Primary Site >> Colorectal Cancer
Gene >> H2AFX
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Ref: Assessment of apoptosis by immunohistochemical markers compared to cellular morphology in ex vivo-stressed colonic mucosa. PMID: 15684335 |
Ref: 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation. PMID: 17085668 |
Ref: Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells. PMID: 17540426 Ref: Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. PMID: 17875720 Ref: Radiosensitization by the histone deacetylase inhibitor PCI-24781. PMID: 18006784 |
Ref: Clofarabine acts as radiosensitizer in vitro and in vivo by interfering with DNA damage response. PMID: 18037589 Ref: Survivin antisense oligonucleotides effectively radiosensitize colorectal cancer cells in both tissue culture and murine xenograft models. PMID: 18406888 Ref: Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli. PMID: 18454178 Ref: Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. PMID: 18594007 Ref: Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions. PMID: 18641004 |
Ref: Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis. PMID: 19028473 Ref: Mouse embryonic fibroblasts null for the Kruppel-like factor 4 gene are genetically unstable. PMID: 19137014 Ref: Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells. PMID: 19735649 |
Ref: DNA damage response to the Mdm2 inhibitor nutlin-3. PMID: 19788889 Ref: DNA damage signaling is activated during cancer progression in human colorectal carcinoma. PMID: 20023412 Ref: Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth. PMID: 20051375 Ref: Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells. PMID: 20227390 |
Ref: A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe. PMID: 20024691 Ref: In vivo and in vitro assessment of the action of SN 28049, a benzonaphthyridine derivative targeting topoisomerase II, on the murine Colon 38 carcinoma. PMID: 20697772 Ref: H2AX phosphorylation in response to DNA double-strand break formation during bystander signalling: effect of microRNA knockdown. PMID: 21183548 Ref: A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. PMID: 21338495 Ref: Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. PMID: 21382167 Ref: Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts. PMID: 21567080 Ref: 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells. PMID: 21616090 Ref: DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status. PMID: 21674128 Ref: Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair. PMID: 21720182 |
Ref: Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer. PMID: 22586065 Ref: The anticancer effect of saffron in two p53 isogenic colorectal cancer cell lines. PMID: 22640402 Ref: Reduction of ultraviolet light-induced DNA damage in human colon cancer cells treated with a lactoferrin-derived peptide. PMID: 22901475 Ref: Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. PMID: 23097684 Ref: Phenethyl caffeate benzo[kl]xanthene lignan with DNA interacting properties induces DNA damage and apoptosis in colon cancer cells. PMID: 23123449 |
Ref: Mechanism of enhancement of radiation-induced cytotoxicity by sorafenib in colorectal cancer. PMID: 22923745 Ref: PES1 regulates sensitivity of colorectal cancer cells to anticancer drugs. PMID: 23333390 Ref: Reactive oxygen species mediate tolfenamic acid-induced apoptosis in human colorectal cancer cells. PMID: 23896517 Ref: Kruppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. PMID: 23919723 |
Ref: Decay of gamma-H2AX foci correlates with potentially lethal damage repair and P53 status in human colorectal carcinoma cells. PMID: 24363165 Ref: Radiosensitization by thymidine phosphorylase inhibitor in thymidine phosphorylase negative and overexpressing bladder cancer cell lines. PMID: 24940699 Ref: Benzylidenetetralones, cyclic chalcone analogues, induce cell cycle arrest and apoptosis in HCT116 colorectal cancer cells. PMID: 25008568 Ref: Carbon-ion beam irradiation kills X-ray-resistant p53-null cancer cells by inducing mitotic catastrophe. PMID: 25531293 |
Ref: High expression of phospho-H2AX predicts a poor prognosis in colorectal cancer. PMID: 25862913 Ref: 5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair. PMID: 25909291 Ref: Combined olaparib and oxaliplatin inhibits tumor proliferation and induces G2/M arrest and gamma-H2AX foci formation in colorectal cancer. PMID: 26543375 |
Ref: Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases. PMID: 26542539 Ref: Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner. PMID: 26687759 Ref: Herbal Formulation C168 Attenuates Proliferation and Induces Apoptosis in HCT 116 Human Colorectal Carcinoma Cells: Role of Oxidative Stress and DNA Damage. PMID: 26884792 Ref: Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. PMID: 26934368 Ref: Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma. PMID: 27045955 Ref: c-MET inhibition enhances the response of the colorectal cancer cells to irradiation in vitro and in vivo. PMID: 27073569 Ref: Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10-/- Mice. PMID: 27245408 Ref: Twist1 and Slug mediate H2AX-regulated epithelial-mesenchymal transition in breast cells. PMID: 27315462 Ref: Validation data supporting the characterization of novel copper complexes as anticancer agents. PMID: 28054019 |
Ref: Carboxylated nanodiamonds can be used as negative reference in in vitro nanogenotoxicity studies. PMID: 28165139 Ref: miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1. PMID: 28255246 Ref: Measurement of DNA damage in peripheral blood by the gamma-H2AX assay as predictor of colorectal cancer risk. PMID: 28291710 Ref: Inactivation of JNK2 as carcinogenic factor in colitis-associated and sporadic colorectal carcinogenesis. PMID: 28383667 Ref: Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP. PMID: 28386336 Ref: NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations. PMID: 28915668 Ref: Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. PMID: 28928376 Ref: Combined therapy of colon carcinomas with an oncolytic adenovirus and valproic acid. PMID: 29228615 |
Ref: 53BP1 loss suppresses the radiosensitizing effect of icotinib hydrochloride in colorectal cancer cells. PMID: 29388453 Ref: Silencing Artemis Enhances Colorectal Cancer Cell Sensitivity to DNA-damaging Agents. PMID: 29426373 Ref: WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage. PMID: 29925347 Ref: Increased Levels of Oxidative Damage in Liver Metastases Compared with Corresponding Primary Colorectal Tumors: Association with Molecular Subtype and Prior Treatment. PMID: 30031728 |