Primary Site >> Colorectal Cancer

Gene >> FZD7

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Ref: Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway.
PMID: 11786918
Ref: Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer.
PMID: 12239632
 Ref: Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth.
PMID: 15901282
Ref: Comparative genomics on ROR1 and ROR2 orthologs.
PMID: 16211313
 Ref: Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids.
PMID: 17016432
Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs.
PMID: 17273804
Ref: Frizzled7 dictates embryonic morphogenesis: implications for colorectal cancer progression.
PMID: 17485397
Ref: A human three-dimensional cell line model allows the study of dynamic and reversible epithelial-mesenchymal and mesenchymal-epithelial transition that underpins colorectal carcinogenesis.
PMID: 17587804
 Ref: Frizzled-7 as a potential therapeutic target in colorectal cancer.
PMID: 18592008
 Ref: Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells.
PMID: 19773752
 Ref: Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment.
PMID: 19655379
 Ref: Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome).
PMID: 21165777
Ref: Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis.
PMID: 22109528
 Ref: Frizzled7 as an emerging target for cancer therapy.
PMID: 22182510
 Ref: Possible involvement of Wnt11 in colorectal cancer progression.
PMID: 22161723
 Ref: RNA-seq reveals determinants for irinotecan sensitivity/resistance in colorectal cancer cell lines.
PMID: 24966994
 Ref: PTK7 localization and protein stability is affected by canonical Wnt ligands.
PMID: 28420671
Ref: RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway.
PMID: 28600110
 Ref: Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.
PMID: 28560804
Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
PMID: 29786110