Primary Site >> Colorectal Cancer
Gene >> GDF15
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Ref: Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. PMID: 12624183 Ref: Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells. PMID: 12767058 Ref: MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. PMID: 12855642 Ref: Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation. PMID: 14578467 Ref: An unsupervised hierarchical dynamic self-organizing approach to cancer class discovery and marker gene identification in microarray data. PMID: 14594719 Ref: Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. PMID: 14614330 |
Ref: Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. PMID: 14633654 Ref: Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. PMID: 14662774 Ref: Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. PMID: 15308587 Ref: Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. PMID: 15377673 |
Ref: Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. PMID: 15670751 Ref: The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells. PMID: 15677629 Ref: Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53. PMID: 15750621 Ref: The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15. PMID: 15767558 Ref: Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. PMID: 16010409 Ref: 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-infl PMID: 16155208 |
Ref: Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. PMID: 16286461 Ref: Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells. PMID: 16328068 Ref: Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. PMID: 16477629 Ref: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. PMID: 16731769 |
Ref: NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells. PMID: 17191121 Ref: Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. PMID: 17258704 Ref: NAG-1/GDF-15: no evidence for an inhibitory role in colon cancer? PMID: 17383450 Ref: The rare benign liver tumors. PMID: 17694811 Ref: [Induction of NAG-1 gene expression in colon cancer cells by non-steroidal anti-inflammatory drugs]. PMID: 17899765 Ref: Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. PMID: 17964072 Ref: Study of molecular mechanisms of pro-apoptotic activity of NCX 4040, a novel nitric oxide-releasing aspirin, in colon cancer cell lines. PMID: 17971198 |
Ref: 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. PMID: 17957723 Ref: Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. PMID: 18058799 |
Ref: A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. PMID: 19375854 Ref: The effects of heparin on DLD-1 colon cancer cell line. PMID: 19408822 Ref: Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells. PMID: 19540205 Ref: 15-lipoxygenase-1 in colorectal cancer: a review. PMID: 19752603 Ref: Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. PMID: 19926935 |
Ref: Loss of GDF-15 abolishes sulindac chemoprevention in the ApcMin/+ mouse model of intestinal cancer. PMID: 19784846 Ref: Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. PMID: 19858293 Ref: Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach. PMID: 19924834 Ref: NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3. PMID: 20110283 Ref: The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta). PMID: 20130018 Ref: Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells. PMID: 20230799 Ref: Pleurospermum kamtschaticum extract induces apoptosis via mitochondrial pathway and NAG-1 expression in colon cancer cells. PMID: 20378978 Ref: MCC-555-induced NAG-1 expression is mediated in part by KLF4. PMID: 20385121 Ref: Endoscopic treatment of praecancerous colorectal lesions and early colorectal cancer. PMID: 20429313 Ref: Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53. PMID: 20709524 Ref: In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells. PMID: 23136612 |
Ref: Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status. PMID: 21380817 Ref: Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer. PMID: 21468045 Ref: Improved efficacy of prebiotic by flaxseed oil and horse chestnut in experimental colon cancer. PMID: 21585119 Ref: Preoperative staging of colon cancer patients: ultrasound can be a valuable alternative to computed tomography. PMID: 21585121 Ref: Pharmacology and cellular/molecular mechanisms of action of aspirin and non-aspirin NSAIDs in colorectal cancer. PMID: 22122764 |
Ref: Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells. PMID: 21852088 Ref: Serum macrophage inhibitory cytokine-1 (MIC-1/GDF15): a potential screening tool for the prevention of colon cancer? PMID: 22144502 Ref: Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC delta-independent mechanism. PMID: 22410117 Ref: Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1. PMID: 22511768 Ref: 2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells. PMID: 22648623 Ref: Inhibition of GSK-3beta reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells. PMID: 22683934 Ref: Macrophage inhibitory cytokine-1: a review of its pleiotropic actions in cancer. PMID: 23220850 |
Ref: Enteropathogenic Escherichia coli-induced macrophage inhibitory cytokine 1 mediates cancer cell survival: an in vitro implication of infection-linked tumor dissemination. PMID: 23503457 Ref: Multiplexed VeraCode bead-based serological immunoassay for colorectal cancer. PMID: 24161315 |
Ref: Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. PMID: 24440808 Ref: Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents. PMID: 24530873 Ref: A prospective study of macrophage inhibitory cytokine-1 (MIC-1/GDF15) and risk of colorectal cancer. PMID: 24565956 |
Ref: ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells. PMID: 25767681 Ref: Absolute quantification of DcR3 and GDF15 from human serum by LC-ESI MS. PMID: 25823874 Ref: Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality. PMID: 26026393 Ref: Reconstitution of TGFBR2-Mediated Signaling Causes Upregulation of GDF-15 in HCT116 Colorectal Cancer Cells. PMID: 26114631 Ref: The H6D genetic variation of GDF15 is associated with genesis, progress and prognosis in colorectal cancer. PMID: 26365480 |
Ref: GDF15 promotes EMT and metastasis in colorectal cancer. PMID: 26497212 Ref: Plasma Inflammatory Markers and Risk of Advanced Colorectal Adenoma in Women. PMID: 26511487 Ref: Portal of medical data models: information infrastructure for medical research and healthcare. PMID: 26868052 Ref: Acquisition of Chemoresistance and Other Malignancy-related Features of Colorectal Cancer Cells Are Incremented by Ribosome-inactivating Stress. PMID: 26961878 Ref: MiRComb: An R Package to Analyse miRNA-mRNA Interactions. Examples across Five Digestive Cancers. PMID: 26967326 Ref: Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer. PMID: 26990020 |
Ref: ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. PMID: 28143522 Ref: Circulating MIC-1/GDF15 is a complementary screening biomarker with CEA and correlates with liver metastasis and poor survival in colorectal cancer. PMID: 28206963 Ref: Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy. PMID: 28287848 Ref: MIC1/GDF15 as a Bone Metastatic Disease Biomarker. PMID: 28314325 Ref: Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors. PMID: 28475119 Ref: Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia. PMID: 28569401 Ref: Erratum: Genomic variants in mouse model induced by azoxymethane and dextran sodium sulfate improperly mimic human colorectal cancer. PMID: 28572667 Ref: Development and validation of a panel of five proteins as blood biomarkers for early detection of colorectal cancer. PMID: 29184444 |
Ref: Growth/differentiation factor 15 (GDF-15) as new potential serum marker in patients with metastatic colorectal cancer. PMID: 29400662 Ref: Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages. PMID: 29580202 Ref: Author Correction: Kanglaite sensitizes colorectal cancer cells to Taxol via NF-kappaBeta inhibition and connexin 43 upregulation. PMID: 29643394 Ref: GPF15 promotes epithelial-to-mesenchymal transition in colorectal carcinoma. PMID: 29771147 Ref: Correction: Effects of immune suppression for transplantation on inflammatory colorectal cancer progression. PMID: 30065288 Ref: Correction: Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p. PMID: 30115914 Ref: Author Correction: Anti-angiogenic drug scheduling optimisation with application to colorectal cancer. PMID: 30262882 Ref: An Assessment of Novel Biomarkers in Bone Metastatic Disease Using Multiplex Measurement and Multivariate Analysis. PMID: 30343636 |