Primary Site >> Colorectal Cancer
Gene >> GSTK1
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Ref: Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors. PMID: 2466554 Ref: Glutathione S-transferases in normal and cancerous human colon tissue. PMID: 2591027 Ref: Time-dependent activity and expression of glutathione S-transferases in the human colon adenocarcinoma cell line Caco-2. PMID: 2604734 |
Ref: Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines. PMID: 1682279 Ref: Immunohistochemical localization of glutathione S-transferases alpha, mu, and pi in normal tissue and carcinomas from human colon. PMID: 1747943 Ref: Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa. PMID: 1988173 |
Ref: Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid. PMID: 1731759 |
Ref: Biochemical characterization of a mitomycin C resistant colon cancer cell line variant. PMID: 7903534 Ref: Glutathione S-transferase activity in patients with cancer of the digestive tract. PMID: 8270599 |
Ref: Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis. PMID: 8069858 |
Ref: Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells. PMID: 7488239 Ref: Cellular basis for differential sensitivity to cisplatin in human germ cell tumour and colon carcinoma cell lines. PMID: 7710929 Ref: Glutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer. PMID: 7796404 Ref: Induction of NAD(P)H:quinone reductase by vitamins A, E and C in Colo205 colon cancer cells. PMID: 8529207 |
Ref: Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. PMID: 8567338 Ref: Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide. PMID: 8758929 |
Ref: Importance of glutathione and associated enzymes in drug response. PMID: 9406235 |
Ref: Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase. PMID: 9635580 Ref: Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases alpha and pi, glutathione and aldehyde dehydrogenase. PMID: 9652800 Ref: Glutathione S-transferase GSTM1 and GSTT1 polymorphisms and colorectal cancer risk: a prospective study. PMID: 9829708 |
Ref: Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer. PMID: 10207630 Ref: Regulatory network of mitomycin C action in human colon cancer cells. PMID: 10391098 Ref: Glutathione S-transferase (GST) M1, T1, P1, N-acetyltransferase (NAT) 1 and 2 genetic polymorphisms and susceptibility to colorectal cancer. PMID: 10434361 Ref: The glutathione S-transferases: influence of polymorphism on cancer susceptibility. PMID: 10493261 |
Ref: P-glycoprotein, glutathione and glutathione S-transferase increase in a colon carcinoma cell line by colchicine. PMID: 11321524 |
Ref: Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor. PMID: 11408349 Ref: Glutathione S-transferase M1 and T1 null genotypes and the risk of gastric and colorectal cancers. PMID: 11410321 Ref: Glutathione-S-transferase-pi expression regulates sensitivity to glutathione-doxorubicin conjugate. PMID: 11604559 Ref: The glutathione biotransformation system and colorectal cancer risk in humans. PMID: 11768564 |
Ref: Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase. PMID: 11747988 Ref: Loss of glutathione S-transferase (GST) mu phenotype in colorectal adenocarcinomas from patients with a GSTM1 positive genotype. PMID: 11809532 Ref: Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer. PMID: 12072547 Ref: Genetic polymorphisms in the cytochrome P450 1A1, glutathione S-transferase M1 and T1, and susceptibility to colon cancer. PMID: 12210502 Ref: Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. PMID: 12507929 |
Ref: Cellular determinants of oxaliplatin sensitivity in colon cancer cell lines. PMID: 12504667 Ref: Cancer and phase II drug-metabolizing enzymes. PMID: 12570745 Ref: Possible influence of glutathione S-transferase GSTT1 null genotype on age of onset of sporadic colorectal adenocarcinoma. PMID: 12682546 Ref: Molecular biomarkers of colorectal carcinogenesis and their role in surveillance and early intervention. PMID: 12736102 Ref: Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate. PMID: 12896903 Ref: Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs? PMID: 12897434 Ref: Glutathione-S-transferase pi expression and activity is increased in colonic neoplasia. PMID: 14598612 |
Ref: Meat consumption patterns and preparation, genetic variants of metabolic enzymes, and their association with rectal cancer in men and women. PMID: 15051825 |
Ref: Expression pattern of epithelial cell adhesion molecule on normal and malignant colon tissues. PMID: 15637741 Ref: Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate. PMID: 15829614 Ref: Glutathione S-transferase M1, T1, P1 genotypes and risk for development of colorectal cancer. PMID: 15932063 Ref: Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. PMID: 16083918 Ref: Cancer and molecular biomarkers of phase 2. PMID: 16399374 Ref: Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease. PMID: 16399377 |
Ref: Polymorphism of glutathione S-transferase omega gene and risk of cancer. PMID: 15992993 Ref: Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer. PMID: 16328000 |
Ref: Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancer. PMID: 17542627 Ref: Antitumor and cytotoxic effects of Phyllanthus polyphyllus on Ehrlich ascites carcinoma and human cancer cell lines. PMID: 17827693 Ref: Chemopreventive effect of chitosan oligosaccharide against colon carcinogenesis. PMID: 18062235 |
Ref: Interactions between XIAP associated factor 1 and a nuclear co-activator, CBP, in colon cancer cells. PMID: 18362468 Ref: Glutathione level and glutathione-dependent enzyme activities in blood serum of patients with gastrointestinal tract tumors. PMID: 18394427 |
Ref: Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study. PMID: 19124514 Ref: Glutathione S-transferase polymorphisms and survival in African-American and white colorectal cancer patients. PMID: 19748847 Ref: Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population. PMID: 19960570 |
Ref: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients. PMID: 20078613 Ref: Oxidative alterations induced in vitro by the photodynamic reaction in doxorubicin-sensitive (LoVo) and -resistant (LoVoDX) colon adenocarcinoma cells. PMID: 20404024 Ref: Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study. PMID: 20526440 Ref: Effect modification of meat intake by genetic polymorphisms on colorectal neoplasia susceptibility. PMID: 20843102 |
Ref: Genetic polymorphisms of glutathione S-transferase genes and susceptibility to colorectal cancer: a case-control study in an Indian population. PMID: 20688591 Ref: [Analysis of gene expression patterns in an irinotecan-resistance colon cancer cell by cDNA microarray]. PMID: 21355292 Ref: Antioxidant enzyme activities of iron-saturated bovine lactoferrin (Fe-bLf) in human gut epithelial cells under oxidative stress. PMID: 21486205 Ref: Glutathione S-transferase (GST) gene polymorphisms, cigarette smoking and colorectal cancer risk among Chinese in Singapore. PMID: 21803734 Ref: TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells. PMID: 21826244 Ref: Effect of selenium-saturated bovine lactoferrin (Se-bLF) on antioxidant enzyme activities in human gut epithelial cells under oxidative stress. PMID: 21919840 Ref: Glutathione S-transferase mu gene variants and colorectal cancer development--use of sequence-specific probes for an Iranian population. PMID: 22126490 |
Ref: GSTP1 I105V polymorphism and susceptibility to colorectal cancer in Kashmiri population. PMID: 21711092 Ref: The activity of antioxidant enzymes in colorectal adenocarcinoma and corresponding normal mucosa. PMID: 23189274 Ref: Potential chemoprevention activity of pterostilbene by enhancing the detoxifying enzymes in the HT-29 cell line. PMID: 23464466 |
Ref: Glutathione S-transferase M1-null genotype as risk factor for SOS in oxaliplatin-treated patients with metastatic colorectal cancer. PMID: 23287989 Ref: Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas. PMID: 24106402 |
Ref: Genetic variants in the glutathione S-transferase genes and survival in colorectal cancer patients after chemotherapy and differences according to treatment with oxaliplatin. PMID: 24842074 Ref: GST gene polymorphisms and the risk of colorectal cancer development. PMID: 25258576 |
Ref: Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer. PMID: 25686853 |
Ref: The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer. PMID: 25408419 Ref: Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. PMID: 26673998 Ref: Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders. PMID: 27458849 |
Ref: Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan. PMID: 28714190 Ref: GSTM1, GSTT1, and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers. PMID: 29765533 Ref: Expression of CYP and GST in human normal and colon tumor tissues. PMID: 30092668 Ref: The diagnostic potential of glutathione S-transferase (GST) polymorphisms in patients with colorectal cancer. PMID: 30106268 Ref: Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma. PMID: 30228782 |