Primary Site >> Colorectal Cancer
Gene >> FGF2
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Ref: Characterization of tumors produced by signal peptide-basic fibroblast growth factor-transformed cells. PMID: 2469690 |
Ref: Basic fibroblast growth factor: a potential autocrine regulator of human glioma cell growth. PMID: 1964181 Ref: Growth-regulatory factors for normal, premalignant, and malignant human cells in vitro. PMID: 2404378 |
Ref: Identification of basic fibroblast growth factor sensitivity and receptor and ligand expression in human colon tumor cell lines. PMID: 1310324 |
Ref: Effects of modulation of basic fibroblast growth factor on tumor growth in vivo. PMID: 8418301 |
Ref: Basic fibroblast growth factor increases the multiplication and migration of a serum-free derivative of CACO-2 but does not affect differentiation. PMID: 7923221 |
Ref: Comparison of basic fibroblast growth factor levels in clone A human colon cancer cells in vitro with levels in xenografted tumours. PMID: 7599036 Ref: Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. PMID: 7664263 Ref: Identification of a monoclonal antibody, TV-1, directed against the basement membrane of tumor vessels, and its use to enhance the delivery of macromolecules to tumors after conjugation with interleukin 2. PMID: 7780984 |
Ref: HOXB7 constitutively activates basic fibroblast growth factor in melanomas. PMID: 8756643 Ref: Progressive upregulation of metastasis-related genes in human colon cancer cells implanted into the cecum of nude mice. PMID: 8869966 Ref: Serum basic fibroblast growth factor and vascular endothelial growth factor and tumour growth kinetics in advanced colorectal cancer. PMID: 8922199 Ref: Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A. PMID: 8944008 Ref: A phase I study of pentosan polysulfate sodium in patients with advanced malignancies. PMID: 9006745 Ref: Expression of basic fibroblast growth factor in colorectal carcinoma. PMID: 21544349 |
Ref: Heparin oligosaccharides: inhibitors of the biological activity of bFGF on Caco-2 cells. PMID: 9000592 Ref: Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners. PMID: 9046331 Ref: Invasion of human colorectal carcinoma cells is promoted by endogenous basic fibroblast growth factor. PMID: 9139874 Ref: A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. PMID: 9334727 |
Ref: Involvement of vascular endothelial growth factor and urokinase-type plasminogen activator receptor in microvessel invasion in human colorectal cancers. PMID: 9583734 Ref: Quantitative analysis of basic fibroblast growth factor and vascular endothelial growth factor in human colorectal cancer. PMID: 9743297 Ref: Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. PMID: 9788974 Ref: Involvement of macrophage migration inhibitory factor (MIF) in the mechanism of tumor cell growth. PMID: 9932108 |
Ref: An aggressive desmoid tumor in a patient with familial adenomatous polyposis: immunohistochemical findings. PMID: 10022664 Ref: Increased expression of angiogenic factors in human colonic angiodysplasia. PMID: 10201485 Ref: Coordinated modulation of the fibroblast growth factor dual receptor mechanism during transformation from human colon adenoma to carcinoma. PMID: 10389767 Ref: Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. PMID: 10463618 Ref: Vascular endothelial growth factor overproduced by tumour cells acts predominantly as a potent angiogenic factor contributing to malignant progression. PMID: 10607018 |
Ref: Expression of Von Willebrand factor, an endothelial cell marker, is up-regulated by angiogenesis factors: a potential method for objective assessment of tumor angiogenesis. PMID: 10629090 Ref: Plasma vascular endothelial but not fibroblast growth factor levels correlate with colorectal liver mestastasis vascularity and volume. PMID: 10737380 Ref: Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. PMID: 10999768 |
Ref: Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray. PMID: 11299727 Ref: Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. PMID: 11313939 Ref: Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha. PMID: 11420751 Ref: Cyclooxygenase-2: a novel target for cancer chemotherapy? PMID: 11469677 Ref: Matrilysin stimulates DNA synthesis of cultured vascular endothelial cells and induces angiogenesis in vivo. PMID: 11597792 Ref: Concurrent expression of angiogenic growth factors and neovascularization during tumourigenesis in colorectal carcinoma patients. PMID: 11669335 Ref: [Receptors of selected cytokines and angiokine bFGF in patients with colorectal cancer (a preliminary study)]. PMID: 11852807 |
Ref: Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors. PMID: 11847221 Ref: Tumour markers as early predictors of response to chemotherapy in advanced colorectal carcinoma. PMID: 12196369 Ref: Antiangiogenic effect of octreotide inhibits the growth of human rectal neuroendocrine carcinoma. PMID: 12239460 Ref: Plasma basic fibroblast growth factor levels in colorectal cancer: a clinically useful assay? PMID: 12553380 Ref: Tumour's angiogenesis--the function of VEGF and bFGF in colorectal cancer. PMID: 12898895 |
Ref: Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism. PMID: 12561070 Ref: Expression of platelet-derived endothelial cell growth factor in inflammatory bowel disease. PMID: 12673445 Ref: Circulating angiogenic growth factor levels in mice bearing human tumors using Luminex Multiplex technology. PMID: 12721760 Ref: Pituitary tumor transforming gene and fibroblast growth factor-2 expression: potential prognostic indicators in differentiated thyroid cancer. PMID: 12727994 Ref: Trefoil factors and human gastric cancer (review). PMID: 12792801 Ref: Soluble markers for the detection of hypoxia under antiangiogenic treatment. PMID: 12820365 |
Ref: LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice. PMID: 14593497 Ref: Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. PMID: 15353307 Ref: Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis. PMID: 15844657 |
Ref: Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials. PMID: 15705616 Ref: Effect of thalidomide on colorectal cancer liver metastases in CBA mice. PMID: 16028287 Ref: TSU-68 (SU6668) inhibits local tumor growth and liver metastasis of human colon cancer xenografts via anti-angiogenesis. PMID: 16077974 Ref: Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44. PMID: 16288042 |
Ref: Impact of laparotomy and liver resection on the peritoneal concentrations of fibroblast growth factor 2, vascular endothelial growth factor and hepatocyte growth factor. PMID: 16249905 Ref: FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. PMID: 16465403 Ref: Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases. PMID: 16474912 Ref: The intratumoral microvessel density and expression of bFGF and nm23-H1 in colorectal cancer. PMID: 16554912 Ref: ACTIBIND, an actin-binding fungal T2-RNase with antiangiogenic and anticarcinogenic characteristics. PMID: 16586499 Ref: EGF receptor-related protein (ERRP) inhibits invasion of colon cancer cells and tubule formation by endothelial cells in vitro. PMID: 16619503 Ref: An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. PMID: 16777983 Ref: The emerging role of pituitary tumor transforming gene in tumorigenesis. PMID: 16809406 Ref: Decreased growth rate of lung metastatic lesions after splenectomy in mice. PMID: 16940732 Ref: A recombinant human RNASET2 glycoprotein with antitumorigenic and antiangiogenic characteristics: expression, purification, and characterization. PMID: 17109444 |
Ref: Expression of the REG IV gene in ulcerative colitis. PMID: 17260007 Ref: Angiogenic effect of naive and 5-fluorouracil resistant colon carcinoma on endothelial cells in vitro. PMID: 17686575 |
Ref: [Spheres isolated from Colo205 cell line possess cancer stem-like cells under serum-free culture condition]. PMID: 18250051 Ref: Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. PMID: 18360718 Ref: Heparin--a unique stimulator of human colon cancer cells' growth. PMID: 18421780 Ref: Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion. PMID: 18423981 Ref: Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex). PMID: 18506586 Ref: A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer. PMID: 18549879 |
Ref: Overexpression of the fibroblast growth factor receptor-1 gene correlates with liver metastasis in colorectal cancer. PMID: 19082464 Ref: Resistance to EGF-R (erbB-1) and VEGF-R modulating agents. PMID: 19124237 Ref: Keratinocyte growth factor induces vascular endothelial growth factor-A expression in colorectal cancer cells. PMID: 19148469 Ref: Increased lymphatic vascular density is seen before colorectal cancers reach stage II and growth factor FGF-2 is downregulated in tumor tissue compared with normal mucosa. PMID: 19245594 Ref: Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. PMID: 19328625 Ref: Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase. PMID: 19525225 Ref: Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. PMID: 19652095 Ref: [Cultivation and characterization of tumor spheres generated from human colorectal cancer cell lines]. PMID: 19950614 |
Ref: Mechanism of antitumor effect of a novel bFGF binding peptide on human colon cancer cells. PMID: 20331620 Ref: Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. PMID: 20354121 Ref: An N-, C-terminally truncated basic fibroblast growth factor and LPD (liposome-polycation-DNA) complexes elicits a protective immune response against murine colon carcinoma. PMID: 20543584 |
Ref: A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor. PMID: 21482699 Ref: A novel combined conjugate vaccine: enhanced immunogenicity of bFGF with CRM197 as a carrier protein. PMID: 21720718 Ref: The clinical implications of platelet derived growth factor B, vascular endothelial growth factor and basic fibroblast growth factor in colorectal cancer. PMID: 21766497 Ref: Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma. PMID: 22030865 Ref: Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma. PMID: 22111880 |
Ref: Effects of macrophage metalloelastase on the basic fibroblast growth factor expression and tumor angiogenesis in murine colon cancer. PMID: 21814804 Ref: A phase I trial of PX-12, a small-molecule inhibitor of thioredoxin-1, administered as a 72-hour infusion every 21 days in patients with advanced cancers refractory to standard therapy. PMID: 21863237 Ref: Dab2 is pivotal for endothelial cell migration by mediating VEGF expression in cancer cells. PMID: 22265793 Ref: Biomarkers for antitumor activity of bevacizumab in gastric cancer models. PMID: 22273502 Ref: VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients. PMID: 22402885 Ref: Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. PMID: 22409373 Ref: [Perioperative immunologic changes in colorectal cancer patients]. PMID: 22480118 Ref: Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition. PMID: 22547830 Ref: Prognostic value of tumor growth factor levels during chemotherapy in patients with metastatic colorectal cancer. PMID: 22580817 Ref: Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer. PMID: 22701615 Ref: EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis. PMID: 22925500 Ref: Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. PMID: 22992293 |
Ref: Tumor budding, myofibroblast proliferation, and fibrosis in obstructing colon carcinoma: the roles of Hsp47 and basic fibroblast growth factor. PMID: 23265436 Ref: Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance. PMID: 23726839 Ref: [CD133(+) Colo205 colorectal cancer cells express high levels of ALDH1 in serum-free culture]. PMID: 23803205 Ref: Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1alpha and STAT-3. PMID: 23838996 Ref: Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways. PMID: 23843018 Ref: Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. PMID: 24042330 |
Ref: P7 peptides targeting bFGF sensitize colorectal cancer cells to CPT-11. PMID: 24190390 Ref: Pilot study of angiogenic response to yttrium-90 radioembolization with resin microspheres. PMID: 24360887 Ref: Combined therapeutic effects of vinblastine and Astragalus saponins in human colon cancer cells and tumor xenograft via inhibition of tumor growth and proangiogenic factors. PMID: 24660995 Ref: C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2. PMID: 24758762 Ref: Clinical significance of fibroblast growth factor (FGF) expression in colorectal cancer. PMID: 25216410 |
Ref: c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2alpha and promotes tumor angiogenesis and metastasis by upregulating FGF2. PMID: 24704828 Ref: Chronic exposure of VEGF inhibitors promotes the malignant phenotype of colorectal cancer cells. PMID: 25817288 Ref: Chrysin-organogermanium (IV) complex induced Colo205 cell apoptosis-associated mitochondrial function and anti-angiogenesis. PMID: 25914235 Ref: Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin alphavbeta5-mediated adhesion. PMID: 25973543 Ref: Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line. PMID: 26133168 Ref: Anti-angiogenic and anti-proliferative effects of inhibition of HIF-1alpha by p-HIF-1alpha RNAi in colorectal cancer. PMID: 26339356 |
Ref: Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway. PMID: 26847718 Ref: Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model. PMID: 27133199 Ref: The Antitumor Effect of Gekko Sulfated Glycopeptide by Inhibiting bFGF-Induced Lymphangiogenesis. PMID: 27190997 Ref: MicroRNA-195 suppresses colorectal cancer cells proliferation via targeting FGF2 and regulating Wnt/beta-catenin pathway. PMID: 27904776 |
Ref: Expression of angiogenic growth factors VEGF, bFGF and ANG1 in colon cancer after bevacizumab treatment in vitro: A potential self-regulating mechanism. PMID: 27840995 Ref: Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice. PMID: 28133764 Ref: Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis. PMID: 28193521 Ref: Tanshinone IIA inhibits beta-catenin/VEGF-mediated angiogenesis by targeting TGF-beta1 in normoxic and HIF-1alpha in hypoxic microenvironments in human colorectal cancer. PMID: 28602978 Ref: Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer. PMID: 28749961 Ref: Basic fibroblast growth factor as a potential biomarker for diagnosing malignant tumor metastasis in women. PMID: 28789380 Ref: Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis. PMID: 28826099 Ref: Stabilization of Sur8 via PKCalpha/delta degradation promotes transformation and migration of colorectal cancer cells. PMID: 29383184 |
Ref: IL-8 regulates the doxorubicin resistance of colorectal cancer cells via modulation of multidrug resistance 1 (MDR1). PMID: 29693201 Ref: An improved method for culturing patient-derived colorectal cancer spheroids. PMID: 29774115 Ref: Subsite heterogeneity in the profiles of circulating cytokines in colorectal cancer. PMID: 29801973 Ref: Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis. PMID: 29983872 Ref: Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis. PMID: 30188867 |