Primary Site >> Colorectal Cancer
Gene >> HPSE
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Ref: Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells. PMID: 2174463 |
Ref: Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis. PMID: 11021821 |
Ref: Heparanase expression in clinical digestive malignancies. PMID: 11295076 |
Ref: Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T. PMID: 12918105 Ref: [Role of eukaryotic initiation factor-4E (eIF-4E) in regulation of expression of NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon adenocarcinoma cell line]. PMID: 14558943 |
Ref: Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. PMID: 15292202 Ref: Heparanase expression in human colorectal cancer and its relationship to tumor angiogenesis, hematogenous metastasis, and prognosis. PMID: 15334632 |
Ref: The role of heparanase in gastrointestinal cancer (Review). PMID: 15944760 Ref: Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells. PMID: 16093249 Ref: [Effect of exogenous expression of heparanase gene on invasive ability of colorectal cancer cell line HT29]. PMID: 16351786 |
Ref: Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence. PMID: 16607375 |
Ref: Heparanase promotes angiogenesis through Cox-2 and HIF1alpha. PMID: 16890383 |
Ref: Heparanase-2, syndecan-1, and extracellular matrix remodeling in colorectal carcinoma. PMID: 18617780 |
Ref: Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases. PMID: 19240817 |
Ref: Expression and clinical significance of syndecan-1 mRNA and HPA-1 mRNA in colorectal cancer detected with real-time fluorescent quantitative polymerase chain reaction. PMID: 20193112 Ref: Expression characteristics of heparanase in colon carcinoma and its close relationship with cyclooxygenase-2 and angiogenesis. PMID: 21443112 |
Ref: Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. PMID: 21490396 |
Ref: Heparanase enzyme in chronic inflammatory bowel disease and colon cancer. PMID: 22331282 |
Ref: Normal colon tissue and colon carcinoma show no difference in heparanase promoter methylation. PMID: 23313782 |
Ref: Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment. PMID: 25367817 Ref: Tissue-specificity of heparan sulfate biosynthetic machinery in cancer. PMID: 26120938 |
Ref: Antiangiogenic platinum through glycan targeting. PMID: 28451171 |