Primary Site >> Colorectal Cancer
Gene >> FAS
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Ref: Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. PMID: 8168998 |
Ref: Antibody-targeted superantigen therapy induces tumor-infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma. PMID: 8566049 Ref: [Detection of apoptosis and expression of Fas antigen in human colorectal cancer]. PMID: 8741687 Ref: Early detachment of colon carcinoma cells during CD95(APO-1/Fas)-mediated apoptosis. I. De-adhesion from hyaluronate by shedding of CD44. PMID: 8769429 |
Ref: The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis. PMID: 9079683 Ref: Apoptosis induced in human colorectal carcinoma by anti-Fas antibody. PMID: 9084855 Ref: Inhibition of the alloantibody response by CD95 ligand. PMID: 9256273 Ref: Trophoblasts express Fas ligand: a proposed mechanism for immune privilege in placenta and maternal invasion. PMID: 9294848 Ref: Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha. PMID: 21533493 |
Ref: Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis. PMID: 9458101 Ref: Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-alpha (TNF-alpha) and/or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2 expression. PMID: 9472684 Ref: Chemosensitivity of solid tumor cells in vitro is related to activation of the CD95 system. PMID: 9533769 Ref: Dexamethasone-mediated protection from drug cytotoxicity: association with p21WAF1/CIP1 protein accumulation? PMID: 9794234 Ref: p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. PMID: 9841917 Ref: Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells. PMID: 10200495 Ref: Anti-Fas antibody-induced apoptosis in human colorectal carcinoma cell lines: role of the p53 gene. PMID: 14646476 |
Ref: Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. PMID: 10075697 Ref: STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs. PMID: 10080945 Ref: Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells. PMID: 10327065 Ref: Fas and Fas ligand expression in tumor cells and in vascular smooth-muscle cells of colonic and renal carcinomas. PMID: 10328232 Ref: Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism. PMID: 10358077 Ref: Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity. PMID: 10360653 Ref: Fas (APO-1, CD95) receptor expression and new options for immunotherapy in childhood medulloblastomas. PMID: 10652626 |
Ref: Ionizing radiation alters Fas antigen ligand at the cell surface and on exfoliated plasma membrane-derived vesicles: implications for apoptosis and intercellular signaling. PMID: 10630977 Ref: Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma. PMID: 10694814 Ref: Labor-associated changes in Fas ligand expression and function in human placenta. PMID: 10709727 Ref: Effect of diet on colonic-programmed cell death: molecular mechanism of action. PMID: 10720760 Ref: Endothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells. PMID: 10738244 Ref: Regulation of FasL by NF-kappaB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells. PMID: 10744679 Ref: Cutting edge: the tumor counterattack hypothesis revisited: colon cancer cells do not induce T cell apoptosis via the Fas (CD95, APO-1) pathway. PMID: 10799856 Ref: Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict. PMID: 10911913 Ref: Characterization of bile salt-induced apoptosis in colon cancer cell lines. PMID: 10945641 Ref: Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis. PMID: 11056003 Ref: Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). PMID: 11077039 Ref: Endothelin receptor blockade potentiates FasL-induced apoptosis in colon carcinoma cells via the protein kinase C-pathway. PMID: 11078419 Ref: Expression and function of death receptors and their natural ligands in the intestine. PMID: 11193573 |
Ref: Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. PMID: 11313933 Ref: Fas ligand upregulation is an early event in colonic carcinogenesis. PMID: 11477113 Ref: TNF and CD95 promote IL-8 gene transactivation via independent elements in colon carcinoma cells. PMID: 11500086 Ref: Soluble Fas antigen in the serum of patients with colon cancer. PMID: 11550026 Ref: Sustained hyposmotic stress induces cell death: apoptosis by defeat. PMID: 11600436 |
Ref: Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand. PMID: 11935314 Ref: PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells. PMID: 12409223 Ref: Transmission of apoptosis in human colorectal tumor cells exposed to capecitabine, Xeloda, is mediated via Fas. PMID: 12481413 Ref: Helicobacter pylori organisms induce expression of activation and apoptotic surface markers on human lymphocytes and AGS cells: a cytofluorimetric evaluation. PMID: 12510791 |
Ref: Prognostic relevance of Fas (APO-1/CD95) ligand in human colorectal cancer. PMID: 12655257 Ref: Co-expression of bfl-1 enhances host response in the herpes simplex virus-thymidine kinase/ganciclovir gene therapy system. PMID: 12670475 Ref: Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines. PMID: 12766908 Ref: Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines. PMID: 12865931 Ref: NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells. PMID: 12934082 Ref: Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo. PMID: 12949796 Ref: Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells. PMID: 14612511 Ref: Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells. PMID: 14615069 |
Ref: Apoptosis induced by oxaliplatin in human colon cancer HCT15 cell line. PMID: 15015600 Ref: [Expression of leucocyte cell-surface antigens on colon cancer cell line HR8348]. PMID: 15067730 Ref: Interferon-gamma and TRAIL in human breast tumor cells. PMID: 15110183 Ref: Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells. PMID: 15150117 Ref: The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites. PMID: 15161716 Ref: The breakdown of apoptotic mechanism in the development and progression of colorectal carcinoma. PMID: 15274324 Ref: Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. PMID: 15480430 |
Ref: Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor. PMID: 15365741 Ref: DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. PMID: 15563452 Ref: Impaired CD95 expression predisposes for recurrence in curatively resected colon carcinoma: clinical evidence for immunoselection and CD95L mediated control of minimal residual disease. PMID: 15831912 Ref: Apoptosis and release of CD44s in bleomycin-treated L132 cells. PMID: 15844216 Ref: Increase in autoantibodies against Fas (CD95) during carcinogenesis in the human colon: a hope for the immunoprevention of cancer? PMID: 15864586 Ref: FAS/FAS ligand ratio: a marker of oxaliplatin-based intrinsic and acquired resistance in advanced colorectal cancer. PMID: 16000573 Ref: beta-Catenin, Nf-kappaB and FAS protein expression are independent events in head and neck cancer: study of their association with clinical parameters. PMID: 16253770 Ref: Addressing the "Fas counterattack" controversy: blocking fas ligand expression suppresses tumor immune evasion of colon cancer in vivo. PMID: 16267003 |
Ref: Multiplex detection of surface molecules on colorectal cancers. PMID: 16485257 |
Ref: Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. PMID: 16917513 |
Ref: Critical role for c-FLIP(L) on Fas resistance in colon carcinoma cell line HT-29. PMID: 18243739 Ref: The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. PMID: 18357397 Ref: Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells. PMID: 18609706 Ref: Antibody targeting of camptothecin-loaded PLGA nanoparticles to tumor cells. PMID: 18627195 |
Ref: Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. PMID: 19054763 Ref: Combining radiotherapy with APO010 in cancer treatment. PMID: 19276268 Ref: A common hereditary single-nucleotide polymorphism in the gene of FAS and colorectal cancer survival. PMID: 19298528 Ref: Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. PMID: 19483104 Ref: Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver. PMID: 19524576 Ref: Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. PMID: 19846903 |
Ref: Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation. PMID: 19798106 Ref: CD95 is cytoprotective for intestinal epithelial cells in colitis. PMID: 20049944 Ref: Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. PMID: 20140201 Ref: Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells. PMID: 20188103 Ref: Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. PMID: 20428773 Ref: Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability. PMID: 20565851 Ref: Tumor promoting effects of CD95 signaling in chemoresistant cells. PMID: 20573240 Ref: CD95 is a key mediator of invasion and accelerated outgrowth of mouse colorectal liver metastases following radiofrequency ablation. PMID: 20832890 Ref: GREEN TEA POLYPHENOLS MEDIATED APOPTOSIS IN INTESTINAL EPITHELIAL CELLS BY A FADD-DEPENDENT PATHWAY. PMID: 21687829 |
Ref: Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways. PMID: 21271215 Ref: New bichalcone analogs as NF-kappaB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis. PMID: 21377368 Ref: Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells. PMID: 21550977 Ref: The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion. PMID: 21760611 Ref: GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation. PMID: 22027835 |
Ref: Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. PMID: 22086925 Ref: Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways. PMID: 22389673 Ref: CD95 signaling in colorectal cancer. PMID: 22498253 Ref: Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the betaGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo. PMID: 22752425 |
Ref: Micropropagation effect on the anti-carcinogenic activitiy of polyphenolics from Mexican oregano (Poliomintha glabrescens Gray) in human colon cancer cells HT-29. PMID: 23435631 Ref: Stabilization of MDA-7/IL-24 for colon cancer therapy. PMID: 23481022 Ref: Epigenetic control of NF-kappaB-dependent FAS gene transcription during progression of myelodysplastic syndromes. PMID: 23604035 Ref: Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. PMID: 24091673 |
Ref: Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-kappaB in vitro and in vivo. PMID: 24968890 Ref: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. PMID: 25482938 |
Ref: Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories. PMID: 25445327 Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: Synthetic Bichalcone TSWU-BR23 Induces Apoptosis of Human Colon Cancer HT-29 Cells by p53-Mediated Mitochondrial Oligomerization of BAX/BAK and Lipid Raft Localization of CD95/FADD. PMID: 26408703 |
Ref: CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage. PMID: 28300842 Ref: Loss of Fas expression and high expression of HLA-E promoting the immune escape of early colorectal cancer cells. PMID: 28521443 Ref: FasR and FasL in colorectal cancer. PMID: 28766682 |
Ref: Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component. PMID: 29073716 Ref: The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway. PMID: 30127519 Ref: Neratinib augments the lethality of [regorafenib + sildenafil]. PMID: 30203445 |