Primary Site >> Stomach Cancer

Gene >> F2RL1

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Ref: Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2.
PMID: 10671485
Ref: Expression of protease activated receptor-2 (PAR-2) in gastric cancer.
PMID: 16425301
Ref: Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation.
PMID: 16816379
Ref: Promoter hypomethylation of protease-activated receptor 2 associated with carcinogenesis in the stomach.
PMID: 17517084
Ref: Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells.
PMID: 21488197
Ref: Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells.
PMID: 22941376
Ref: Biological activity of Helicobacter pylori components in mammalian cells: is it independent of proteinase-activated receptors?
PMID: 23388472
Ref: Proteinase activated-receptors-associated signaling in the control of gastric cancer.
PMID: 25232234
Ref: Mast Cells Density Positive to Tryptase Correlate with Microvascular Density in both Primary Gastric Cancer Tissue and Loco-Regional Lymph Node Metastases from Patients That Have Undergone Radical Surgery.
PMID: 27854307
Ref: Tryptase mast cell density, protease-activated receptor-2 microvascular density, and classical microvascular density evaluation in gastric cancer patients undergoing surgery: possible translational relevance.
PMID: 28491140