Primary Site >> Colorectal Cancer

Gene >> HAS2

  • 2002
  • 2003
  • 2004
  • 2005
  • 2008
  • 2009
  • 2013
  • 2014
Ref: Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.
PMID: 12397638
 Ref: Hyaluronan content in experimental carcinoma is not correlated to interstitial fluid pressure.
PMID: 12767932
Ref: Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth.
PMID: 14566823
 Ref: Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer.
PMID: 15065603
Ref: Hyaluronan mediates adhesion of metastatic colon carcinoma cells.
PMID: 15522317
 Ref: Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells.
PMID: 15632176
 Ref: Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.
PMID: 18326857
 Ref: Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity.
PMID: 19231585
 Ref: Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
PMID: 23517721
 Ref: Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.
PMID: 24295787
Ref: Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.
PMID: 25013352