Primary Site >> Colorectal Cancer
Gene >> GPA33
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Ref: Quantitative analysis of antibody localization in human metastatic colon cancer: a phase I study of monoclonal antibody A33. PMID: 2230877 |
Ref: Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy. PMID: 8519646 |
Ref: Phase I/II study of iodine 125-labeled monoclonal antibody A33 in patients with advanced colon cancer. PMID: 8656247 Ref: Enhancement of radiation dose to the nucleus by vesicular internalization of iodine-125-labeled A33 monoclonal antibody. PMID: 8683300 Ref: Organ-specific expression of the colon cancer antigen A33, a cell surface target for antibody-based therapy. PMID: 21541536 |
Ref: The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. PMID: 9012807 Ref: Electrophoretic analysis of the novel antigen for the gastrointestinal-specific monoclonal antibody, A33. PMID: 9150949 Ref: Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. PMID: 9245713 |
Ref: Rapid and specific targeting of monoclonal antibody A33 to a colon cancer xenograft in nude mice. PMID: 9454885 Ref: Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium. PMID: 9542130 |
Ref: 131I radioimmunotherapy and fractionated external beam radiotherapy: comparative effectiveness in a human tumor xenograft. PMID: 10520720 |
Ref: Organ-specific expression of the intestinal epithelium-related antigen A33, a cell surface target for antibody-based imaging and treatment in gastrointestinal cancer. PMID: 10950144 |
Ref: Relative therapeutic efficacy of (125)I- and (131)I-labeled monoclonal antibody A33 in a human colon cancer xenograft. PMID: 11483688 Ref: Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33. PMID: 11559561 |
Ref: A33scFv-cytosine deaminase: a recombinant protein construct for antibody-directed enzyme-prodrug therapy. PMID: 12644833 Ref: Phase I study of anticolon cancer humanized antibody A33. PMID: 12684402 Ref: Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer. PMID: 12684403 Ref: Recombinant antigen expression on yeast surface (RAYS) for the detection of serological immune responses in cancer patients. PMID: 12828452 Ref: Transcriptional regulation of A33 antigen expression by gut-enriched Kruppel-like factor. PMID: 12853980 |
Ref: Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines. PMID: 15296462 Ref: Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. PMID: 15375555 Ref: (131)I-Labeled recombinant anti-glycoprotein A33 antibody single chain variable fragment fused to cytosine deaminase PMID: 20641233 Ref: Radioiodinated humanized monoclonal antibody A33 PMID: 20641323 |
Ref: Radioimmunotherapy and colorectal cancer. PMID: 15739250 Ref: In vitro characterization of 211 At-labeled antibody A33--a potential therapeutic agent against metastatic colorectal carcinoma. PMID: 16248767 |
Ref: Glycoprotein A34, a novel target for antibody-based cancer immunotherapy. PMID: 16405301 Ref: Cellular processing in the SW1222 cell line of mAb A33 directly and indirectly radiohalogenated. PMID: 16786140 Ref: In vitro and in vivo characterization of 177Lu-huA33: a radioimmunoconjugate against colorectal cancer. PMID: 17127172 |
Ref: Design, construction, and in vitro analysis of A33scFv::CDy, a recombinant fusion protein for antibody-directed enzyme prodrug therapy in colon cancer. PMID: 17786329 Ref: Biodistribution of 211At-labeled humanized monoclonal antibody A33. PMID: 17803442 Ref: Influence of size, surface, cell line, and kinetic properties on the specific binding of A33 antigen-targeted multilayered particles and capsules to colorectal cancer cells. PMID: 19206525 |
Ref: A33 antigen displays persistent surface expression. PMID: 18236042 Ref: Biodistribution and efficacy of [131I]A33scFv::CDy, a recombinant antibody-enzyme protein for colon cancer. PMID: 18360720 Ref: Silica-deposited phospholipid nanotubules as a plausible drug targeting system. PMID: 18982520 |
Ref: A novel A33 promoter-based conditionally replicative adenovirus suppresses tumor growth and eradicates hepatic metastases in human colon cancer models. PMID: 19336523 Ref: Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling. PMID: 19454286 Ref: KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. PMID: 19551868 Ref: High-level expression of a phage display-derived scFv in Pichia pastoris. PMID: 19554300 |
Ref: Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. PMID: 19837982 |
Ref: (124)I-huA33 antibody PET of colorectal cancer. PMID: 21764796 |
Ref: Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin alpha-sarcin. PMID: 22718791 Ref: Production and characterization of scFvA33T1, an immunoRNase targeting colon cancer cells. PMID: 22748038 |
Ref: Safety, pharmacokinetics and pharmacodynamics of the anti-A33 fully-human monoclonal antibody, KRN330, in patients with advanced colorectal cancer. PMID: 23294608 Ref: Colon tumour secretopeptidome: insights into endogenous proteolytic cleavage events in the colon tumour microenvironment. PMID: 23684732 Ref: A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry. PMID: 23708196 |
Ref: Quantitative intratumoural microdistribution and kinetics of (131)I-huA33 antibody in patients with colorectal carcinoma. PMID: 24995151 |
Ref: Monoclonal antibody-functionalized multilayered particles: targeting cancer cells in the presence of protein coronas. PMID: 25712076 Ref: Preparation of an engineered safer immunotoxin against colon carcinoma based on the ribotoxin hirsutellin A. PMID: 25752204 Ref: Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin alpha-sarcin in nude mice bearing human colorectal cancer xenografts. PMID: 25883890 Ref: CF750-A33scFv-Fc-Based Optical Imaging of Subcutaneous and Orthotopic Xenografts of GPA33-Positive Colorectal Cancer in Mice. PMID: 26090413 Ref: PET-based compartmental modeling of (124)I-A33 antibody: quantitative characterization of patient-specific tumor targeting in colorectal cancer. PMID: 26194713 Ref: A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations. PMID: 26398937 |
Ref: Intestinal-specific activatable Myb initiates colon tumorigenesis in mice. PMID: 26300002 Ref: Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity (8)(6)Y- or (1)(7)(7)Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates. PMID: 26596724 Ref: Heterogeneous expression of A33 in colorectal cancer: possible explanation for A33 antibody treatment failure. PMID: 27272411 |
Ref: A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma. PMID: 28226180 Ref: Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer. PMID: 28705917 |
Ref: Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer. PMID: 29866746 Ref: A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer. PMID: 29935333 Ref: Development of a Tetravalent Anti-GPA33/Anti-CD3 Bispecific Antibody for Colorectal Cancers. PMID: 30082472 |