiposity and IGF1 bioavailability. PMID: 19067190 Ref: Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer. PMID: 19098285 Ref: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. PMID: 19107235 Ref: Serum IGF-I, IGFBP-3, and matrix metalloproteinase-7 levels and acquired chemo-resistance in advanced colorectal cancer. PMID: 19109398 Ref: Dietary carbohydrate source alters gene expression profile of intestinal epithelium in mice. PMID: 19116885 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: [Association of insulin, insulin-like growth factor and insulin-like growth factor binding proteins with the risk of colorectal cancer]. PMID: 19434535 Ref: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. PMID: 19470733 Ref: IGF-I, IGF-II, IGFBP2, IGFBP3 and acid-labile subunit (ALS) in colorectal cancer patients before surgery and during one year follow up in relation to age. PMID: 19482725 Ref: Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies. PMID: 19491931 Ref: Association between two functional polymorphisms of insulin-like growth factor binding protein 3 and colorectal cancer risk in a Chinese population. PMID: 19492232 Ref: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. PMID: 19686742 Ref: Association of serum retinol and carotenoids with insulin-like growth factors and insulin-like growth factor binding protein-3 among control subjects of a nested case-control study in the Japan Collaborative Cohort Study. PMID: 20553078 Ref: Insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3, and risk of colorectal cancer: a nested case-control study in the Japan Collaborative Cohort study. PMID: 20553081 |
Ref: Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. PMID: 19777566 Ref: Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk. PMID: 19784788 Ref: Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies. PMID: 19810099 Ref: Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer. PMID: 20222170 Ref: Associations of plasma C-peptide and IGFBP-1 levels with risk of colorectal adenoma in a multiethnic population. PMID: 20501760 Ref: Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. PMID: 21037082 |
Ref: Co-expression of matrix metalloproteinase-7 (MMP-7) and phosphorylated insulin growth factor receptor I (pIGF-1R) correlates with poor prognosis in patients with wild-type KRAS treated with cetuximab or panitumumab: a GEMCAD study. PMID: 21099348 Ref: Genomic and epigenomic integration identifies a prognostic signature in colon cancer. PMID: 21278247 Ref: The insulin-like growth factor binding proteins 3 and 7 are associated with colorectal cancer and liver metastasis. PMID: 21525788 Ref: B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PMID: 21738611 Ref: Interactions between plasma levels of 25-hydroxyvitamin D, insulin-like growth factor (IGF)-1 and C-peptide with risk of colorectal cancer. PMID: 22216097 |
Ref: Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps. PMID: 21898383 Ref: Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma. PMID: 21932422 Ref: Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study. PMID: 22354904 Ref: Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites. PMID: 22565227 |
Ref: The importance of metal ions for the formation and isolation of insulin-like growth factor-binding protein 3-transferrin (IGFBP-3-Tf) complexes, and the analysis of their physiological involvement. PMID: 23403918 Ref: Meta-analysis of the association between insulin-like growth factor binding protein 3 genetic polymorphisms and colorectal cancer susceptibility. PMID: 23527244 Ref: Expression of ADAM28 and IGFBP-3 genes in patients with colorectal cancer - a preliminary report. PMID: 23527725 Ref: Correlation of angiogenic biomarker signatures with clinical outcomes in metastatic colorectal cancer patients receiving capecitabine, oxaliplatin, and bevacizumab. PMID: 23634291 Ref: SND1 affects proliferation of hepatocellular carcinoma cell line SMMC-7721 by regulating IGFBP3 expression. PMID: 23878061 Ref: Detection and identification of oxidized insulin-like growth factor-binding proteins and receptors in patients with colorectal carcinoma. PMID: 24051179 Ref: Inhibition of human MCF-7 breast cancer cells and HT-29 colon cancer cells by rice-produced recombinant human insulin-like growth binding protein-3 (rhIGFBP-3). PMID: 24143239 Ref: Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population? PMID: 24175768 |
Ref: Racial differences in the association of insulin-like growth factor pathway and colorectal adenoma risk. PMID: 24194259 Ref: Lack of association of IGFBP-3 gene polymorphisms with colorectal cancer: evidence from 17,380 subjects. PMID: 24464126 Ref: IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. PMID: 24492468 Ref: Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer. PMID: 24587638 Ref: Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression. PMID: 24732966 Ref: Insulin-like growth factors (IGF), IGF-binding proteins (IGFBP), and vascular endothelial growth factor (VEGF) in blood serum of patients with colorectal cancer. PMID: 24770758 Ref: The insulin-like growth factor axis: A biological mechanism linking physical activity to colorectal cancer survival. PMID: 24968815 Ref: Body size, physical activity, early-life energy restriction, and associations with methylated insulin-like growth factor-binding protein genes in colorectal cancer. PMID: 24972776 Ref: IGFBP3 methylation is a novel diagnostic and predictive biomarker in colorectal cancer. PMID: 25127039 |
Ref: An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. PMID: 25557790 Ref: Biomarker signatures correlate with clinical outcome in refractory metastatic colorectal cancer patients receiving bevacizumab and everolimus. PMID: 25695956 Ref: IGFBP-3/transferrin/transferrin receptor 1 complexes as principal mediators of IGFBP-3 delivery to colon cells in non-cancer and cancer tissues. PMID: 25839091 Ref: IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies. PMID: 25966104 Ref: Insulin-like Growth Factor-1, IGF-binding Protein-3, C-peptide and Colorectal Cancer: a Case-control Study. PMID: 25987030 Ref: Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PMID: 26258407 Ref: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. PMID: 26388988 |
Ref: Comparison of plasma levels of obesity-related biomarkers among Japanese populations in Tokyo, Japan, Sao Paulo, Brazil, and Hawaii, USA. PMID: 25714650 Ref: Predictive Value of Growth Factors and Interleukins for Future Liver Remnant Volume and Colorectal Liver Metastasis Volume Growth Following Portal Vein Embolization and Autologous Stem Cell Application. PMID: 27069178 Ref: DNA methylation based biomarkers in colorectal cancer: A systematic review. PMID: 27385266 Ref: Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue. PMID: 27401218 Ref: Pregnancy-specific glycoprotein 9 (PSG9), a driver for colorectal cancer, enhances angiogenesis via activation of SMAD4. PMID: 27528036 |
Ref: Circulating insulin-like growth factor-related biomarkers: Correlates and responses to calcium supplementation in colorectal adenoma patients. PMID: 28467661 Ref: Clinicopathological significance and impact on outcomes of the gene expression levels of IGF-1, IGF-2 and IGF-1R, IGFBP-3 in patients with colorectal cancer: Overexpression of the IGFBP-3 gene is an effective predictor of outcomes in patients with colorec PMID: 28521493 Ref: Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer. PMID: 28540987 Ref: Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk. PMID: 29023587 |
Ref: Higher IGFBP3 is associated with increased incidence of colorectal cancer in older men independently of IGF1. PMID: 29044573 Ref: A prospective, multicenter pilot study to investigate the feasibility and safety of a 1-year controlled exercise training after adjuvant chemotherapy in colorectal cancer patients. PMID: 29168033 Ref: miR197 promotes the invasion and migration of colorectal cancer by targeting insulinlike growth factorbinding protein 3. PMID: 30106114 Ref: Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing. PMID: 30182733 Ref: Meta-analysis of the association of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer. PMID: 30334445 |