Primary Site >> Colorectal Cancer
Gene >> HNF4A
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Ref: Kinetics and function of tumor cytotoxic factor(s) produced by human blood monocytes activated to the tumoricidal state. PMID: 3856062 |
Ref: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. PMID: 9065401 Ref: Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells. PMID: 9259402 |
Ref: Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. PMID: 9515795 Ref: Beta-catenin mutation in carcinoma of the uterine endometrium. PMID: 9721853 Ref: Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas. PMID: 9823469 |
Ref: Identification of Tcf4 residues involved in high-affinity beta-catenin binding. PMID: 10080941 Ref: A common human skin tumour is caused by activating mutations in beta-catenin. PMID: 10192393 Ref: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. PMID: 10201372 Ref: Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis. PMID: 10213492 Ref: Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer. PMID: 10392898 Ref: Germline mutations are frequent in the APC gene but absent in the beta-catenin gene in familial adenomatous polyposis patients. PMID: 10398435 Ref: Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability. PMID: 10485457 Ref: CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. PMID: 10490837 Ref: beta-catenin signaling and cancer. PMID: 10580987 Ref: Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability. PMID: 10597289 Ref: Cross-regulation of beta-catenin-LEF/TCF and retinoid signaling pathways. PMID: 10607566 |
Ref: Rare activation of the TCF/beta-catenin pathway in ovarian cancer. PMID: 10739697 Ref: Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. PMID: 10862053 Ref: alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex. PMID: 10896949 Ref: Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. PMID: 11017067 Ref: Regulation of beta -catenin transformation by the p300 transcriptional coactivator. PMID: 11050151 Ref: Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin. PMID: 11341469 |
Ref: Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway. PMID: 11222711 Ref: Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. PMID: 11244511 Ref: Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation. PMID: 11309309 Ref: The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. PMID: 11313997 Ref: A possible role for the WNT-1 pathway in oral carcinogenesis. PMID: 11345525 Ref: Suppressor of fused negatively regulates beta-catenin signaling. PMID: 11477086 Ref: Genetic alterations in the human Tcf-4 gene in Japanese patients with sporadic gastrointestinal cancers with microsatellite instability. PMID: 11528255 Ref: The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. PMID: 11532957 Ref: Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma. PMID: 11572874 Ref: Correlation of beta-catenin and cyclin D1 expression in colon cancers. PMID: 11574779 Ref: Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas. PMID: 11691783 Ref: Tcf4 can specifically recognize beta-catenin using alternative conformations. PMID: 11713475 Ref: Frequent alterations of the beta-catenin and TCF-4 genes, but not of the APC gene, in colon cancers with high-frequency microsatellite instability. PMID: 11876551 Ref: Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. PMID: 11939410 |
Ref: Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. PMID: 11756231 Ref: Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. PMID: 11774242 Ref: Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway. PMID: 11786918 Ref: Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway. PMID: 11896466 Ref: TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. PMID: 11934263 Ref: Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas. PMID: 11943708 Ref: Molecular cloning and characterization of WRCH2 on human chromosome 15q15. PMID: 11956592 Ref: Frequent up-regulation of WNT5A mRNA in primary gastric cancer. PMID: 11956659 Ref: A new nuclear component of the Wnt signalling pathway. PMID: 11988739 Ref: Genomic structure of the human NLK (nemo-like kinase) gene and analysis of its promoter region. PMID: 12039044 Ref: Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers. PMID: 12096341 Ref: Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin. PMID: 12209953 Ref: Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. PMID: 12234972 Ref: Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. PMID: 12239632 Ref: Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. PMID: 12359720 Ref: Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. PMID: 12384519 Ref: gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth. PMID: 12386812 Ref: Gut-enriched Kruppel-like factor regulates colonic cell growth through APC/beta-catenin pathway. PMID: 12387883 Ref: Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. PMID: 12414619 Ref: The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway. PMID: 12447697 Ref: Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells. PMID: 12460462 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 Ref: beta-Catenin signaling: therapeutic strategies in oncology. PMID: 12642683 Ref: Expression of lymphoid enhancer factor/T-cell factor proteins in colon cancer. PMID: 17031231 |
Ref: Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. PMID: 12517779 Ref: Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy. PMID: 12533679 Ref: Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway. PMID: 12538344 Ref: A new beta-catenin-dependent activation domain in T cell factor. PMID: 12582159 Ref: Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor beta-induced repression of c-myc. PMID: 12591729 Ref: APC, beta-Catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer. PMID: 12633551 Ref: Replicating parvoviruses that target colon cancer cells. PMID: 12767988 Ref: Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. PMID: 12776180 Ref: Caught up in a Wnt storm: Wnt signaling in cancer. PMID: 12781368 Ref: E-cadherin involved in inactivation of WNT/beta-catenin signalling in urothelial carcinoma and normal urothelial cells. PMID: 12799639 Ref: beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. PMID: 12810642 Ref: EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma. PMID: 12830000 Ref: Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. PMID: 12856716 Ref: Survivin and molecular pathogenesis of colorectal cancer. PMID: 12885482 Ref: Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. PMID: 12901858 Ref: Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis. PMID: 12944908 Ref: Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. PMID: 12952568 Ref: Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association. PMID: 14566053 Ref: Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. PMID: 14601048 Ref: TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. PMID: 14695187 |
Ref: Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas. PMID: 14639622 Ref: Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. PMID: 14679305 Ref: Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines. PMID: 14710233 Ref: Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB. PMID: 14720327 Ref: Lymphoid enhancer factor/T cell factor expression in colorectal cancer. PMID: 15000148 Ref: Nuclear export of alpha-catenin: overlap between nuclear export signal sequences and the beta-catenin binding site. PMID: 15051498 Ref: Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. PMID: 15077159 Ref: Effect of nonsteroidal anti-inflammatory drugs on beta-catenin protein levels and catenin-related transcription in human colorectal cancer cells. PMID: 15188006 Ref: Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. PMID: 15215241 Ref: Optimization of a synthetic beta-catenin-dependent promoter for tumor-specific cancer gene therapy. PMID: 15233950 Ref: Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. PMID: 15331612 Ref: Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. PMID: 15377999 Ref: The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. PMID: 15525529 |
Ref: Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. PMID: 15309432 Ref: Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin. PMID: 15492751 Ref: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. PMID: 15592505 Ref: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. PMID: 15670774 Ref: Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. PMID: 15735743 Ref: Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. PMID: 15782138 Ref: Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. PMID: 15888491 Ref: HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. PMID: 15928669 Ref: Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. PMID: 15930030 Ref: Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. PMID: 15965503 Ref: Identification of MYCBP as a beta-catenin/LEF-1 target using DNA microarray analysis. PMID: 15979100 Ref: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. PMID: 16014379 Ref: Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB. PMID: 16051228 Ref: Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate. PMID: 16054165 Ref: Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? PMID: 16126938 Ref: Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. PMID: 16230076 Ref: Oncogenic beta-catenin signaling networks in colorectal cancer. PMID: 16258275 Ref: Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. PMID: 16273202 Ref: Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress. PMID: 16282376 Ref: Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors. PMID: 16288001 Ref: ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. PMID: 16787331 |
Ref: Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. PMID: 16291872 Ref: Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas. PMID: 16299383 Ref: E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts. PMID: 16368435 Ref: Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. PMID: 16400631 Ref: The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals. PMID: 16434966 Ref: The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. PMID: 16523202 Ref: Construction of a novel DNA decoy that inhibits the oncogenic beta-catenin/T-cell factor pathway. PMID: 16648570 Ref: Polysiphonia japonica extract suppresses the Wnt/beta-catenin pathway in colon cancer cells by activation of NF-kappaB. PMID: 16685408 Ref: Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma. PMID: 16705313 Ref: CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. PMID: 16778892 Ref: Wnt activation and alternative promoter repression of LEF1 in colon cancer. PMID: 16809766 Ref: CD97 overexpression in tumor cells at the invasion front in colorectal cancer (CC) is independently regulated of the canonical Wnt pathway. PMID: 16929497 Ref: Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. PMID: 16968065 Ref: Intracellular expression of the T-cell factor-1 RNA aptamer as an intramer. PMID: 16985077 Ref: Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription. PMID: 17005722 Ref: Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells. PMID: 17020613 Ref: Effective treatment of tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector. PMID: 17047077 Ref: The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer. PMID: 17101323 Ref: Targeting the active beta-catenin pathway to treat cancer cells. PMID: 17121933 |
Ref: An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. PMID: 17121828 Ref: The role of cyclooxygenase-2 and prostaglandins in colon cancer. PMID: 17164142 Ref: Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. PMID: 17183061 Ref: Requirement of Pygopus 2 in breast cancer. PMID: 17203217 Ref: Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. PMID: 17234755 Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Transcriptionally targeted nonviral gene transfer using a beta-catenin/TCF-dependent promoter in a series of different human low passage colon cancer cells. PMID: 17274670 Ref: beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1. PMID: 17291450 Ref: Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. PMID: 17300672 Ref: The Intestinal Wnt/TCF Signature. PMID: 17320548 Ref: Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. PMID: 17363564 Ref: CBP/p300 are bimodal regulators of Wnt signaling. PMID: 17410209 Ref: Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer. PMID: 17415713 Ref: Increased pontin expression in human colorectal cancer tissue. PMID: 17442372 Ref: Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. PMID: 17699774 Ref: Turning the tables: Myc activates Wnt in breast cancer. PMID: 17726380 Ref: WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. PMID: 17761539 Ref: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. PMID: 17875709 Ref: Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. PMID: 17875931 Ref: [Mechanism of Wnt signaling pathway regulation by a truncated mutant of Axin2 in colorectal cancer]. PMID: 17927870 Ref: Modulation of beta-catenin-mediated TCF-signalling in prostate cancer cell lines by wild-type and mutant p53. PMID: 17929268 Ref: Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex. PMID: 17983804 |
Ref: Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells. PMID: 17828298 Ref: Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. PMID: 17993259 Ref: Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. PMID: 18084253 Ref: Wnt signaling inside the nucleus. PMID: 18177486 Ref: Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. PMID: 18281465 Ref: Wnt signaling and cancer development: therapeutic implication. PMID: 18348648 Ref: The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression. PMID: 18350253 Ref: DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. PMID: 18408752 Ref: Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. PMID: 18451518 Ref: Frizzled-7 as a potential therapeutic target in colorectal cancer. PMID: 18592008 Ref: Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling. PMID: 18593907 Ref: A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. PMID: 18621708 Ref: Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo. PMID: 18769115 Ref: Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells. PMID: 18774639 Ref: Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. PMID: 18794809 Ref: Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. PMID: 18826597 Ref: KLF4 regulation in intestinal epithelial cell maturation. PMID: 18977346 Ref: Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells. PMID: 18983819 |
Ref: Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. PMID: 19035518 Ref: New Wnt/beta-catenin signaling inhibitors isolated from Eleutherine palmifolia. PMID: 19065597 Ref: NDRG2 expression decreases with tumor stages and regulates TCF/beta-catenin signaling in human colon carcinoma. PMID: 19237607 Ref: Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. PMID: 19244345 Ref: Smad4 restoration leads to a suppression of Wnt/beta-catenin signaling activity and migration capacity in human colon carcinoma cells. PMID: 19284991 Ref: Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. PMID: 19440933 Ref: Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. PMID: 19460168 Ref: The transcriptional activity of Pygopus is enhanced by its interaction with cAMP-response-element-binding protein (CREB)-binding protein. PMID: 19555349 Ref: Use of RNA aptamers for the modulation of cancer cell signaling. PMID: 19565913 Ref: Isoreserpine promotes beta-catenin degradation via Siah-1 up-regulation in HCT116 colon cancer cells. PMID: 19607803 Ref: Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. PMID: 19701245 Ref: A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer. PMID: 19749792 Ref: Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. PMID: 19915572 Ref: Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. PMID: 20049737 |
Ref: The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. PMID: 19734199 Ref: Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. PMID: 19784072 Ref: Murrayafoline A attenuates the Wnt/beta-catenin pathway by promoting the degradation of intracellular beta-catenin proteins. PMID: 19962966 Ref: A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers. PMID: 19966299 Ref: Tumour cell migration in adamantinomatous craniopharyngiomas is promoted by activated Wnt-signalling. PMID: 20131060 Ref: Selective suicide gene therapy of colon cancer cell lines exploiting fibroblast growth factor 18 promoter. PMID: 20187803 Ref: PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. PMID: 20348951 Ref: Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: an update on the molecular mechanisms. PMID: 20381235 Ref: Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells. PMID: 20501702 Ref: Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling. PMID: 20510325 Ref: EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells. PMID: 20571779 Ref: Periplocin from Cortex periplocae inhibits cell growth and down-regulates survivin and c-myc expression in colon cancer in vitro and in vivo via beta-catenin/TCF signaling. PMID: 20596624 Ref: Inhibition of cell growth and potentiation of tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells. PMID: 20674553 Ref: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. PMID: 20691072 Ref: Mapping of liver-enriched transcription factors in the human intestine. PMID: 20712053 Ref: SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma. PMID: 20716954 Ref: Inhibition of the liver enriched protein FOXA2 recovers HNF6 activity in human colon carcinoma and liver hepatoma cells. PMID: 20967225 Ref: Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species. PMID: 21062980 Ref: cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment. PMID: 21426046 |
Ref: L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers. PMID: 21123622 Ref: Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ss-catenin signaling. PMID: 21152855 Ref: WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer. PMID: 21184732 Ref: Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. PMID: 21247902 Ref: HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. PMID: 21317929 Ref: Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating beta-catenin-TCF activity. PMID: 21399610 Ref: Apoptotic Cell Death and Inhibition of Wnt/beta-Catenin Signaling Pathway in Human Colon Cancer Cells by an Active Fraction (HS7) from Taiwanofungus camphoratus. PMID: 21423639 Ref: Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4). PMID: 21454679 Ref: Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/beta-catenin in SW480 human colon cancer cells. PMID: 21781302 Ref: A high resolution genome-wide scan of HNF4alpha recognition sites infers a regulatory gene network in colon cancer. PMID: 21829439 Ref: Expression and prognostic value of transcription factor PROX1 in colorectal cancer. PMID: 21970873 Ref: Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. PMID: 21983179 Ref: Human FasL gene is a target of beta-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. PMID: 22022540 Ref: Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum. PMID: 22033300 Ref: p53 and microRNA-34 are suppressors of canonical Wnt signaling. PMID: 22045851 Ref: Hedgehog signaling and the Gli code in stem cells, cancer, and metastases. PMID: 22114144 Ref: Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth. PMID: 22126303 Ref: Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44. PMID: 22977525 |
Ref: Capsaicin represses transcriptional activity of beta-catenin in human colorectal cancer cells. PMID: 21764279 Ref: gamma-Tocotrienol inhibits cell viability through suppression of beta-catenin/Tcf signaling in human colon carcinoma HT-29 cells. PMID: 21852086 Ref: Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment. PMID: 21861107 Ref: DIF-1 inhibits the Wnt/beta-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines. PMID: 22005519 Ref: VDR/RXR and TCF4/beta-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression. PMID: 22108803 Ref: The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the beta-catenin signaling pathway. PMID: 22198215 Ref: Structure-based discovery of a novel inhibitor targeting the beta-catenin/Tcf4 interaction. PMID: 22224445 Ref: Src tyrosine kinase phosphorylation of nuclear receptor HNF4alpha correlates with isoform-specific loss of HNF4alpha in human colon cancer. PMID: 22308320 Ref: Wnt/beta-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. PMID: 22337891 Ref: Wnt signalling pathway parameters for mammalian cells. PMID: 22363759 Ref: Phosphorylation of beta-catenin at serine 663 regulates its transcriptional activity. PMID: 22369945 Ref: Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21. PMID: 22464014 Ref: Wnt/beta-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells. PMID: 22550094 Ref: A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and beta-catenin transcriptional activity. PMID: 22556201 Ref: UCHL1 acts as a colorectal cancer oncogene via activation of the beta-catenin/TCF pathway through its deubiquitinating activity. PMID: 22641175 Ref: HNF4alpha: a new biomarker in colon cancer? PMID: 22731903 Ref: beta-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells. PMID: 22771508 Ref: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. PMID: 22800197 Ref: A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations. PMID: 22860045 Ref: The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway. PMID: 22935447 |
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