Primary Site >> Colorectal Cancer
Gene >> HRAS
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Ref: Expression of p21ras in fresh primary and metastatic human colorectal tumors. PMID: 3885218 |
Ref: c-Ha-ras-I oncogene-induced differentiation and natural killer cell resistance in a human colorectal carcinoma cell line. PMID: 2180571 |
Ref: [Complex characteristics of the alterations of oncogenes HER-2/ERBB-2, HER-1/ERBB-1, HRAS-1, C-MYC and antioncogenes p53, RB1, as well as deletions of loci of chromosome 17 in colon carcinoma]. PMID: 1470178 |
Ref: Modulation of mdr-1 expression by a H-ras oncogene in a human colon carcinoma cell line. PMID: 8098015 Ref: T-cell immunity to oncogenic proteins including mutated ras and chimeric bcr-abl. PMID: 8103658 Ref: Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas. PMID: 8264230 Ref: Immunodetection of the p21-ras products in human normal and preneoplastic tissues and solid tumors: a review. PMID: 8276374 Ref: An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. PMID: 8336750 Ref: Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics. PMID: 8407887 Ref: Intermediate biomarkers of colon cancer: modulation of expression of ras oncogene by chemopreventive agents during azoxymethane induced colon carcinogenesis. PMID: 8472334 |
Ref: [p21ras expression, DNA ploidy and prognosis in colorectal cancer]. PMID: 7882773 Ref: Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. PMID: 8185648 |
Ref: CD8+ T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (Gly13-->Asp), are cytotoxic towards a carcinoma cell line harbouring the same mutation. PMID: 7728775 Ref: The neurotensin gene is a downstream target for Ras activation. PMID: 7769122 Ref: Detection of p21ras mutations in colorectal adenomas and carcinomas by enzyme-linked immunosorbent assay. PMID: 8625092 Ref: Antibody to ras proteins in patients with colon cancer. PMID: 9815896 |
Ref: Syndecan-1 alterations during the tumorigenic progression of human colonic Caco-2 cells induced by human Ha-ras or polyoma middle T oncogenes. PMID: 8695359 Ref: Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon. PMID: 23888891 |
Ref: Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors. PMID: 9049257 Ref: Genomic instability, as measured by microsatellite alterations, is not associated with liver tumor development in the genetically susceptible B6C3F1 mouse. PMID: 9073604 Ref: Down-regulation of NF-kappaB activity and NF-kappaB p65 subunit expression by ras and polyoma middle T oncogenes in human colonic Caco-2 cells. PMID: 9129150 Ref: N-ras protein: frequent quantitative and qualitative changes occur in human colorectal carcinomas. PMID: 9180144 Ref: [Oncogenic activation of p21ras or pp60c-src in human colonic Caco-2 cells induces post-translation alterations of syndecan-1]. PMID: 9207867 Ref: [P21-ras protein in tumors of the large intestine]. PMID: 9446408 |
Ref: Overexpression of CD44: a useful independent predictor of prognosis in patients with colorectal carcinomas. PMID: 9754757 |
Ref: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. PMID: 10201372 Ref: XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase. PMID: 10533487 Ref: Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. PMID: 10632348 |
Ref: Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells. PMID: 10732765 Ref: ["Field cancerization"--an additional phenomenon in development of colon tumors? K-ras codon 12 mutations in normal colonic mucosa of patients with colorectal neoplasms]. PMID: 11077584 |
Ref: Molecular markers are predictors of recurrence and survival in patients with Dukes B and Dukes C colorectal adenocarcinoma. PMID: 11330579 Ref: Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells. PMID: 11384105 Ref: Prognostic significance of DNA aneuploidy and p21 ras oncoprotein expression in colorectal cancer and their role in the determination of treatment modalities. PMID: 11471902 Ref: Polymorphisms and colorectal tumor risk. PMID: 11487538 Ref: Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer. PMID: 11605075 |
Ref: Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras. PMID: 11875712 Ref: Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A. PMID: 12450255 |
Ref: Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells. PMID: 12748850 Ref: Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival. PMID: 12970747 |
Ref: Characterization of p21Ras-mediated apoptosis induced by protein kinase C inhibition and application to human tumor cell lines. PMID: 14603530 |
Ref: H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. PMID: 15713896 Ref: Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cells. PMID: 15781617 |
Ref: Recurrent KRAS codon 146 mutations in human colorectal cancer. PMID: 16969076 |
Ref: Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. PMID: 17130841 Ref: Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium. PMID: 17133351 Ref: Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. PMID: 17314276 Ref: Analysis of RIN1 gene expression in colorectal cancer. PMID: 17390061 Ref: Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns. PMID: 17693665 |
Ref: Genetic pathways to colorectal cancer. PMID: 19576232 Ref: Association of H-ras polymorphisms and susceptibility to sporadic colon cancer. PMID: 19787272 Ref: Cloning of a novel splicing variant of RIN1 and its expression in gastric and colon cancer. PMID: 19806790 |
Ref: The prognostic value of p73 overexpression in colorectal carcinoma: a clinicopathologic, immunohistochemical, and statistical study of 204 patients. PMID: 19956069 Ref: NRAS mutations are rare in colorectal cancer. PMID: 20736745 Ref: [Immunoreactivity of monoclonal anti-p21Ras antibody KGH-R1 in colorectal benign and malignant lesions]. PMID: 21138685 Ref: Screening for common copy-number variants in cancer genes. PMID: 21156252 Ref: ML264: An Antitumor Agent that Potently and Selectively Inhibits Kruppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progression PMID: 23762940 |
Ref: SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer. PMID: 21528083 Ref: RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo. PMID: 22812185 |
Ref: A molecular signature for oncogenic BRAF in human colon cancer cells is revealed by microarray analysis. PMID: 22515520 Ref: Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation. PMID: 22800643 Ref: Mutational analysis of key EGFR pathway genes in Chinese breast cancer patients. PMID: 23317280 |
Ref: Companion-diagnostic testing limited to KRAS codons 12 and 13 misses 17% of potentially relevant RAS mutations in colorectal cancer. PMID: 23832066 Ref: The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells. PMID: 24211581 |
Ref: KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells. PMID: 25933688 Ref: Screening of potential diagnostic markers and therapeutic targets against colorectal cancer. PMID: 26185457 Ref: Absolute Quantification of Endogenous Ras Isoform Abundance. PMID: 26560143 |
Ref: HRAS G13D, a new mutation implicated in the resistance to anti-EGFR therapies in colorectal cancer, a case report. PMID: 26561417 Ref: Mutation spectra of RAS gene family in colorectal cancer. PMID: 27394063 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up. PMID: 27709558 Ref: [A Case of Metastatic Colorectal Cancer with HER2 Overexpression/Amplification]. PMID: 28133304 |
Ref: A Cluster Randomized Trial of a Personalized Multi-Condition Risk Assessment in Primary Care. PMID: 27639785 Ref: Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. PMID: 28218467 Ref: Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer. PMID: 28259994 Ref: Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance. PMID: 28593995 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer. PMID: 28678173 Ref: Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer. PMID: 29212173 |
Ref: RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer. PMID: 29196555 Ref: Histone deacetylase inhibitor trichostatin A and autophagy inhibitor chloroquine synergistically exert anti-tumor activity in H-ras transformed breast epithelial cells. PMID: 29344672 Ref: Delineating the underlying molecular mechanisms and key genes involved in metastasis of colorectal cancer via bioinformatics analysis. PMID: 29517105 Ref: A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer. PMID: 29619072 Ref: Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma. PMID: 29643917 Ref: Upregulation of c-mesenchymal epithelial transition expression and RAS mutations are associated with late lung metastasis and poor prognosis in colorectal carcinoma. PMID: 29725370 |