Primary Site >> Colorectal Cancer
Gene >> GSK3B
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Ref: Cadherin and catenin biology represent a global mechanism for epithelial cancer progression. PMID: 9536277 |
Ref: Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. PMID: 9426055 Ref: Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. PMID: 9501208 Ref: Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. PMID: 9515795 Ref: Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. PMID: 9601641 Ref: Beta-catenin mutation in carcinoma of the uterine endometrium. PMID: 9721853 Ref: Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. PMID: 9734785 Ref: [Beta-catenin expression and its significance for metastasis in curatively operated rectum carcinoma]. PMID: 9931888 |
Ref: An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. PMID: 10228155 Ref: The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling. PMID: 10347231 Ref: Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer. PMID: 10392898 Ref: Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. PMID: 10545105 Ref: beta-catenin signaling and cancer. PMID: 10580987 |
Ref: Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells. PMID: 10699468 Ref: Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin. PMID: 10722668 Ref: Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin. PMID: 10906131 Ref: More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats. PMID: 10965019 Ref: Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. PMID: 11035789 Ref: Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas. PMID: 11048797 |
Ref: Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. PMID: 11157977 |
Ref: Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. PMID: 11809809 Ref: TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. PMID: 11934263 Ref: Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. PMID: 12124333 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 Ref: beta-Catenin signaling: therapeutic strategies in oncology. PMID: 12642683 |
Ref: Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. PMID: 12771132 Ref: Reduction of beta-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated beta-catenin. PMID: 12813129 Ref: [Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms]. PMID: 14685680 |
Ref: The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis. PMID: 15617833 Ref: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. PMID: 15670774 Ref: The calpain system is involved in the constitutive regulation of beta-catenin signaling functions. PMID: 15817486 Ref: G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway. PMID: 15837931 Ref: Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. PMID: 15930030 Ref: Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta. PMID: 15940626 Ref: Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. PMID: 15946992 Ref: Beta-catenin, cancer, and G proteins: not just for frizzleds anymore. PMID: 16014605 Ref: Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. PMID: 16043125 Ref: The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. PMID: 16103100 Ref: Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. PMID: 16158975 |
Ref: Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection. PMID: 16670426 Ref: Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression. PMID: 16772034 Ref: CD97 overexpression in tumor cells at the invasion front in colorectal cancer (CC) is independently regulated of the canonical Wnt pathway. PMID: 16929497 Ref: Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. PMID: 16968065 Ref: Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay. PMID: 17652946 |
Ref: Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines. PMID: 17219422 Ref: Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. PMID: 17241872 Ref: Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues. PMID: 17380482 Ref: Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. PMID: 17875931 |
Ref: Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. PMID: 18794809 |
Ref: Increased expression of beta-catenin, phosphorylated glycogen synthase kinase 3beta, cyclin D1, and c-myc in laterally spreading colorectal tumors. PMID: 19064714 Ref: Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. PMID: 19190323 Ref: Knockin of mutant PIK3CA activates multiple oncogenic pathways. PMID: 19196980 Ref: The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. PMID: 19576224 Ref: Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. PMID: 19701245 Ref: The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta. PMID: 19779850 Ref: beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. PMID: 19797085 Ref: Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. PMID: 19903789 Ref: Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer. PMID: 20008853 |
Ref: Expression of adenomatous polyposis coli protein in reactive astrocytes in hippocampus of kainic acid-induced rat. PMID: 19655246 Ref: Murrayafoline A attenuates the Wnt/beta-catenin pathway by promoting the degradation of intracellular beta-catenin proteins. PMID: 19962966 Ref: Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions. PMID: 20084281 Ref: NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3. PMID: 20110283 Ref: SGK1-dependent intestinal tumor growth in APC-deficient mice. PMID: 20110688 Ref: Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. PMID: 20133737 Ref: EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells. PMID: 20571779 Ref: Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin signal via ISGylation of beta-catenin. PMID: 20581239 Ref: Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules. PMID: 20628792 Ref: Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells. PMID: 20661477 Ref: Independent interactions of phosphorylated beta-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. PMID: 21152425 |
Ref: beta-Catenin and NF-kappaB cooperate to regulate the uPA/uPAR system in cancer cells. PMID: 20473943 Ref: Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}. PMID: 21205744 Ref: Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumorigenesis. PMID: 21205878 Ref: Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3beta. PMID: 21303975 Ref: Lithium reduces tumorigenic potential in response to EGF signaling in human colorectal cancer cells. PMID: 21369697 Ref: Upregulation of glycogen synthase kinase 3beta in human colorectal adenocarcinomas correlates with accumulation of CTNNB1. PMID: 21609933 |
Ref: The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling. PMID: 21873734 Ref: Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran. PMID: 22207181 Ref: Diet-induced obesity elevates colonic TNF-alpha in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. PMID: 22209007 Ref: A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. PMID: 22279539 Ref: Wnt signalling pathway parameters for mammalian cells. PMID: 22363759 Ref: Ras stabilization through aberrant activation of Wnt/beta-catenin signaling promotes intestinal tumorigenesis. PMID: 22494971 Ref: Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3beta pathway in colon cancer. PMID: 22581840 Ref: MENA is a transcriptional target of the Wnt/beta-catenin pathway. PMID: 22615875 Ref: Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer. PMID: 22682314 Ref: The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway. PMID: 22935447 Ref: Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives. PMID: 23036956 Ref: Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. PMID: 23272949 |
Ref: Nuclear expression of glycogen synthase kinase-3beta and lack of membranous beta-catenin is correlated with poor survival in colon cancer. PMID: 23389968 Ref: Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells. PMID: 23393221 Ref: Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. PMID: 23729362 Ref: Epithelial-mesenchymal transition associates with maintenance of stemness in spheroid-derived stem-like colon cancer cells. PMID: 24039918 Ref: Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of beta-catenin/TCF transcription. PMID: 24060489 Ref: Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. PMID: 24399733 Ref: Octreotide stimulates somatostatin receptor-induced apoptosis of SW480 colon cancer cells by activation of glycogen synthase kinase-3beta, A Wnt/beta-catenin pathway modulator. PMID: 24634935 |
Ref: Chronic ulcerative colitis and colorectal cancer. PMID: 23941831 Ref: Tussilagone suppresses colon cancer cell proliferation by promoting the degradation of beta-catenin. PMID: 24269588 Ref: Delayed administration of a single dose of lithium promotes recovery from AKI. PMID: 24408869 Ref: Involvement of CDX2 in the cross talk between TNF-alpha and Wnt signaling pathway in the colon cancer cell line Caco-2. PMID: 24501326 Ref: Anticancer activity of protocatechualdehyde in human breast cancer cells. PMID: 24712725 Ref: Moguntinones--new selective inhibitors for the treatment of human colorectal cancer. PMID: 24743703 Ref: The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4. PMID: 24829151 Ref: The organochlorine p,p'-dichlorodiphenyltrichloroethane induces colorectal cancer growth through Wnt/beta-catenin signaling. PMID: 24968063 Ref: GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis. PMID: 24984063 Ref: NF-kappaB signaling inhibition and anticancer activities of LLDT-246 on human colorectal cancer HCT-116 cells in vitro. PMID: 24986326 Ref: MACC1 promotes carcinogenesis of colorectal cancer via beta-catenin signaling pathway. PMID: 25003996 Ref: MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of beta-catenin signaling. PMID: 25193986 Ref: Thymosin beta4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/beta-catenin signaling pathway. PMID: 25218472 Ref: The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of beta-catenin. PMID: 25266658 Ref: Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation. PMID: 25352148 Ref: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. PMID: 25443414 Ref: The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells. PMID: 25494848 Ref: MicroRNA-302a functions as a putative tumor suppressor in colon cancer by targeting Akt. PMID: 25542007 |
Ref: Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by beta-catenin activity. PMID: 25109331 Ref: Cathelicidin, an antimicrobial peptide produced by macrophages, promotes colon cancer by activating the Wnt/beta-catenin pathway. PMID: 25596747 Ref: A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells. PMID: 25659031 Ref: Kruppel-like factor 5 incorporates into the beta-catenin/TCF complex in response to LPA in colon cancer cells. PMID: 25683913 Ref: Lithium chloride induces mesenchymaltoepithelial reverting transition in primary colon cancer cell cultures. PMID: 25738332 Ref: Attenuation of enoyl coenzyme A hydratase 1 expression in colorectal cancer cells using small interfering RNA inhibits cell proliferation and migration. PMID: 25739098 Ref: Sasa quelpaertensis Leaf Extract Inhibits Colon Cancer by Regulating Cancer Cell Stemness in Vitro and in Vivo. PMID: 25941936 Ref: Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination. PMID: 25943886 Ref: Brewers' rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats. PMID: 26269672 Ref: FAK/PYK2 promotes the Wnt/beta-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3beta. PMID: 26274564 Ref: GSK3beta and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer - Targeting GSK3beta downregulates the signaling pathway and reduces cell proliferation. PMID: 26385428 Ref: Mechanism of Chemoprevention against Colon Cancer Cells Using Combined Gelam Honey and Ginger Extract via mTOR and Wnt/beta-catenin Pathways. PMID: 26434873 Ref: Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3beta pathway in human colon cancer. PMID: 26452029 Ref: The Anti-Tumor Activity of Succinyl Macrolactin A Is Mediated through the beta-Catenin Destruction Complex via the Suppression of Tankyrase and PI3K/Akt. PMID: 26544726 Ref: Novel beta-carbolines against colorectal cancer cell growth via inhibition of Wnt/beta-catenin signaling. PMID: 27551464 |
Ref: Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells. PMID: 26014148 Ref: RNA binding protein RBM3 increases beta-catenin signaling to increase stem cell characteristics in colorectal cancer cells. PMID: 26331352 Ref: FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3beta/beta- catenin signaling cascade via FGFR4 activation. PMID: 26498355 Ref: Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3beta-inhibitor 2-PP1 positive feedback loop. PMID: 26655089 Ref: Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3beta Signaling Pathway. PMID: 26792278 Ref: MicroRNA-224 sustains Wnt/beta-catenin signaling and promotes aggressive phenotype of colorectal cancer. PMID: 26822534 Ref: Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells. PMID: 26857144 Ref: Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin. PMID: 26915040 Ref: The involvement of cyclin D1 degradation through GSK3beta-mediated threonine-286 phosphorylation-dependent nuclear export in anti-cancer activity of mulberry root bark extracts. PMID: 26926171 Ref: DDA1 promotes stage IIB-IIC colon cancer progression by activating NFkappaB/CSN2/GSK-3beta signaling. PMID: 26942699 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: High expression of Rab3D predicts poor prognosis and associates with tumor progression in colorectal cancer. PMID: 27046094 Ref: Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells. PMID: 27068260 Ref: Cytotoxic activity of aeroplysinin-1 against colon cancer cells by promoting beta-catenin degradation. PMID: 27120392 Ref: Computational Identification of Novel Stage-Specific Biomarkers in Colorectal Cancer Progression. PMID: 27243824 Ref: Procaine Inhibits Osteo/Odontogenesis through Wnt/beta-Catenin Inactivation. PMID: 27257912 Ref: PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells. PMID: 27313176 Ref: Enhanced TLR4 Expression on Colon Cancer Cells After Chemotherapy Promotes Cell Survival and Epithelial-Mesenchymal Transition Through Phosphorylation of GSK3beta. PMID: 27354597 Ref: Walnut Phenolic Extract and Its Bioactive Compounds Suppress Colon Cancer Cell Growth by Regulating Colon Cancer Stemness. PMID: 27455311 Ref: The destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma. PMID: 27462886 Ref: B-cell translocation gene 3 overexpression inhibits proliferation and invasion of colorectal cancer SW480 cells via Wnt/beta-catenin signaling pathway. PMID: 27468874 Ref: Simultaneous destabilization of beta-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer. PMID: 27470214 Ref: Ubiquitin Ligase, Fbw7, Targets CDX2 for Degradation via Two Phosphodegron Motifs in a GSK3beta-Dependent Manner. PMID: 27470268 Ref: CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3beta signaling pathway. PMID: 27634891 Ref: Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells. PMID: 27670681 Ref: Wnt-beta-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer. PMID: 27709738 |
Ref: Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells. PMID: 27871156 Ref: Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/beta-catenin signaling pathways in hepatocellular and colorectal carcinoma cells. PMID: 27901475 Ref: Oncogenic retinoic acid receptor alpha promotes human colorectal cancer growth through simultaneously regulating p21 transcription and GSK3beta/beta-catenin signaling. PMID: 27932034 Ref: Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis. PMID: 28245338 Ref: Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. PMID: 28275297 Ref: p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. PMID: 28339031 Ref: Genome-wide network-based pathway analysis of CSF t-tau/Abeta1-42 ratio in the ADNI cohort. PMID: 28558704 Ref: Origin of Somatic Mutations in beta-Catenin versus Adenomatous Polyposis Coli in Colon Cancer: Random Mutagenesis in Animal Models versus Nonrandom Mutagenesis in Humans. PMID: 28578586 Ref: FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. PMID: 28619760 Ref: Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/beta-catenin-ABCG2 signaling pathway in ALDHA1(+) colorectal cancer stem cells. PMID: 28639895 Ref: Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/beta-catenin signaling pathways in human colon cancer cells. PMID: 28688953 Ref: Molecular genetics and targeted therapy of WNT-related human diseases (Review). PMID: 28731148 Ref: Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells. PMID: 28870200 Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. PMID: 29110225 Ref: MiR-92a promotes stem cell-like properties by activating Wnt/beta-catenin signaling in colorectal cancer. PMID: 29254202 Ref: Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer. PMID: 29258530 Ref: Anti-cancer activity of Bacillus amyloliquefaciens AK-0 through cyclin D1 proteasomal degradation via GSK3beta-dependent phosphorylation of threonine-286. PMID: 29442024 |
Ref: Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway. PMID: 28684297 Ref: Identification and characterization of functional single nucleotide polymorphisms (SNPs) in Axin 1 gene: a molecular dynamics approach. PMID: 28770488 Ref: Simvastatin induces G1 arrest by up-regulating GSK3beta and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells. PMID: 28833099 Ref: Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1. PMID: 29274585 Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: Interaction of the Wnt/beta-catenin and RAS-ERK pathways involving co-stabilization of both beta-catenin and RAS plays important roles in the colorectal tumorigenesis. PMID: 29449169 Ref: Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress. PMID: 29500295 Ref: Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. PMID: 29534875 Ref: Cytotoxic activity of the twigs of Cinnamomum cassia through the suppression of cell proliferation and the induction of apoptosis in human colorectal cancer cells. PMID: 29554905 Ref: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells. PMID: 29568348 Ref: A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer. PMID: 29619072 Ref: Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3beta and F-box and WD repeat domain-containing 7. PMID: 29628506 Ref: HOXA4, down-regulated in lung cancer, inhibits the growth, motility and invasion of lung cancer cells. PMID: 29700285 Ref: SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma. PMID: 29786668 Ref: Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. PMID: 29895675 Ref: Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin. PMID: 29899829 Ref: Alternative NF-kappaB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3. PMID: 29973688 Ref: Activation of WNT/beta-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations. PMID: 29978469 Ref: Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/beta-catenin signaling pathway. PMID: 30008817 Ref: miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3beta and Wnt/beta-catenin signaling pathways. PMID: 30013659 Ref: Inhibitory effect of selenomethionine on carcinogenesis in the model of human colorectal cancer in vitro and its link to the Wnt/beta-catenin pathway. PMID: 30016378 Ref: Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells. PMID: 30097126 Ref: Retinoic Acid Receptor alpha Knockdown Suppresses the Tumorigenicity of Esophageal Carcinoma via Wnt/beta-catenin Pathway. PMID: 30155836 Ref: MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/beta-catenin positive feedback loop. PMID: 30253791 Ref: Characterisation of mesenchymal colon tumour-derived cells in tumourspheres as a model for colorectal cancer progression. PMID: 30272331 Ref: FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3beta-related pathways. PMID: 30275459 |