Primary Site >> Colorectal Cancer
Gene >> FCGR3A
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Ref: Effect of human blood mononuclear cell populations in antibody dependent cellular cytotoxicity (ADCC) using two murine (CO17-1A and Br55-2) and one chimeric (17-1A) monoclonal antibodies against a human colorectal carcinoma cell line (SW948). PMID: 3198133 Ref: Antibody-mediated killing of human tumor cells by attached effector cells. PMID: 3335025 |
Ref: A phase I clinical trial of recombinant interleukin-2 by periodic 24-hour intravenous infusions. PMID: 2783732 |
Ref: Patterns of human tumor-infiltrating lymphocytes in 120 human cancers. PMID: 1689143 Ref: Effects of radiolabelled monoclonal antibody infusion on blood leukocytes in cancer patients. PMID: 1968968 Ref: Time course of changes in phenotypes of cultured tumor-infiltrating lymphocytes isolated from human colorectal cancer. PMID: 2347471 |
Ref: Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage-mediated antibody dependent cellular cytotoxicity. PMID: 1675219 Ref: Immunological effects of levamisole in vitro. PMID: 1790137 Ref: Factors influencing the establishment of tumour-infiltrating lymphocyte cultures from human breast carcinoma and colon carcinoma tissue. PMID: 1827279 Ref: Immunotherapy with IL2 by constant infusion and weekly doxorubicin. PMID: 1830717 Ref: Modulatory effects of VIP and related peptides from the gastrointestinal tract on cell mediated cytotoxicity against tumour cells in vitro. PMID: 1874558 Ref: Perforin expression in lymphocytes infiltrated to human colorectal cancer. PMID: 1892750 Ref: Changes in leucocyte populations following murine bifunctional antibody infusion in colon cancer patients. PMID: 2025955 Ref: Lymphocytopenia, T-lymphocyte subsets, and colorectal polyps in automotive pattern and model makers. PMID: 2037906 |
Ref: Tumor infiltrating cells in human cancer. On the possible role of CD16+ macrophages in antitumor cytotoxicity. PMID: 1501443 Ref: Immunomodulation by orally administered protein-bound polysaccharide PSK in patients with gastrointestinal cancer. PMID: 1622733 Ref: Clinical trials of intrasplenic arterial infusion of interleukin-2 (IS-IL-2) to patients with advanced cancer. PMID: 1622739 Ref: Cytotoxic functions of blood mononuclear cells in patients with colorectal carcinoma treated with mAb 17-1A and granulocyte/macrophage-colony-stimulating factor. PMID: 1638551 Ref: Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. PMID: 1727781 |
Ref: Low-dose interleukin-2 in combination with interferon-alpha effectively modulates biological response in vivo. PMID: 7683166 Ref: The role of lymphocyte surface binding sites for wheat germ agglutinin in the negative regulation of cancer patients. PMID: 8219608 Ref: Hepatic arterial infusions of interleukin-2-based immunochemotherapy in the treatment of unresectable liver metastases from colorectal cancer. PMID: 8221817 Ref: Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. PMID: 8242612 Ref: Spontaneous cytotoxicity of intestinal intraepithelial lymphocytes: clues to the mechanism. PMID: 8252812 Ref: Study of effect of surgical stress on immunity in patients with gastrointestinal cancer. PMID: 8274052 Ref: Peri-operative modulation of cellular immunity in patients with colorectal cancer. PMID: 8403515 |
Ref: Alteration in lymphocyte phenotype associated with administration of adjuvant levamisole and 5-fluorouracil. PMID: 7515770 Ref: The effect of previous blood transfusion on lymphocyte subsets and natural killer cell function in patients with colorectal cancer. PMID: 7975450 Ref: Interferon-gamma enhances monoclonal antibody 17-1A-dependent neutrophil cytotoxicity toward colorectal carcinoma cell line SW11-16. PMID: 8137553 |
Ref: Generation of lymphokine-activated killer (LAK) cell activity from malignant peritoneal effusions. PMID: 7624448 Ref: Effect of essential fatty acids on natural cytotoxicity in patients with colorectal cancer. PMID: 7781792 Ref: Treatment of heterotransplanted Hodgkin's tumors in SCID mice by a combination of human NK or T cells and bispecific antibodies. PMID: 8581383 |
Ref: Interleukin-12 increases bispecific-antibody-mediated natural killer cell cytotoxicity against human tumors. PMID: 8625370 Ref: Necessity of biotherapeutic treatments inducing TH1 cell functions in colorectal cancer. PMID: 10851498 Ref: Immunological directives for biotherapy improvement in the treatment of colorectal cancer. PMID: 10851527 |
Ref: Dietary supplementation with L-arginine: modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer. PMID: 9052446 Ref: Adverse effects of intraportal chemotherapy on natural killer cell activity in colorectal cancer patients. PMID: 9142191 Ref: Interleukin-2-activated killer cell activity in colorectal tumor patients: evaluation of in vitro effects by prothymosin alpha1. PMID: 9292704 Ref: Prothymosin alpha 1 effects in vitro on chemotaxis, cytotoxicity and oxidative response of neutrophils from melanoma, colorectal and breast tumor patients. PMID: 9568546 Ref: Preclinical studies with prothymosin alpha1 on mononuclear cells from tumor patients. PMID: 9637344 Ref: The sCEA molecule suppressive role in NK and TH1 cell functions in colorectal cancer. PMID: 10851473 Ref: Immunological implications of alterations in the c-Ki-ras and p53 genes in the stepwise progression of colorectal cancer: indications for the improvement of prognosis, biotherapy treatment and tumor biology understanding PMID: 10851492 |
Ref: Inhibitory effects of transforming growth factor-beta (TGF-beta) on certain functions of intraepithelial lymphocytes. PMID: 10193412 Ref: Characterisation of tumour infiltrating lymphocytes and correlations with immunological surface molecules in colorectal cancer. PMID: 10505031 |
Ref: Investigating the role of immunomodulation for colon cancer prevention: results of an in vivo dose escalation trial of levamisole with immunologic endpoints. PMID: 11341354 Ref: Changes in T cell subsets, interleukin-6 and C-reactive protein after laparoscopic and open colorectal resection for malignancy. PMID: 11727135 |
Ref: Cell surface phenotyping and cytokine production of Epstein-Barr Virus (EBV)-transformed lymphoblastoid cell lines (LCLs). PMID: 12191505 |
Ref: [Expression of leucocyte cell-surface antigens on colon cancer cell line HR8348]. PMID: 15067730 Ref: Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. PMID: 15187109 Ref: Tissue detection of natural killer cells in colorectal adenocarcinoma. PMID: 15363095 Ref: Regulation of activities of NK cells and CD4 expression in T cells by human HNP-1, -2, and -3. PMID: 15369771 |
Ref: Overview of monoclonal antibodies and small molecules targeting the epidermal growth factor receptor pathway in colorectal cancer. PMID: 16336752 Ref: Lymphocyte subsets in peripheral blood as prognostic factors in colorectal cancer. PMID: 17343340 |
Ref: Immunomodulation with low dose levamisole in patients with colonic polyps. PMID: 16458451 Ref: Proliferating endothelial cells and leukocyte infiltration as prognostic markers in colorectal cancer. PMID: 17059898 Ref: In vivo migration of labeled autologous natural killer cells to liver metastases in patients with colon carcinoma. PMID: 17105663 |
Ref: Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer. PMID: 18307280 Ref: GRP-induced up-regulation of Hsp72 promotes CD16+/94+ natural killer cell binding to colon cancer cells causing tumor cell cytolysis. PMID: 18350254 Ref: Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients. PMID: 18547033 |
Ref: Expression of GRP and its receptor is associated with improved survival in patients with colon cancer. PMID: 19430935 Ref: [Effect of enterosorption on immunologic parameters of patients with colorectal cancer in the postoperative period]. PMID: 19435203 Ref: CEA in activated macrophages. New diagnostic possibilities for tumor markers in early colorectal cancer. PMID: 19661342 Ref: Humanised IgG1 antibody variants targeting membrane-bound carcinoembryonic antigen by antibody-dependent cellular cytotoxicity and phagocytosis. PMID: 19904275 |
Ref: Molecular predictors of combination targeted therapies (cetuximab, bevacizumab) in irinotecan-refractory colorectal cancer (BOND-2 study). PMID: 21036743 |
Ref: Tumor infiltration by FcgammaRIII (CD16)+ myeloid cells is associated with improved survival in patients with colorectal carcinoma. PMID: 20715106 Ref: The anti-tumoral drug enzastaurin inhibits natural killer cell cytotoxicity via activation of glycogen synthase kinase-3beta. PMID: 20934407 Ref: Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab. PMID: 21788356 Ref: Characterization of the immunological microenvironment of tumour buds and its impact on prognosis in mismatch repair-proficient and -deficient colorectal cancers. PMID: 22034888 Ref: Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer. PMID: 22117530 |
Ref: Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5-fluorouracil-based therapy together with cetuximab-irinotecan. PMID: 22486600 Ref: Prognostic impact of beta-2-microglobulin expression in colorectal cancers stratified by mismatch repair status. PMID: 22859396 Ref: Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer. PMID: 22973451 Ref: The impact of preoperative immunonutrition and other nutrition models on tumor infiltrative lymphocytes in colorectal cancer patients. PMID: 23010614 |
Ref: Properties of monocytes generated from haematopoietic CD34(+) stem cells from bone marrow of colon cancer patients. PMID: 23180014 Ref: A high throughput method for enrichment of natural killer cells and lymphocytes and assessment of in vitro cytotoxicity. PMID: 23680234 |
Ref: KRAS mutation confers resistance to antibody-dependent cellular cytotoxicity of cetuximab against human colorectal cancer cells. PMID: 24136682 Ref: Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy. PMID: 24496456 Ref: GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer. PMID: 24737547 |
Ref: Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+ Colorectal Cancer Cells. PMID: 26566946 Ref: Fc-gamma Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer. PMID: 27179112 Ref: Combination of NK Cells and Cetuximab to Enhance Anti-Tumor Responses in RAS Mutant Metastatic Colorectal Cancer. PMID: 27314237 Ref: Chemotherapy of colorectal liver metastases induces a rapid rise in intermediate blood monocytes which predicts treatment response. PMID: 27471631 Ref: Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage. PMID: 27519478 Ref: Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15. PMID: 27777574 |
Ref: Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer. PMID: 26719303 Ref: Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis. PMID: 27897268 Ref: Monocyte subpopulations study in patients with plaque psoriasis. PMID: 28673565 |
Ref: The influence of FCGR2A and FCGR3A polymorphisms on the survival of patients with recurrent or metastatic squamous cell head and neck cancer treated with cetuximab. PMID: 28719596 Ref: CD16+ Macrophages Mediate Fibrosis in Inflammatory Bowel Disease. PMID: 29304229 Ref: Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer. PMID: 29388200 Ref: Fc-gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer. PMID: 30318772 |