Primary Site >> Colorectal Cancer
Gene >> HSPA4
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Ref: Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. PMID: 1321338 |
Ref: Effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on HSP70 and HSP28 gene expression and thermotolerance development in human colon carcinoma cells. PMID: 7802695 Ref: Mechanism of quercetin-induced suppression and delay of heat shock gene expression and thermotolerance development in HT-29 cells. PMID: 7845388 Ref: Effect of staurosporine on the transcription of HSP70 heat shock gene in HT-29 cells. PMID: 8037750 |
Ref: Heat shock proteins are differentially expressed in human gastrointestinal cancers. PMID: 8528482 |
Ref: Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells. PMID: 8989916 Ref: Increase of P-glycoprotein-mediated drug resistance by hsp 90 beta. PMID: 8991187 |
Ref: Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells. PMID: 9126997 |
Ref: Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response. PMID: 9585177 Ref: Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. PMID: 9679980 Ref: Differential Hsp70 plasma-membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency. PMID: 9714069 |
Ref: Preoperative treatment of rectal cancer with radiation, chemotherapy and hyperthermia: analysis of treatment efficacy and heat-shock response. PMID: 10190501 |
Ref: Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. PMID: 10850441 |
Ref: Proteasome inhibitor induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5. PMID: 11161273 Ref: Differential anthracycline sensitivity in two related human colon carcinoma cell lines expressing similar levels of P-glycoprotein. PMID: 11248426 Ref: Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. PMID: 11322385 |
Ref: Defining characteristics of Types I and II apoptotic cells in response to TRAIL. PMID: 12407450 Ref: Heat shock protects HCT116 and H460 cells from TRAIL-induced apoptosis. PMID: 12460647 Ref: Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion. PMID: 12499245 Ref: Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels. PMID: 12530536 |
Ref: Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. PMID: 12633846 Ref: Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer. PMID: 12753152 |
Ref: Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. PMID: 14604899 Ref: Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer. PMID: 14689240 Ref: Heat shock protein 70 is induced in mouse human colon tumor xenografts after sublethal radiofrequency ablation. PMID: 15070600 Ref: Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial. PMID: 15173076 Ref: Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity. PMID: 15539949 Ref: [Expression of HSP70 and P53 in malignant tumor tissues and its relationship to heat syndrome of TCM]. PMID: 15553822 |
Ref: Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. PMID: 15841378 Ref: NF-kappaB and Hsp70 are involved in the phospholipase Cgamma1 signaling pathway in colorectal cancer cells. PMID: 15996687 Ref: Nucleofection of non-B cells with mini-Epstein-Barr virus DNA. PMID: 16055146 Ref: P53 and heat shock protein 70 expressions in colorectal adenocarcinoma. PMID: 16228064 Ref: Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation. PMID: 16294035 |
Ref: Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter. PMID: 16420102 Ref: Stress-induced phosphorylation of caveolin-1 and p38, and down-regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines. PMID: 16817319 Ref: Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. PMID: 17114002 |
Ref: Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma--immunohistochemistry and Western blot analysis. PMID: 17233550 Ref: Increased expression of HSP70 by colon cancer cells is not always associated with access to the dendritic cell cross-presentation pathway. PMID: 17235439 Ref: What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor? PMID: 17323428 Ref: Hsp70 response to 5-fluorouracil treatment in human colon cancer cell lines. PMID: 17390142 Ref: Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis. PMID: 17580361 Ref: Bone morphogenetic protein-4 inhibits heat-induced apoptosis by modulating MAPK pathways in human colon cancer HCT116 cells. PMID: 17640799 Ref: [Effects of blocking phospholipase C-gamma1 signaling pathway on proliferation and apoptosis of human colorectal cancer cell line LoVo]. PMID: 17927852 Ref: Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA). PMID: 17994629 |
Ref: Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. PMID: 18053307 Ref: Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma. PMID: 18334280 Ref: Identification of 5-fluorouracil response proteins in colorectal carcinoma cell line SW480 by two-dimensional electrophoresis and MALDI-TOF mass spectrometry. PMID: 18575723 Ref: Influence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide-activated human natural killer (NK) cells. PMID: 18759005 Ref: Molecular mechanism of protection against chemically and gamma-radiation induced apoptosis in human colon cancer cells. PMID: 18812638 |
Ref: HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins. PMID: 19179333 Ref: Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. PMID: 19208367 Ref: HSP70 protects BCL2L12 and BCL2L12A from N-terminal ubiquitination-mediated proteasomal degradation. PMID: 19376117 Ref: Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report. PMID: 19549307 Ref: [Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis]. PMID: 19598015 Ref: [Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics]. PMID: 19635199 |
Ref: HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon cancer cells. PMID: 19243468 Ref: Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis. PMID: 19578980 Ref: Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. PMID: 19739077 Ref: A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. PMID: 20012863 Ref: Translational control analysis by translationally active RNA capture/microarray analysis (TrIP-Chip). PMID: 20123731 Ref: Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells. PMID: 20188076 Ref: Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin. PMID: 20525756 Ref: A novel quinone-based derivative (DTNQ-Pro) induces apoptotic death via modulation of heat shock protein expression in Caco-2 cells. PMID: 20590589 Ref: Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma. PMID: 20617406 Ref: Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation. PMID: 20664927 Ref: A cell-based screen for inhibitors of protein folding and degradation. PMID: 20717760 |
Ref: In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody. PMID: 20406322 Ref: High levels of acute phase proteins and soluble 70 kDa heat shock proteins are independent and additive risk factors for mortality in colorectal cancer. PMID: 20730518 Ref: ShRNA-mediated gene silencing of heat shock protein 70 inhibits human colon cancer growth. PMID: 21725599 Ref: Label-free nondestructive discrimination of colon carcinoma sublines and biomolecular insights into their differential Hsp70 expression: DNA/RNA nucleobase specific changes. PMID: 21739554 Ref: Cell to cell interaction in clusters enhances thermosensitivity in HT29 human colon cancer cells. PMID: 22024067 |
Ref: Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. PMID: 22285593 Ref: High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer. PMID: 22535481 Ref: Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer. PMID: 22669480 Ref: Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery. PMID: 22855633 |
Ref: Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. PMID: 23230278 Ref: Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer. PMID: 23319326 Ref: Hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis: role of heat shock proteins and dissecting effects of hyperthermia. PMID: 23456378 Ref: DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment. PMID: 23710334 Ref: The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. PMID: 23983126 |
Ref: TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells. PMID: 24362470 Ref: Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor. PMID: 25175595 Ref: Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity? PMID: 25389454 |
Ref: Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia. PMID: 24973890 Ref: Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis. PMID: 25418925 Ref: Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease. PMID: 25437815 Ref: The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression. PMID: 25767680 Ref: A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. PMID: 25820723 Ref: Role of membrane Hsp70 in radiation sensitivity of tumor cells. PMID: 26197988 Ref: Identification of miR-215 mediated targets/pathways via translational immunoprecipitation expression analysis (TrIP-chip). PMID: 26287603 Ref: Heat shock protein 70 is a useful marker for predicting colorectal cancer. PMID: 26854442 |
Ref: Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. PMID: 25823022 Ref: Hyperthermic intraperitoneal chemotherapy leads to an anticancer immune response via exposure of cell surface heat shock protein 90. PMID: 25867070 Ref: Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells. PMID: 27112151 Ref: Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule. PMID: 27224913 Ref: Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-mu. In Vitro Synergy Quantification of Pifithrin-mu Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. PMID: 27455212 Ref: Correction: Griffith, D.M., et al. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-mu. In Vitro Synergy Quantification of Pifithrin-mu Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules 2016, 21, 949. PMID: 27869678 Ref: Microbiota Composition, HSP70 and Caspase-3 Expression as Marker for Colorectal Cancer Patients in Aceh, Indonesia. PMID: 28143990 |
Ref: The novel hypoxia-inducible factor-1alpha inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. PMID: 28569777 Ref: Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis. PMID: 29403306 |
Ref: Multi-panel assay of serum autoantibodies in colorectal cancer. PMID: 29691673 Ref: Hemidesmus indicus induces immunogenic death in human colorectal cancer cells. PMID: 29849952 Ref: Aberrant expression of stress-induced phosphoprotein 1 in colorectal cancer and its clinicopathologic significance. PMID: 29879402 Ref: Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells. PMID: 29930764 Ref: Therapeutic potency of heat-shock protein-70 in the pathogenesis of colorectal cancer, current status and perspectives. PMID: 30273495 |