Primary Site >> Pancreatic Cancer
Gene >> GLI2
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Ref: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. PMID: 15645142 Ref: Hedgehog signaling pathway and gastric cancer. PMID: 16258256 |
Ref: Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription. PMID: 18357592 |
Ref: Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation. PMID: 19797115 Ref: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. PMID: 19860666 |
Ref: Small-molecule modulators of the Sonic Hedgehog signaling pathway. PMID: 20024066 Ref: Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PMID: 20098680 |
Ref: GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin. PMID: 20972463 Ref: Holoclone forming cells from pancreatic cancer cells enrich tumor initiating cells and represent a novel model for study of cancer stem cells. PMID: 21826251 Ref: Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PMID: 22087285 |
Ref: Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics. PMID: 21796625 |
Ref: GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. PMID: 23200667 Ref: Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice. PMID: 23684930 Ref: Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. PMID: 23935937 Ref: GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1. PMID: 24165159 |
Ref: Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm of pancreas. PMID: 24072181 |
Ref: GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1. PMID: 25807524 |
Ref: Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms. PMID: 27543868 Ref: Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. PMID: 27633013 Ref: Pancreatic fibroblasts smoothen their activities via AKT-GLI2-TGFalpha. PMID: 27664234 |
Ref: Association between methylation of tumor suppressor gene SOCS1 and acute myeloid leukemia. PMID: 29916533 Ref: The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer. PMID: 30382189 |