Primary Site >> Colorectal Cancer
Gene >> HDAC6
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Ref: Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation. PMID: 2288877 |
Ref: Colon carcinoma cells blocked in polarization exhibit increased expression of carcinoembryonic antigen. PMID: 8241027 |
Ref: Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. PMID: 15782138 |
Ref: CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. PMID: 16731764 Ref: CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. PMID: 16891455 Ref: Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence. PMID: 17019713 |
Ref: R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. PMID: 18000499 |
Ref: Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors. PMID: 18348516 |
Ref: Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation. PMID: 19583815 Ref: Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. PMID: 20451378 Ref: Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity. PMID: 21073160 |
Ref: Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation. PMID: 21936551 |
Ref: Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. PMID: 22322857 |
Ref: A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. PMID: 23322205 Ref: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. PMID: 23770684 |
Ref: Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. PMID: 24172857 Ref: Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors. PMID: 24742384 Ref: Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells. PMID: 24766560 Ref: Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. PMID: 25203782 |
Ref: The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. PMID: 25307283 Ref: Aceroside VIII is a new natural selective HDAC6 inhibitor that synergistically enhances the anticancer activity of HDAC inhibitor in HT29 cells. PMID: 25590368 Ref: Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells. PMID: 26309122 Ref: Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acry lamide in human colorectal cancer cells in vitro and in vivo. PMID: 26462017 |
Ref: Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression. PMID: 26848526 Ref: Acetylation modification regulates GRP78 secretion in colon cancer cells. PMID: 27460191 |
Ref: Class I histone deacetylases regulate p53/NF-kappaB crosstalk in cancer cells. PMID: 27838375 Ref: The HDAC6 Inhibitor Tubacin Induces Release of CD133(+) Extracellular Vesicles From Cancer Cells. PMID: 28452069 Ref: Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6. PMID: 28599312 Ref: PKCepsilon phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation. PMID: 29038521 |
Ref: The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer. PMID: 29483217 Ref: The HDAC6 inhibitor ACY1215 enhances the anticancer activity of oxaliplatin in colorectal cancer cells. PMID: 29749542 Ref: A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells. PMID: 29917295 Ref: The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death. PMID: 30318510 |